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1 pp. GPI GPI GPI GPI GPI GPI GPI GPI GPI GPI C GPI GPI C PLC PI C PI- PLC Biosynthesis and remodeling of GPI-anchored proteins Morihisa Fujita Department of Immunoregulation, Research Institute for Microbial Diseases, Osaka University, Yamada-oka, Suita, Osaka, Japan GPI VSG Thy- GPI GPI Ino P GlcN Man EtNP EtNP- -Man-α-Manα-Man-α-GlcN-α-Ino-P- GPI GPI GPI Man Man EtNP Man Man α-man ManR Man Man EtNP R Man β-n - GalNAc R Man β-n - GlcNAc
2 GPI Man EtNP GPI β-galnac GPI GPI GPI sn- Ino R sn- GPI Step GlcNAc-PI GPI PI PI -stearoyl- -arachidonyl-pi C C sn- PI N - GlcNAc GlcNAc-PI PIGA PIGC PIGH PIGP PIGQ PIGY DPM GPI- GnT PIGA carbohydrate-active enzyme CAZy glycosyltransferase family GT DPM GPI-GnT PIGY GPI-GnT PIGA Eri p PIGY GPI-GnT Eri p Ras Ras GPI-GnT Ras PIGY GPI-GnT Step GlcNAc-PI GlcNAc-PI N - PIGL GlcN-PI PIGL P A -H- P A -DD HxxH Step GPI GPI Step Step GlcN-PI in vitro ATP Step Ino GlcN-PI Ino C GlcN- acyl PI PIGW CoA Gwt p PIGW Ino Gwt p GPI - -butylbenzyl isoquinoline BIQ E BIQ PIGW Step PI GPI GPI GlcN-PI GlcN- acyl PI
3 GPI GPI-GlcNAc GPI-GnT UDP-GlcNAc PIGA Xp. PNH GPI GPI MCAHS PIGC q -q GPI PIGH q. GPI PIGP q. GPI PIGQ p. GPI PIGY q. ERI DPM q. DPM -CDG GlcNAc-PI PIGL p -p. CHIME syndrome GPI Not identified Ino Palmitoyl-CoA PIGW q GWT PI Not identified α-man I GPI-MT I Dol-P-Man PIGM q. GPI GPI PIGX q PBN ARV α-man II GPI-MT II Dol-P-Man PIGV p. HPMR GPI PGA EtNP I GPI-ET I PE PIGN q. GPI MCAHS MCD α-man III GPI-MT III Dol-P-Man PIGB q. GPI M α-man IV GPI-MT IV Dol-P-Man PIGZ SMP q SMP EtNP III GPI-ET III PE PIGO p. HPMR GPI PIGF p -p GPI EtNP II GPI-ET II PE PIGG GPI p. GPI PIGF p -p GPI GPI GPI-TA PIGK p. GPI GPAA q. GAA PIGS p. GPI PIGT q -q. GPI GPI PIGU q. GAB Ino PGAP q. BST EtNP PGAP MPPE p. CDC TED GPI A PGAP q PER GPI Stearyl-CoA? PGAP p. HPMR CWH -N? Not identified GUP CR Ceramide? CWH -C? p CWH Dol-P-Man DPM DPM q. CDG-Ie DPM DPM q. DPM -CDG DPM q CDG-Io DPM Dol-P-Glucose MPDU p. -p CDG-If PNH: paroxysmal nocturnal hemoglobinuria, HPMR: hyperphosphatasia with mental retardation syndrome, CHIME: coloboma, congenital heart disease, ichthyosiform dermatosis, mental retardation, and ear anomalies syndrome, MCAHS: multiple congenital anomalies-hypotonia-seizures syndrome, CDG: Congenital disorder of glycosylation.
