_LAPOUSHS

Transcription

1 13 ﾇ 0404 閨 ｦ ｸ ｧ ｨB 0ｹ0 6ｾ ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ 閨0ｹ ｧ9 0ｹ apple086ｦ004090ｹ0 縺 ｹ0, ｧ8 04/ ﾑ802apple 6ｧ9 000ｸ704090ｹ ｧ9 0ｹ0, ﾒ204fi0706 0ｹ0 6ｾ402 6ｦ003080ｹ0, ｷ fi ｦﾐ ｦ ｧ ｾ40208applefi0ｹ ｹ0 apple 03086ｦ004 0ｹ ｧ9 0ｹ0 6ｧ 閨 ｷ apple06 6ｧ90ｷ 閨 ｸ70ｹ ｧ ｨB 0ｹ0 6ｾ ｹ0 (04096ｾ4). ﾇ 0ｸ apple ｧ apple 040ｸ ｧ9 006ｧ apple030ｷ302006ｦ ｹ0 apple ｹ ｦ007080ｸ apple 036ｧ804000ｷ ｧ ｹ 閨02090ｹ0 6ｧ 閨0ｹ ｧ9 0ｹ 縺 ｦ apple6ｧ9apple ｹ fi03090ｹ0, 02090ｹ0 HDL-C, 02090ｹ0 LDL-C ｷ ｸ ｧ90ｷ307, apple0804fi ｧ ｹ0 10 ml, 036ｧ applefi ｧ8, applefi 120ｷ ｧ ｦ ﾞ0ｸ702fi fi ﾞ07 030ｸ7026ｧ8 (OLYMPUS AU-560). 08apple ｧ apple6ｧ904090ｹ ｧ ｹ0 0007ｨB 0ｹ ｹ0. 縺 ｦ ｷ apple6ｧ9apple00 020ｷ apple06-6ｧ90ｷ307, ｧ9 0ｹ ｸ ｾ4, 02090ｹ ｧ9 0ｹ ｸ7 086ｦ003080ｸ ｦ ｸ ｦ fi ｹ ｸ70ｹ0, apple08066ｧ ﾞ ｸ ｦ ｹ 閨07 07 apple (One Way Anova) apple apple ｸ ｧ904000ｷ307 Scheffe post-hoc. 6ﾒ2 apple 閨 陦 fi ｸ7apple6ｧ 閨0ｹ ｸ70902 閨 ｷ ｷ apple06 6ｧ90ｷ 閨 ｧ ｦ ｹ0 apple03080ｹ ｾ4 02 apple 陦 fi0206 0ｸ7apple6ｧ ｧ apple6ｧ9apple00 020ｷ ﾌ 02. 縺 ｹ0 apple086ｦ004090ｹ0 006ｧ ｸ ｧ80ｹ0 ﾞ090ｷ3096ｧ80ｹ0, 6ｾ fi0ｹ0 6ｾ46ｦ ｸ703080ｹ0 04.6ﾑ ｹ ｧ80ｹ0 04/ ｹ0 6ﾑ802apple 6ｧ9 000ｸ704090ｹ ｧ9 0ｹ0, ﾌ 02. 6ｾ402 6ｦ003080ｹ0 6ﾒ204fi0706 0ｹ0 006ｧ ｸ ｧ80ｹ0 ﾞ090ｷ3096ｧ80ｹ0, ｹ ｷ fi ｦﾐ ｦ ﾒ ｹ0 020ｸ ｧ80ｹ0 ﾞ090ｷ3096ｧ80ｹ0. 257

2 13Eapple E02apple ｸ ｷ ｸ ｧ90ｷ ｷ ｨBfi ｷ307 02fi000ｷ307, apple080ｸ7 076ｧ 閨0ｹ ｧ9000ｹ ｾ4 ( ｧ9, 0ｸ7apple 閨 , apple 046ｦ ) F(2,117)=18,01 p<, apple6ｧ9apple ｹ0 HDL-C F(2,117)=4,53 p<,013. 6ｾ40ｸ700apple , ｧ907 0ｸ707080ｹ 閨0ｹ 閨0ｹ0 apple 036ｧ ｹ0 applefi 02 0ｸ 閨07 00apple6ｧ9apple apple06 6ｧ90ｷ307, ｧ9 apple080ｸ7 00apple ｧ ｧ applefi apple ｧ ｧ9, 00apple ｧ ｷ303006ｧ9 00 閨040ｷ ｹ ｷ304090ｹ ｸ ｸ70ｹ0. 閨 ｹ : 006ｧ ｹ0 0007ｨB 0ｹ ｹ0, apple 040ｸ ｧ9, ｸ ｧ ｧ90709, HDL-C, LDL-C. Abstract The purpose of this study was to assess the lipids level and their relation to the Body Mass Index (BMI). Dyslipidemia and obesity are primary risk factors for cardiovascular disease. The study sample was 120 students aged years. To assess the levels of cholesterol, HDL-C, LDL-C and triglycerides, blood volume of 10 ml, was taken from each student, after 12-hour fast and analyzed in Automatic Biochemical Analyzer (OLYMPUS AU-560). Also body mass index was computed. To investigate the differences in lipid levels because of body mass index, age and gender, one-way Anova (ANOVA) test was used and multiple comparisons Scheffe post-hoc. Results revealed that there were no differences in lipid concentration in relation to age and gender. Also results revealed that there was a statistically significant difference in triglyceride levels of the examined individuals belonging to different categories of body mass index (normal, overweight, obese), F(2,117)=18,01, p <0,00 and levels of HDL -C F(2,117)=4,53 p <0,013. In conclusion, the risk for future heart disease than elevated levels of lipids, a process that may begin in childhood, may be reduced by lowering the weight. Key words: body mass index, obesity, cholesterol, triglycerides, HDL-C, LDL-C. 1. 