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1 136ﾑｧｧ9 2009; 21 (4): ﾞ fiapple ｦ apple apple ｹ0 (09 閨03080ｹ0 I: ｧ8 ﾞｧｸ7 apple ｸｸ7) ﾒ. ﾒ. ﾒ080ｸｦｹ apple086ｦ003080ｸｧｦ apple ｦｧ apple ｦｸｧ80ｹ apple086ｧｹｸ700 閨ｧｧｧ8, 02 08apple086ｧ9 apple ｦ fi 040ｸ fi 02080ｸ7 04apple ｦｦｦ0. ﾒｹｸ702 6ｧ9 0ｹｧ9 0ｹ apple ｦ閨 apple 閨ｧｧ80ｹ0 閨03000ｸ707 0ｹ0, applefi apple086ｧ9 閨 apple ｦ fi 閨 fi 03fi apple 閨ｹ0 04apple ｧ80ｹｹ0. 6ｾ40208 apple 閨03080ｹｹ0 apple 03086ｦ004 0ｹ fiapple ｹ fi 閨ｹｧ9 0ｹｧｸ703096ｧ9 020ｷ307 apple ｸｷ307. 閨ｹ : 02026ｧ90709, ｧ90709, apple ｦ , 閨0ｹ E ｷ3096ｧ8 ｦ fi 04apple006ｧ903 00, apple08036ｦ0apple ｸ700 閨ｧｸ7, 040ｸ fi fi fi 02080ｸｦ0, apple ｹｧ apple086ｧｧ apple ｸｧ apple03fi080ｸ70308, apple080ｸｸ707 閨閨ｸ7 Bowman. O 04apple fi0ｹ fi0ｹ fi0ｹ0, apple0602fi 00apple6ｧ9apple00 08, apple ｧ applefi ｦｸｸｷｦｧ9080ｸ7, apple080ｸ7 apple ｦｷｧ9040ｷｷ307 04apple , apple ｧｧ (6ｾ4ｦﾌ09) apple ｦ , apple080ｸ7 00apple0007 6ｦ0080ｸ閨010ｷ3 00apple ｹ0. K0ｸ fi0ｹ0 026ｦｹｧｸ7 apple ｸｸ fi ｦ 006ｧ800, 縺 fi ｧ908 ﾞｦﾐappleapple ﾞ fi 6ﾑｧ , ｦﾐｧ8 6ｾｧ8, 6ﾑ fi ﾒ apple fi apple ｧﾞｦ apple ｦ apple ｦ0apple02080ｸ閨 applefi ｸｦｦｸｸｦ apple , apple ｹｹ0 apple03fi ｹ閨0ｹ0 applefi 02060ｹ0 08apple086ｧ9000ｹ0 03 apple ｦｸ apple ｦ O 020ｸ fi0ｹ0 026ｦｹ0 020ｷ apple 閨070ｷ307 apple ｸｷｧ apple 6ｦﾞ0ｸ702fi 006ｧ apple0802 閨ｹ apple ｹ0 閨ｹ0 020ｷｧ90ｷ307 apple080ｸ7 apple ｸ apple03fi ｸ7 020ｸｦ0 026ｦｸ7, fiapple0ｷ30ｹｸ702036ｧ907000ｹ0 (cyclins) ｹ0 applefi 02060ｹ0 020ｸ702036ｧ907000ｹｹ0 (cyclin-dependent kinases, CDK), ｷ

2 13 ﾒ. ﾒO08ｦ 06O08ｦ 6ｾ4O6ｾ4,. 03 ﾞﾒO09O08 O08 6ﾑｧ o03o096ｧ9 21, ｧｹｷ302000ｹ107000ｹ0 020ｷ307 apple apple ｾ40ｸｧｹ0: 6ﾑ8 ﾒ: 0409: ｧ8 apple030ｷ302000ｹ10709, 6ﾑｸ apple030ｷ302000ｹ10709, 6ｾ404: 閨0ｹｷｸ70ｹ0, 020ｷ閨0ｷｹｹ0 020ｷｸ (cyclin kinase inhibitors). 