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1 GPI GPI GPI-AP GPI GPI GPI GPI GPI-AP GPI GPI-AP GPI-AP GPI GPI-AP GPI GPI GPI GPI GPI A GPI-AP GPI GPI-AP B GPI GPI GPI-AP GPI-AP GPI GPI-AP GPI-AP GPI GPI UniProt GPI-AP Biochemistry of glycosylphosphatidylinositol GPI anchored proteins Taroh Kinoshita WPI Immunology Frontier Research Center and Research Institute for Microbial Diseases, Osaka University, Yamada-oka, Suita, Osaka, Japan GPI-AP pp.
2 GPI-AP A GPI B GPI GPI GPI-AP GPI-AP GPI-AP AA-EtNP- -Man- -Man- - EtNP- -Man- - GlcN- -myopi PI - GlcN -Man
3 EtNP GlcN Man EtNP EtN AA Man Man Man - GPI N- GPI-AP sn- sn- sn- A B GPI-AP GPI GPI A PI PI UDP-N- UDP-GlcNAc GlcNAc GlcNAc-PI GPI-GlcNAc PIGA PIGC PIGH PIGP PIGQ PIGY DPM PIGA UDP-GlcNAc glycosyltransferase family PIGQ PIGC PIGH PIGP PIGY DPMGPI Man DPMGPI-GlcNAc GPI PIGA PIGC PIGH PIGP GPI-AP PIGQ PIGY DPM GPI-AP GlcNAc-PI GlcNAc N- -PI GlcN-PI PIGL N- GPI PIGL GlcNAc-PI GPI-AP GlcN-PI GlcN-PI GPI GlcN-PI GlcN- acyl PI PIGW CoA PIGW GPI-AP GlcN- acyl PI PI GlcN- acyl PI - CHOGPI
4 GPI GlcN- acyl PI Man Man-GlcN- acyl PI GPI GPI-MTI PIGM PIGX PIGM glycosyltransferase family PIGM PIGX GPI-AP GlcN- acyl PI Man Man Man-Man-GlcN- acyl PI GPI GPI-MTII PIGV PIGV glycosyltransferase family PIGV GPI-AP Man-GlcN- acyl PI EtNP-Man-GlcN- acyl PI Man Man- EtNP Man-GlcN- acyl PI GPI GPI- ETI PIGN PIGN GPI-AP Man Man-Man- EtNP Man-GlcN- acyl PI GPI GPI-MTIII PIGB PIGB glycosyltransferase family PIGB GPI-AP Man- EtNP Man-GlcN- acyl PI Man EtNP-Man-Man- EtNP Man-GlcN- acyl PI bridging ethanolamine phosphate PIGO PIGF GPI GPI-ETIII PIGO PIGF GPI- AP Man GPI EtNP-Man- EtNP Man- EtNP Man-GlcN- acyl PI PIGG PIGF GPI GPI-ETII PIGG EtNP- Man-Man- EtNP Man-GlcN- acyl PI GPI-AP GPI Man Man GPI GPI-MTIV PIGZ PIGZ PIGB glycosyltransferase family GPI GPI-AP GPI GPI-AP signal recognition particle SRP GPI GPI GPI GPI GPI PIGK GPAA PIGS PIGT PIGU A C PIGK GPAA GPI GPI-AP GPI GPI-AP B
5 COPII GPI-AP GPI PGAP GPI-AP COPII GPI-AP p GPI-AP bulk GPI-AP GPI-AP GPI-AP GPI PI C PI-PLC PI-PLC PGAP GPI-AP PI-PLC GPI Man PIGG PIGF GPI-AP PGAP PGAP ERGIC PGAP GPI-AP GPI-AP COPII GPI-AP COPII GPI-AP p p p p p p p TMED GPI-AP p TMED GPI-AP GPI p COPII Sec GPI-AP ERGIC GPI-AP p GPI PI sn- sn- PGAP CREST PGAP GPI A PGAP PGAP sn- GPI-AP PGAP sn- GPI- AP GPI-AP detergent-resistant membrane DRM GPI GPI GPI Piga GPI GPI GPI GPI PIGA
