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1 pp. IgE FcεRI JST-CREST Role of zinczinc transporter in allergic response Keigo Nishida and Toshio Hirano RIKEN Research Center for Allergy and Immunology, Laboratory for Cytokine Signaling,, Suehiro, Tsurumi, Yokohama, Kanagawa, Japan Laboratory of Developmental Immunology, Graduate School of Frontier Biosciences, Graduate School of Medicine, and WPI Immunology Frontier Research Center, Osaka UniversityJST-CREST β FcεRI kg g
2 ZIPZrt-, Irt-like protein Zntzinc transporter acrodermatitis enteropathicaae ZIP AE ZIP AE lethal milk Znt Znt ZnT ZnT β ZnT ZIP ZnT
3 SLCA ZIP KO SLCA ZIP KO SLCA ZIP KO T SLCA ZIP KO hslca hzip mutation SLCA ZIP KO hslca hzip mutation SLCA ZnT KO hslca hznt mutation SLCA ZnT KO SLCA ZnT mutation SLCA ZnT KO SLCA ZnT KO SLCA ZnT KO hslca hznt SNP TPEN AI TPEN TPEN BTPEN ZIP I TPENN,N, N,N-tetrakis--pyridylmethyl ethylendiamine TPEN A TPEN TPEN B TPEN TPEN IL- TNFα TPEN
4 TPEN TPEN A CD GFP TPEN B TPEN FcεRI TPEN FcεRI SykLAT PLC γ TPEN TPEN CD GFP TPEN
5 II CPKC PKCβ IL- PKC Bcl MaltIL- TNFα NF-κBnuclear factor-κb PKC TPEN IL- TNFα A TPEN B NF-κB TPEN IκB IKKI-κB kinase PKCβ A TPEN BTPEN
6 Znt Znt TPEN PKC TPEN TPEN PKCβ TNFα ZnT ZnT ZnT ZnT ER ZnT His Znt Znt Znt Znt Znt ZntZnt ZnT Znt Znt ZnT Znt IL-TNFα Kit W-sh Kit W-sh Znt Kit W-sh Kit W-sh Znt Kit W-sh Kit W-sh ZnT Znt IL-TNFα Znt Znt
7 Znt Znt ELISA AIL-BTNFα Znt DNP-HSA NF-κB IKK I-κB IKKI-κBNF-κB PKC PKC DAG PKC PKCβ Znt PKCβ PKCβ PKCβ Znt PKCβ phorbol myristate acetatepma Znt PKC IKKI-κBNF-κB IL-TNFα ZnT PKCβ PKCβ Znt PKCβ ZnT PKCNF-κB ZnT PKCβ PKC PKC ZnT PKC ZnT PKC PKC
8 PKC ZnT ZnT ZnTZnT ER zinc wave A BNewport Green zinc wave zinc wave Syk PLCγ IPIPR zinc wave zinc wave RasMAPK MEK zinc wave zinc wave MAPK MAPK EGF zinc wave zinc wave zinc wave Newport Green Newport Green zinc wave zinc wave zinc wave mrna MAPK zinc wave MAPK zinc wave zinc wave zinc wave
9 epithelialmesenchymal transitionemt STAT STAT STAT STAT ZIP E- EMT Snail STAT ZIP Snail Snail-GFP ZIP Snail Snail Snail Snail STAT ZIP Snail lipopolysaccharidelps Toll-like receptortlr MHC T Newport Green LPS
10 MHC TPEN LPS MHC T ZIP mrna ZnT mrna LPS mrna LPS mrna ZIP MHC T Galli, S.J., Maurer, M., & Lantz, C.S.Curr. Opin. Immunol.,,. Wedemeyer, J., Tsai, M., & Galli, S.J.Curr. Opin. Immunol.,,. Gustafson, G.T.Lab. Invest.,,. Colvin, R.A., Fontaine, C.P., Laskowski, M., & Thomas, D. Eur. J. Pharmacol.,,. Zalewski, P.D., Millard, S.H., Forbes, I.J., Kapaniris, O., Slavotinek, A., Betts, W.H., Ward, A.D., Lincoln, S.F., & Mahadevan, I.J. Histochem. Cytochem.,,. Palmiter, R.D. & Huang, L.Pflugers Arch.,,. Eide, D.J.Pflugers Arch.,,. Kambe, T., Yamaguchi-Iwai, Y., Sasaki, R., & Nagao, M. Cell. Mol. Life Sci.,,. Wang, K., Zhou, B., Kuo, Y.M., Zemansky, J., & Gitschier, J. Am.J.Hum.Genet.,,. Huang, L. & Gitschier, J.Nat. Genet.,,. Chowanadisai, W., Lonnerdal, B., & Kelleher, S.L.J. Biol. Chem.,,. Sladek, R., Rocheleau, G., Rung, J., Dina, C., Shen, L., Serre, D., Boutin, P., Vincent, D., Belisle, A., Hadjadj, S., Balkau, B., Heude, B., Charpentier, G., Hudson, T.J., Montpetit, A., Pshezhetsky, A.V., Prentki, M., Posner, B.I., Balding, D.J., Meyre, D., Polychronakos, C., & Froguel, P.Nature,,. Fukada, T., Civic, N., Furuichi, T., Shimoda, S., Mishima, K.,