020ｸ , fiapple0ｷ30ｹ0 閨ｧｧ9000ｹｦｧｸｧ9 0ｹ0, apple ｦｨB080ｸ707 apple030ｷ302000ｹ107000ｹ0 apple080ｸ閨ｸｸ fi 026ｦ , fiapple0ｷ30ｹ p27, p21, p57, apple 03080ｸｨB080ｸｷ300 閨0709 閨 apple030ｷ302000ｸ apple080ｸ apple ｸ707, fiapple0ｷ30ｹｸ702036ｧ907000ｹ0 D, A, B Ki ｦ apple ｦｧ9ｨB applefi 006ｧｸ700 閨ｧｧｧ8 4. ﾞapple ｦ applefi 閨07 000ｸ閨03000ｹ0 020ｸ fi , applefi apple086ｧｦ007 apple030ｷｧ90ｹｧｹ0 apple080ｸｧ apple03080ｹ apple ｧｧ809080ｸ apple08-030ｸｹ0 000ｸｧ90ｹ0 apple 閨0ｹ0, 02060ｹ0 apple ｧ90ｹ0 apple 閨0ｹ0 (0909), 00 閨040ｷ3 020ｷ307 08apple086ｧ90ｷ307 apple ｾ4ｦﾌ09 (6ﾑ ). O apple ｦｸ7036ｦ閨0708, fi ｸ fi ｸ7, fi ｧｸ7 apple ｸｸ7. 09 閨040ｷ3 020ｷ apple ｦｸ707 閨ｾ4ｦﾌ09, apple ｦ O apple ｧ9ｨB ｹ0 閨07 apple08036ｦ0apple ｧ902020ｸ708 apple080ｸ7 apple ｯｧ803080ｸ apple ｧ8 (6ﾑ ). ｦｧｸ70ｹｧ9ｨB ｸ applefi 閨ｸ700 閨0708 6ｧ902020ｸｧ90ｷｧ907090ｹ0, apple086ｧ908 apple ｧｧｸ7 020ｸｦ0. ｦｦ0 020ｷ apple ｸｷ307, apple ｸ70ｹ , ｸ applefi 006ｧ9 apple ｧ800 apple080ｸ E ﾇ apple08036ｦ0apple ｧｸ7 apple ｸｸ7 fiapple0ｷ30ｹ0 apple ｧ9ｨb ｧｦ apple6ｧ9080ｸ fi ｹ0 閨ｹ0 ( ) ｷ304090ｹ0 ( ). 0909: ｧ90ｹ0 apple 閨0ｹ0 6ｾ404: 6ｾ閨0ｹ ( ｧ8 applefi 0208 Histology Learning System Boston University / ｸ7 02fi0ｹ0 02fiapple080ｹ0: histology). 274

3 136ﾑｧｧ9 21, 2009 E O ｹ閨0ｹｧｧ8 046ｦ apple 閨0ｹ0 020ｷ307 apple apple ( ﾇ fi fiapple fi ｹ0 閨ｹ0). ( ｧ8 applefi 0208 Histology Learning System 02080ｸ7 Boston University/ ｸ7 02fi0ｹ0 02fiapple080ｹ0: fi fiapple0608 apple ｨb ｸｨB 閨0ｹ (6ｾ404). ｦ 08 6ｾｧ apple ｧｦｸｧｹｧ80ｹ0 0ｷ30ｹ0 apple03080ｹ閨ｹ0 066ｧｹ0, ｹ0 00apple 鐶pple ｦ閨03000ｸｸｦｷｧ90ｷ apple08 6ｧ9ｨB apple ｷｧ90ｷｸ7 apple ｹ05. ﾇ 020ｸｧﾇ 020ｸｧｷｯ 00apple ｷ307 apple ｸｷ307, apple 03080ｸｨB ｧ90ｹ閨0ｹｧｧ8 046ｦ apple 閨0ｹ0, ｸ708 6ｧ9 apple080ｸ7 閨 apple 086ｧｸ7 Bowman, ｧ8 apple080ｸ7 040ｸ707 閨ｾ4ｦﾌ09, apple ｧｸ7 6ｾ404 (6ﾑ ). ﾇｸ708 6ｧ9 apple ｧｹ0 020ｸｧ80ｹｹ0 00apple ｦ0apple applefi 閨ｸ70208apple030ｷ302000ｸ , apple086ｧｧ閨 apple ｧｸ7036ｧ90ｷ30ｹ0 applefi ｸ70208apple030ｷ302000ｹ10709 apple ｸ7-016ｧﾇ apple ｸ7016ｧｧｧｸ70208apple030ｷ302000ｹ10709, apple080ｸｸｧｹ0 