6 PIGM GPI inherited GPI deficiency IGD GPI i paroxysmal nocturnal hemoglobinuria PNH GPI PNH PNH PNH GPI X PIGA X PIGA GPI PIGA GPI ii PNH GPI CD CD CD decay-accelerating factor DAF C CD C b- C b- C C PNH PNH C C C a C b- C a C b- PNH PIGA GPI GPI T T CD GPI CD GPI T NKG D GPI ULBP - GPI CD d NKT GPI PNH PNH PNH iii PNH PIGA X GPI
7 GPI PIGA GPI GPI PNH PIGA PIGA GPI GPI PIGA GPI PIGA GPI PNH PIGA GPI GPI PIGT PNH PNH iv PNH PIGA GPI PIGA GPI GPI-N - N - GPI CD CD GPI GPI PNH GPI C GPI ER associated degradation ERAD PNH - CD CD b CD upa CD CD CD GPI GPI IGD i GPI GPI hyperphosphatasia mental retardation syndrome Mabry syndrome CHIME syndrome West syndrome Ohtahara syndrome GPI N - O - congenital deficiencies of glycosylation CDG -CDG ALG -CDG GPI CDG PIGM-CDG ii GPI GPI GPI GPI GPI GPI GPI GPI GPI-AP GPI
8 GPI GPI GPI GPI PNH PIGA CDCD GPI ERAD GPI C GPI GPI PIGA PIGQ PIGL PIGW PIGM PIGV PIGN PIGO IDG GPI GPI GPI GPI GPI GPI GPI ERAD PIGT GPI GPI GPI GPI-AP PGAP GPI PGAP GPI-AP PGAP GPI-AP GPI-AP GPI-AP p p p p TMED PI sn- PGAP PGAP PGAP GPI-AP PGAP GPI-AP GPI-AP GPI-AP D GPI-AP GPI-PLD GPI-AP GPI-AP GPI-PLD PGAP GPI-AP Mabry PGAP PGAP GPI-AP PI sn- GPI A PGAP GPI-AP sn- GPI-AP DRM PGAP GPI-AP PGAP PGAP GPI-AP GPI-AP in vitro in vivo GPI-AP GPI
9 GPI GPI- AP GPI-AP Homans, S.W., Ferguson, M.A., Dwek, R.A., Rademacher, T. W., Anand, R., Williams, A.F.Nature,,. Ferguson, M.A., Homans, S.W., Dwek, R.A., Rademacher, T.W.Science,,. Kinoshita, T., Fujita, M., Maeda, Y.J. Biochem.,,.,. Miyata, T., Takeda, J., Iida, Y., Yamada, N., Inoue, N., Takahashi, M., Maeda, K., Kitani, T., Kinoshita, T.Science,,. Inoue, N., Watanabe, R., Takeda, J., Kinoshita, T. Biochem. Biophys. Res. Commun.,,. Kamitani, T., Chang, H.M., Rollins, C., Waneck, G.L., Yeh, E.T.H.J. Biol. Chem.,,. Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M., Kinoshita, T. EMBO J.,,. Watanabe, R., Inoue, N., Westfall, B., Taron, C.H., Orlean, P., Takeda, J., Kinoshita, T.EMBO J.,,. Murakami, Y., Siripanyaphinyo, U., Hong, Y., Tashima, Y., Maeda, Y., Kinoshita, T.Mol. Biol. Cell,,. Maeda, Y., Tomita, S., Watanabe, R., Ohishi, K., Kinoshita, T.EMBO