6ﾑ ｷ3096ｧ8 ﾌ06 apple ｹ ｦ007080ｸ ( ﾒ ﾞ ﾞ) ｸ70ｹ0 07 閨080ｸ70ｹ0, fiapple0ｷ30ｹ0 006ｧ apple 040ｸ ｧ9, ｷ300 閨 ｸ ｧ fi fi0ｹ0 0203fiapple080ｹ0 ｨB0ｷ36ｧ80ｹ0, 0ｸ ｦ apple03 閨0807 0ｷ30ｹ0 0203fiapple080ｹ0 ｨB0ｷ36ｧ80ｹ0 applefi ｧ9 020ｷ 閨0ｷ307 (Eisenmann, 2003) apple ｧ9 fi apple 03 apple07070ｷ3 apple ｹ0 apple ｦ ｦ ｸ7 006ｧ ｨB 0ｹ ｹ ｧ

3 13 ﾇ 0404 閨 ｦ ｸ ｧ ｨB 0ｹ0 6ｾ ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ 閨0ｹ ｸ707 02fi apple ｸ apple 040ｸ ｧ9 0ｹ ｸ702 閨0ｹ ｹ ｧ9000ｹ0 (Goran, Kaskoun & Shuman, 1995) 閨02000ｹ0, apple086ｧ9000ｹ ｧ 閨080ｸ70ｹ ｧ ｸ70ｹ ｸ7030ｷ3apple 0ｸ802 閨0ｹ ｹ0, ｷ ｸ702 6ｧ90ｷ , 006ｧ ｸ707 fi0206 0ｸ7apple ｧ , 0906 閨 ｸ fi 0203fiapple ｧ90ｷ304090ｹ ｸ702fi ｦ ｷ307 0ｸ7apple 閨 ｷ apple 046ｦ ｷ307 02fi000ｷ apple ｧ9ｨB fi % 020ｷ307 apple ｷ ｧ86 50ｷ ｧ ｸ7apple 閨 閨 ｹ0, 04096ｾ4 6ｧ ｧ ｦ applefi fi ｸ702fi 0208 apple fi 040ｸ ｹ0 0ｸ (Ogden, Flegel, Carroll & Johnson, 2002). To fi0ｹ0 0ｸ702fi 00apple applefi apple03fi 閨0209 NHANES ( ), apple080ｸ7 006ｧ fi0206 apple fi 17,4% 020ｷ ｧ86 50ｷ307 ( ) ,8% 020ｷ307 apple ( ) 006ｧ ｸ7apple 閨 (Ogden, Carroll, Curtin, McDowell, Tabak, Flegal & 2006). ﾒ ｷ apple ｧ 閨0ｹ 閨0ｹ ｹ 閨0ｹ ｹ0 020ｷ307 apple ｷ ｧ86 50ｷ307, apple080ｸ7 006ｧ ｷ30ｹ0 apple0802 閨 ｦ ｸ7 00apple06apple ｦ ｹ0 apple 040ｸ ｧ9 0ｹ0 applefi 14,0% ,2% (Hayman, Meininger, Daniels, McCrindle, Helden, Ross, et al. 2007). ﾇ 6ｦ0apple ｸ7apple ｦ ｸ70ｹ apple 040ｸ ｧ ｸ70ｹ0 07 閨080ｸ70ｹ ｧ ｸ70ｹ0 閨 ｧ9 apple 0902fi apple03fi fi0406 0ｸ709006ｧ ｷ3036ｧ9ｨB ｷ30ｹ0 閨07 0ｹ fi0ｹ0 apple ｹ ｦ007080ｸ 閨0ｹ 閨 ｹ ｧ ｨB0ｷ36ｧ8 (Ogden, et al., 2006 ) fi ｹ 閨02000ｹ ｧ902080ｸ70ｹ0, fiapple0ｷ30ｹ0 006ｧ 閨0209 Framingham, 閨04080ｸ ｧ fi ｷ fi ｹ ｸ7 02fi00080ｸ7 閨 閨 (Kannel, D ｯAgostino & Cobb 1996). 6ﾒ fi ｧ ｸ fi, 06fi ｸ 閨 ｸ70407fi ｹ ｹ0 apple 040ｸ ｧ9 0ｹ0 040ｸ ｦ ｹ0 apple fi ｹ 閨0ｹ applefi ｸ70ｹ0 apple ｹ ｦ ｦ007080ｸ7, 02fi ｧ ｧ9 (Freedman, Serdula, Srinivasan & Berenson, 1999). ｦﾐ 06 6ｧ ｧ ｸ7036ｧ apple080ｸ7 006ｧ ｸ707 fi apple030ｷ ｧ ｷ 閨 ｹ0 036ｧ9ｨB000ｹ ｹ apple ｧ ｧ ｧ9 (Dietz, 1998). 6ﾒ apple apple 046ｦ ｸ70ｹ ｧ90ｹ ｧ907080ｸ ｧ907080ｸ707 apple 046ｦ ｧ90ｷ30409 (Whitaker, Wright, Pepe, Seidel & Dietz, 1997), ｦ0apple apple 040ｸ ｧ9 0ｹ 閨080ｸ70ｹ0 006ｧ apple ｷ fi0ｹ0 apple ｹ apple 040ｸ ｧ ｧ ｨB0ｷ36ｧ8, applefi ｷ fi ｹ0 020ｷ ｷ307 (Whitaker, et al., 1997). ﾌ ｧ9, apple080ｸ7 040ｸ707 閨080ｸ ｸ7apple fi ｹ fi 026ｧ907 0ｸ70708, ｧ ｹ 閨070806, 0ｷ30402fi ｦ ｹ0 apple 040ｸ ｧ9 0ｹ ｸ7apple apple ｧ9 006ｧ ｹ ｷ 閨0709 (Lind, Lithell & Pollare, 1993). 040ｸ apple ｧ9 006ｧ ｧ8 020ｷ apple06 6ｧ90ｷ ｸ7 6ｧ ｹ ｧ ｸ 閨 ｸ70902 閨 ｷ apple06 6ｧ90ｷ307 6ｧ8 0306apple08apple030ｷ302000ｸ ﾒ fi 03fi

