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ひろじもちやま
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1 Parkin Parkin C RING IBR in-between-ring fingers RBR RING-IBR-RING Parkin E Parkin E Parkin RBR Parkin Parkin E E E E E ATP C E How E activity of Parkin is enhanced by damaged mitochondria Fumika Koyano and Noriyuki Matsuda Protein Metabolism Project and Laboratory of Protein Metabolism, Tokyo Metropolitan Institute of Medical Science, Kamikitazawa, Setagaya-ku, Tokyo, Japan E E E C - K - K - LUBAC linear ubiquitin chain assembly complex E N E E E E E RING RING E HECT HECT E U-box U-box E RING E RING E RING E - discharge RING E RING RING E E - E - U-box E pp.

2 RING E Ub E E E HECT E E HECT HECT E E E E RBR RBR E Parkin PARKIN PD PARKIN PARKIN PD PARKIN PARKIN PD Parkin N Ubiquitin-like domainc RING IBR in-between- RING fingers RBR RING-IBR-RING Parkin E Parkin RING E Parkin Parkin E Parkin E N Parkin E Parkin E NIH Richard Youle Parkin Parkin Parkin

3 Youle PINK Parkin Parkin PD PINK PINK PINK Youle PINK Youle PINK Parkin PINK PINK Parkin Parkin Ser PINK Parkin Parkin E Parkin Mitofusin VDAC Miro ATP PINK Parkin Parkin E RING E Parkin E Parkin E Youle Parkin E Parkin E Parkin Parkin PINK Parkin PINK Parkin PINK Parkin

Parkin E Parkin E Parkin Parkin E Parkin Rachel Klevit Nature HHARI human homolog of Drosophila ariadne Parkin RING-IBR-RING E HHARI RING Cys Klevit RING-IBR-RING HHARI E RING HECT Klevit E RING HECT

4 Parkin E Parkin E Parkin Parkin E Parkin Rachel Klevit Nature HHARI human homolog of Drosophila ariadne Parkin RING-IBR-RING E HHARI RING Cys Klevit RING-IBR-RING HHARI E RING HECT Klevit E RING HECT hybrids Klevit Parkin RING HECT E Parkin RBR E HOIP haem-oxidized IRP ubiquitin ligase- HOIL- interacting protein RBR E RING E HECT E E E Parkin Parkin HHARI Cys Parkin Cys CS CCCP m- Parkin CS CCCP Parkin CS Mfn CS Cys RBR E Ub E RBR E RING RBR E RING

5 dead-end C Cys Parkin CS PINK Youle Tony Hunter Jennifer Johnston Parkin Cys Parkin E E Parkin RING Cys transthiolation Cys Parkin RING E RING HECT hybrid E Parkin Cys Parkin Parkin Cys Parkin Parkin Parkin Parkin N Ubl RING unique Parkin domain UPD RINGIBR REP repressor element of ParkinRING REP RING REP RING RING Cys RING A Parkin Parkin E Parkin Parkin RING RING Cys RINGREP BWeb Cys Parkin E REP RING AT W A RING RING FY Parkin Parkin Cys Parkin RING RING RING REP RING REP RING RING Parkin Parkin PINK PINK Parkin Parkin PINK PINK Parkin N Ubl Parkin PINK Parkin PINK Parkin

Parkin A B B 18 PDB# 4K95 Youle Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., Shimizu, N.Nature,,. Shimura, H., Hattori, N., Kubo, S.

,,. Narendra, D., Tanaka, A., Suen, D.F., Youle, R.J.J. Cell Biol.,,. Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C.A., Sou, Y.S., Saiki, S., Kawajiri, S., Sato, F., Kimura, M.

6 Parkin A B B 18 PDB# 4K95 Youle Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., Shimizu, N.Nature,,. Shimura, H., Hattori, N., Kubo, S., Mizuno, Y., Asakawa, S., Minoshima, S., Shimizu, N., Iwai, K., Chiba, T., Tanaka, K., Suzuki, T.Nat. Genet.,,. Matsuda, N., Kitami, T., Suzuki, T., Mizuno, Y., Hattori, N., Tanaka, K.J. Biol. Chem.,,. Narendra, D., Tanaka, A., Suen, D.F., Youle, R.J.J. Cell Biol.,,. Matsuda, N., Sato, S., Shiba, K., Okatsu, K., Saisho, K., Gautier, C.A., Sou, Y.S., Saiki, S., Kawajiri, S., Sato, F., Kimura, M., Komatsu, M., Hattori, N., Tanaka, K. J. Cell Biol.,,. Narendra, D.P., Jin, S.M., Tanaka, A., Suen, D.F., Gautier, C. A., Shen, J., Cookson, M.R., Youle, R.J.PLoS Biol.,, e. Yamano, K. Youle, R.J.Autophagy,,. Okatsu, K., Oka, T., Iguchi, M., Imamura, K., Kosako, H., Tani, N., Kimura, M., Go, E., Koyano, F., Funayama, M., Shiba-Fukushima, K., Sato, S., Shimizu, H., Fukunaga, Y., Taniguchi, H., Komatsu, M., Hattori, N., Mihara, K., Tanaka, K., Matsuda, N.Nat. Commun.,,. Iguchi, M., Kujuro, Y., Okatsu, K., Koyano, F., Kosako, H., Kimura, M., Suzuki, N., Uchiyama, S., Tanaka, K., Matsuda, N.J. Biol. Chem.,,. Shiba-Fukushima, K., Imai, Y., Yoshida, S., Ishihama, Y., Kanao, T., Sato, S., Hattori, N.Sci. Rep.,,. Tanaka, A., Cleland, M.M., Xu, S., Narendra, D.P., Suen, D.F.,

7 Karbowski, M., Youle, R.J. J. Cell Biol.,,. Yoshii, S.R., Kishi, C., Ishihara, N., Mizushima, N. J. Biol. Chem.,,. Wenzel, D.M., Lissounov, A., Brzovic, P.S., Klevit, R.E. Nature,,. Lazarou, M., Narendra, D.P., Jin, S.M., Tekle, E., Banerjee, S., Youle, R.J.J. Cell Biol.,,. Zheng, X. Hunter, T.Cell Res.,,. Riley, B.E., Lougheed, J.C., Callaway, K., Velasquez, M., Brecht, E., Nguyen, L., Shaler, T., Walker, D., Yang, Y., Regnstrom, K., Diep, L., Zhang, Z., Chiou, S., Bova, M., Artis, D.R., Yao, N., Baker, J., Yednock, T., Johnston, J.A. Nat. Commun.,,. Trempe,J.F.,Sauve,V.,Grenier,K.,Seirafi,M.,Tang,M.Y., Menade, M., Al-Abdul-Wahid, S., Krett, J., Wong, K., Kozlov, G., Nagar, B., Fon, E.A., Gehring, K.Science,,. Koyano, F., Okatsu, K., Kosako, H., Tamura, Y., Go, E., Kimura, M., Kimura, Y., Tsuchiya, H., Yoshihara, H., Hirokawa, T., Endo, T., Fon, E.A., Trempe, J.F., Saeki, Y., Tanaka, K., Matsuda, N.Nature,,. Kane, L.A., Lazarou, M., Fogel, A.I., Li, Y., Yamano, K., Sarraf, S.A., Banerjee, S., Youle, R.J.J. Cell Biol.,,. http: protein jpn research matsuda-team.html PD E http: protein jpn research matsuda-team.html