J.,,. Nakamura, N., Inoue, N., Watanabe, R., Takahashi, M., Takeda, J., Stevens, V.L., Kinoshita, T.J. Biol. Chem.,,. Watanabe, R., Ohishi, K., Maeda, Y., Nakamura, N., Kinoshita, T.Biochem. J.,,. Sagane, K., Umemura, M., Ogawa-Mitsuhashi, K., Tsukahara, K., Yoko-o, T., Jigami, Y.J. Biol. Chem.,,. Murakami, Y., Siripanyapinyo, U., Hong, Y., Kang, J.Y., Ishihara, S., Nakakuma, H., Maeda, Y., Kinoshita, T. Mol. Biol. Cell,,. Houjou, T., Hayakawa, J., Watanabe, R., Tashima, Y., Maeda, Y., Kinoshita, T., Taguchi, R.J. Lipid Res.,,. Braverman, N.E., Moser, A.B.Biochim. Biophys. Acta,,. Kanzawa, N., Maeda, Y., Ogiso, H., Murakami, Y., Taguchi, R., Kinoshita, T. ( Proc. Natl. Acad. Sci. USA,,. Kanzawa, N., Shimozawa, N., Wanders, R.J., Ikeda, K., Murakami, Y., Waterham, H.R., Mukai, S., Fujita, M., Maeda, Y., Taguchi, R., Fujiki, Y., Kinoshita, T.J. Lipid Res.,,. Maeda, Y., Watanabe, R., Harris, C.L., Hong, Y., Ohishi, K., Kinoshita, K., Kinoshita, T.EMBO J.,,. Oriol, R., Martinez-Duncker, I., Chantret, I., Mollicone, R., Codogno, P.Mol. Biol. Evol.,,. Ashida, H., Hong, Y., Murakami, Y., Shishioh, N., Sugimoto, N., Kim, Y.U., Maeda, Y., Kinoshita, T.Mol. Biol. Cell,,. Kang, J.Y., Hong, Y., Ashida, H., Shishioh, N., Murakami, Y., Morita, Y.S., Maeda, Y., Kinoshita, T. J. Biol. Chem.,,. Hong, Y., Maeda, Y., Watanabe, R., Ohishi, K., Mishkind, M., Riezman, H., Kinoshita, T. J. Biol. Chem.,,. Ohba, C., Okamoto, N., Murakami, Y., Suzuki, Y., Tsurusaki, Y., Nakashima, M., Miyake, N., Tanaka, F., Kinoshita, T., Matsumoto, N., Saitsu, H.Neurogenetics,,. Takahashi, M., Inoue, N., Ohishi, K., Maeda, Y., Nakamura, N., Endo, Y., Fujita, T., Takeda, J., Kinoshita, T. EMBO J.,,. Hong, Y., Maeda, Y., Watanabe, R., Inoue, N., Ohishi, K., Kinoshita, T.J. Biol. Chem.,,. Inoue, N., Kinoshita, T., Orii, T., Takeda, J.J. Biol. Chem.,,. Shishioh, N., Hong, Y., Ohishi, K., Ashida, H., Maeda, Y., Kinoshita, T.J. Biol. Chem.,,. Taron, B.W., Colussi, P.A., Wiedman, J. M., Orlean, P., Taron, C. H.J. Biol. Chem.,,. Ast, T., Cohen, G., Schuldiner, M.Cell,,. Eisenhaber, B., Eisenhaber, S., Kwang, T.Y., Gruber, G., Eisenhaber, F.Cell Cycle,,. Ohishi, K., Inoue, N., Maeda, Y., Takeda, J., Riezman, H., Kinoshita, T.Mol. Biol. Cell,,. Ohishi, K., Inoue, N., Kinoshita, T.EMBO J.,,. Hong, Y., Ohishi, K., Kang, J.Y., Tanaka, S., Inoue, N., Nishimura, J., Maeda, Y., Kinoshita, T.Mol. Biol. Cell,,. Vainauskas, S. Menon, A.K.J. Biol. Chem.,, Tanaka, S., Maeda, Y., Tashima, Y., Kinoshita, T. J. Biol. Chem.,,. Fujita, M., Watanabe, R., Jaensch, N., Romanova-Michaelides, M., Satoh, T., Kato, M., Riezman, H., Yamaguchi, Y., Maeda, Y., Kinoshita, T.J. Cell