4 13Eapple E02apple ｸ ｷ ｸ703096ｧ ｹ ｧ9ｨB fi ｧ9 apple ｹ0, 00016ｧ904080ｸ7 fi000ｷ30ｹ fi 03fi0308 apple 6ｧ9ｨB fiapple080ｹ ｧ90ｷ304090ｹ ｸ7 02fi00080ｸ7 (Salminen, Lehtimaki, Fan, Vahlberg & Kivela, 2006). ﾞ 閨0ｹ0 閨03000ｸ707000ｹ ｧ fi 02090ｹ 閨04090ｹ0 020ｷ apple06 6ｧ90ｷ fiapple ｧ90ｷ304090ｹ ｸ7 02fi00080ｸ7, apple03fi ｧ80ｹ ｧ ｨB 0ｹ ｹ0 (Nethononda, Essop, Mbewu & Galpin, 2004). 6ﾒ208 0ｸ7apple fi 040ｷ fi 036ｧ9apple080ｹ0 040ｸ ｧ9ｨB ｸ 閨07 00apple6ｧ9apple ｧ80ｹ ｧ907090ｹ003 (LDL-C) ｸ ｧ90ｷ ｷ300 閨07 00apple6ｧ9apple ｧ80ｹ ｧ907090ｹ003 (HDL-C) (Eisenmann, Womack, Reeves, Pivarnik & Malina, 2001) apple ｧ9 fi ｸ apple6ｧ9apple fi03090ｹ0 (NCEP 2001), ｸ ｧ90ｷ307 (Satoh, Nishino, Tomita & Tsutsui, 2006), ｧ80ｹ0 apple0ｸ70207fi ｹ0 0306apple08apple030ｷ302000ｹ107000ｹ0 (Marz, Scharnagl, Winkler, Tiran, Nauck, Boehm & Winkelmann, 2004) apple6ｧ9apple fi03090ｹ0 0ｸ ｧ80ｹ0 apple0ｸ70207fi ｹ0 (HDL-C) (Boden 2000) 03080ｸ apple ｸ703fi 020ｷ apple ｦ ｹ 閨 ｹ ｧ9 0ｹ0 07fi04080ｸ7 (Sharrett, Ballantyne & Coady, 2001). ﾒ 閨07 006ｧ ｸ707 fi ｸ 閨0ｹ0 040ｸ ｹ ｧ80ｹ fi03090ｹ0, ｸ ｧ90ｷ ｧ80ｹ0 apple0ｸ70207fi ｹ0 0306apple08apple030ｷ302000ｸ (LDL-C) 006ｧ apple ｹ ｦ007080ｸ ｷ307 (Sharrett, et al. 2001). 6ﾑ8apple6ｧ904090ｹ0, 閨 ｧ9 fi ｸ 閨07 00apple6ｧ9apple apple08apple030ｷ302000ｸ ｸ ｧ80ｹ0 apple0ｸ70207fi ｹ0 (HDL-C) 00apple ｦ ｧ90ｷ ｸ ｦ ｦ007080ｸ7 (Sharrett, et al., 2001). ﾇ ｧ9 020ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ apple ｧ ｧ ｧ9 006ｧ ｧ904080ｸ ｧ 閨02000ｹ0 0ｸ ｧ9 0ｹ0 apple ｦ0080ｸ707 fi apple ｹ ｧ8030ｷ304090ｹ ｸ applefi 0ｸ702 閨0ｹ ｹ ｧ9000ｹ ｧ9ｨB ｸ apple6ｧ9apple ｹ fi03090ｹ ｹ0 LDL-C apple6ｧ9apple ｹ0 HDL-C (Knuiman, Hermus & Hautvast, 1980). 6ｾ ｧ9 apple ｹ ｦ ｸ 閨0ｹ 閨 ｹ0, fiapple0ｷ30ｹ0 006ｧ ｸ 閨07 00apple6ｧ9apple00 LDL-C apple6ｧ9apple00 HDL-C 02006ｧ907080ｸ ｸ 閨080ｸ70ｹ0, 0000 apple08-02 閨 ｸ7apple ｸ 閨07080ｹ0 026ｧ907 0ｸ707080ｹ 閨0ｹ 閨 ｹ 鐶pple ｨB0ｷ36ｧ ｸ70ｹ0 (Grundy, Bazzarre, Cleeman, D ｯAgostino, Hill & HoustonｨCMiller, 2000). ﾇ 00006ｧ90ｷ ｷ307 00apple06apple 陦0ｷ ｹ fi03090ｹ ｸ70ｹ0 07 閨080ｸ70ｹ0 00apple ｧ ｧ ｧ ｧ90ｷ ｷ ｧ90ｷ307 00apple ｧ90ｷ ｹ fi ｹ ｧ9 0ｹ0 020ｷ apple 036ｧ804000ｷ307. 6ﾑ8apple0006 6ｧ8 fi000ｷ30ｹ ｸ7apple ｸ apple03fi ｹ 閨02000ｹ 閨 ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ ｸ7 6ｧ ｹ0 apple080ｸ ｦ apple ｧ ｧ ｷ307 00apple 02fi03080ｸ7030ｷ ｧ90ｷ apple 036ｧ804000ｷ 鐶pple ｨB0ｷ36ｧ8, 閨0409 0ｸ7026ｧ8 apple ｦ0apple applefi 閨 ｧ9 (Lauer, Lee & Clarke, 1988). 260