040ｸ707 閨ｸｸ fi ｷｹ0 NHERV ｹ0 00ｨB036ｧ907090ｹ0, fiapple0ｷ30ｹ0 閨 apple ｧ applefi 閨02000ｹ0 02fi apple fiｨB0ｷｸｧ9, fi ｰｹ0 ｱ 020ｸ閨0ｹ閨0ｹ apple00060ｷ307 apple ｸｷ307 (6ﾑ ). ｦｷ3020ｸｧｹ0 apple030ｷ302000ｹ107090ｹ0 閨 apple 閨0ｹ fi ｹ0, apple080ｸｦ fi ｧ fi0ｹ0 fi ｧ閨0708. ﾇ apple ｸ7016ｧｸ閨ｧｹ0 020ｸｧ80ｹｧ80ｹ0, ｹ apple fiｨB0ｷ閨03- MO06ｦﾐﾞﾒﾇﾞ0601ｦﾐｦ 6ﾑ8 ﾒｦ O03ｦﾐﾒﾇｦ O08 09O04O ﾒ08ｦｦﾞ06O ｹ0 040ｸ閨07090ｹ0 apple030ｷ302000ｹ107090ｹ0 apple ｧ apple06apple 陦0ｷｸｧ9 0ｷ3036ｧｹ0 020ｷ307 apple ｸｷﾞｧ閨02090ｹ0 閨 apple 閨ｧｹ0 apple ｸ7016ｧ907090ｹ0 0ｷ30ｹ0 006ｧ apple ｸｸ7-036ｧ9 0ｹｯ 00apple 閨ｷ30ｹ0 閨ｸ7 006ｧｦｹｹ0 04apple ｧ80ｹｹｧ9 006ｦｧ8 apple030ｷ302000ｹｹｸ708 6ｧ9 0ｹ0 apple ｧ80ｹｹ0 020ｸｧ80ｹｹ0, apple080ｸ7 閨 apple ｧｸｧ GLEPP1 (glomerular epithelial protein 1, apple030ｷ302000ｹｸ7 04apple ｦ0 00apple ｧ9080ｸ7), apple080ｸ7 08 6ｧ apple6ｧ904090ｹｸ閨ｧｹｧ80ｹｸ7 apple ｸｸ fi GLEPP1 閨 apple6ｧ904090ｹ0 apple ｧｷ30ｹ0 閨ｹ0 006ｧｹ applefi ｹ0 apple030ｷ30208apple ｦ00ｹｧ80ｹ0 04apple ｧ8030ｸｹ apple006ｧｧ8 8. ﾇｧ8 apple ｧｹ0 020ｸｧ80ｹｹ0 040ｸ707 閨ｾ4ｦﾌ09 00 閨040ｷ3 6ｦｷｸ700apple03fi- 020ｷｸ70902fi ｹ0, 020ｷｷ307 0ｸｸ (6ﾑ ). O ｧ907000ｹ0 006ｧｧ90ｹｧ9 0ｸ7apple ｧ90ｹ0 apple080ｸ7 apple ｸｹ0 6ｾ4ｦﾌ09 ( ｧ , fi ｦ0apple080ｸ7 IV). ﾇｧｧ apple 03 6ｧｷ3036ｧｷ307 apple ｸｷ307, ｹ閨ｧｹ0 apple ｧｷ307 apple apple apple fiｨB0ｷ3, ｧｷｷｷｧ9 00apple6ｧ904090ｹｷ , apple0802fi apple ｸｷ apple030ｷ302000ｸ807080ｸ7036ｧ9 9. O ｧｹ0 040ｸ707 閨080ｸｸｾ4ｦﾌｸ fi 00 閨040ｷｹ apple6ｧｧ80ｹｸ70ｹ閨07 046ｦｸ apple apple030ｷ302000ｸｸｷｧ90709 (apple ｧ90709, ｧ90709, ｸ7036ｧ90709, ｧ ) (6ﾑ ) ｸ702fi fiapple08 030ｸ703006ｧ9- ｨB080ｸｸｧｹｧ907090ｹｸ7 020ｸｦ0, ｸ702fi apple08apple ｦｹ0 040ｸ閨0ｹｸ70ｹ fi ｹｸｧ (6ﾑ ). ﾇ 6ｾ4ｦﾌ09, fi0ｹ0 020ｷ , 040ｸ707 閨 apple6ｧ904090ｹｸ fi 020ｷ307 apple apple 閨040ｷ3 020ｷｸｸ , ｧ90ｷ307 apple080ｸｧ apple ｧ9 0ｷ30ｹ0 026ｦｸｸ7 040ｸ704026ｧｹ0 apple fi ｹｦ0 020ｷｸ70ｸﾇ - 0ｸｸｸ707 閨ｧｧｹ0 6ｾ4ｦﾌ09, ｸｸｸ707 閨ｧｸ7 020ｸｦ0, 00 閨040ｷｹ0 080ｸｧ907090ｹ011. ﾒ 02 ｯｧｸ70ｸｦ , 閨ｦ apple030ｷ302000ｸｹ0 020ｸｧ80ｹｹ0, ｸｹ0 (,6 5,09, ), 08 6ｧｸｸ apple6ｧｷ307 0ｸｸｹｧ907000ｹ0 (6ﾑ ) 4,12. 6ｾ