Biol.,,. Roberts, W.L., Santikarn, S., Reinhold, V.N., Rosenberry, T.L.J. Biol. Chem.,,. Roberts, W.L., Myher, J.J., Kuksis, A., Low, M.G., Rosenberry, T.L.J. Biol. Chem.,,. Fujita, M., Maeda, Y., Ra, M., Yamaguchi, Y., Taguchi, R., Kinoshita, T.Cell,,. Strating, J.R. Martens, G.J.Biol. Cell,,. Hirata, R., Nihei, C., Nakano, A.J. Biol. Chem.,,. Theiler, R., Fujita, M., Nagae, M., Yamaguchi, Y., Maeda, Y., Kinoshita, T.J. Biol. Chem.,,. Maeda, Y., Tashima, Y., Houjou, T., Fujita, M., Yoko-o, T., Jigami, Y., Taguchi, R., Kinoshita, T.Mol. Biol. Cell,,. Tashima, Y., Taguchi, R., Murata, C., Ashida, H., Kinoshita, T., Maeda, Y.Mol. Biol. Cell,,. Nozaki, M., Ohishi, K., Yamada, N., Kinoshita, T., Nagy, A., Takeda, J.Lab. Invest.,,. Takeda, J., Miyata, T., Kawagoe, K., Iida, Y., Endo, Y., Fujita, T., Takahashi, M., Kitani, T., Kinoshita, T.Cell,,.
10 Almeida, A.M., Murakami, Y., Layton, D.M., Hillmen, P., Sellick, G.S., Maeda, Y., Richards, S., Patterson, S., Kotsianidis, I., Mollica, L., Crawford, D.H., Baker, A., Ferguson, M., Roberts, I., Houlston, R., Kinoshita, T., Karadimitris, A. Nat. Med.,,. Krawitz, P.M., Schweiger, M.R., Rodelsperger, C., Marcelis, C., Kolsch, U., Meisel, C., Stephani, F., Kinoshita, T., Murakami, Y., Bauer, S., Isau, M., Fischer, A., Dahl, A., Kerick, M., Hecht, J., Kohler, S., Jager, M., Grunhagen, J., de Condor, B.J., Doelken, S., Brunner, H.G., Meinecke, P., Passarge, E., Thompson, M.D., Cole, D.E., Horn, D., Roscioli, T., Mundlos, S., Robinson, P.N.Nat. Genet.,,. Parker, C., Omine, M., Richards, S., Nishimura, J., Bessler, M., Ware, R., Hillmen, P., Luzzatto, L., Young, N., Kinoshita, T., Rosse, W., Socie, G., International, P.N.H.I.G. Blood,,. Rother, R.P., Rollins, S.A., Mojcik, C.F., Brodsky, R.A., Bell, L.Nat. Biotechnol.,,. Murakami, Y., Kosaka, H., Maeda, Y., Nishimura, J., Inoue, N., Ohishi, K., Okabe, M., Takeda, J., Kinoshita, T. Blood,,. Hanaoka, N., Murakami, Y., Nagata, M., Horikawa, K., Nagakura, S., Yonemura, Y., Murata, S., Sonoki, T., Kinoshita, T., Nakakuma, H.Br. J. Haematol.,,. Gargiulo, L., Papaioannou, M., Sica, M., Talini, G., Chaidos, A., Richichi, B., Nikolaev, A.V., Nativi, C., Layton, M., de la