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ACS Circulation Journal Vol. 72, Suppl. IV, 2008 1347

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C ACSacute coronary syndrome STEMIST-elevation myocardial infarction ST PCIpercutaneous coronary intervention CABGcoronary artery bypass grafting CCUcoronary care unit T vulnerable plaque Davies Fuster ACS 23positive remodeling T DeWood 1350 Circulation Journal Vol. 72, Suppl. IV, 2008

T 2 Vulnerable Patient CRP ACS Erosive Thrombosis.. //.. CCU... MONICA // hypokinesis akinesisdyskinesis dp/dt Frank-Starling Circulation Journal Vol. 72, Suppl. IV, 2008 1351

STEMI autopsy HurlerFabry CO DIC STEMI STEMI B B STEMICCU ACC/AHA A chain of survival C chain of survival B STEMICCU STEMI STEMI ventricular fibrillationvf VF automated external defibrillator AED AED 1352 Circulation Journal Vol. 72, Suppl. IV, 2008

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B STEMIMONA B STEMI FAXC a B 1 STEMI..C.I. -. ACC/AHA TIMI flow facilitated PCI TIMI flow primary PCI TIMI flowprimary PCI Step 1.1512 12 2ST Step 2.10 180mmHg 15mmHg 110mmHg 3 6 CPR10 Step 3. 1PCI 100/ < 100mmHg Killip Step 2 1 1354 Circulation Journal Vol. 72, Suppl. IV, 2008

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ACS C ACS C V R B ST.mVST STEMI STEMI Thyperacute T Hyperacute TR STQSTEMI ACS V R V RmmST ST ST STEMI ST ST STV - V ST V -V ST STT ST V -V STQS ST ST avr STPR avrst PR WPWST-T QRS mm ST V -V mmstqrs mmststemi QRS V V V qr STQRS V rrr Yamaji avr STV ST C STEMI 1358 Circulation Journal Vol. 72, Suppl. IV, 2008

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C C C C C C a C b C echo free space diastolic collapse intimal flap C STEMI Killip3 Killip mmhgmmhg SHOCK registry TIMI / simple risk index CADILAC Killip TIMI STEMI 1360 Circulation Journal Vol. 72, Suppl. IV, 2008

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..mg. mg AmgC mg mg STEMI mg mg mg PCI ACT C a tpapro-ukmutant tpa aptt C C PCI ACTactivated clotting time TIMI tpa tpa aapttactivated partial thromboplastin time STEMI A C mmhgc / C C C C PCI 1362 Circulation Journal Vol. 72, Suppl. IV, 2008

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PCI rescue PCI STEMI primary PCIC b primary PCI B primary PCI C a PCI B facilitated PCI PCI facilitated PCI PCI facilitated PCI B a B ac bc rescue PCI PCI A a PCI B STEMI PCI C 1366 Circulation Journal Vol. 72, Suppl. IV, 2008

PCI B PCI B a C C b C a STEMIPCI B STEMIPCI no reflow TIMI PCI B PCI B B STEMI ST A B a STEMI PCI B CABG B CABGC CABG C STEMICABG CABG PCI STEMICABG PCI PCI PCI ST rescue PCI TIMIblushTIMI Circulation Journal Vol. 72, Suppl. IV, 2008 1367

blush ST STEMI C PCI ac tpapro-ukmutant tpa STEMIPCI PCI ACC/AHA U/kg UaPTT.. U/hr ACTaPTT STEMI bb HIT ACS PCI HIT.mg/kg/ / PCI.mg/kg g/kg/actaptt.g/kg/ ACTaPTT A STEMI B STEMI mg/mg/ 1368 Circulation Journal Vol. 72, Suppl. IV, 2008

b/a PCI ab ab STEMIPCI.g/kg/ STEMI J-WIND A STEMIPCI PCI no reflow mg PCI B b PCI B. mg/dl.mg Cigarroa ml kg mm/ mg/dl PCI STEMICCU CCU Day Kansas Bethany Philadelphia Presbyterian Toronto CCU Cardiac Care Unit Circulatory Care Unit Chest Pain Center Circulation Journal Vol. 72, Suppl. IV, 2008 1369

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CCU bc Foley C C A CCU CCU ACC/AHA PCI CCU no reflow A Ab a STEMI. ac C DVTbC DVT C heparin-induced thrombocytopenia HIT C ac bc stunned myocardium Circulation Journal Vol. 72, Suppl. IV, 2008 1371

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mg/ ACC/AHA mmhg B..mg/kg.mg/ kg/hrtorsades de Pointes..mg/kg..mg/kg/hr mg/mg/kg STEMI electrical storm IABP PCl a >.meq/l >.mg/dl CmEq/ g A KMg ph CAST Na STEMI Na C C STEMI implantable cardioverter-defibrillatoricd ICD ICD STEMI> STEMI Circulation Journal Vol. 72, Suppl. IV, 2008 1375

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B pulseless electrical activity STEMI bpm C STEMI C STEMI STEMI bpm.mg. mg/kg mg / kg STEMI Mobitz a.mobitz. QTc b STEMI STEMI Mobitz STEMI amobitz STEMI Mobitz I STEMI Circulation Journal Vol. 72, Suppl. IV, 2008 1377

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NaKMg B BNPnesiritide AANP ACE SAVE TRACE AIRE ARB STEMIARB ACE OPTIMAAL VALIANT IABP B C PCI CABG A PCI CABG B C a Swan-Ganz C PCI CABG B mmhgmmhg ml/ STEMI X Swan-Ganz g/kg/ g/kg/ <g/kg/ >g/kg/ g/kg/ g/kg/ PDE - IABP STEMI PCI CABG SHOCK. vs. 1382 Circulation Journal Vol. 72, Suppl. IV, 2008