4 13 ﾒ. ﾒO08ｦ 06O08ｦ 6ｾ4O6ｾ4,. 03 ﾞﾒO09O08 O08 6ﾑｧ o03o096ｧ9 21, 2009 E ｾｧ8 apple000602fi ｦ apple apple (0909) ｸｦ00ｹｹ0 (6ｾ404) 00 閨040ｷｸ7 08apple086ｧ9080ｸ7 040ｸ707 閨 ( ｧ8 applefi Brenner and Rector ｯs The Kidney 4 ). 026ｧ8 apple ｧｹ0 020ｸｧ80ｹｹ0 020ｷ307 apple apple 閨ｸｧ apple030ｷ302000ｹ10709 apple08 08apple03 076ｧ90709, 02090ｹ0 08apple086ｧ9 0ｹ0 fi000ｷ30ｹ fi03080ｹ0 apple 閨ｷｹ013. O 020ｸ fi0ｹｧ907090ｹ0 ﾇｧｹｸｦ0 006ｦ003080ｸ70ｹ0 020ｷ307 6ｾｹ0 040ｸｹ0 020ｷ307 apple apple ｾ4ｦﾌ09 閨ｧｧ902000ｸｸ7 020ｸｦｸ7 apple ｸｸ7. ﾒｹ apple ｧ8 066ｧｧｧ9 0ｸｧｧ9, apple030800apple0803 閨ｸ703 閨0ｹ0 0ｸｹ0 apple fi ｹ0, fi ｸｦ00ｹ0 07 apple ｧ80ｹｹｧ80ｹ0 020ｷ , fi apple ｹ0 0ｸ7 03 0ｸｧ80ｹｹ0 020ｷ307 04apple ,15. ﾇｧｸ7 020ｸｦ0 08 6ｧｧｹ0 04apple 閨ｹ0, ｹ apple apple ｦ , applefi apple086ｧ9 apple ｦ0apple02080ｸ apple ｦ , apple ｦ fi020ｸ7apple ｸｸｷ307, ｨB ｹ0 00fi0306 fiapple0ｷ30ｹｧ90709, apple080ｸ7 apple ｧ9 040ｸ fi 020ｷ307 apple03086ｦ004060ｷｧｸｧ90ｷｸ7 020ｸｦ0 020ｷ307 apple apple O 020ｸ fi0ｹ0 020ｷ307 apple ｸｷ307 apple ｧ applefi 3 040ｸ : ｸ8076ｧ9 06 ( ｸ7 7-9 nm), ｧ9 06 ( 閨ｸ7 10 nm) ｸ70ｹｷｧｸ70ｹ0 ( 閨ｸ7 24 nm). O ｷｧｧ9 06 apple ｦｦ fi fi 020ｷ307 apple030ｷｧ804000ｷｸ7 020ｸｦｹ017. O apple 閨04080ｸ707 閨07 apple0ｸ70207fi 6ｧ902020ｸｸｧ90ｷｧ907090ｹ0, apple080ｸ7 040ｸ707 閨ｸ , 00 閨040ｷ3 020ｷｧ90ｷｸ7 6ｾ404 18, ｾ4ｦﾌ09. 6ｾ402060ｹ apple ｧ閨 apple02fi 6ｧ902020ｸｸｧ90ｷｧｹ0 apple , apple086ｧ fi apple03080ｹｹ0 apple030ｷｧ90ｹｧｹｧ9 000ｹｸ707 閨ｸ70ｹｷｧｸ70ｹ0. ﾇｧｧｷｸｧ90ｷｧ907090ｹ0 006ｧ G ｧ90709 (globular actin, ｧｧ90709), 09 08apple086ｧ9 apple08030ｸｧ9ｨb , ｧ9ｨB ｹｧ9-06 F ｧ907090ｹ0 (filamentous actin, ｹｧ90709). H F ｧｧｧ9 040ｸｧ8 0ｸｧ apple6ｧ9 apple08 fi ｹ apple08030ｸｦ0, ｹｧ802080ｹｹｹ apple0ｷ30ｹ0 閨ｧ閨0209 apple ｸｷｧｦ apple6ｧ9080ｸ7, ｧｸ707 閨 apple ｸ708046ｧ90709 II, ｧｸ707 