4 GPI GlcN- acyl PI Step Man GlcN- acyl PI α-man Dol-P-Man PIGM PIGX GPI- GPI-MT I PIGM GT PIGX PIGM PIGM Arv p GlcN- acyl PI GPI-MT I Step Man Dol-P-Man GPI-MT II PIGV Man-GlcN- acyl PI α-man PIGV GT PIGV PIGM PIGV PIGB GPI Dol-P-Man Pga p PIGV Gpi p Step Man EtNP Man EtNP PIGN PIGN PEEtNP Codinea simplex YW BE A PIGN EtNP Step PIGN GPI Step Man PIGB Man- EtNP Man-GlcN- acyl PI α- Man PIGB GT PIGM PIGV Dol-P-Man Step M Man Man GT PIGZ α-man Man-Man- EtNP Man-GlcN- acyl PI Step EtNP Step Man EtNP Man EtNP PIGO PIGF GPI- EtNP III PIGO PIGN PIGF PIGO Step PIGW Ino EtNP-Man-Man- EtNP Man-GlcN- acyl PI GPI H
5 Step Man EtNP Man EtNP PIGG PIGF GPI-EtNP II PIGG PIGN PIGO PIGF GPI- EtNP II III PIGO PIGG GPI H Man EtNP GPI EtNP H H GPI PIGG GPI GPI GPI GPI PIGK GPI EtNP H EtNP H GPI Step GPI N C GPI GPI C GPI EtNP GPI ω-site GPI GPI i ω-site ii ω Gly Ala Ser iii ω iv C GPI GPI PIGK GAA PIGS PIGT PIGU GPI PIGK Cys His PIGK PIGU PIGM GPI PIGT PIGK GPI PIGK GAA PIGT TbGPI TbGAA TbGPI PIGS PIGU TTA TTA TTA PIGS TTA TTA GPI Step GPI GPI GPI PIGW Ino PGAP PGAP GxSxG PGAP Bst p GPI GPI
6 GPI Bst p GPI Gas p Gas p GPI Gas p ERAD-L Gas p Gas p Pmt p Pmt p O - O - Pgap otocephaly holoprosencephaly Oto Pgap Pgap Wnt Nodal Pgap Step GPI GPI EtNP EtNP PGAP PGAP Mn PGAP KxKxx PGAP EtNP PGAP GPI GPI EtNP GPI PGAP EtNP PGAP Ted p Cdc p Ted p Gas p CDC GPI PER GUP Step GPI PGAP PGAP GPI GPI II COPII GPI PI COPII GPI COPII p Golgi dynamics GOLD COPII COPI I p α β γ δ GOLD p I COPI p Emp p Erv p Erp p Erp p GPI p β p δ GPI GPI PGAP PGAP GPI p GPI GPI p ph GPI p COPII Sec p p EMPERV GPI BST sec bypass-of-sec-thirteen BST GPI PER TED GUP p ERP ERP BST
7 sec Sec p Sec p COPII Sec p GPI GPI pgpi Sec p COPII GPI GPI p COPII Sec Sec Sec A B C D Sec Sec p Sfb p Lst p Sec C D Lst p p Sec C D lst GPI p GPI COPII Step GPI GPI sn- C C GPI sn- C sn- C GPI GPI GPI GPI PGAP Per p PGAP PGAP PGAP Per p PGAP Per p GPI DRM PGAP PGAP GPI PGAP GPI PLD PGAP membrane-bound O-acyltransferase MBOAT Gup p Step CR GPI Cwh p Cwh p N PGAP C C C GPI GPI GPI GPI Cwh p C CWH -C Cwh p CWH -C CWH -C GPI GPI GPI GPI PI-PLC GPI GPI D
8 GPI-PLDGPI-PLD CEA CDProstasin Cripto GPI ACE I GPI Ace ACE GPI ACE TEX GPI TEX ADAM ACE ADAM Ace TEX ADAM Tex TEX ADAM Notum Wnt Notum α β- Notum GPI Dally-like protein Dlp GPI Notum GPI GPI GDE GDE Notch GDE GPI RECK GPI GDERECK ADAM ADAM Notch Delta-like Notch GDE GDE GDE GPI GDE GPI GPI GPI PNH PNH PIGA PIGA GPI X GPI GPI CDCD GPI GPI Alexion Pharmaceuticals C GPI PNH Piga GPI GPI GPI HPMR CHIME GPI GPI PIGA PIGL PIGM PIGV PIGN PIGO PIGT PGAP PIGO GPI HPMR GPI GPI PIGV PIGO GPI GPI GPI