. vs..p<. ACE STEMI 11 V R B C C C IABP C C a CABG C STEMI V R mmst Kussmaul 6 / CPAP/ NPPV 35mg IABP >100mmHg 70100mmHg < 70mmHg NTG0.051.0g/kg/ ISDN0.22.0g/kg/ 0.01250.1g/kg/ 13g/kg/ 0.520g/kg/ 0.520g/kg/ 0.030.3g/kg/ ACE ARB PCICABG CPAP NTG NPPV ISDN IABP ACE PCI ARB CABG Circulation Journal Vol. 72, Suppl. IV, 2008 1383

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mg C XCT/MRIMRA C A B a A b C STEMI.. STEMI STEMI STEMI SAVE Killip STEMI STEMI MRIMRA X CT STEMI PCI mg/ mg/ INR STEMI distal protection device 1388 Circulation Journal Vol. 72, Suppl. IV, 2008

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B 8 WPW ASE AHA normokinesis hypokinesisakinesis dyskinesisaneurysm CPK STEMI stunned myocardium B B a I-BMIPP C 1. 2. 3. 4. 5. 6. 7. a 1. 2. 3. 4. b 1. 2. 2. STEMI Tl m Tc- MIBI m Tc-tetrofosmin m Tc Berman uptake uptake m Tc-MIBI Circulation Journal Vol. 72, Suppl. IV, 2008 1391

Tl m Tc Quantitative Gated SPECTQGS QGS I-BMIPP SPECT Tl I-BMIPP m Tc-pyrophosphate peak CK a MRI C MRI C MRI MRI STEMI MRI / thickening radial shortening Late Gadolinium Enhanced LGEMRI LGE LGE-MRI SPECTLGE-MRI / no reflow microvascular obstructionmo MO STEMI MR LGE MO LGE-MRISTEMI Choi LGE. Tl-SPECT LGE-MRISTEMI KitagawaSTEMI LGE-MRI Tl-SPECT LGE-MRI Tl-SPECT a B B 1392 Circulation Journal Vol. 72, Suppl. IV, 2008

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A a BNP B STEMI BBNP STEMI A B B C a C C STEMI CABG PCI STEMI a B b T B STEMI ICD ICD QRS Talternans ICD / C 1396 Circulation Journal Vol. 72, Suppl. IV, 2008

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a A C HbA C.B STEMI B ACS Japan Diabetes Complications StudyJDCS /,.... STEMI UKPDS HbA C HbA C HbA C. BMI B BMI.-.BMI A C B B / C mg/ A mg/ mg/ C mg/ mg/ B a mg/ 1406 Circulation Journal Vol. 72, Suppl. IV, 2008

B mg/ mg/mg/ mg/ B B C C GPb/a ISIS- STEMI mg/ Antithrombotic Trialists CollaborationATC STEMI mg JAMIS STEMImg/ mg/ JMIC-M STEMI ACC/AHA/SCAI FDA * A * B a *STEMI A C STEMI STEMI STEMI ACE Circulation Journal Vol. 72, Suppl. IV, 2008 1407

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PT-INR PCI STEMI A KLIS LISK PATE MEGA JELIS 1410 Circulation Journal Vol. 72, Suppl. IV, 2008

. Rentrop KP, Blanke H, Karsch KR, et al. Acute myocardial infarction: intracoronary application of nitroglycerin and streptokinase. Clin Cardiol ; :. DeWood MA, Spores J, Notske R, et al. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med ; :. Kodama K, Asakura M, Ueda Y, et al. The role of plaque rupture in the development of acute coronary syndrome evaluated by the coronary angioscope. Intern Med ; :. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation ; :. Libby P. Molecular bases of the acute coronary syndromes. Circulation ; : -.. Davies MJ, Thomas AC. Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina. Br Heart J ; :. Fuster V, Badimon L, Badimon JJ, Chesebro JH. The pathogenesis of coronary artery disease and the acute coronary syndromes (). N Engl J Med ; :. Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation ; : -.. ; : -.. Yamagishi M, Terashima M, Awano K, et al. Morphology of vulnerable coronary plaque: insights from follow-up of patients examined by intravascular ultrasound before an acute coronary syndrome. J Am Coll Cardiol ; :. Ueda Y, Ohtani T, Shimizu M, et al. Color of culprit lesion at months after plain old balloon angioplasty versus stenting in patients with acute myocardial infarction. Am Heart J ; :. Libby P. Act local, act global: inflammation and the multiplicity of "vulnerable" coronary plaques. J Am Coll Cardiol ; : -.. Asakura M, Ueda Y, Yamaguchi O, et al. Extensive development of vulnerable plaques as a pan-coronary process in patients with myocardial infarction: an angioscopic study. J Am Coll Cardiol ; : -.. Naghavi M, Libby P, Falk E, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation ; : -.. Zairis MN, Papadaki OA, Manousakis SJ, et al. C-reactive protein and multiple complex coronary artery plaques in patients with primary unstable angina. Atherosclerosis ; :. van der Wal AC, Becker AE, van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation ; : -.. Okumura K, Yasue H, Matsuyama K, et al. Effect of acetylcholine on the highly stenotic coronary artery: difference between the constrictor response of the infarctrelated coronary artery and that of the noninfarct-related artery. J Am Coll Cardiol ; :... CCU CCU CCU ; :.. Kubo M, Kiyohara Y, Kato I, et al. Trends in the incidence, mortality, and survival rate of cardiovascular disease in a Japanese community: the Hisayama study. Stroke ; : -.. ; : -.. Forrester JS, Wyatt HL, Da Luz PL, et al. Functional significance of regional ischemic contraction abnormalities. Circulation ; : -.. White H, Norris R, Brown M, et al. Left ventricualr endsystolic volume as the major determinant of survival after recovery from myocardial infarction. Circulation ; : -.. Pfeffer MA, Braunwald E. Ventricular remodeling after myocardial infarction. Experimental observations and clinical implications. Circulation ; : -.. Pfeffer MA, Lamas GA, Vaughan DE, et al. Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction. N Engl J Med ; : -.. Ceremuzynski L. Hormonal and metabolic reactions evoked by acute myocardial infarction. Circ Res ; :. Cheitlin M, McAllister H, de Castro C. Myocardial infarction without atherosclerosis. JAMA ; :. Pristipino C, Beltrame JF, Finocchiaro ML, et al. Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction. Circulation ; : -.. Bertrand ME, LaBlanche JM, Tilmant PY, et al. Frequency of provoked coronary arterial spasm in consecutive patients undergoing coronary arteriography. Circulation ; Circulation Journal Vol. 72, Suppl. IV, 2008 1411