apple0208apple08 6ｧ90709, 00fi apple086ｧ apple ｦｸ fi ｸｸｧ閨040ｷｹｸ7036ｧ907090ｹｹｧ907090ｹ0 (6ﾑ ) 20. ﾇ 040ｸ707 apple0208apple08 6ｧｧｧ9 apple03086ｦ apple ｧ apple030ｷ302000ｹ10709 apple080ｸ7 閨ｧｨB in vitro, 02fi apple fiｨB0ｷ3 fi ｷ3apple08, ｸ700 閨07 020ｸｧ , fiapple0ｷ30ｹｧ902000ｹ0 020ｷｸｷ apple ｧ90ｹ0 apple 閨0ｹ0 020ｷ307 apple ｸｷｸ703006ｧ9ｨB

5 136ﾑｧｧ9 21, 2009 MO06ｦﾐﾞﾒﾇﾞ0601ｦﾐｦ 6ﾑ8 ﾒｦ O03ｦﾐﾒﾇｦ O08 09O04O ﾒ08ｦｦﾞ06O08 E ｾｧ8 apple000602fi ｸ7 020ｸｦｧ907090ｹｹ apple6ｧｹｸｧ8 apple ｧｹ0 020ｸｧ80ｹｹ0. 6ｾ40ｸｧｹ0: S: 6ｾ40ｸ707 apple ｧ90709, ﾞ: ｧ , 6ｾ4ｦﾌ09: 6ｾ4apple ｧｧ : ｧ90ｹ0 apple 閨0ｹ0 096ﾑ8: 09030ｷｧ80ｹ ( ｧ8 applefi Asanuma K ｸ ) ｸ703096ｧｧ9 0ｷ307 F ｧ907090ｹ0, 00 閨040ｷｹ apple6ｧｧ80ｹｹｧﾑ8apple6ｧ904090ｹ0, ｸ707- 閨ｸｹ0 apple030ｷ302000ｹ107000ｹｹｧ80ｹ0 apple ｧ80ｹｹ0 020ｸｧ80ｹｹｹ0 6ｾｸ fi 23,24 (6ﾑ , 6ｾ404. 1). 6ｾ400 閨ｹ0 040ｸ707 apple0208apple08 6ｧ907090ｹ0, 02 apple ｦ apple 03080ｸｨB080ｸ fi03080ｷｸ7 020ｸｦｸｧ9 020ｸｧ80ｹｸ704090ｹ0, fi0ｹ0 apple080ｸｧ9ｨB fi ｹ0 040ｸ閨07090ｹ0 apple030ｷ302000ｹ107090ｹｦｹ0 040ｸｧ80ｹ0 0ｸｧ80ｹ0 020ｷｸｧ90ｷｧ907090ｹ022,25. ﾇｧｧｧ9 apple030ｷ302000ｹ10709 apple080ｸ7 040ｸ fi F ｧ90709, fi ｹ0 apple030ｷ302000ｹｹｹ0 020ｸｧ80ｹｹ apple086ｧｷｧ9 0ｷ307 F ｧ907090ｹｸ7 020ｸｦ0, ｸ702fi ｧｹｸ703006ｧ9ｨB applefi ｸ70902 閨ｷｸｸｧ9-080ｸ7 Ca ｹｧ apple080ｸ7 020ｷ apple ｧｧｦｧ8030ｷ30409 apple030ｷｸ807080ｸ7036ｧ9 0ｹ0, apple ｸ apple ｹｧ80ｹｧ80ｹ0 04apple ｧ8030ｸｹ0, fiapple0ｷ30ｹ0 閨 apple ｷ303006ｧ9 applefi 閨0ｹ閨02000ｹｧ90ｹ閨0ｹｷ fi 046ｦｦ閨0ｹ (6ｾ404) ﾇｧ8 apple ｧ8 00apple 086ｧ80ｹｦ0 6ｦｷ307, apple ｸｷｧｾ404. O06 apple ｹ閨02000ｹｧｦ apple6ｧ9080ｸ7 apple 閨ｾ404 0ｷ30ｹ0 006ｧ9 apple apple080ｸｸｦｦｦ apple ｧ8 apple030ｷ302000ｹｸ7 6ｾ404, ｧﾇｧ