5 13 ﾇ 0404 閨 ｦ ｸ ｧ ｨB 0ｹ0 6ｾ ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ 閨0ｹ ﾒ2 apple 閨 , fi000ｷ30ｹ0, apple ｸ , apple080ｸ ｦ 閨 ｦ0 020ｷ307 apple 03 09fi07020ｷ ｦ007080ｸ 閨0ｹ 閨 ｹ ｸ7 apple ｧ ｷ apple06 6ｧ90ｷ307, 閨 ｸ7fi ｸ700apple , ｧ9 0ｹ0 020ｷ ｧ804000ｷ ｷ307 apple 閨03000ｸ707 0ｹ0 6ｧ ｷ ｧ ｷ apple080ｸ fi ｧ9 applefi 0ｸ702 閨0ｹ0 (Eisenmann, et al., 2001). 6ﾑ8apple6ｧ ｹ0, 0400 apple 閨0ｹ0 applefi 0ｸ702 閨0ｹ ｹ0 閨03000ｸ707000ｹ0 040ｸ ｧ 閨 , 0000 apple0802 閨 ｧ ｸ ｧ apple 閨 , 00apple0006 6ｧ ｧ ｷ3036ｧ ｷ 閨0ｷ307 00apple ｦ apple ｧ ｷ apple06 6ｧ90ｷ ｸ702 閨0ｹ ｹ ｧ9000ｹ0 (Berenson, Srinivasan, Cresanta, Foster & Webber, 1981) apple 03 apple07070ｷ3, 閨 ｷ ｸ fi , ｸ702 閨0ｹ ｹ ｧ9000ｹ0, applefi0ｹ ｹ0 apple 03086ｦ004 0ｹ0 閨03000ｸ707 0ｹ0 6ｧ ｸ7-076ｧ ｧ , applefi apple6ｧ9apple00 020ｷ apple06 6ｧ90ｷ ｧ ｧ ｧ9ｨB apple 040ｸ ｧ apple ｸ 閨 ｧ ｨB 0ｹ ｹ ｸ7 02fi00080ｸ7. 09 閨 ｹ ｧ ｨBfi ﾒ ｧ ｹ0 閨03000ｸ707 0ｹ0 apple0802 閨 閨0ｹ0 (59 09fi ｧ ) ｧ9 0ｹ ﾇ 040ｸ ｧ8 020ｷ ｧ ｧ apple ｧ8 閨 ｸ704 6ｧ fiapple08. 6ｾ40ｸ ｧ fi 閨0ｹ apple086ｧ90806 apple fi 閨 apple ｧ 閨03080ｸ70ｹ0 020ｷ 閨0ｷ307 6ｧ fi070ｷ ｸ70ｹ0, fi 閨07020ｸ7apple ｧ ｹ 閨0ｹ ｹ0. 縺 ｧ ｸ7 6ｧ ｹ0 applefi 02080ｸ70ｹ 閨0ｹ0, apple ｸ700 閨070ｷ30ｹ ｧ90ｹ ｸ70ｹ ｸ70ｹ apple086ｦ00ｹ ｹ0 閨03000ｸ707 0ｹ ｸ7apple 閨 ｧ8030ｷ ｸ700080ｷ3076ｧ9 0ｹ ｧ ｸ7 6ｧ ｹ0 applefi ｸ700 閨0708 apple ｷ3apple06-02fi. 6ﾒ2 apple 閨 ｷ ｷ307 6ｧ ｸ ｹ0 apple ｷ3apple ｧ apple0804fi ｧ ｹ0 10 ml applefi 120ｷ ｸ ｧ9. 6ｾ ｧ ｧ ｹ0 閨 ｸ 閨 apple6ｧ ｸ70ｹ apple08066ｧ ﾞ0ｸ702fi ｹ fi0ｹ0 ﾞ07 030ｸ7026ｧ80ｹ0 OLYMPUS AU-560. ﾇ 040ｸ70902 閨 ｷ ｷ ｸ ｧ90ｷ ｧ 閨 ｹ ｹ ｹ ｸ fi03090ｹ0 (GPO-PAP), ｸ70902 閨 ｷ ｹ fi03090ｹ ｧ 閨 ｹ ｹ ｹ fi03090ｹ0 (CHOD-PAP) ｸ70902 閨 ｷ ｹ0 HDL-C ｧ8 00 閨 ﾒ2 閨03080ｹ0, 09 LDL-C 0ｸ7apple ｧ ｧ ｹ0 02fi- 261

6 13Eapple E02apple ｸ ｷ ｸ703090ｹ ｧ9040ｷ304090ｹ0: LDL-C=TC-(HDL-C ｸ ｧ9 06 /5) (Friedewald, Levy & Fredrickson, 1972). 6ｾ40ｷ ｧ8 0007ｨB 6ﾒ ｹ ｧ ｷ3036ｧ90ｹ0 apple apple086ｦ , 閨0ｹ0 08fi ｹ apple08066ｧ ｧ ｧ8 ｨB0ｸ ｧ ｹ0 0,2 kg. ﾇ 02036ｧ ｹ0 ｨB0ｸ ｹ fi ｸ apple086ｧ ｷ ｦ ｹ0 5 kg. 6ｨ ｹ0 To 6ｦ ｹ0 020ｷ ｧ fi 閨0409, 040ｷ3036ｧ90ｹ0 apple apple086ｦ ﾒ2 applefi ｷ ｨBfi ｷ307 apple 03 閨 , 閨 ｹ0, 09 apple ｷ ｨB0800 閨070ｷ ｸ700apple086ｦ ｧ ﾑ802026ｧ apple 040ｸ ｧ9 0ｹ0 縺 ｸ7apple fi 02080ｸ7 006ｧ ｨB 0ｹ ｹ apple08066ｧ apple09036ｧ ｸ ｸ70ｹ0 apple03080ｹ ｦ ｹ ｷ30708 ( ｹ0/6ｦ ｹ02). 6ｾ ｧ ｸ70409 縺 ｦ ｷ apple6ｧ9apple00 020ｷ apple06 6ｧ90ｷ307, ｧ9 0ｹ ｸ7 006ｧ ｨB 0ｹ ｹ0, 02090ｹ ｧ9 0ｹ ｸ7 086ｦ003080ｸ ｦ ｸ ｦ fi ｹ ｸ70ｹ0, apple08066ｧ ﾞ ｸ ｦ ｹ 閨07 07 apple (One Way Anova) apple apple ｸ ｧ904000ｷ307 Scheffe post-hoc. 縺 ｧ ｸ ｹ0 閨03000ｸ707 0ｹ apple08066ｧ fi apple 02 閨0208 SPSS 17 (SPSS inc., Chicago, Illinois, USA) ｷ30ｹ0 00apple6ｧ9apple fi ｹ ｧ p<0.5. ﾞapple 閨 ﾌ06 00 閨04000ｹ 閨0ｹ ｹ0 040ｸ70902 閨 ｷ304090ｹ0 020ｷ ｸ ｧ90ｷ307, 02090ｹ fi03090ｹ0, 02090ｹ0 LDL-C, 02090ｹ0 HDL-C, ｸ7 006ｧ ｨB 0ｹ ｹ ｧ ｦ00308 apple 03080ｸ ｨB apple6ｧ