: -.. CCU CCU ICU CCU ; :. ; : -.. SOS-KANTO Committee: Incidence of ventricular fibrillation in patients with out-of-hospital cardiac arrest in Japan. Survivors after out-of-hospital cardiac arrest in Kanto Area (SOS-KANTO). Circ J ; : -.. American Heart Association (AHA) in collaboration with International Liaison Committee on Resuscitation (ILCOR) : Guidelines for cardio-pulmonary resuscitation and emergency cardiovascular care, An international consensus of science. Circulation ; : I--.. CCU Ther Res ; :. Antman EM, Anbe DT, Armstrong PW, et al : ACC/AHA Guideline for the Management of Patients With ST-Elevation Myocardial Infarction. Circulation ; :. Hedges JR, Feldman HA, Bitner V, et al, for the REACT Study Group. Impact of Community intervention to reduce patient delay time on use of reperfusion therapy for acute myocardial infarction : Rapid Early Action for Coronary Treatment (REACT) trial. Acad Emerg Med ; :. Canto JG, Zalenski RJ, Ornato JP, et al, for the National Registry of Myocardial Infarction Investigators. Use of emergency medical services in acute myocardial infarction and subsequent quality of care : observations from the National Registry of Myocardial Infarction. Circulation ; : -.. Goldberg R, Goff D, Cooper L, et al.age and sex differences in presentation of symptoms among patients with acute coronary disease : the Trial : Rapid Early Action for Coronary Treatment (REACT). Coron Artery Dis ; :. Hutchings CB, Mann NC, Daya M, et al, for the Rapid Early Action for Coronary Treatment Study. Patients with chest pain calling -- or self transporting to reach definitive care: which mode is quicker? Am Heart J ; : -. Cardiopulmonary resuscitation by stander with chest compression only (SOS-KANATO): an observation study: Lancet ; : -.. Iwami T, Kawamura T, Hiraide A, et al. Effectiveness of bystander-initiated cardiac-only resuscitation for patients with out-of-hospital cardiac arrest. Circulation ; : -.. De Luca G, Suryapranata H, Ottervanger JP, Antman EM. Time delay to treatment and mortality in primary angioplasty for acute myocardial infarction: every minute of delay counts. Circulation ; : -.. http//www. fdma. go.jp/neuter/topic/statistics/pdf/h-kyukyu-kyujo.pdf. : -.. Fibrinolytic Therapy Trialists (FTT) Collaborative Group. Indication for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomized trials of more patients. Lancet : :. Gruppo Italiano per lo Studio della Streptochinasi nell Infarto Mioc-ardico (GISSI): Effectiveness intravenous thrombolytic treatment in acute myocardial infarction. Lancet ; :. Armstrong PW, Collen D, Antman E. Fibrinolysis for acute myocardial Infarction: the future is here and now. Circulation : : -.. The American Heart Association in collaboration with the International Liaison Committee on Resuscitation and Emergency Cardiovascular Care; Part : the era of reperfusion: session : acute coronary syndromes (acute myocardial infarction). Circulation ; (Suppl. I): I--I-.. Dussiox P, Reuille O, Verin V, et al. Time savings with prehospital thrombolysis in an urban area Eur J Emerg Med ; : -.. Watanabe K. Nagao K. Watanabe I. Kanmatsuse K. Relationship between the door-to-timi- flow time and the infarct size inpatients suffering from acute myocardial infarction : analysis based on the fibrinolysis and subsequent transluminal (FAST-) trial. Circulation : :. Nakao K, Sawamura T, Katayama N, et al. Facilitated PCI as a medical service sysytem in Japan. J Jpn Coron Assoc ; : -.. Kimura K, Tsukahara K, Usui T, et al. Low-dose Tissue plasminogen activator followed by planned rescue angioplasty reduced time to reperfusion for myocardial infarction treated at community hospitals Jpn Circ J ; :. Moriuchi I, Ohsato K, Murakami T, et al. The comparison of Half-dose and Full-dose mutant tissue-type plasminogen activator for acute myocardial infarction J Jpn Coll Angiol ; :. EBM EBM. Hamm CW, Goldmann BU, Heeschen C, et al. Emergency room triage of patients with acute chest pain by means of rapid testing for cardiac troponin T or troponin I. N Engl J Med ; : -. 1412 Circulation Journal Vol. 72, Suppl. IV, 2008

