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15 3 45 57 2000 QOL 1950 Cardiac Arrhythmia Suppression Trial 10 WPW 1 10 1990 1996 409-3898 1110 2000 5 23 2000 6 2 4

46 2 2 3 2 1 1 3 3 40 1 10 6 12 Cardiac Arrhythmia Suppression Trial CAST 4 1 3 CAST 5 1982 Scheinman 6 1987 Borggrefe 7 WPW Kent 4 mm large-tip Jackman 8

47 50 9,10 500 khz WPW 1 WPW Kent Ë 2 WPW 3 4 5 Ë 5 30 50 WPW 90 WPW 1,000 2, 3 11,12 2 Wolf-Perkonson-White QRS RR RR 230 msec

48 3 ABL USER1 4 30 60 HRA Abl His RV

49 5 25 5 QRS 30 2 2 6 slow potential 13 7 45 3 8 9 1 1 250 / 10 1 1 14

50 6 ab1-2 SP slow potential 7 3 QRS 5

51 8 9 1 1 250 /

52 10 10 2 4 QRS QRS 15 11 28 QRS 12 Purkinje 13 16 1980 CCU 17 QRS

53 11 QRS 12 2 ABL 37 msec

54 13 14 18,19 1996 4 4 3 9 15 Brugada 20

55 14 2 QRS 3

56 15 59 Brugada Burgada 20 1) Ijiri H, Komori S, Kohno I, Sano S, Yin DF, et al.: Improvement of exercise tolerance by single-lead VDD pacemaker: Evaluation using cardiopulmonary Exercise Test. PACE 23: 1336 1342, 2000. 2) Coumel P, Leenhardt A: Mental activity, adrenergic modulation, and cardiac arrhythmias in patients with heart disease. Circulation. 83 (4 Suppl): II58 70, 1991. 3) Mukharji J, Rude RE, Poole WK, Gustafson N, Thomas LJ Jr, et al.: Risk factors for sudden cardiac death after myocardial infarction: Two-year followup. Am J Cardiol 54: 31 36, 1984. 4) Cardiac Arrhythmia Suppression Trial (CAST) Investigators: Increased mortality due to encainide or flecainide in a randamized trial of arrhythmia suppression after myocardial infarction. N Engl J Med 321; 406 412, 1989. 5) Beazell J, Tan K, Criley O, Schulman J: The electrosurgical production of heart block without thoracotomy. Western Society for Clinical Research: 137A, 1976. 6) Scheinman MM, Evans-Bell T, Executive Committee of the Percutaneous Cardiac Mapping and Ablation Registry: Catheter ablation of the atrioventricular junction: A report of the percutaneous cardiac mapping and ablation registry. Circulation 70: 1024 1029, 1984. 7) Borggrefe M, Budde T, Podczech A, Breithardt G: High frequency alternating current ablation of an accessory pathway in humans. J Am Coll Cordiol 10: 576 82, 1987. 8) Jackman WN, Wang X, Friday KJ, Roman CA, Moulton KP, et al.: Catheter ablation of accessory pathway (Wolf-Perkinson-White syndrome) by radiofrequency current. N Engl J Med 324: 1605 1611, 1991. 9) Haines DE, Verow AF: Observations on electrotissue interface temperature and effect on electrical impedance during radiofrequency ablation of ventricular myocardium. Circulation 82: 1034 1038, 1990. 10) Haines DE: Determinants of lesion size during radiofrequency catheter ablation: the role of electrode-tissue contact pressure and duration of energy delivery. J Cardiovasc Electrophysiol 2: 509 515, 1991. 11) Sano S, Komori S, Amano T, Kohno I, Ishihara T, et al.: Prevalence of ventricular preexcitation in

57 Japanese schoolchildren. Heart 79; 374 378, 1998. 12) Sano S, Komori S, Amano T, Tamura K: Followup of ventricular preexcitation in Japanese schoolchildren. Lancet 351, 1789, 1998. 13) Haissaguerre M, Gaita F, Fisher B: Elimination of atrioventricular nodal reentrant tachycardia using discrete slow potentials to guide application of radiofrequency energy. Circulation 85: 2162 2175, 1992. 14) Kohno I, Ishihara T, Umetani K, Sawanobori T, Ijiri H, et al.: Pathological findings of isthmus between the inferior vena cava and tricuspid annuals ablated by radiofrequency application. PACE 23: 921 923, 2000. 15) Komori S, Takeda S, Tachibana K, Yamamoto K, Sano S, et al.: Exercise-induced Monomorphic ventricular tachycardia from left ventricle outflow tract. Jpn Circ J 62; 629 631, 1998. 16) Morady F, Harvey M, Kalbfleisch SJ: Radiofrequency catheter ablation of ventricular tachycardia in patients with coronary artery disease. Circulation 87: 363 372, 1993. 17) Volpi A, Cavalli A, Franzosi MG, Maggioni A, Mauri F, et al.: One-year prognosis of primary ventricular fibrillation complicating acute myocardial infarction. Am J Cardiol 63: 1174 1178, 1989. 18) Moss AJ, Hall WJ, Cannom DS, Daubert JP, Haggins SL, et al. for the Multicenter Autonomic Defibrillator Implantation Trial Investigators: Improved survival with an implanted defibrillator in patients with coronary artery disease at high risk for ventricular arrhythmia. N Engl J Med 335: 1933 1940, 1996. 19) The Antiarrhythmics Versus Implantable Defibrillators (AVID) Investigators: A comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from nearfatal sustained ventricular arrhythmias. N Engl J Med 337: 1576 1585, 1997.