本文／ＹＡ６１５２Ｃ

Size: px

Start display at page:

Download "本文／ＹＡ６１５２Ｃ"

ぜんぺいいんそん
5 years ago
Views:

1 Bourne, J. & Harris, K.M.Curr. Opin. Neurobiol.,,. Zhang, F., Aravanis, A.M., Adamantidis, A., de Lecea, L., & Deisseroth, K.Nat. Rev. Neurosci.,,. Molecular basis of long-term memory Naoki Matsuo Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Dengakugakubo, Kutsukake, Toyoake, Aichi, Japan JAXA - - E E E S Cbl-b MuRF- Siah- A MAFbx-atrogin- Chip MuRF- MAFbx-atrogin- atrogenes DNA IGF-insulin-like growth factor- IGF- Akt- PKB protein kinase B atrogenes Akt-PKB FOXO forkhead box O Akt-PKB FOXO atrogenes atrogenes

2 Sandrietal.,Cell MAFbx-muscle atrophy F-box protein- atrogin- HECT homologous to the E -AP C-terminus U RING really interesting novel gene SCF Skp cullin-f-boxmafbx-atrogin- SCF SCF cullin RbxRoc RING E Skp F MAFbx- atrogin- F kda SCF Nedd CANDcullin-associated Nedd -dissociated MAFbx-atrogin- MAFbx-atrogin- A MAFbx-atrogin- MAFbx-atrogin- A MyoD MAFbx-atrogin- MAFbx-atrogin- MyoD MAFbx-atrogin- eif MAFbx-atrogin- MuRF-muscle RING finger protein- MuRF-kDa N E RING RING Labeit M

3 E I MuRF- GMEB-glucocorticoid modulatory element binding protein- MuRF- co-activator co-repressor Cbl-b Cbl-b c-cbl Cbl kda RING MuRF- RING RING MFC MuRF B-Box B CC AR E Ub N TKB tyrosine kinase binding RING C Cbl-b Vav EGF PI K Cbl-b IGF- IGF- Cbl-b IRS-insulin receptor substrate- IGF- Cbl-b atrogin- HECT Nedd KIAA RING Ozz U UFD CHN- KIAA TATA TIP B Ozz β-ufd CHN-

4 Cbl TKB RING RING Pro LZ UBA E Ub UCN- Cbl-b IRS- ACbl-b IRS- Cbl-b IRS- Cbl inhibitor Cblin IRS- IRS- A B IRS- IP IB

5 B MAFbx- atrogin- JAXA Ikemoto, M., Nikawa, T., Takeda, S., Watanabe, C., Kitano, T., Baldwin, K.M., Izumi, R., Nonaka, I., Towatari, T., Teshima, S., Rokutan, K. & Kishi, K.FASEB J.,,. Nikawa, T., Ishidoh, K., Hirasaka, K., Ishihara, I., Ikemoto, M., Kano, M., Kominami, E., Nonaka, I., Ogawa, T., Adams, G.R., Baldwin, K.M., Yasui, N., Kishi, K., & Takeda, S. FASEB J.,,. Bodine, S.C., Latres, E., Baumhueter, S., Lai, V.K., Nunez, L., Clarke, B.A., Poueymirou, W.T., Panaro, F.J., Na, E., Dharmarajan, K. Pan, Z.Q., Valenzuela, D.M., DeChiara, T.M., Stitt, T. N., Yancopoulos, G.D., & Glass, D.J.Science,,. Gomes, M.D., Lecker, S.H., Jagoe, R.T., Navon, A., & Goldberg, A.L.Proc. Natl. Acad. Sci. USA,,. Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S.H., & Goldberg, A.L.Cell,,. Li, H.H., Kedar, V., Zhang, C., McDonough, H., Arya, R., Wang, D.Z., & Patterson, C.J. Clin. Invest.,,. Tintignac, L.A., Lagirand, J., Batonnet, S., Sirri, V., Leibovich, M.P., & Leibovich, S.A.J. Biol. Chem.,,. Csibi, A., Leibovitch, M.P., Cornille, K., Tintignac, L.A. & Leibovitch, S.A.J. Biol. Chem.,,. Centner, T., Yano, J., Kimura, E., McElhinny, A.S., Pelin, K., Witt, C.C., Bang, M.L., Trombitas, K., Granzier, H., Gregorio, C.C., Sorimachi, H., & Labeit, S.J. Mol. Biol.,,. Clarke, B.A., Drujan, D., Willis, M.S., Murphy, L.O., Corpina, R.A., Burova, E., Rakhilin, S.V., Stitt, T.N., Patterson, C., Latres, E., & Glass, D.J.Cell Metab.,,. Kedar, V., McDonough, H., Arya, R., Li, H., Rockman, H.A., & Patterson, C.Proc. Natl. Acad. Sci. USA,,. McElhinny, A.S., Kakinuma, K., Sorimachi, H., Labeit, S., & Gregorio, C.C.J. Biol. Chem.,,. Tsygankov, A.in CBL proteins Tsygonkov, A. ed., pp., Nova Science Publishers, Inc., New York. Suzue, N., Nikawa, T., Onishi, Y., Yamada, C., Hirasaka, K., Ogawa, T., Furochi, H., Kosaka, H., Ishidoh, K., Gu, H., Takeda, S., Ishimaru, N., Hayashi, Y., Yamamoto, H., Kishi, K., & Yasui, N.J. Bone Miner. Res.,,. Nakao, R., Hirasaka, K., Goto, J., Ishidoh, K., Yamada, C., Ohno, A., Okumura, Y., Nonaka, I., Yasutomo, K., Baldwin, K.M., Kominami, E., Higashibata, A., Nagano, K., Tanaka, K., Yasui, N., Mills, E.M., Takeda, S., & Nikawa, T.Mol. Cell. Biol., in press. Development of ubiquitin ligase inhibitor as a drug against unloading-mediated muscle atrophy Takeshi Nikawa Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Kuramoto-cho, Tokushima, Japan

PowerPoint プレゼンテーション

PowerPoint プレゼンテーション Anti-muscle atrophy peptides/proteins The University of Tokushima Graduate School, Institute of Health Biosciences, Department of Physiological Nutrition Takeshi Nikawa, MD and PhD (nikawa@tokushima-u.ac.jp)