. Ryan TJ,Anderson JL,Antman EM,et al: ACC/AHA Guideline for the management of patients with acute myocardial infarction: A report ofthe American College of Cardiology/ American Heart Association Task Force on practice guidelines (Committee on management of acute myocardial infarction). J Am Coll Cardiol ; : -.. Ryan TJ, Antman EM, Brooks NH, et al: update: ACC/AHA Guideline for the management of patients with acute myocardial infarction: Executive summary and recommendations: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (Committee on management of acute myocardial infarction). Circulation ; : -.. Herlitz J, Blohman AP, Hartford M, et aldelay time in suspected acute myocardial infarction and the importance of its modification. Clin Cardiol ; :. Nallamothu BK, Bates ER. Percutaneous coronary intervention versus fibrinolytic therapy in acute myocardial infarction: is timing (almost) everything? Am J Cardiol ; :. Kannel WB. Prevalence and clinical aspects of unrecognized myocardial infarction and sudden unexpected death. Circulation ; : II-.. Grimm RH, Jr, Tillinghast S, Daniels K, et al. Unrecognized myocardial infarction: experience in the Multiple Risk Factor Intervention Trial (MRFIT). Circulation ; : II-.. Kosuge M, Kimura K, Ishikawa T, et al. Differences Between Men and Women in Clinical Features of ST-Segment Elevation Acute Myocardial Infarction. Circ J ; :. Patel H, Rosengren A, Ekman I. Symptoms in acute coronary syndromes: does sex make a difference? Am Heart J : ; -.. Maynard C, Litwin PE, Martin JS, Weaver WD. Gender differences in the treatment and outcome of acute myocardial infarction. Results from the Myocardial Infarction Triage and Intervention Registry. Arch Intern Med ; :. Weaver WD, Litwin PE, Martin JS, et al. Effect of age on use of thrombolytic therapy and mortality in acute myocardial infarction. J Am Coll Cardiol ; :. ; :. Killip T rd, Kimball JT. Treatment of myocardial infarction in a coronary care unit. A two year experience with patients. Am J Cardiol ; :. Timmis AD. Early diagnosis of acute myocardial infarction. BMJ ; :. Tsukahara K, Kimura K, Kosuge M, et al. Clinical implications of intermediate QRS prolongation in the absence of bundle-branch block in patients with ST-segment-elevation acute myocardial infarction. Circ J ; : -.. Hirano T, Tsuchiya K, Nishigaki K, et al. Clinical features of emergency electrocardiography in patients with acute myocardial infarction caused by left main trunk obstruction. Circ J ; :. Hochrein J, Sun F, Pieper KS, et al. Higher T-wave amplitude associated with better prognosis in patients receiving thrombolytic therapy for acute myocardial infarction (a GUSTO-I substudy). Am J Cardiol ; : -.. Braat SH, Brugada P, de Zwaan C, et al. Value of electrocardiogram in diagnosing right ventricular involvement in patients with an acute inferior wall myocardial infarction. Br Heart J ; :. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than patients. Fibrinolytic Therapy Trialists (FTT) Collaborative Group. Lancet ; :. The TIMI IIIB Trial Group. Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-q-wave myocardial infarction. Circulation ; : -.. Rude RE, Poole WK, Muller JE, et al. Electrocardiographic and clinical criteria forrecognition of acute myocardial infarction based on analysis of, patients.am J Cardiol ; :. Weaver WD, Eisenberg MS, Martin JS, et al. Myocardial Infarction Triage and Intervention Project-phase I: patient characteristics and feasibility of prehospital Initiation of thrombolytic therapy. J Am Coll Cardiol ; :. Karlson BW, Herlitz J, Wiklund O, et al. Early prediction of acute myocardial infarction from clinical history, examination and electrocardiogram in the emergency room. Am J Cardiol ; :. Fisch C. The clinical electrocardiogram: sensitivity and specificity. ACC Current Journal Review ; : -.. Wang K, Asinger RW, Marriott HJ. ST-segment elevation in conditions other than acute myocardial infarction. N Engl J Med ; : -.. Sgarbossa EB, Pinski SL, Barbagelata A, et al. Electrocardiographic diagnosis of evolving acute myocardial infarction in the presence of left bundle-branch block. GUSTO- (Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries) Investigators. N Engl J Med ; :. ; : -.. Yamaji H, Iwasaki K, Kusachi S, et al. Prediction of acute left main coronary artery obstruction by -lead Circulation Journal Vol. 72, Suppl. IV, 2008 1413