9 GPI Slein, M.W. & Logan, G.F., Jr.J. Bacteriol.,, Ikezawa, H.Biol. Pharm. Bull.,, Ferguson, M.A., Homans, S.W., Dwek, R.A., & Rademacher, T.W.Science,, Homans, S.W., Ferguson, M.A., Dwek, R.A., Rademacher, T. W., Anand, R., & Williams, A.F.Nature,, Ferguson, M.A., Kinoshita, T., & Hart, G.W.Glycosylphosphatidylinositol Anchors. in Essentials of Glycobiology Varki, A., Cummings, R.D., Esko, J.D., Freeze, H.H., Stanley, P., Bertozzi, C.R., Hart, G.W., & Etzler, M.E. eds., pp., Cold Spring Harbor Laboratory Press, New York. Fukushima, K., Ikehara, Y., Kanai, M., Kochibe, N., Kuroki, M., & Yamashita, K.J. Biol. Chem.,, Roberts, W.L., Santikarn, S., Reinhold, V.N., & Rosenberry, T.L.J. Biol. Chem.,, Kinoshita, T., Fujita, M., & Maeda, Y.J. Biochem.,, Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M., & Kinoshita, T EMBO J.,, Murakami, Y., Siripanyaphinyo, U., Hong, Y., Tashima, Y., Maeda, Y., & Kinoshita, T.Mol. Biol. Cell,, Sobering, A.K., Watanabe, R., Romeo, M.J., Yan, B.C., Specht, C.A., Orlean, P., Riezman, H., & Levin, D.E. Cell,, Watanabe, R., Ohishi, K., Maeda, Y., Nakamura, N., & Kinoshita, T.Biochem. J., Pt, Handa, N., Terada, T., Kamewari, Y., Hamana, H., Tame, J. R., Park, S.Y., Kinoshita, K., Ota, M., Nakamura, H., Kuramitsu, S., Shirouzu, M., & Yokoyama, S.Protein Sci.,, Urbaniak, M.D., Crossman, A., Chang, T., Smith, T.K., van Aalten, D.M., & Ferguson, M.A.J. Biol. Chem.,, Vishwakarma, R.A. & Menon, A.K.Chem. Commun. Camb., Murakami, Y., Siripanyapinyo, U., Hong, Y., Kang, J.Y., Ishihara, S., Nakakuma, H., Maeda, Y., & Kinoshita, T. Mol. Biol. Cell,, Sagane, K., Umemura, M., Ogawa-Mitsuhashi, K., Tsukahara, K., Yoko-o, T., & Jigami, Y.J. Biol. Chem.,, Tsukahara, K., Hata, K., Nakamoto, K., Sagane, K., Watanabe, N.A., Kuromitsu, J., Kai, J., Tsuchiya, M., Ohba, F., Jigami, Y., Yoshimatsu, K., & Nagasu, T.Mol. Microbiol.,, Umemura, M., Okamoto, M., Nakayama, K., Sagane, K., Tsukahara, K., Hata, K., & Jigami, Y.J. Biol. Chem.,, Hata, K., Horii, T., Miyazaki, M., Watanabe, N.A., Okubo, M., Sonoda, J., Nakamoto, K., Tanaka, K., Shirotori, S., Murai, N., Inoue, S., Matsukura, M., Abe, S., Yoshimatsu, K., & Asada, M. Antimicrob. Agents Chemother.,, Houjou, T., Hayakawa, J., Watanabe, R., Tashima, Y., Maeda, Y., Kinoshita, T., & Taguchi, R.J. Lipid Res.,, Kanzawa, N., Maeda, Y., Ogiso, H., Murakami, Y., Taguchi, R., & Kinoshita, T.Proc. Natl. Acad. Sci. USA,, Kanzawa, N., Shimozawa, N., Wanders, R.J., Ikeda, K., Murakami, Y., Waterham, H.R., Mukai, S., Fujita, M., Maeda, Y., Taguchi, R., Fujiki, Y., & Kinoshita, T.J. Lipid