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Respiratory 4000 Medicine, -Apr. 000, 2005 1 135 2 14 Key Words : sleep apnea syndrome, management, CPAP, surgical treatment, children sleep disordered breathing SDB SDB sleep apnea-hypopnea syndromesassahs 4 SDB nasal continuous positive airway pressurencpap SDB SAS SDB SDB obstructive sleep apnea-hypopnea syndromeosahssas SDB OSAHS 1 Non-surgical and surgical managements for sleep disordered breathing. 1 Nobuo OHYA, M.D., Ph.D. & Tomoko SAKURAI, M.D., Ph.D.: 0020-0034 9-52; Senior Clinical Researchers, The Seimindo Sleep Lab Systems, Morioka 020-0034, JAPAN 2 Shigeru SAKURAI, M.D., Ph.D.: 3 4 5

2 1 2 OSAHSrisk factor 3 SDB 4 OSAHS 5 OSAHSindependent risk factor 67 8 9 SAS OSAHS ncpap 10 11 ncpap 12 OSAHS 7 13 ncpap 7 4 14 central sleep apneahypopnea syndromecsahs CO2CO2 CO2 kyphoscoliosis COPD 2 CO2 OSAHS REM CO2 Cheyne-Stokes CSR 1 crescendo-decrescendo45 15 CSR 16 CPAP CPAPLVEF Naughton 17 3 CPAP 1212 CPAPLVEF CPAPCSR 18

Respiratory Medicine, Apr. 2005 3 n p 19 0.7l CSR CPAPCSR CSR CSR CPAP CSR UARS OSAHS UARS respiratory effort related arousalsrera ncpap

4 SAS polysomnographypsg SDB PSG SAS bed partner 20 7 4 43cm 21 SDB body mass index28kg/m 2 OSA OSA75 22 500 23 PSG PSG SAS SAS SAS apnea

Respiratory Medicine, Apr. 2005 5 hypopnea indexahi SASAHI 5 14 86 AHI15 308085 AHI3079 24 PSGCPAP PSGSAS SDB 25 AHI2040 8 AHI 5 1CPAP CPAPSAS 1 ncpap CPAP ResMed CPAP 26 PSG PSG 6 CPAP 1 split-night protocol 27 2 8 PSG. CPAP A12 B123 11 40 2 11 20 2 3

6 2004 4 1 26 AHI20 RERACPAP AHI40 CPAP PSG CPAP CPAP 50 2 4 28 29 1 CPAP CPAP nasal pillow 7 4 C-flex Respironics 600

Respiratory Medicine, Apr. 2005 7 ResMed 30 SASCPAP NPPV CSA 2 CPAP CPAP AHICPAP oral applianceoamandibular advancement CPAP CPAP 31 AHI 32 PSG PSG 33 3 34 SAS10 SAS 35 PSG

8 CPAP orthopharyngeal maxillofacial PSG 1 UPPP LAUP RFA UPPP 854050SAS 50 36 80 1 UPPP 2LAUP LAUPOSAHS LAUPUPPP 8090 37 OSAHS4050 38 3RFA RFALAUP 4maxillofacial surgery maxillomandibular advancement surgery 7 4 90 100 39 maxillomandibular advancement surgery 5 CPAP SAS SAS CPAP OSAS ADHD 40

Respiratory Medicine, Apr. 2005 PSG OSASAS OSA 1 75100 CPAP45 OSAQOL 1 CPAP volume reduction CPAP CPAP SDB SAS 9 1Fogel R, Malhotra A, Pillar G, et al. Genioglossal Activation in Patients with Obstructive Sleep Apnea versus Control Subjects. Am J Respir Crit Care Med 2001 ; 164 : 2025. 2acoustic reflection 1997 ; 22 : 415. 3Flemons WW. Clinical practice : obstructive sleep apnea. N Engl J Med 2002 ; 3477: 498. 4Guilleminault C, Stoohs R, Kim YD, et al. Upper airway sleep-disordered breathing in women. Ann Intern Med 1995 ; 1227: 493. 5Kushida CA, Efron B, Guilleminault C, et al. A predictive morphometric model for the obstructive sleep apnea syndrome. Ann Intern Med 1997 ; 127 : 581. 6Peppard PE, Young T, Palta M, et al. Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 2000 ; 34219: 1378. 7Nieto FJ, Young TB, Lind BK, et al. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 2000 ; 28314: 1829. Erratum, JAMA 2002 ; 28816: 1985. 8He J, Kryger MH, Zorick FJ, et al. Mortality and apnea index in obstructive sleep apnea : experience in 385 male patients. Chest 1988 ; 941: 9. 9Mohsenin V. Sleep-related breathing disorders and risk of stroke. Stroke 2001 ; 326: 1271. 10Faccenda JF, Mackay TW, Boon NA, et al. Randomized placebo-controlled trial of continuous positive airway pressure on blood pressure in the sleep apnea-hypopnea syndrome. Am J Respir Crit Care Med 2001 ; 1632: 344. 11Mansfield DR, Gollogly NC, Kaye DM, et al. Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 2004 ; 1693: 361. 12Sandberg O, Franklin KA, Bucht G, et al. Nasal continuous positive airway pressure in stroke patients