electrocardiography. ST segment elevation in lead avr with less ST segment elevation in lead V(). J Am Coll Cardiol ; : -.. Barron HV, Harr SD, Radford MJ, et al. The association between white blood cell count and acute myocardial infarction mortality in patients > years of age: findings from the cooperative cardiovascular project. J Am Coll Cardiol ; : -.. Kojima S, Sakamoto T, Ishihara M, et al. Japanese Acute Coronary Syndrome Study (JACSS) investigators. The white blood cell count is an independent predictor of no-reflow and mortality following acute myocardial infarction in the coronary interventional era. Ann Med ; :. Wahab NN, Cowden EA, Pearce NJ, et al. ICONS Investigators. Is blood glucose an independent predictor of mortality in acute myocardial infarction in the thrombolytic era? J Am Coll Cardiol ; : -.. Iwakura K, Ito H, Ikushima M, et al. Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol ; : -.. Kosuge M, Kimura K, Kojima S, et al. Japanese Acute Coronary Syndrome Study (JACSS) Investigators. Effects of glucose abnormalities on in-hospital outcome after coronary intervention for acute myocardial infarction. Circ J ; :. Katus HA, Remppis A, Looser S, et al. Enzyme linked immuno assay of cardiac troponin T for the detection of acute myocardial infarction in patients. J Mol Cell Cardiol ; : -.. Ahumada G, Roberts R, Sobel BE. Evaluation of myocardial infarction with enzymatic indices. Prog Cardiovasc Dis ; :. Lee TH, Goldman L. Serum enzyme assays in the diagnosis of acute myocardial infarction. Recommendations based on a quantitative analysis. Ann Intern Med ; :. Halkin A, Stone GW, Grines CL, et al. Prognostic implications of creatine kinase elevation after primary percutaneous coronary intervention for acute myocardial infarction. J Am Coll Cardiol ; :. Tanaka K, Seino Y, Ohbayashi K, Takano T. Cardiac emergency triage and therapeutic decisions using whole blood rapid troponin T test for patients with suspicious acute coronary syndrome. Jpn Circ J ; :. Antman E, Bassand J, Klein W, et al. Myocardial infarction redefined- a consensus document of The joint European Society of Cardiology/ American College of Cardiology committee for the redefinition of myocardial infarction : The Joint European Society of Cardiology/ American Collage of Cardiology CommitteeJ Am Coll Cardiol ; ;. Antman EM, Tanasijevic MJ, Thompson B, et al. Cardiacspecific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med ; : -.. Antman EM, Sacks DB, Rifai N, et al. Time to positivity of a rapid bedside assay for cardiac-specific troponin T predicts prognosis in acute coronary syndromes: a Thrombolysis in Myocardial Infarction (TIMI) A substudy. J Am Coll Cardiol ; :. Ohman EM, Armstrong PW, Christenson RH, et al. Cardiac troponin T levels for risk stratification in acute myocardial ischemia. GUSTO IIA Investigators. N Engl J Med ; : -.. Lindahl B, Venge P, Wallentin L. Relation between troponin T and the risk of subsequent cardiac events in unstable coronary artery disease. The FRISC study group.circulation ; : -.. Hamm CW, Heeschen C, Goldmann B, et al. Benefit of abciximab in patients with refractory unstable angina in relation to serum troponin T levels. ce Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) Study Investigators. N Engl J Med ; : -.. Seino Y, Ogata K, Takano T, et al. Use of a whole blood rapid panel test for heart-type fatty acid-binding protein in patients with acute chest pain: comparison with rapid troponin T and myoglobin tests. Am J Med ; :.. Kontos MC, Arrowood JA, Paulsen WH, Nixon JV. Early echocardiography can predict cardiac events in emergency department patients with chest pain. Ann Emerg Med ; :. Autore C, Agati L, Piccininno M,et al. Role of echocardiography in acute chest pain syndrome. Am J Cardiol ; : G-G.. Lee KL, Woodlief LH, Topol EJ, et al. Predictors of -day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of, patients. GUSTO- Investigators. Circulation ; : -.. Mehilli J, Kastrati A, Dirschinger J, et al. Sex-based analysis of outcome in patients with acute myocardial infarction treated predominantly with percutaneous coronary intervention. JAMA ; :. Kosuge M, Kimura K, Kojima S, et al. on behalf of the Japanese Acute Coronary Syndrome Study (JACSS) Investigators. Sex differences in early mortality of patients undergoing primary stenting for acute myocardial infarction. Circ J ; :. Mehta RH, O neill WW, Harjai KJ, et al. Primary Angioplasty in Myocardial Infarction (PAMI) and the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) Investigators. 1414 Circulation Journal Vol. 72, Suppl. IV, 2008