7 13 ﾇ 0404 閨 ｦ ｸ ｧ ｨB 0ｹ0 6ｾ ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ 閨0ｹ ｧ ｹ 閨04000ｹ 閨0ｹ ｸ7apple0602 閨0ｹ0 apple ｧ ｹ0 020ｷ ｸ ｷ ｷ ｸ ｧ90ｷ307, 02090ｹ ｧ907090ｹ0, 02090ｹ0 LDL-C, 02090ｹ0 HDL-C, 02090ｹ0 VO2 max ｸ7 006ｧ ｨB 0ｹ ｹ ｧ ｦ00308 ﾇ ｧ9 6ﾒ ｸ LDL-C HDL-C ｾ4 ( 閨0209) ｧ ｧ90709 (mg/dl) (mg/dl) Kgr/m2 (mg/dl) (mg/dl) (TA) (TA) (6ﾒ2A) (6ﾒ2 ﾞ) (TA) ﾞ09fi ,27 165,45 96,09 57,45 19,44 (22,00) (31,73) (23,74) (12,77) (2,66) ,81 170,88 105,31 53,19 22,20 (28,79) (28,43) (23,64) (10,24) (3,56) ,43 168,57 103,86 52,71 22,18 (22,56) (30,50) (25,71) (10,44) (4,29) ,82 159,00 98,36 47,09 25,87 (43,10) (36,55) (32,61) (13,57) (5,69) ﾒ08036ｧ ,71 181,53 112,53 53,53 22,31 (46,99) (27,95) (19,58) (15,77) (4,27) ,93 178,40 106,33 56,20 23,73 (29,23) (23,84) (25,40) (11,26) (4,60) ,47 171,00 105,53 55,41 22,77 (17,92) (34,65) (29,79) (10,90) (4,14) ,08 161,67 95,67 56,50 22,29 (11,20) (25,71) (23,81) (10,61) (3,94) ｸ ｦ ｹ0 (Anova) 020ｷ 閨070ｷ ｸ ｧ9 06, fi0309, LDL-C HDL-C. ﾞ ｹ 閨0ｹ0 6ｧ ｧ9000ｹ0 apple080ｸ7 076ｧ ｧ ｨB 0ｹ0 6ｾ ｹ0. 030ｹ0 apple03080ｹ ｧ ｨB 0ｹ ｹ0, 閨0ｹ apple ｧ ｸ ｦ00ｹ0, 0ｸ7apple 閨 ｸ70ｹ apple 046ｦ ｸ70ｹ ｧ ｦ00308, 046ｦ000080ｷ ｹ0 apple fi ｸ7 006ｧ ｨB 0ｹ ｹ0, fi ｷ ｷ ｸ7apple 閨 ｷ apple 046ｦ ｷ307 apple ｧ9 0ｹ (Cole Bellizzi, Flegal, Dietz, 2000). 縺06 apple ｧ9 020ｷ

8 13Eapple E02apple ｸ ｷ307 09fi0306, 閨0ｹ 閨0ｹ ｸ ｾ4 006ｧ ｸ fi ｹ0 ﾜ22,60 kg/m2, ｸ7apple fi ｹ0 applefi 22,60-27,60 kg/m apple 040ｸ ｧ9 ﾝ27,60 kg/m2. 縺 ｧ ｹ0 6ｧ9 06 0ｹ ｧ9 0ｹ ｧ ｹ 閨0ｹ0 006ｧ ｾ4 ﾜ23,30 kg/m2, 23,30 ﾜ04096ｾ4 ﾜ28,60 kg/m ｾ4 ﾝ28,60 kg/m2. 6ﾒ2 00apple6ｧ9apple00 020ｷ apple06-6ｧ90ｷ ｸ7 6ｧ ｹ0, 02 08apple086ｧ ｷ3036ｧ fi ｧ apple07070ｷ3 applefi ｸ fi fi030608, 6ｧ fi mg/dl, ｸ ｧ mg/dl, LDL-C 130 mg/dl, HDL-C <40 mg/dl (NCEP, 2001). 6ﾑ , ｧ8, applefi0408 0ｸ7apple ｸ 閨0ｹ apple6ｧ9apple00 020ｷ apple06-6ｧ90ｷ307 03fi090ｷ ｸ ｾ fi00080ｸ7. ﾌ06 00 閨04000ｹ 閨0ｹ ｸ7apple0602 閨0ｹ0 apple ｧ ｹ0 020ｷ307 00apple06apple 陦0ｷ ｷ ｸ ｧ90ｷ307, 02090ｹ ｧ907090ｹ0, 02090ｹ0 LDL-C ｹ0 HDL-C, ｧ ｧ ｨB 0ｹ0 6ｾ ｹ0 apple 03080ｸ ｨB apple6ｧ ｧ ｹ 閨04000ｹ 閨0ｹ0 020ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ ｧ ｸ7 006ｧ ｨB 0ｹ ｹ0 ﾒ ｧ 閨04080ｹ0 6ﾒ20ｸ7apple06026ｧ ｾ ｹ0 ﾞapplefi ﾒ ｸ ｧ9 06 (mg/dl) 020ｸ ｧ , apple 閨 ｦ ｧ90709 (mg/dl) 020ｸ ｧ apple 閨 ｦ LDL-C (mg/dl) 020ｸ ｧ , apple 閨 ｦ HDL-C (mg/dl) 020ｸ ｧ apple 閨 ｦ ｹ0 apple03080ｹ ｾ4 02 apple 閨 陦 fi0206 0ｸ7apple6ｧ ｧ ) apple6ｧ9apple00 020ｷ ｸ ｧ90ｷ ｷ ｨBfi ｷ307 02fi000ｷ307, apple080ｸ 閨0ｹ ｧ9000ｹ ｾ4 ( ｧ9, 0ｸ7apple 閨 , apple 046ｦ ) F(2,117) = 18,01 p<, ) apple6ｧ9apple ｹ0 HDL-C F(2,117) = 4,53 p<,013. 6ﾑ8apple6ｧ904090ｹ0, 閨 fi ｸ7apple6ｧ ｧ ｷ30ｹ0 apple03080ｹ apple6ｧ9-264