Fuente, J., Roberts, I., Luzzatto, L., Notaro, R., Karadimitris, A.Blood,,. Inoue, N., Izui-Sarumaru, T., Murakami, Y., Endo, Y., Nishimura, J., Kurokawa, K., Kuwayama, M., Shime, H., Machii, T., Kanakura, Y., Meyers, G., Wittwer, C., Chen, Z., Babcock, W., Frei-Lahr, D., Parker, C.J., Kinoshita, T. Blood,,. Yamada, N., Miyata, T., Maeda, K., Kitani, T., Takeda, J., Kinoshita, T.Blood,,. Nafa, K., Mason, P.J., Hillmen, P., Luzzatto, L., Bessler, M. Blood,,. Pramoonjago, P., Wanachiwanawin, W., Chinprasertsak, S., Pattanapanayasat, K., Takeda, J., Kinoshita, T. Blood,,. Araten, D.J., Nafa, K., Pakdeesuwan, K., Luzzatto, L. Proc. Natl. Acad. Sci. USA,,. Krawitz, P.M., Hochsmann, B., Murakami, Y., Teubner, B., Kruger, U., Klopocki, E., Neitzel, H., Hoellein, A., Schneider, C., Parkhomchuk, D., Hecht, J., Robinson, P.N., Mundlos, S., Kinoshita, T., Schrezenmeier, H.Blood,,. Krawitz, P.M., Murakami, Y., Hecht, J., Kruger, U., Holder, S. E., Mortier, G.R., Delle Chiaie, B., De Baere, E., Thompson, M.D., Roscioli, T., Kielbasa, S., Kinoshita, T., Mundlos, S., Robinson, P.N., Horn, D.Am. J. Hum. Genet.,,. Krawitz, P.M., Murakami, Y., Riess, A., Hietala, M., Kruger, U., Zhu, N., Kinoshita, T., Mundlos, S., Hecht, J., Robinson, P. N., Horn, D.Am. J. Hum. Genet.,,. Kuki, I., Takahashi, Y., Okazaki, S., Kawawaki, H., Ehara, E., Inoue, N., Kinoshita, T., Murakami, Y.Neurology,,. Howard, M.F., Murakami, Y., Pagnamenta, A.T., Daumer- Haas, C., Fischer, B., Hecht, J., Keays, D.A., Knight, S.J., Kolsch, U., Kruger, U., Leiz, S., Maeda, Y., Mitchell, D., Mundlos, S., Phillips, J.A., 3rd, Robinson, P.N., Kini, U., Taylor, J.C., Horn, D., Kinoshita, T., Krawitz, P.M. Am. J. Hum. Genet.,,. Hansen, L., Tawamie, H., Murakami, Y., Mang, Y., ur Rehman, S., Buchert, R., Schaffer, S., Muhammad, S., Bak, M., Nöthen, M.M., Bennett, E.P., Maeda, Y., Aigner, M., Reis, A., Kinoshita, T., Tommerup, N., Baig, S.M., Jamra, R.A. Am. J. Hum. Genet.,,. Martin, H.C., Kim, G.E., Pagnamenta, A.T., Murakami, Y., Carvill, G.L., Meyer, E., Copley, R.R., Rimmer, A., Barcia, G., Fleming, M.R., Kronengold, J., Brown, M.R., Hudspith, K.A., Broxholme, J., Kanapin, A., Cazier, J.B., Kinoshita, T., Nabbout, R., Consortium, W.G.S., Bentley, D., McVean, G., Heavin, S., Zaiwalla, Z., McShane, T., Mefford, H.C., Shears, D., Stewart, H., Kurian, M.A., Scheffer, I.E., Blair, E., Donnelly, P., Kaczmarek, L.K., Taylor, J.C.Hum. Mol. Genet.,,. Murakami, Y., Tawamie, H., Maeda, Y., Buttner, C., Buchert, R., Radwan, F., Schaffer, S., Sticht, H., Aigner, M., Reis, A., Kinoshita, T., Jamra, R.A. PLoS