Prediction of one-year mortality among -day survivors after primary percutaneous coronary interventions. Am J Cardiol ; :. Jeger RV, Harkness SM, Ramanathan K, et al. SHOCK Investigators. Emergency revascularization in patients with cardiogenic shock on admission: a report from the SHOCK trial and registry. Eur Heart J ; :. Hochman JS, Sleeper LA, White HD et al. for the Should We Emergency Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) Investigators. One-year survival followihg early revascularizaton for cardiogenic shock. JAMA ; :. Hochman JS, Sleeper LA, Webb JG, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. N Engl J Med ; :. Morrow DA, Antman EM, Charlesworth A, et al. TIMI risk score for ST-elevation myocardial infarction: A convenient, bedside, clinical score for risk assessment at presentation: An intravenous npa for treatment of infarcting myocardium early II trial substudy. Circulation ; : -.. Morrow DA, Antman EM, Giugliano RP, et al. A simple risk index for rapid initial triage of patients with ST-elevation myocardial infarction: an InTIME II substudy. Lancet ; : -.. Halkin A, Singh M, Nikolsky E, et al. Prediction of mortality after primary percutaneous coronary intervention for acute myocardial infarction: the CADILLAC risk score. J Am Coll Cardiol ; : -.. Maroko PR, Radvany P, Braunwald E, Hale SL. Reduction of infarct size by oxygenin halation follwing acute coronary occlusion. Circulation ; :. Fillmore SJ, Shapiro M, Killip T. Arterial oxygen tension in acute myocardial infarction. Serial analysis of clinical state and blood gas changes. Am Heart J ; :. Bussmann WD, Passek D, Seidel W, Kaltenbach M. Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin. Circulation ; :. GISSI-: effects of lisinopril and transdermal glyceryl trinitrate singly and together on -week mortality and ventricular function after acute myocardial infarction. Gruppo Italiano per lo Studio della Sopravvivenza nell'infarto Miocardico. Lancet ; : -.. ISIS-: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in, patients with suspected acute myocardial infarction. ISIS- (Fourth International Study of Infarct Survival) Collaborative Group. Lancet ; :. Cheitlin MD, Hutter AM Jr, Brindis RG, et al. Use of Sildenafil (Viagra) in patients with cardiovascular disease. J Am Coll Cardiol ; :. ISIS- Collaborative Group. Randomized trial of intravenous strept-okinase, oral aspirin, both or neither among, cases of suspected myocardial infarction. N Engl J Med ; : -.. ISIS- (Second International Study of Infarct Survival) Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among, cases of suspected acute myocardial infarction: ISIS-. Lancet ; :. Freimark D, Matetzky S, Leor J, et al. Timing of aspirin administration as a determinant of survival of patients with acute myocardial infarction treated with thrombolysis. Am J Cardiol ; :. Barbash IM, Freimark D, Gottlieb S, et al. Israeli working group on intensive cardiac care, Israel heart society. Outcome of myocardial infarction in patients treated with aspirin is enhanced by pre-hospital administration. Cardiology ; :. Fuster V, Dyken ML, Vokonas PS, et al. Aspirin as a therapeutic agent in cardiovascular disease. Special Writing Group. Circulation ; :. Becker RC. Antiplatelet therapy in coronary heart disease: emerging strategies for the treatment and prevention of acute myocardial infarction. Arch Pathlo Lab Med ; : -.. Juul-Moller S, Edvardsson N, Jahnmatz B, et al. Doubleblind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. The Swedish Angina Pectoris Aspirin Trial (SAPAT) Group. Lancet ; : -.. Yasue H, Ogawa H, Tanaka H, et al. on behalf of the Japanese Antiplatelets Myocardial Infarction Study (JAMIS) Investigators: Effects of aspirin and trapidil on cardiovascular events after acute myocardial infarction. Am J Cardiol ; : -.. MacMahon S, Collins R, Knight C, et al. Reduction in major morbidity and mortality by heparin in acute myocardial infarction. Circulation ; : II-.. Verheugt FW, Liem A, Zijlstra F, et al. High dose bolus heparin as initial therapy before primary angioplasty for acute myocardial infarction: results of the Heparin in Early Patency (HEAP) pilot study. J Am Coll Cardiol ; :. de Bono DP, Simoons ML, Tijssen J, et al. Effect of early intravenous heparin on coronary patency, infarct size, and bleeding complications after alteplase thrombolysis: results of a randomised double blind European Cooperative Study Group trial. Br Heart J ; :. Bleich SD, Nichols TC, Schumacher RR, et al. Effect of heparin on coronary arterial patency after thrombolysis with tissue plasminogen activator in acute myocardial infarction. Am J Cardiol ; : -.. ISIS- (First International Study of Infarct Survival) Circulation Journal Vol. 72, Suppl. IV, 2008 1415

Collaborative Group. Randomized trial of intravenous atenolol among, cases of suspected acute myocardial infarction. Lancet ; : -. The BHAT Research Group. A randomized trial of propranolol in patients with acute myocardial infarction: I. mortality results. JAMA ; : -.. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction (NMS). N Engl J Med ; :. Beta-Blocker Heart Attack Study Group. The beta-blocker heart attack trial. JAMA ; : -.. Freemantle N, Cleland J, Young P, et al. beta Blockade after myocardial infarction: Systematic review and meta regression analysis. BMJ ; : -.. Roberts R, Rogers WJ, Mueller HS, et al. Immediate versus deferred beta-blockade following thrombolytic therapy in patients with acute myocardial infarction: Results of the thrombolysis in myocardial infarction (TIMI) II-B study. Circulation ; :. Kernis SJ, Harjai KJ, Stone GW, et al. Does beta-blocker therapy improve clinical outcomes of acute myocardial infarction after successful primary angioplasty? J Am Coll Cardiol ; : -. Halkin A, Grines CL, Cox DA, et al. Impact of intravenous beta-blockade before primary angioplasty on survival in patients undergoing mechanical reperfusion therapy for acute myocardial infarction. J Am Coll Cardiol ; : -.. Anderson HR, Neilsen TT, Rasmussen K, et al. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med ; :. Grine CL, Westerhausen DR, Jr, Grine LL, et al. A randomized trial for transfer for primary angioplasty versus on-site thrombolysis in patients with high risk myocardial infarction: the Air primary angioplasty in myocardial infaction study. J Am Coll Cardiol ; : -.. Widimsky P, Groch L, Zerizko M, et al. Multicenter randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. Eur Heart J ; :. Vermeer F, Oude Ophuis AJ, Van de Berg EJ, et al. Prospective randomized comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and fieasibility study. Heart ; :. Windimsky P, Budesinsky T, Vorac D, et al. Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction. Final results of randomized national multicenter trial-prague-. Eur Heart J ; : -.. Bonnefoy E, Lapostolle F, Leizorovicz A, et al., for the Comparison of Angioplasty and Prehospital Thrombolysis in Acute Myocardial Infarction study group. Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study. Lancet ; :. Steg PG, Bonnefoy E, Chabaud S, et al. Impact of time to treatment on mortality after prehospital fibrinolysis or primary angioplasty: data from the CAPTIM randomized clinical trial. Circulation ; : -.. Widimsky P, Budesinsky T, Vorac D, et al. Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction: final results of the randomized national multicentre trial: PRAGUE-. Eur Heart J ; : -.. Antman EM. General hospital management. In: Julian DG, Braunwald E, eds. Management of acute myocardial infarction. London, England: WB Saunders ; -.. Lincoff AM, Califf RM, Van de Werf F, et al., for the Global Use of Strategies To Open Coronary Arteries (GUSTO) Investigators. Mortality at year with combination platelet glycoprotein IIb/IIIa inhibition and reduced-dose fibrinolytic therapy vs conventional fibrinolytic therapy for acute myocard ial infarction: GUSTO V randomized trial. JAMA ; : -.. Zijlstra F, Beukema WP, van t Hof AW, et al. Randomized comparison of primary coronary angioplasty with thrombolytic therapy in low risk patients with acute myocardial infarction. J Am Coll Cardiol ; :. Grinfield L, Berrocal D, Bellardi J, et al. Fibrinolytics versus primary angioplasty in acute myocardial infarction (FAP): a randomized trial in a community hospital in Argentina. J Am Coll Cardiol ; : A.. Zijlstra F, de Boer MJ, Hoorntje JC, et al. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med ; :. Widimsky P, Groch L, Zelizko M, et al. Multicentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory: the PRAGUE study. Eur Heart J ; :. de Boer MJ, Ottervanger JP, van t Hof AW, et al., for the Zwolle Myocardial Infarction Study Group. Reperfusion therapy in elderly patients with acute myocardial infarction: a randomized comparison of primary angioplasty and thrombolytic therapy. J Am Coll Cardiol ; : -.. Akhras F, Ousa AA, Swann G, et al. Primary coronary angioplasty or intravenous thrombolysis for patients with acute myocardial infarction? Acute and late follow-up results 1416 Circulation Journal Vol. 72, Suppl. IV, 2008