9 13 ﾇ 0404 閨 ｦ ｸ ｧ ｨB 0ｹ0 6ｾ ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ 閨0ｹ apple ｹ fi03090ｹ ｹ0 LDL-C. 6ﾒ2 閨03080ｹ0, 09 Post Hoc ｸ 閨 Scheffe 02090ｹ 閨07090ｹ ｧ80ｹ ｸ ｧ 閨 ｧ9 apple080ｸ7 076ｧ ｾ4 (080ｸ ｧ9, 0ｸ7apple 閨 , apple 046ｦ ) 陦 fi0206 0ｸ7apple ｸ 閨0ｹ 閨0ｹ ｦ0 020ｷ ｸ ｷ307 0ｸ7apple 閨 ｷ ｦ0 020ｷ307 apple 046ｦ ｷ ｷ307 0ｸ7apple 閨 ｷ307. 6ﾒ2 apple 閨 陦 fi ｸ7apple ｧ ｷ30ｹ0 apple03080ｹ apple6ｧ9apple ｹ fi03090ｹ0, 02090ｹ0 LDL-C, 02090ｹ0 HDL-C ｷ ｸ ｧ90ｷ307 0ｷ30ｹ0 apple03080ｹ ｧ9 ( ) 02080ｸ ｨBfi ｸ7 006ｧ ｹ0. 6ﾑ8apple6ｧ904090ｹ0, 0007 apple ｧ ｧ apple6ｧ9apple00 08 p< apple 閨 apple6ｧ9apple00 020ｷ apple06 6ｧ90ｷ 閨 ｦ00308 ( 09fi0306 ｨC ｧ ). ﾌ fi0ｹ apple fi 020ｷ ｸ fi07020ｷ307, 0ｷ30ｹ0 apple03080ｹ ｹ ｧ9000ｹ0 apple080ｸ7 076ｧ (00apple06030ｸ ｧ8, apple06026ｧ907 0ｸ ｧ9 0ｸ ｦ ｦ007080ｸ7) ｸ70ｹ ｨBfi ｸ70ｹ0 apple ｹ0 apple 03080ｸ ｨB apple6ｧ ｧ ｹ0 3. ﾒ ｧ8 040ｸ fi07020ｷ 閨0209 0ｷ30ｹ0 apple03080ｹ apple6ｧ9apple00 020ｷ ｸ ｧ90ｷ307, 02090ｹ ｧ80ｹ fi03090ｹ ｦ0, 02090ｹ0 HDL-C, 02090ｹ0 LDL-C ｸ7 006ｧ ｨB 0ｹ ｹ0 ﾒ ｧ9 6ﾑ8apple06030ｸ ｧ8 ﾌ apple06026ｧ907 0ｸ fi0ｹ0 026ｧ907 0ｸ707080ｹ0 ﾞ fi0ｹ fi ﾞ fi0ｹ fi ﾞ fi0ｹ fi 040ｸ (%) 040ｸ (%) 040ｸ (%) 6ﾒ ｸ ｧ ,8 1 0,8 1 0, fi , ,7 3 2,5 HDL-C 35 29, ,5 10 8,3 LDL-C , ,0 5 4,2 0809ｦﾐ 66 55, , ,7 6ｾ40ｸ7ｨB6ｧ ﾇ 閨03000ｸ707 閨 applefi apple ｷ303006ｧ 閨 ｦ ｹ0 040ｷ ｧ80ｹ0 0007ｨB 0ｹ0 (apple 040ｸ ｧ9 0ｹ0) 0ｷ30ｹ0 apple ｦ007080ｸ 閨0ｹ 閨 ｹ ｷ ｦ003060ｷ307 apple 03 09fi07020ｷ ｦ007080ｸ7 ( 0ｸ 閨0709 LDL-C, ｸ ｧ9 06, fi ｷ300 閨0709 HDL-C) 閨080ｸ70ｹ0. 6ｾ apple 03086ｦ004 閨03000ｸ707 apple ｦ fi0206 0ｸ7apple ｧ8 040ｸ70404 閨 ｸ7 006ｧ ｨB 0ｹ ｹ ｹ ｨBfi ｹ ｧ9000ｹ

10 13Eapple E02apple ｸ ｷ apple6ｧ9apple00 020ｷ ｸ ｧ90ｷ ｹ0 HDL-C. ﾌ06 080ｸ ｦ ｸ70ｹ ｨBfi 閨0ｹ0 006ｧ ｷ300 閨07 00apple6ｧ9apple ｸ ｧ90ｷ ｸ 閨07 00apple6ｧ9apple ｧ80ｹ fi03090ｹ0, 040ｸ fi ｸ70ｹ0 0ｸ7apple 閨 ｸ70ｹ0. 6ﾒ2 apple 閨 閨 ｸ700080ｷ3076ｧ apple ｦ ｹ 閨0ｹ0 020ｷ307 Hu, Hannah, Gray, Jablonski, Henderson, Robbins, Lee, Welty Howard (2000) ｷ307 Donahue, Orchard, Kuller Drash (1985) Beaver County Lipid Study, 046ｦ000080ｷ ｹ0 08apple086ｧ9000ｹ0 o 04096ｾ ｧ9ｨB ｸ ｧ HDL-C. 6ﾑ8apple6ｧ ｹ0, 040ｸ700080ｷ307086ｦ apple 閨 ｹ0 閨03000ｸ707 0ｹ0 (Stea, Wandel, Mansoor, Uglem, & Fr08lich, 2009) 閨080ｸ70ｹ0, 046ｦ000080ｷ apple086ｧ apple6ｧ9apple ｸ ｾ ｧ9ｨB ｸ70902 閨 ｷ ｹ0 HDL-C ｸ700080ｷ307086ｦ007 fi000ｷ30ｹ0, ｸ7036ｧ ｹ0 6ｧ9 06 0ｹ0 閨03000ｸ707 0ｹ0, fiapple080ｸ 閨 ｸ70404 閨 apple6ｧ9apple ｸ ｾ ｹ0 LDL-C. 6ﾒ2 閨03080ｹ0, 02 apple 閨 ｸ700080ｷ307086ｦ 閨03000ｸ707000ｹ 閨080ｸ70ｹ0 (Sempos, et. al., 2003) apple080ｸ ｧ809080ｸ fi ｧ90ｷ ｷ307 0ｸ apple ｷ apple06-6ｧ90ｷ ｧ9ｨB ｧ90ｷ ｹ0 apple 040ｸ ｧ9 0ｹ0. ﾇ apple 03080ｸ7046ｧ9 0ｸ ｸ ｧ90ｷ ｧ900 00apple ｧ ｸ7036ｦ apple ｧ ｸ709006ｧ9 0ｹ0. ﾇ 0404 閨 ｸ ｧ90ｷ ｧ apple08030ｸ7046ｦ , ｸ apple6ｧ9apple ｸ ｧ90ｷ ｷ303006ｧ fi ｧ apple fi apple06026ｧ907 0ｸ apple 046ｦ ﾇ ｧ ｸ7 0203fiapple080ｸ7 ｨB0ｷ36ｧ80ｹ ｷ ｧ apple fi 00 閨 ｧ90ｷ ｷ ｸ ｧ90ｷ ｷ3036ｧ90ｹ ｸ 閨0ｹ0 apple ｹ0. ﾇ 00006ｧ90ｷ ｸ ｸ70ｹ0, fi ｸ707 0ｸ707ｨB ｧ8 040ｷ ｧ ｧ ｸ707 02fi apple6ｧ9apple00 020ｷ ｸ ｧ90ｷ applefi ｸ70ｹ0 apple ｹ0 (NCEP, 1988) ｸ7apple6ｧ 閨0ｹ ｹ0 040ｸ ｹ ｹ fi03090ｹ ｹ0 LDL-C ｹ ｨBfi ｹ ｧ9000ｹ0. 