Genet.,, e. Kato, M., Saitsu, H., Murakami, Y., Kikuchi, K., Watanabe, S., Iai, M., Miya, K., Matsuura, R., Takayama, R., Ohba, C., Nakashima, M., Tsurusaki, Y., Miyake, N., Hamano, S., Osaka, H., Hayasaka, K., Kinoshita, T., Matsumoto, N. Neurology,,. Chiyonobu, T., Inoue, N., Morimoto, M., Kinoshita, T., Murakami, Y.J. Med. Genet.,,. Ng, B.G., Hackmann, K., Jones, M.A., Eroshkin, A.M., He, P., Wiliams, R., Bhide, S., Cantagrel, V., Gleeson, J.G., Paller, A. S., Schnur, R.E., Tinschert, S., Zunich, J., Hegde, M.R., Freeze, H.H.Am. J. Hum. Genet.,,. Maydan, G., Noyman, I., Har-Zahav, A., Neriah, Z.B., Pasmanik-Chor, M., Yeheskel, A., Albin-Kaplanski, A., Maya, I., Magal, N., Birk, E., Simon, A.J., Halevy, A., Rechavi, G., Shohat, M., Straussberg, R., Basel-Vanagaite, L. J. Med. Genet.,,. Johnston, J.J., Gropman, A.L., Sapp, J.C., Teer, J.K., Martin, J. M., Liu, C.F., Yuan, X., Ye, Z., Cheng, L., Brodsky, R.A., Biesecker, L.G.Am. J. Hum. Genet.,,. Kvarnung, M., Nilsson, D., Lindstrand, A., Korenke, G.C., Chiang, S.C., Blennow, E., Bergmann, M., Stodberg, T., Makitie, O., Anderlid, B. M., Bryceson, Y.T., Nordenskjold, M., Nordgren, A.J. Med. Genet.,,. Brady, P.D., Moerman, P., De Catte, L., Deprest, J., Devriendt, K., Vermeesch, J.R.Eur. J. Med. Genet.,,. Horn, D., Wieczorek, D., Metcalfe, K., Baric, I., Palezac, L., Cuk, M., Petkovic Ramadza, D., Kruger, U., Demuth, S., Heinritz, W., Linden, T., Koenig, J., Robinson, P.N., Krawitz, P. Eur. J. Hum. Genet.,,. Belet, S., Fieremans, N., Yuan, X., Van Esch, H., Verbeeck, J., Ye, Z., Cheng, L., Brodsky, B.R., Hu, H., Kalscheuer, V.M., Brodsky, R.A., Froyen, G.Hum. Mutat.,,. Swoboda, K.J., Margraf, R.L., Carey, J.C., Zhou, H., Newcomb, T.M., Coonrod, E., Durtschi, J., Mallempati, K., Kumanovics, A., Katz, B.E., Voelkerding, K.V., Opitz, J.M. Am. J. Med. Genet. A,,. van der Crabben, S.N., Harakalova, M., Brilstra, E.H., van Berkestijn, F.M., Hofstede, F.C., van Vught, A.J., Cuppen, E., Kloosterman, W., Ploos van Amstel, H.K., van Haaften, G., van Haelst, M.M.Am. J. Med. Genet. A,,. Freeze, H.H.J. Biol. Chem.,,. Murakami, Y., Kanzawa, N., Saito, K., Krawitz, P.M., Mundlos, S., Robinson, P.N., Karadimitris, A., Maeda, Y., Kinoshita, T.J. Biol. Chem.,,.