in a new cardiac unit. J Am Coll Cardiol ; : A-A.. Grines CL, Browne KF, Marco J, et al., for the Primary Angioplasty in Myocardial Infarction Study Group. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. N Engl J Med ; :. Ribichini F, Steffenino G, Dellavalle A, et al. Comparison of thrombolytic therapy and primary coronary angioplasty with liberal stenting for inferior myocardial infarction with precordial ST-segment depression: immediate and long-term results of a randomized study. J Am Coll Cardiol ; : -.. Garcia E, Elizaga J, Perez-Castellano N, et al. Primary angioplasty versus systemic thrombolysis in anterior myocardial infarction. J Am Coll Cardiol ; :. The Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes (GUSTO IIb) Angioplasty Substudy Investigators. A clinical trial comparing primary coronary angioplasty with tissue plasminogen activator for acute myocardial infarction. N Engl J Med ; : -.. Le May MR, Labinaz M, Davies RF, et al. Stenting versus thrombolysis in acute myocardial infarction trial (STAT). J Am Coll Cardiol ; :. Schomig A, Kastrati A, Dirschinger J, et al., for the Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction Study Investigators. Coronary stenting plus platelet glycoprotein IIb/IIIa blockade compared with tissue plasminogen activator in acute myocardial infarction. N Engl J Med ; :. Vermeer F, Oude Ophuis AJ, vd Berg EJ, et al. Prospective randomised comparison between thrombolysis, rescue PTCA, and primary PTCA in patients with extensive myocardial infarction admitted to a hospital without PTCA facilities: a safety and feasibility study. Heart ; :. Kastrati A, Mehilli J, Dirschinger J, et al., for the Stent versus Thrombolysis for Occluded Coronary Arteries in Patients with Acute Myocardial Infarction (STOPAMI-) Study. Myocardial salvage after coronary stenting plus abciximab versus fibrinolysis plus abciximab in patients with acute myocardial infarction: a randomised trial. Lancet ; :. Aversano T, Aversano LT, Passamani E, et al. Thrombolytic therapy vs primary percutaneous coronary intervention for myocardial infarction in patients presenting to hospitals without on-site cardiac surgery: a randomized controlled trial. JAMA ; : -.. Grines CL, Westerhausen DR, Jr, Grines LL, et al. A randomized trial of transfer for primary angioplasty versus on-site thrombolysis in patients with high-risk myocardial infarction: the Air Primary Angioplasty in Myocardial Infarction study. J Am Coll Cardiol ; : -.. Andersen HR, Nielsen TT, Rasmussen K, et al., for the DANAMI- Investigators. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction. N Engl J Med ; :. Ribeiro EE, Silva LA, Carneiro R, et al. Randomized trial of direct coronary angioplasty versus intravenous streptokinase in acute myocardial infarction. J Am Coll Cardiol ; :. Gibbons RJ, Holmes DR, Reeder GS, et al., for the Mayo Coronary Care Unit and Catheterization Laboratory Groups. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. N Engl J Med ; :. Mori T, Nosaka H, Kimura T, et al. Long-term follow-up of patients treated with intracoronary thrombolysis or percutaneous transluminal coronary angioplasty for acute myocardial infarction. J Cardiol ; :. Keeley EC, Boura JA, Grines CL. Primary angioplasty versus intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review of randomised trials. Lancet ; : -.. Cragg DR, Friedman HZ, Bonema JD, et al. Outcome of patients with acute myocardial infarction who are ineligible for thrombolytic therapy. Ann Intern Med ; :. Brodie BR, Weintraub RA, Stuckey TD, et al. Outcomes of direct coronary angioplasty for acute myocardial infarction in candidates and non-candidates for thrombolytic therapy. Am J Cardiol ; : -.. Himbert D, Juliard JM, Steg PG, et al. Primary coronary angioplasty for acute myocardial infarction with contraindication to thrombolysis. Am J Cardiol ; :. Zahn R, Schuster S, Schiele R, et al., for the Maximal Individual Therapy in Acute Myocardial Infarction (MITRA) Study Group. Comparison of primary angioplasty with conservative therapy in patients with acute myocardial infarction and contraindications for thrombolytic therapy. Cathet Cardiovasc Interv ; :. Grzybowski M, Clements EA, Parsons L, et al. Mortality benefit of immediate revascularization of acute ST-segment elevation myocardial infarction in patients with contraindications to thrombolytic therapy: a propensity analysis. JAMA ; : -.. Lotfi M, Mackie K, Dzavik V, et al. Impact of delays to cardiac surgery after failed angioplasty and stenting. J Am Coll Cardiol ; :. Ellis SG, Armstrong P, Betriu A, et al. Facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention: design and rationale of the Facilitated Intervention with Enhanced Reperfusion Speed Circulation Journal Vol. 72, Suppl. IV, 2008 1417