Res.,, Kajiwara, K., Watanabe, R., Pichler, H., Ihara, K., Murakami, S., Riezman, H., & Funato, K.Mol. Biol. Cell,, Hirata, T., Fujita, M., Kanzawa, N., Murakami, Y., Maeda, Y., & Kinoshita, T.J. Biochem.,, Sato, K., Noda, Y., & Yoda, K.Mol. Biol. Cell,, Hong, Y., Maeda, Y., Watanabe, R., Ohishi, K., Mishkind, M., Riezman, H., & Kinoshita, T.J. Biol. Chem.,, Sutterlin, C., Horvath, A., Gerold, P., Schwarz, R.T., Wang, Y., Dreyfuss, M., & Riezman, H. EMBO J.,, Vainauskas, S. & Menon, A.K.J. Biol. Chem.,, Takahashi, M., Inoue, N., Ohishi, K., Maeda, Y., Nakamura, N., Endo, Y., Fujita, T., Takeda, J., & Kinoshita, T. EMBO J.,, Taron, B.W., Colussi, P.A., Wiedman, J.M., Orlean, P., & Taron, C.H.J. Biol. Chem.,, Grimme, S.J., Westfall, B.A., Wiedman, J.M., Taron, C.H., & Orlean, P.J. Biol. Chem.,, Hong, Y., Maeda, Y., Watanabe, R., Inoue, N., Ohishi, K., & Kinoshita, T.J. Biol. Chem.,, Guther, M.L. & Ferguson, M.A.EMBO J.,, Shishioh, N., Hong, Y., Ohishi, K., Ashida, H., Maeda, Y., & Kinoshita, T.J. Biol. Chem.,, Benachour, A., Sipos, G., Flury, I., Reggiori, F., Canivenc- Gansel, E., Vionnet, C., Conzelmann, A., & Benghezal, M. J. Biol. Chem.,, Fujita, M., Yoko-o, T., Okamoto, M., & Jigami, Y.J. Biol. Chem.,,
10 Fujita, M., Maeda, Y., Ra, M., Yamaguchi, Y., Taguchi, R., & Kinoshita, T.Cell,, Orlean, P. & Menon, A.K.J. Lipid Res.,, Ohishi, K., Inoue, N., Maeda, Y., Takeda, J., Riezman, H., & Kinoshita, T.Mol. Biol. Cell,, Ohishi, K., Nagamune, K., Maeda, Y., & Kinoshita, T. J. Biol. Chem.,, Nagamune, K., Ohishi, K., Ashida, H., Hong, Y., Hino, J., Kangawa, K., Inoue, N., Maeda, Y., & Kinoshita, T. Proc. Natl. Acad. Sci. USA,, Tanaka, S., Maeda, Y., Tashima, Y., & Kinoshita, T. J. Biol. Chem.,, Fujita, M., Yoko-o, T., & Jigami, Y.Mol. Biol. Cell,, Goder, V. & Melero, A.J. Cell Sci.,, Hirayama, H., Fujita, M., Yoko-o, T., & Jigami, Y.J. Biochem.,, Ueda, Y., Yamaguchi, R., Ikawa, M., Okabe, M., Morii, E., Maeda, Y., & Kinoshita, T. J. Biol. Chem.,, McKean,D.M.&Niswander,L.Biol. Open,, Zoltewicz, J.S., Ashique, A.M., Choe, Y., Lee, G., Taylor, S., Phamluong, K., Solloway, M., & Peterson, A.S.PLoS One,, e Fujita, M., Watanabe, R., Jaensch, N., Romanova-Michaelides, M., Satoh, T., Kato, M., Riezman, H., Yamaguchi, Y., Maeda, Y., & Kinoshita, T.J. Cell