6ｾ400 0ｸ702 閨0ｹ ｹ ｧ9000ｹ apple6ｧ9apple ｹ fi03090ｹ0 006ｧ , ｹ ｧ9 0ｹ ｸ fi ｧ90ｷ30409 (Berenson, et. al., 1981). 6ｾ apple 03086ｦ004 閨03000ｸ apple fi 閨04000ｹ 閨0ｹ0 020ｷ apple06 6ｧ90ｷ307 6ｧ apple 03 apple036ｧ ｹ0, 閨 apple03fi 閨0209 (CHASE) apple080ｸ7 閨 apple (Donin, Nightingale, Owen, Rudnicka, McNamara, Prynne ｸ ), (170,4 mg/dl 閨 ,4 mg/dl ｧ fi0309, 103,7 mg/dl 閨 ,3 mg/dl LDL-C, 54,1 mg/dl 閨 ,9 mg/dl HDL-C ,8 mg/dl 閨 ,74 mg/dl ｸ ｧ9 06 ). 6ｾ 閨 閨 ｹ0 040ｸ ｹ0 020ｷ apple06 6ｧ90ｷ ｦ0 020ｷ307 0ｸ7apple 閨 ｷ apple 046ｦ ｷ ｨBfi ｷ307, fi0ｹ0 apple080ｸ7 閨 ｸ700080ｷ3076ｧ apple 閨 ｷ307 (Choi, Paio & Kim 2002) 0400 apple 046ｦ ｸ70ｹ0 07 閨080ｸ70ｹ 閨 ｧ ｦ0 020ｷ ｹ 閨0ｹ0 020ｷ ｨBfi ｷ apple06 6ｧ90ｷ307, ｧ ｸ7036ｧ ｹ 閨02090ｹ0, apple080ｸ

11 13 ﾇ 0404 閨 ｦ ｸ ｧ ｨB 0ｹ0 6ｾ ｹ ｷ307 00apple06apple 陦0ｷ ｷ apple06 6ｧ90ｷ 閨0ｹ 閨 fi ｧ 閨04080ｸ ｸ fi ｹ 閨0ｹ0 TC LDLｨCC applefi 02 09fi0306 (Hayman, Meininger, Daniels, McCrindle, Helden, Ross, et al., 2007 ), 閨 fi000ｷ30ｹ0 0ｸ fi ｹ0 00 閨04080ｹ0 fi03080ｹ ｧ80ｹ fi03090ｹ0 (170,4 mg/dl) 閨 apple 03 06fi apple ｸ ｧ 閨0209 (NHANES III) 020ｷ ｨC1994. H 閨 ｷ ｷ307 00apple6ｧ9apple00 0ｷ ｷ apple06 6ｧ90ｷ307 0ｷ30ｹ0 apple03080ｹ 閨07080ｹ0 006ｧ apple08030ｸ7-046ｦ ｨB6ｧ ｧ8 apple ｦ apple ｧ86 50ｷ 閨 fi apple00036ｧ ｹ ｹ0 0707apple020ｸ701090ｹ0 00apple 閨 ｹ 閨0ｹ ｹ ｧ907090ｹ fi apple020ｸ ｧ ｧ ｦ (Labarthe, Nichaman, Harrist, Grunbaum & Da, 1997). ﾞapplefi 02 apple 閨 ｹ0 閨03000ｸ707 0ｹ0 apple ｦ0apple fi0206 apple fi apple00036ｧ9apple080ｸ7 15% 020ｷ 閨0ｷ ｹ0 閨03000ｸ707 0ｹ0 006ｧ apple6ｧ9apple00 TC>200 mg/dl, apple fi apple080ｸ7 006ｧ ｦ % 閨 閨 ｷ307 Hickman, Briefel, Carroll, Rifkind, Cleeman, Maurer & Johnson (1998). 6ﾑ8apple6ｧ904090ｹ0, 閨04080ｹ0 fi03080ｹ0 020ｷ ｷ ｨBfi ｷ apple06 6ｧ90ｷ 閨 ｸ 閨07080ｹ ｧ apple03 閨 apple ｹ0 00 閨 ｹ 閨0ｹ0 020ｷ ｧ804000ｷ ｧ907090ｹ ｹ0 apple000306fi 080ｸ7 (Hickman, et. al., 1998). H apple 03086ｦ004 閨03000ｸ707 閨 ｧ fi ｧ apple ｧ ｷ apple06 6ｧ90ｷ ｷ ｸ fi07020ｷ 閨0ｷ307 閨 ｸ fi ｹ 閨0ｹ 閨 ｹ 閨0ｹ0 020ｷ 閨0ｷ ｹ 閨02090ｹ0 03HANES ｦﾐｦﾐｦﾐ ( ). 6ｾ40ｸ fi apple 閨 ｸ7026ｧ80ｹ ｹ 閨02090ｹ0, 09 apple 03086ｦ004 apple 03080ｸ ｨB0006 0ｸ 閨03 00apple6ｧ9apple00 LDL-C (+8,79 ml/dl), ｧ80ｹ fi03090ｹ0 (+5,43 ml/dl) HDL-C ,16 ml/dl (Hayman, et al., 2007). 6ﾒ2 apple 閨 ｧ apple03 鐶pple ｦ007 0ｸ7applefi 閨 ｹ 鐶pple ｸ709006ｧ9 0ｹ0 020ｷ , 06fi ｦ000080ｷ 閨 ｹ 閨02090ｹ0 Bogalusa, apple fi 70% 020ｷ apple080ｸ7 006ｧ ｸ 閨07 00apple6ｧ9apple fi03090ｹ ｦ ｸ ｸ 閨07 00apple6ｧ9apple ｹ ｧ90ｷ304090ｹ0 (Webber Srinivasan, Wattigney, Berenson 1991). 