11 GPI GPI GPI http: biken men-ekihuzen index.html
本文／ＹＡ９１９１Ｃ
pp. GPI GPI GPI GPI GPI GPI GPI GPI GPI GPI C GPI GPI C PLC PI C PI- PLC Biosynthesis and remodeling of GPI-anchored proteins Morihisa Fujita Department of Immunoregulation, Research Institute for Microbial
先天性GPI欠損症の診療ガイドライン2018改訂版
1 2 PGAP6! GPIPLD 細胞膜 ラフト ゴルジ体 PGAP4! PGAP2! PGAP3 ラフト GDP DPM1! DPM2! DPM3 MPDU1! N C PGAP 遺伝子群 N 小胞体 PIGT PIGA PIGL PIGW PIGX! PIGM PIGO PIGV PIGN PIGG! PIGB PIGF PIGF! GPAA1! PIGS! PIGU! PIGK! PGAP1
1) van Meer, G., Op den Kamp, J. A.: J. Cell. Biochem., 19, 193-2040982) 2) Gaffet, P., Bettache, N., Bienvenue, A.: Biochemistry, 34, 6762-6769(1995) 3) Sims, P. J., Wiedmer, T.: Thromb. Haemost., 86,
drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:
Various function and toxicity of iron Key words 1) Hentze, M. W. et al: Cell, 117, 285-297 (2004) 2) Ganz, T.: Blood, 102, 783-788 (2003) 3) Nemeth, E. et al.: Science, 306, 2090-2093 (2004) 4) Hentze,
要件の判定に必要な事項 1. 患者数 100 人未満 2. 発病の機構未解明 ( 遺伝子異常による疾患であるが病態については未解明 ) 3. 効果的な治療方法未確立 ( 根本的な治療法はない 種々の対症療法 ピリドキシンの補充療法が有効な症例がある ) 4. 長期の療養必要 ( 発症後 生涯にわたっ
320 先天性グリコシルホスファチジルイノシトール (GPI) 欠損症 概要 1. 概要糖脂質からなる GPI アンカーは ほ乳類の細胞においては 150 種以上の蛋白質の膜結合に用いられている GPI が欠損するとこれらの全ての蛋白質が細胞表面に発現できない 現在までに 27 個の遺伝子が GPI アンカー型蛋白質の生合成や 修飾に必要であることがわかっている 最近 これらの遺伝子の変異による先天性グリコシルホスファチジルイノシトール
Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)
1) Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L., Coyle, J.T.: Neuron, 2, 1547-1558 (1989) 2) Pellegrini-Giampietro, D.E., Cherici, G., Ale siani,m., Carla, V., Moroni, F.: J. Neuro science,10,
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1) Y. Hatefi: Annu. Rev. Biochem., 54, 1015 (1985). 2) H. Weiss, T. Friedrich, G. Hofhaus & D. Preis: Eur. 4) M. Yamaguchi & Y. Hatefi: Biochemistry, 32, 1935 (1993). 5) K. Leonard, H. Haiker & H. Weiss:
Database Center for Life Science Online Service Signal transduction of growth factor mediated by heparin heparan sulfate
Signal transduction of growth factor mediated by heparin heparan sulfate 1) Zhu. X.. Komiya, H., Chirino, A.. Faham. S.. Fox, G. M., Arakawa, T., Hsu, B.T., Rees, D. C.: Science. 251, 90-93 (1991)
64) M.L. Gefter, R.L. Russell: J. Mol. Biol., 39, 145 (1969) 65) F. Harada, F. Kimura and S. Nishimura: Biochim. Biophys. Acta., 182, 590 (1969) 65a) F.H.C. Crick: J. Mol, Biol., 19, 548 (1966); M. Nirenberg
Database Center for Life Science Online Service (http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*,
(http : // taxonomy.zoology.gla.ac.uk/rod/treeview.html) Takaaki Abe, Michiaki Unno*, Tohru Onogawa*, E mail : takaabe@mail.cc.tohoku.ac.jp Taro Tokui, Molecular identification of organic anion transporter