10 with sleep apnoea : a randomized treatment study. Eur Respir J 2001 ; 184: 630. 13Teran-Santos J, Jimenez-Gomez A, Cordero- Guevara J. The association between sleep apnea and the risk of traffic accidents. Cooperative Group Burgos-Santander. N Engl J Med 1999 ; 34011: 847. 14George CF. Reduction in motor vehicle collisions following treatment of sleep apnoea with nasal CPAP. Thorax 2001 ; 567: 508. 15Javaheri S, Parker TJ, Wexler L, et al. Occult sleepdisordered breathing in stable congestive heart failure. Ann Intern Med 1995 ; 1227: 487.Erratum, Ann Intern Med 1995 ; 1231: 77. 16 2 1998 ; 35 : 132. 17Naughton MT, Liu PP, Bernard DC, et al. Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure. Am J Respir Crit Care Med 1995 ; 1511: 92. 18CSR In Update 2002. p. 32. 19Sin DD, Logan AG, Fitzgerald FS, et al. Effects of continuous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne-Stokes respiration. Circulation 2000 ; 102 : 61. 20Olson EJ, Moore WR, Morgenthaler TI, et al. Obstructive sleep apnea-hypopnea syndrome. Mayo Clin Proc 2003 ; 7812: 1545. 21Schellenberg JB, Maislin G, Schwab RJ. Physical findings and the risk for obstructive sleep apnea : the importance of oropharyngeal structures. Am J Respir Crit Care Med 2000 ; 1622 Pt 1: 740. 22Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea : a population health perspective. Am J Respir Crit Care Med 2002 ; 1659: 1217. 23 SAS 7 4 2005 ; 22 : 59. 24Flemons WW. Sleep-related breathing disorders in adults : recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999 ; 225: 667. 25He J, Kryger MH, Zorick FJ, et al. Mortality and apnea index in obstructive sleep apnea : experience in 385 male patients. Chest 1988 ; 941: 9. 26C107-2 In 16 4 2004. 27Yamashiro Y, Kryger MH. CPAP titration for sleep apnea using split-night protocol. Chest 1995 ; 107 : 62. 28Zozula R, Rosen R. Compliance with continuous positive airway pressure therapy : assessing and improving treatment outcomes. Curr Opin Pulm Med 2001 ; 76: 391. 29Hoy CJ, Vennelle M, Kingshott RN, et al. Can intensive support improve continuous positive airway pressure use in patients with the sleep apnea/ hypopnea syndrome? Am J Respir Crit Care Med 1999 ; 1594 Pt 1: 1096. 30 ncpap 2003 ; 4152 : 1. 31Randerath WJ, Heise M, Hinz R, et al. An individually adjustable oral appliance vs continuous positive airway pressure in mild-to-moderate obstructive sleep apnea syndrome. Chest 2002 ; 1222: 569. 32Mehta A, Qian J, Petocz P, et al. A randomized, controlled study of a mandibular advancement splint for obstructive sleep apnea. Am J Respir Crit Care Med 2001 ; 1636: 1457. 33Flemons WW. Sleep-related breathing disorders in adults : recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999 ; 225: 667. 34Stoohs RA, Dement WC. Snoring and sleep-related breathing abnormality during partial sleep deprivation. N Engl J Med 1993 ; 32817: 1279.

Respiratory Medicine, Apr. 2005 35Peppard PE, Young T, Palta M, et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA 2000 ; 28423: 3015. 36Sher AE, Schechtman KB, Piccirillo JF. The efficacy of surgical modifications of the upper airway in adults with obstructive sleep apnea syndrome. Sleep 1996 ; 192: 156. 37Coleman JA Jr. Laser-assisted uvulopalatoplasty : long-term results with a treatment for snoring. Ear Nose Throat J 1998 ; 771: 22, 26, 32. 38Mickelson SA, Ahuja A. Short-term objective and long-term subjective results of laser-assisted 11 uvulopalatoplasty for obstructive sleep apnea. Laryngoscope 1999 ; 1093: 362. 39Waite PD, Wooten V, Lachner J, et al. Maxillomandibular advancement surgery in 23 patients with obstructive sleep apnea syndrome. J Oral Maxillofac Surg 1989 ; 4712: 1256 ; discussion 1262. 40American Academy of Pediatrics Subcommittee on Obstructive Sleep Apnea Syndrome, Section on Pediatric Pulmonology. Clinical practice guideline : diagnosis and management of childhood obstructive sleep apnea syndrome. Pediatrics 2002 ; 109 4: 704.