6ｾ apple 03086ｦ004 閨03000ｸ707 apple ｧ 閨 ｸ7 006ｧ ｨB 0ｹ ｹ0, apple 03fi0308 apple080ｸ7 閨 ｧ 閨 fi0308 apple080ｸ ｧ9ｨB ｧ8 apple 040ｸ ｧ9, applefi ｧ8 036ｧ9apple080ｸ70ｹ ｧ , 0ｷ30ｹ0 apple ｹ0 0ｸ 閨07080ｸ ｦ ｦ007080ｸ7, (Larsen, Bengtsson, Bj02rntorp, Lapidus, Sj02str02m, Sv01rdsudd ｸ ). 6ﾒ ｹ0 03fi apple ｦ ｧ804080ｸ707, ｧ ｸ70ｹ0 07 閨080ｸ70ｹ ｧ ｸ70ｹ ｾ ｸ703006ｧ9 07 apple ｧ fi apple ｧ90ｷ ｸ ｦ007080ｸ 閨0ｹ 閨 ｹ , 閨0ｹ 閨 ｹ ｸ ｹ0 006ｧ ｷ30402fi fi ｧ9ｨB ｹ0 0ｷ3036ｧ ｹ ｧ ｧ9 (Freedman, et. al., 1999) ｦ , 閨0806 閨04080ｸ fi fi ｧ8 apple 040ｸ ｧ9, ｧ applefi ｧ9apple080ｸ70ｹ ｧ applefi 02080ｸ70ｹ ｧ ｹ0 (Goran, Kaskoun & Shuman, 1995), 00apple0800 閨070ｷ30ｹ fi03080ｹ ｹ applefi ｹ0 036ｧ9apple080ｸ70ｹ ｧ 閨 fi03060ｹ ｧ

12 13Eapple E02apple ｸ ｷ ｧ9ｨB ｧ ｸ70ｹ0 (Sangi & Mueller, 1991). 6ﾒ2036ｧ , 0ｸ7apple ｸ 閨0ｹ ｦ0 020ｷ307 0ｸ ｦ0030ｷ307 apple080ｸ7 040ｸ707 閨 ｧ8 apple 040ｸ ｧ9, fiapple080ｸ ｹ ｧ907080ｸ 閨04080ｸ ｦ 閨 ｹ0 apple 閨 閨04090ｹ0 applefi 02060ｹ0 090ｸ707 6ｧ902000ｹ0 (National Cholesterol Education Program, 2002). 6ﾑ8apple06apple ｹ 閨0ｹ0 閨03000ｸ707000ｹ0 6ﾒ2 000ｸ7036ｧ ｹ0 閨03000ｸ707 0ｹ0 006ｧ ｸ707 02fi 07 00apple ｸ apple03fi ｷ ｸ70ｹ0 07 閨080ｸ70ｹ 閨 ｸ70ｹ0. 6ｾ46ｦ000080ｷ apple 閨 , 09 apple030ｷ ｧ8 apple03fi apple03 鐶pple apple ｹ fiapple08 ｨB0ｷ36ｧ80ｹ0, fiapple080ｸ7 03 apple03 鐶pple ｧ 閨 ｧ90ｷ ｹ0 0003fi ｹ fi ｹ ｧ ｸ ｸ70ｹ ｸ ｧ ｦ apple6ｧ9apple00. 6ﾑ8apple06apple03 閨0807, 閨02000ｹ0 apple03 鐶pple ｸ707 閨 apple ｹ0, apple080ｸ7 03 閨04080ｸ707 0ｷ30ｹ0 0402fi apple08apple086ｧ ｸ7 0203fiapple080ｸ ｧ90ｷ304090ｹ0, ｦ ｹ ｹ ｹ0 080ｸ ｧ80ｹ fi ｹ ｧ90ｷ ｹ ｧ80ｹ0, 02fi fi fi fi apple ｧ9 Berenson, G.S., Srinivasan, S.R., Cresanta, J.L., Foster, T.A. Webber, L.S. (1981). Dynamic changes of serum lipoproteins in children during adolescence and sexual maturation. American Journal of Epidemiology, 113, 157ｨC170. Boden, W.E. (2000). High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: assessing the data from Framingham to the Veterans Affairs High-Density Lipoprotein Intervention Trail. American Journal of Cardiology 86: 19LｨC22L. Choi Jong, Pai Soo and Kim Soon. (2002). Associations Between Total Body Fat and Serum Lipid Concentrations in Obese Human Adolescents. Annals of Clinical & Laboratory Science, 32, Cole, T.J., Bellizzi, M.C., Flegal, K.M., Dietz, W.H. (2000) Establishing a standard definition for child overweight and obesity worldwide: international survey BMJ, 320, Dietz, W.H. (1998). Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics, 101, 518ｨC525. Donahue, R.P., Orchard, T.J., Kuller, L.H., Drash, A.L. (1985). Lipids and lipoproteins in a young adult population. American Journal of Epidemiology, 122, 458ｨC

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