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欧州特許庁米国特許商標庁との共通特許分類 CPC (Cooperative Patent Classification) 日本パテントデータサービス ( 株 ) 国際部 2019 年 1 月 17 日 CPC 版のプレ リリースが公開されました 原文及び詳細はCPCホームページの C
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Database Center for Life Science Online Service
1) Epps, H. M., Gale, E. F.: Biochem. J., 36, 619-623 (1942) 2) Monod, J.: Recherches sur la croissance des cultures bacteriennes, Ph. D. thesis. Her mann,paris (1942) 3) Magasanik, B.: Cold Spring Harbor
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1/3 A. 電気所 ( 発電所, 変電所, 配電塔 ) における変圧器の空き容量 覧 < 留意事項 > (1) 空容量は 安であり 系統接続の前には 接続検討のお申込みによる詳細検討が必要となります その結果 空容量が変更となる場合があります (2) 熱容量を考慮した空き容量を記載しております その他の要因 ( や系統安定度など ) で連系制約が発 する場合があります (3) 表 は 既に空容量がないため
2/8 一次二次当該 42 AX 変圧器 なし 43 AY 変圧器 なし 44 BA 変圧器 なし 45 BB 変圧器 なし 46 BC 変圧器 なし
1/8 A. 電気所 ( 発電所, 変電所, 配電塔 ) における変圧器の空き容量一覧 < 留意事項 > (1) 空容量は目安であり 系統接続の前には 接続検討のお申込みによる詳細検討が必要となります その結果 空容量が変更となる場合があります (2) 特に記載のない限り 熱容量を考慮した空き容量を記載しております その他の要因 ( や系統安定度など ) で連系制約が発生する場合があります (3)
Tomohiro Terada, Ken-ichi Inui, Peptide transporter family situ 1) Matthews, D.M. : Physiol. Rev., 55, 537-608(1975) 2) Ganapathy, V.. Leibach, F.H.: Am. J. Physiol. Gastro intest. Liver Physiol.,
寄稿論文 規則性無機ナノ空間が創り出す新しい触媒能 | 東京化成工業
MCM-41 M41 MCM-41 M41 2 3 m 2 /g nm nm Mn Ti Ti H N 2 S Ti-MCM-41, H H N H H 2 2 -Urea, CH 2 Cl 2, H 2 S + S 1b 2b 3b 54%, 58% ee Ti M41 H 2 As 4 ZP 4 ZP ZS ZS 5 Me Me Me Me M41 / 15 mg MeH 1.0 mmol 89%
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Database Center for Life Science Online Service
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Amyloid Fibril Formation and Protein Science Yuji GOTO Institute for Protein Research, Osaka University E-mail: ygoto@protein.osaka-u.ac.jp Abstract: Amyloid fibrils have been a critical subject in recent
食糧 その科学と技術 No.48( )
79 +.* + 1/* A + 80, E + + Bioaccessibility +, 81,. 0* nm bo, Caco-, +* - - 82 - Caco, + Pow +, b-carotene ;,, a-carotene ; -, b-cryptoxanthin ;., lutein ; /, zeaxanthin ; 0, canthaxanthin ; 1, astaxanthin
1/120 別表第 1(6 8 及び10 関係 ) 放射性物質の種類が明らかで かつ 一種類である場合の放射線業務従事者の呼吸する空気中の放射性物質の濃度限度等 添付 第一欄第二欄第三欄第四欄第五欄第六欄 放射性物質の種類 吸入摂取した 経口摂取した 放射線業 周辺監視 周辺監視 場合の実効線 場合
1/120 別表第 1(6 8 及び10 関係 ) 放射性物質の種類が明らかで かつ 一種類である場合の放射線業務従事者の呼吸する空気中の放射性物質の濃度限度等 添付 第一欄第二欄第三欄第四欄第五欄第六欄 放射性物質の種類 吸入摂取した 経口摂取した 放射線業 周辺監視 周辺監視 場合の実効線 場合の実効線 務従事者 区域外の 区域外の 量係数 量係数 の呼吸す 空気中の 水中の濃 る空気中 濃度限度
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Kazuo Emoto, Masato Umeda, E-mail : emoto@rinshoken.or.jp pliakov, 0., De Camilli, P.: Neuron, 24, 143-154 (1999) 8) Takei, K., Haucke, V., Slepnev, V., Farsad, K., Salazar, M., Chen, H., De Camilli,