6 13 ﾒ. ﾒO08ｦ 06O08ｦ 6ｾ4O6ｾ4,. 03 ﾞﾒO09O08 O08 6ﾑｧ o03o096ｧ9 21, 2009 ｦｲ6ﾒ2 FAT NEPH1-3 ｦｭｦｦｵｦｱｦｩｦｭｦｧｦｰO6ﾒ2Oｦｪｦｩｦｭｦｧ TCRP6 ｦｪｦｦｭｦｳｦｶｦｦｱｦｩｦｭｦｦｲ ZO-1 NCK 1,2 CD2AP ｦｲｦｴｦｭｦｦｰｦｳOｦｰOｦｭ6ﾒ2ｦｩｦｭｦｧ Ca++ N-WASP ｦｪOPTAKTINH CapZ ｦ -ｦﾁｦﾊｦﾓｦﾉｦﾍ0ﾋ7ｦﾍｦﾇ 4 ｦｪｦｦｳｦｦｭｦｩｦｭｦｦｲｦｪｦｴｦｳｦｳｦｦｱOｦｰｦｫｦｦｲｦｬｦｦｪｦｴｦｳｦｳｦｦｱOｦｲｦｪｦｦｫｦｦｳOｦｲｦｦｪｦｳｦｩｦｭｦｧｦｲ 6ｾｾ fi ｹ0 apple08036ｦ0apple ｹｧ80ｹ0 046ｦｹｸｦ00ｹｹ0 6ｾ404. ｦ 6 5 閨ｦ0080ｸｹｦ00ｹ apple6ｧｹｦ0 020ｷ307 apple030ｷ302000ｸｸ7 6ｾｸ7 020ｸｦｧ907090ｹ0 006ｧｧ9 apple030ｷ302000ｹｦﾌ 180kDa, apple080ｸ7 076ｧｸ7036ｦ閨ｷｹ0 08apple086ｧ9 0ｹｷ3020ｸｧ800 apple apple ｨb080ｸ704000ｹ IgG apple 閨0ｹ0 (6ﾑ ) 30. ﾒ0ｷ apple ｧ applefi ｧ NPHS1, ｸ7 08apple086ｧ9080ｸ7 000ｸ7036ｦｸ閨0ｹｷ fi 046ｦｦ0 026ｦ0apple080ｸ731, apple086ｧｸ7 040ｸ閨07080ｸｧ9080ｸ apple fiｨB0ｷｧｨB06026ｧ8 apple030ｷ302000ｸ807080ｸ7036ｧ fi ｾｷ3apple08 09 apple030ｷ302000ｸ807080ｸｧｧ8 07fi04080ｹ0 閨ｸｧｷ300 閨0709 閨 fi ｹｧ907090ｹ0, fi ｸ7 mrna 02090ｹ033, 34, ｸ閨0709 apple030ｷ302000ｹ10709 閨 apple ｧｷ30ｹ0 閨07 0ｹ0 apple ｹ0 006ｧｹｹ0 020ｷ307 apple ｸｷｧ apple ｾｾ fi ｧ907090ｹ0 apple 03080ｸｨB080ｸ707 0ｸｧ80ｹ0 040ｸ70909 閨ｹｦ00ｹｧ9ｨB ｹｧ8. ｦ 00010ｷ3020ｸｷｧ90ｷｧｹ apple ｸｷ apple ｦ007, 040ｸｹｧｸｧ8 046ｦｷ307 apple apple ,37, ｸｸ fi ｹ0 040ｸ閨ｧｷ307 apple03080ｹｸ fi. 00apple0ｷ30ｹ0 閨ｧ9 applefi in vitro 閨02000ｹ0 ( ｸ閨0ｹ閨0ｹ0 apple ｸｷ307 apple ｦ0), ｧｧ fi apple 閨ｦｸ7 020ｸ apple ｹ0, ｹ apple fi 0ｸ7apple 陦 TRPC6 (transient receptor potential ion channel 6), 08 08apple086ｧ9080ｹｸｧ9 0ｷ30ｹｧ9 06fi07020ｷ307 Ca ｸ703006ｧ9ｨB ｸ閨ｾｷ3apple ｸｧ9080ｸ7 apple080ｸ7 020ｷ apple ｧ TRPC6 閨ｧ9 fi0206 apple ｧｧｧｧ8 04apple ｧ8030ｸｦﾐ 06 6ｧｹｧ9 0ｹ0 006ｧ apple6ｧｹｧ907090ｹｸ fi 02026ｧ907090ｹ0, 09 08apple086ｧ9 00apple06-020ｸ閨040ｷ3 006ｧ9 0ｹ0 apple ｹ (6ｾ404. 1) ｹ fi0ｹ0 090ｷ3096ｧ80ｹｷ307 apple03080ｹｸ fi 020ｷ , apple080ｸ7 閨ｧ閨07 in vitro, ｷｸ7036ｧ90ｷｸｸｸｸｦｸｹｧ907090ｹｦｧｸｸｧ8 apple030ｷｹ10709 Nck (non-catalytic tyrosine kinase adaptor protein). ｦｦ000apple apple080ｸ7 apple ｦ0apple ｸ707 閨ｸ N-WASP (neuronal Wiskott-Aldrich syndrome protein), 00 閨040ｷｹ0 08apple086ｧ9 0ｹ0 00apple ｸｧ8 036ｦｷｧ90ｷｧｹ040, , ｧ apple ｸ fi 02026ｧ907090ｹ0 00 閨040ｷｹｸｹ0 046ｦｧ80ｹｹ apple ｧ CD2AP. ﾇ apple ｧｧｧｧ8 apple030ｷ302000ｹｦﾌ 42kDa ｧ8 apple080ｸ7 apple ｨb ｸ70302 閨02, ｦｸｸｸｧ9080ｸ7 NPHS2, apple080ｸ7 006ｧｸ7apple006ｦ0030ｸｷ apple086ｧ909046ｧｹ0, apple ｧ fi ｷ fi 046ｦﾇ apple ｧｧ9ｨB ｧｧｧｦｹｹ0 0ｷ30ｹｧ

