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- れいな あかさか
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1 tmrna tmrna RNA mrna turnover RNase class I peptide release factor RF ribosome rescue trna mrna transfer-messenger RNA tmrna RNA tmrna SmpB trna transtranslation C tmrna mrna ATP tmrna tmrna tmrna-independent ribosome rescue systems in bacteria and mitochondria Nobukazu Nameki Division of Molecular Science, Faculty of Science and Technology, Gunma University, Tenjincho, Kiryu-shi, Gunma, Japan tmrna tmrna SmpB tmrna ssra mrna tmrna tmrna YaeJ ArfA YaeJ RF trna PTH GGQ Gly-Gly-Gln YaeJ tmrna YaeJ ICT DNA mtdna tmrna SmpB ICT GGQ Corf tmrna GGQ pp.
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3 GGQ A GGQ GGQ GGQ αi α-helix BGGQ α β α-helix β-strand -helix C CorfPDB code RSM ICTJ mrna YaeJ mrna RNase mrna A-site cleavagetmrna SmpB YaeJ Steitz YaeJ Thermus thermophilus
4 YaeJ ICT Corf A SDS YaeJ PTH B RNAi ICT Corf si-nt non-targeting duplex sirnas C ICT Corf MitoTracker Red CMXRos MitoTracker Green FM Flow cytometry RF P trna trna YaeJ C α-helix mrna entry channels mrna α-helix flexible linker α-helix S SmpB YaeJ C tmrna SmpB A C α-helix mrna entry channel YaeJ SmpB YaeJ S RNA G syn anti mrna A YaeJ mrna entry channel mrna YaeJ C YaeJ T. thermophilus ICT ICTHT-D immature colon carcinoma cell transcript ICT Chrzanowska-Lightowlers ICT
5 ICT sirna ICT mtdna S ICT PTH nonstop mrna ICT ICT mtdna Corf tmrna SmpB ICT ICT GGQ Corf corf nonsense Corf corf nonsense Shoubridge ICT ICT c COX Corf ICT ICT S nonstop mrna PTH PTH PTH ICT Corf Flow cytometry ICTCorf RNAi ICT Corf B Corf ICT C ICT Corf ICT Corf GGQ YaeJ ArfA yhdl ArfA ArfA tmrna ArfA mrna C RNase III nonstop mrna tmrna SmpB ArfA C tmrna SmpB tmrna ArfA ArfA ArfA tmrna YaeJ ArfA GGQ PTH
6 RF ArfA trna ArfA RF tmrna SmpB ArfA NeisserialesEnterobacteriales YaeJ ICT Corf tmrna Moore, S.D. & Sauer, R.T.Annu. Rev. Biochem.,,. Hayes, C.S. & Keiler, K.C.FEBS Lett.,,. Janssen, B.D. & Hayes, C.S. Adv. Protein Chem. Struct. Biol.,,. Handa, Y., Inaho, N., & Nameki, N.Nucleic Acids Res.,,. Handa, Y., Hikawa, Y., Tochio, N., Kogure, H., Inoue, M., Koshiba, S., Güntert, P., Inoue, Y., Kigawa, T., Yokoyama, S., & Nameki, N.J. Mol. Biol.,,. Kogure, H., Hikawa, Y., Hagihara, M., Tochio, N., Koshiba, S., Inoue, Y., Güntert, P., Kigawa, T., Yokoyama, S., & Nameki, N.Proteins,,. Chadani, Y., Ono, K., Kutsukake, K., & Abo, T.Mol. Microbiol.,,. Asano, K., Kurita, D., Takada, K., Konno, T., Muto, A., & Himeno, H.Nucleic Acids Res.,,. Ivanova, N., Pavlov, M.Y., Felden, B., & Ehrenberg, M. J. Mol. Biol.,,. Shimizu, Y.J. Mol. Biol.,,. Sunohara, T., Jojima, K., Tagami, H., Inada, T., & Aiba, H. J. Biol. Chem.,,. Hayes, C.S. & Sauer, R.T.Mol. Cell,,. Gagnon, M.G., Seetharaman, S.V., Bulkley, D., & Steitz, T.A. Science,,. Kurita, D., Muto, A., & Himeno, H.J. Nucleic Acids,,. Neubauer, C., Gillet, R., Kelley, A.C., & Ramakrishnan, V. Science,,. van Belzen, N., Diesveld, M.P., van der Made, A.C., Nozawa, Y., Dinjens, W.N., Vlietstra, R., Trapman, J., & Bosman, F.T. Eur. J. Biochem.,,. Richter, R., Rorbach, J., Pajak, A., Smith, P.M., Wessels, H.J., Huynen, M.A., Smeitink, J.A., Lightowlers, R.N., & Chrzanowska-Lightowlers, Z.M.EMBO J.,,. Antonicka, H., Ostergaard, E., Sasarman, F., Weraarpachai, W., Wibrand, F., Pedersen, A.M., Rodenburg, R.J., van der Knaap, M.S., Smeitink, J.A., Chrzanowska-Lightowlers, Z.M., & Shoubridge, E.A.Am.J.Hum.Genet.,,. Shimazaki, H., Takiyama, Y., Ishiura, H., Sakai, C., Matsushima, Y., Hatakeyama, H., Honda, J., Sakoe, K., Naoi, T., Namekawa, M., Fukuda, Y., Takahashi, Y., Goto, J., Tsuji, S., Goto, Y., Nakano, I., & Japan Spastic Paraplegia Research, C. J. Med. Genet.,,. Chadani, Y., Ono, K., Ozawa, S., Takahashi, Y., Takai, K., Nanamiya, H., Tozawa, Y., Kutsukake, K., & Abo, T. Mol. Microbiol.,,. Garza-Sanchez, F., Schaub, R.E., Janssen, B.D., & Hayes, C.S. Mol. Microbiol.,,. Chadani, Y., Ito, K., Kutsukake, K., & Abo, T.Mol. Microbiol.,,.
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