to Stop Events (FINESSE) trial. Am Heart J ; : E.. The TIMI Research Group. Immediate vs delayed catheterization and angioplasty following thrombolytic therapy for acute myocardial infarction: TIMI II A results. JAMA ; : -.. Topol EJ, Califf RM, George BS, et al. A randomized trial of immediate versus delayed elective angioplasty after intravenous tissue plasminogen activator in acute myocardial infarction. N Engl J Med ; :. Sadanandan S, Buller C, Menon V, et al. The late open artery hypothesis: a decade later. Am Heart J ; :. Dzavik V, Sleeper LA, Cocke TP, et al., for the SHOCK Investigators. Early revascularization is associated with improved survival in elderly patients with acute myocardial infarction complicated by cardiogenic shock: a report from the SHOCK Trial Registry. Eur Heart J ; :. Dauerman HL, Goldberg RJ, Malinski M, et al. Outcomes and early revascularization for patients greater than or equal to years of age with cardiogenic shock. Am J Cardiol ; :. Dauerman HL, Ryan TJ, Piper WD, et al. Outcomes of percutaneous coronary intervention among elderly patients in cardiogenic shock: a multicenter, decade-long experience. J Invasive Cardiol ; :. Simoons ML, Arnold AE, Betriu A, et al. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty. Lancet ; :. Ross AM, Coyne KS, Reiner JS, et al., for the PACT (Plasminogen-activator Angioplasty Compatibility Trial). Investigators: A randomized trial comparing primary angioplasty with a strategy of short-acting thrombolysis and immediate planned rescue angioplasty in acute myocardial infarction: the PACT trial. J Am Coll Cardiol ; : -.. Montalescot G, Barragan P, Wittenberg O, et al., for the ADMIRAL (Abciximab before Direct Angioplasty and Stenting in Myocardial Infarction Regarding Acute and Long- Term Follow-up) Investigators. Platelet glycoprotein IIb/IIIa inhibition with coronary stenting for acute myocardial infarction. N Engl J Med ; : -.. Zeymer U, Uebis R, Vogt A, et al., for the ALKK-Study Group. Randomized comparison of percutaneous transluminal coronary angioplasty and medical therapy in stable survivors of acute myocardial infarction with single-vessel disease: a study of the Arbeitsgemeinschaft Leitende Kardiologische Krankenhausarzte. Circulation ; : -.. Scheller B, Hennen B, Hammer B, et al., for the SIAM III Study Group. Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction. J Am Coll Cardiol ; :. Stenestrand U, Wallentin L. Early revascularisation and -year survival in -day survivors of acute myocardial infarction: a prospective cohort study Lancet ; : -.. Gupta M, Chang WC, Van de Werf F, et al., for the ASSENT II Investigators. International differences in inhospital revascularization and outcomes following acute myocardial infarction: a multilevel analysis of patients in ASSENT-. Eur Heart J ; : -.. Gibson CM, Karha J, Murphy SA, et al., for the TIMI Study Groupe. Early and long-term clinical outcomes associated with reinfarction following fibrinolytic administration in the Thrombolysis in Myocardial Infarction trials. J Am Coll Cardiol ; : -.. Fernandez-Aviles F, Alonso JJ, Castro-Beiras A, et al. Routine invasive strategy within hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA-): a randomised controlled trial. Lancet ; : -.. Svilaas T, Vlaar PJ, van der Horst IC, et al. Thrombus aspiration during primary percutaneous coronary intervention. N Engl J Med ; :. Ikari Y, Sakurada M, Kozuma K, et al., for the VAMPIRE Investigators. Upfront Thrombus Aspiration in Primary Coronary Intervention for Patients With ST-Segment Elevation Acute Myocardial Infarction: Report of the VAMPIRE (VAcuuM aspiration thrombus REmoval) Trial. J Am Coll Cardiol Intv ; :. AMI ; :. ; :. AMI CABGCoronary ; :. AMI ; :. ; :. White HD, Assmann SF, Sanborn TA, et al. Comparison of percutaneous coronary intervention and coronary artery bypass grafting after acute myocardial infarctions complicated by cardiogenic shock: results from the Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock (SHOCK) trial. Circulation ; : -.. Gibson CM, Cannon CP, Murphy SA, et al. Relationship of TIMI myocardial perfusion grade to mortality after administration of thrombolytic drugs. Circulation ; : 1418 Circulation Journal Vol. 72, Suppl. IV, 2008