7 136ﾑｧｧ9 21, ｷ307, ｸ702fi ｸｧｷ30ｹｧ90ｷｧｧｹ apple ｹｸｹ0 apple 閨0ｹ0 020ｷ307 apple030ｷ302000ｸ apple080ｸ7 apple ｨb080ｸｧ90709 (NEPH1, NEPH2, ｧ90709), ｧｸ7 020ｸｦ0, 00 閨040ｷｹ0 CD2AP (6ｾ404. 1). ﾇ閨ｷ307 apple030ｷ302000ｸ apple080ｸ7 apple ｨB080ｸｧ90709 apple ｹ閨0ｹ0 apple030ｷ302000ｹ107000ｹ0, 02060ｹ0 NEPH1, NEPH ｧ90709 (NEPH3). ﾇ閨ｷ307 apple030ｷ302000ｸ NEPH 040ｸ閨 fi ｧ90709, ｦｸ70ｹ0. ﾇ NEPH NEPH apple ｦｷ3-020ｸｧｹｧ907090ｹ0, ｸ707 0ｸ7 0400fi0ｹｹｧ907090ｹ NEPH1, apple apple08030ｸ fi 02090ｹｧ907090ｹ0, 02080ｸｦｦｧ9080ｸｸ7 020ｸｦ0 020ｷ307 apple apple ﾇｧｧｧ9 apple03fi ｸｧｧ8 apple030ｷ302000ｹ10709, 02090ｹ0 08apple086ｧ9 0ｹｷ300 閨0709 閨ｧ9000ｹ apple6ｧ apple apple , 0ｸ7apple apple ｧ8 0000apple ｧｹ apple 閨ｷ307 apple030ｷ302000ｸ807080ｸ fi040ｷﾇ CD2AP (CD2 associated protein) 006ｧｧ9 apple030ｷ302000ｹｸ7 6ｾｦﾌ 80kDa apple080ｸ7 040ｸ707 閨ｸ fi ｸｹｧｹｸ fi 020ｷ307 apple apple ﾞｦｦｦ , fiapple080ｸ7 apple ｧ9 apple030ｷ302000ｹｸｧｸ7 020ｸｦ0 46. ﾇ CD2AP apple ｧｸ7 020ｸｦ , ｧ90ｷ307 fiapple0ｷ30ｹｧ90709 (cortactin), ｸ707 apple0208apple08 6ｧ CapZ (actin filament barbed end capping protein) (6ｾ404. 1) ｧ apple036ｧ80309 閨ｹ0 Cd2ap ( fi apple ｧ fi apple CD2AP) apple0003 6ｧ907080ｸ707 03fi090ｷｧ80ｹ0 0700apple ｹ0, apple ｧｧ8 閨ｧｹ0 apple 03080ｸｨB080ｸｧ8 04apple ｧ8030ｸｸｧ9080ｸ7 apple080ｸ7 006ｧｸ7apple006ｦ0030ｸ CD2AP apple ｧ9 00apple6ｧ904090ｹｧ8 04apple ｧ8030ｸｷ3apple O06 FAT1, P ｧ90709 (P-cadherin) VE ｧ90709 (vascular epithelium cadherin) ｧｸｦ0 00apple ｧ9080ｸ7 006ｧｧ90ｹ0 apple030ｷｹ107000ｹ0 apple080ｸ7 076ｧ802080ｸ閨ｷｸ閨04080ｸ707 00apple6ｧ904090ｹｧｧｸ7 6ｾ O FAT1 006ｧｧｧ8 apple030ｷ302000ｹｦﾌ 500kDa, 076ｧｷ307 apple030ｷ , 08 6ｧ apple 6ｧ9ｨB fi 03fi ｧｸ7 006ｦ003080ｸ70ｹｸ7 6ｾ , fiapple0ｷ30ｹ0 