1 9924 2260 CAS 107186 H 2 C CH CH 2 OH 2- -1- C 3 H 6 O 58.08 1 99 1. 2, 3 3, 4, 5-129 96-97 2 21c.c. 24o.c. 2 6, 7 378 6, 7 2.5-18 d 20 4 0.8540 2, 5 2.00 = 1 2.7 kpa 20 mmhg204.3 kpa 32 mmhg30 4 log Pow0.17 8 0.01 8 m/z57 1.0 31 0.34 39 0.22 9 Koc =1.47 10 1 ppm = 2.41 mg/m 3, 201 mg/m 3 = 0.414 ppm
2 2. 8 27,931 t 27,931 t 0 11 1 3. 1 12 2 100 mg/l 30 mg/l BOD 86 OH OH 6 13 OH = 1.210 9 l /molsec 10 OH 110-17 M 2 2 14 3 ppb ppb ppm B/A B/A B/A B/A 3/15 7 5060 ng/m 3 50 B/A
3 4. LC 50 mg/l EC 50 mg/l OECD : 15 Daphnia magna 13 Pimephales promelas 13, 16 Carassious auratus 4, 13 0.32 96-h 1 24-h 0.25 96-h :very toxic very toxic OECD OECD 5. 10, 17, 18, 19 1 LD 50 85-96 mg/kg 64 mg/kg 71 mg/kg LC 50 211 ppm 2h 1,060 ppm 1h 165 ppm 4h 76 ppm 8h LD 50 45-89 mg/kg LD 50 45 mg/kg LD 50 78 mg/kg LD 50 60 mg/kg 37 mg/kg 1 42.7 mg/kg 10 1 10 ml/kg 1 ALT 4 10 30 mg/kg P-450 10 10 ml/kg 3 P-450 10
4 2 1,060 ppm 1 165 ppm 4 76 ppm 8 18 3 87 mg/kg 1-2 20.3 mg/kg 24 ALT P-450 6-36 21 42.7 mg/kg 10 4 230 mg/kg 1 ASTALT 4 -GTP 24 22 40 mg/kg 10 2 20 mg 10, 17 3 4 1 9.7 mg/kg/day 30 23 0.0050.010.020.08 4.88.314.048.2 mg/kg/day 6.26.917.158.4 mg/kg/day 15 0.01 24
5 2 204060 ppm 7 / 5 / 12 20 ppm 40 ppm 60 ppm 25 7 ppm 7 / 28 25 2 ppm 127-134 25 4060100 ppm 100 ppm 10, 19 5 in vitro * S9 +/- 10, 17 S9-100 µmol/l S9-50 µg/plate 17 5 10 1 10 1 µmol/l 17 * 6 7 1 25 mg/kg/day 7 / 1-4 5.1 mg/kg/day 7 / 5-11 1 26 6. 1 23 12.5 ppm 25 ppm 10, 18, 23, 25 25
6 ppm 23 10, 18, 23 10, 18, 23, 25 23 10, 18 25 ppm 10, 18, 23, 25 1 23 2 10 27 28, 29, 30 3 EPA 1999 EU 1998 NTP 1998 IARC 1999 1999 1999 1999 1999 ACGIH 1998 A4 1998 1999 29, 30 4 ACGIH 1998 TWA: 2 ppm 4.8 mg/m 3 STEL: 4 ppm 9.5 mg/m 3 1998 1 ppm 2.4 mg/m 3 7. 10 120 mg/kg 15-120 9-10 µg/ml 30 mg/kg 24 10, µg/ml15 4 µg/ml1 23 10, 1 23 mg 23 23
7 N- P-450 P-450 19 23 23 19 19 8. OECD 15 1) 3 2 1-3 1-2 2) very toxic 9. 1 in vitro OH 1 OH 2 2 1 2 3 in vitro 12 4
8 1 1999. 2 The Merck Index, 12th. Ed., Merck & Co., Inc. 1996. 3, 1994. 4 Handbook of Environmental Data on Organic Chemicals, 3rd. Ed., Van Nostrand Reinhold Co. 1996. 5,, 1985. 6,, 1996. 7 IPCS, International Chemical Safety Cards 1993. 8 C Log P,. 9 NIST Library of 54K Compounds. 10 Hazardous Substances Data Bank HSDB, U.S.National Library Medicine 1998. 11 8,. 12,,, 1992. 13 IUCLID International Uniform Chemical Information Data Base Data Sheet, EU 1995. 14, 1998. 15 OECD, Proposal for a Harmonized Classification System based on Acute Toxicity 1996. 16 AQUIRE US EPAECOTOX Database System. 17 Registry of Toxic Effects of Chemical Substances RTECS, US NIOSH 1998. 18 ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices 1991. 19 Luigi Atzori, Drug Metabolism and drug interactions, 7 4, 295-319 1989. 20 Marco Ferrali, Biochemical Pharmacology, 40 7, 1485-1490 1990. 21 L. E. Rikans, The Journal of Pharmacology and Experimental Therapeutics, 243 1, 20-26 1987. 22 Dean E. Brenner, Cancer Research, 47, 3259-3265 1987. 23,,,, 1994. 24 Integrated Risk Information System IRIS, U.S. Environmental Protection Agency 1998. 25,, 1994. 26 P. C. Jenkinson, Mutation Research, 229, 173-184 1990. 27 M. K. Dunlap, Arch. Ind. Health, 18, 303-311 1958. 28 JETOC,,, 4 1999. 29 ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices 1996. 30,, 40, 129-153 1998.
9 1 2
( ) mg/kg/day 30 day 15 w 7 d/w11 w 100 10 42.7 30 5.1-25 P-450 9.7 6.9-8.3 1
( ) ppm 8 h 7 h/d5 d/w12 w 7 h/d28 t 100 76 60 40 100 20 10 7 4 STEL ACGIH 2 TWA ACGIH 1 1