11 Higashiyama, H., Idaira, Y., Asada, Y., Kitamura, H., Yamasaki, S., Hojyo, S., Nakayama, M., Ohara, O., Koseki, H., Dos Santos, H.G., Bonafe, L., Ha-Vinh, R., Zankl, A., Unger, S., Kraenzlin, M.E., Beckmann, J.S., Saito, I., Rivolta, C., Ikegawa, S., Superti-Furga, A., & Hirano, T.PLoS One,, e. Andrews, G.K.Biometals,,. Kabu, K., Yamasaki, S., Kamimura, D., Ito, Y., Hasegawa, A., Sato, E., Kitamura, H., Nishida, K., & Hirano, T.J. Immunol.,,. Nishida, K., Yamasaki, S., Ito, Y., Kabu, K., Hattori, K., Tezuka, T., Nishizumi, H., Kitamura, D., Goitsuka, R., Geha, R. S., Yamamoto, T., Yagi, T., & Hirano, T.J. Cell Biol.,,. Nechushtan, H., Leitges, M., Cohen, C., Kay, G., & Razin, E. Blood,,. Klemm, S., Gutermuth, J., Hultner, L., Sparwasser, T., Behrendt, H., Peschel, C., Mak, T.W., Jakob, T., & Ruland, J. J. Exp. Med.,,. Suto, H., Nakae, S., Kakurai, M., Sedgwick, J.D., Tsai, M., & Galli, S.J.J. Immunol.,,. Inoue, K., Matsuda, K., Itoh, M., Kawaguchi, H., Tomoike, H., Aoyagi, T., Nagai, R., Hori, M., Nakamura, Y., & Tanaka, T. Hum. Mol. Genet.,,. Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y., & Kambe, T. J. Biol. Chem.,,. Suzuki, T., Ishihara, K., Migaki, H., Nagao, M., Yamaguchi- Iwai, Y., & Kambe, T.J. Biol. Chem.,,. Nishida, K., Hasegawa, A., Nakae, S., Oboki, K., Saito, H., Yamasaki, S., & Hirano, T.J. Exp. Med.,,. Corbalan-Garcia, S. & Gomez-Fernandez, J.C.Biochim. Biophys. Acta,,. Yamasaki, S., Sakata-Sogawa, K., Hasegawa, A., Suzuki, T., Kabu, K., Sato, E., Kurosaki, T., Yamashita, S., Tokunaga, M., Nishida, K., & Hirano, T.J. Cell Biol.,,. Maret, W., Jacob, C., Vallee, B.L., & Fischer, E.H. Proc. Natl. Acad. Sci. USA,,. Yamashita, S., Miyagi, C., Carmany-Rampey, A., Shimizu, T., Fujii, R., Schier, A.F., & Hirano, T.Dev. Cell,,. Yamashita, S., Miyagi, C., Fukada, T., Kagara, N., Che, Y.S., & Hirano, T.Nature,,. Kitamura, H., Morikawa, H., Kamon, H., Iguchi, M., Hojyo, S., Fukada, T., Yamashita, S., Kaisho, T., Akira, S., Murakami, M., & Hirano, T.Nat. Immunol.,,. Hirano, T., Murakami, M., Fukada, T., Nishida, K., Yamasaki, S., & Suzuki, T.Adv. Immunol.,,. Murakami, M. & Hirano, T.Cancer Sci.,,.
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MHC-II II MHC-II MHC- II CD T T TCR T T MHC-II MHC-II T MHC-II MHC-II MHC-II MHC-II Ii Ii-MHC-II MHC-II antigen processing compartment MIIC Regulation of cell surface expression of MHC-II in dendritic
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pp. E- -SH X in vitro in vivo -SH Structure-based drug development and medical biological application of cathepsin specific inhibitors Nobuhiko Katunuma Institute for Health Sciences, Tokushima Bunri University,Nishihamabouji,
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pp. T T B T T T NKT T Ig B BCR T TCR Generation of T-lineage cells and their functions Kazunori Onoé Division of Immunobiology, Department of Pathophysiology, Institute for Genetic Medicine, Hokkaido University,
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Suzuki, K., Kumanogoh, A., & Kikutani, H. Nat. Immunol.,,. Luo, Y., Raible, D., & Raper, J.A. Cell,,. Pasterkamp, R.J. & Kolodkin, A.L. Curr. Opin. Neurobiol.,,. Nogi,T.etal. Nature,,. Gu,C.etal. Science,,.
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The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical
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pp. Perspective of prevention and treatment for allergic diseases Yasuyuki Ishii Laboratory for Vaccine Design, RIKEN Research Institute for Allergy and Immunology,, Suehiro-chou, Tsurumi, Yokohama, Kanagawa,
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IL- IL- Mucosal immunology and IL- -induced intestinal injury Rei Kawashima School of Allied Health Sciences, Kitasato University, Kitasato, Minami-ku, Sagamihara, Kanagawa, Japan Toll-like receptor TLR
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Short Review Hidenori Takagi, Fumio Takaiwa, E-mail : takaiwa@nias.affrc.go.jp 13) Hirahara, K. et al. : J. Allergy Clin. Immunol., 102, 961-967 (1998) 14) Takagi, H. et al.: Proc. Natl. Acad. Sci.
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Amyloid Fibril Formation and Protein Science Yuji GOTO Institute for Protein Research, Osaka University E-mail: ygoto@protein.osaka-u.ac.jp Abstract: Amyloid fibrils have been a critical subject in recent