閨ｧ apple 閨 apple fiｨB0ｷ3, ｧ904040ｸｹ0 apple fi ｹｦ apple apple ｧ閨ｸ7 FAT1 apple 03080ｸｨB080ｸ707 apple030ｷｸ807080ｸ7036ｧｷ307 apple apple O FAT1 006ｧ apple 03 6ｧｹ fi 02080ｸ7 6ｾ404, ｸ707026ｧｸｦｧ9080ｸｹｸ708 6ｧ9 0ｹ0 apple ｧ80ｹｹ0 020ｸｧ80ｹｹ apple08030ｸ fi 02090ｹｧ907090ｹ0. ﾇ P ｧ90709, 00apple6ｧ904090ｹ0 閨ｧ9 fi ｸ閨 fi 02080ｸ7 6ｾ404, 040ｷ3036ｧ90ｹ0 fi000ｷ30ｹ0 07 閨 apple ｧ9 fi 閨ｧｹ0 00apple ｨB ｧｸｧ9, VE ｧ90709 apple03fi 閨ｸｧ9 0ｷ30ｹ0 040ｸ fi 02080ｸ7 6ｾｾ40ｸ700apple ﾇ 046ｦ閨03000ｸ707 閨ｧ fi 03fi ｷ307 apple ｸｷ307 0ｷ30ｹ fi 040ｸ fi 02080ｸ7 04apple ｦｦｦｸｧｸ70ｹ apple 閨 fi ｷｦｷ307, fi ｷ307 00apple6ｧｷ307 apple030ｷ302000ｸ807080ｸ fi040ｷ fi0308 apple080ｸｸ702 6ｧ9 0403fi0706 閨04080ｸｧｧ fi ｹｧ80ｹｧ80ｹｸ70ｹ0, 07 apple ｸ703086ｦ apple 閨07080ｸ707 apple ｧｷ3026ｧ apple08036ｦ0apple ｧ9 020ｷ307 apple ｸｷ307. ﾇ 040ｸｨBfi 閨03000ｸ apple036ｧ fi ｹｧ80ｹｹｸ703096ｧ9 0ｹｸ7 apple ｸｸ7 006ｧｧ80ｹｧ9 0ｹ0, ｹ0 apple ｧ9 apple applefi ｸ閨0ｷ307, ｸ700 閨070ｷ apple000ｸｷ apple ｹ0 020ｷ307 04apple fi040ｷ307. Summary MO06ｦﾐﾞﾒﾇﾞ0601ｦﾐｦ 6ﾑ8 ﾒｦ O03ｦﾐﾒﾇｦ O08 09O04O ﾒ08ｦｦﾞ06O08 K. Koutroutsos, L. Nakopoulou. Podocyte and glomerulopathies. (Part ｦﾐ: Molecular architecture of the podocyte). Hellen Nephrol 2009; 21 (4): Podocytes are highly differentiated epithelial cells with specialized morphology and molecular architecture that are main contributors for sustaining the glomerular filtration barrier. During the past decade research has demonstrated the central role of the podocyte as both the cause of glomerular damage, and the determinantion of progression to glomerulosclerosis. The purpose of the first part of this review is to present the recent advances in understanding podocyte biology and its contribution to glomerular damage. Keywords: actin, nephrin, podocyte, slit diaphragm. 279

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