Biol.,, Imhof, I., Flury, I., Vionnet, C., Roubaty, C., Egger, D., & Conzelmann, A.J. Biol. Chem.,, Haass, F.A., Jonikas, M., Walter, P., Weissman, J.S., Jan, Y. N., Jan, L.Y., & Schuldiner, M.Proc. Natl. Acad. Sci. USA,, Losev, E., Papanikou, E., Rossanese, O.W., & Glick, B.S. Mol. Cell. Biol.,, Strating, J.R. & Martens, G.J.Biol. Cell,, Belden, W.J. & Barlowe, C.J. Biol. Chem.,, Marzioch, M., Henthorn, D.C., Herrmann, J.M., Wilson, R., Thomas, D.Y., Bergeron, J.J., Solari, R.C., & Rowley, A. Mol. Biol. Cell,, Schimmoller, F., Singer-Kruger, B., Schroder, S., Kruger, U., Barlowe, C., & Riezman, H.EMBO J.,, Bonnon, C., Wendeler, M.W., Paccaud, J.P., & Hauri, H.P. J. Cell Sci.,, Takida, S., Maeda, Y., & Kinoshita, T.Biochem. J.,, Elrod-Erickson, M.J. & Kaiser, C.A.Mol. Biol. Cell,, Copic, A., Latham, C.F., Horlbeck, M.A., D Arcangelo, J.G., & Miller, E.A.Science,, Silvius, J.Science,, Miller, E.A., Beilharz, T.H., Malkus, P.N., Lee, M.C., Hamamoto, S., Orci, L., & Schekman, R.Cell,, Peng, R., De Antoni, A., & Gallwitz, D.J. Biol. Chem.,, Maeda, Y., Tashima, Y., Houjou, T., Fujita, M., Yoko-o, T., Jigami, Y., Taguchi, R., & Kinoshita, T.Mol. Biol. Cell,, Sipos, G., Reggiori, F., Vionnet, C., & Conzelmann, A. EMBO J.,, Tashima, Y., Taguchi, R., Murata, C., Ashida, H., Kinoshita, T., & Maeda, Y.Mol. Biol. Cell,, Fujita, M., Umemura, M., Yoko-o, T., & Jigami, Y. Mol. Biol. Cell,, Pei, J., Millay, D.P., Olson, E.N., & Grishin, N.V. Biol. Direct,,. Bosson, R., Jaquenoud, M., & Conzelmann, A.Mol. Biol. Cell,, Reggiori, F., Canivenc-Gansel, E., & Conzelmann, A. EMBO J.,, Ghugtyal, V., Vionnet, C., Roubaty, C., & Conzelmann, A. Mol. Microbiol.,, Umemura, M., Fujita, M., Yoko-o, T., Fukamizu, A., & Jigami, Y.Mol. Biol. Cell,, Vionnet, C., Roubaty, C., Ejsing, C.S., Knudsen, J., & Conzelmann, A.J. Biol. Chem.,, Zhan,X.,Wang,C.,Liu,A.,Liu,Q.,&Zhang,Y. Acta Biochim. Biophys. Sin. Shanghai,, Verghese, G.M., Gutknecht, M.F., & Caughey, G.H. Am. J. Physiol. Cell Physiol.,, C Watanabe, K., Bianco, C., Strizzi, L., Hamada, S., Mancino, M., Bailly, V., Mo, W., Wen, D., Miatkowski, K., Gonzales, M., Sanicola, M., Seno, M., & Salomon, D.S.J. Biol. Chem.,, Wilhelm, O.G., Wilhelm, S., Escott, G.M., Lutz, V., Magdolen, V., Schmitt, M., Rifkin, D.B., Wilson, E.L., Graeff, H., & Brunner, G.J. Cell Physiol.,, Yamamoto, Y., Hirakawa, E., Mori, S., Hamada, Y., Kawaguchi, N., & Matsuura, N.Biochem. Biophys. Res. Commun.,, Kondoh, G., Tojo, H., Nakatani, Y., Komazawa, N., Murata, C., Yamagata, K., Maeda, Y., Kinoshita, T., Okabe, M., Taguchi, R., & Takeda, J.Nat. Med.,, Fujihara, Y., Tokuhiro, K., Muro, Y., Kondoh, G., Araki, Y., Ikawa, M., & Okabe, M.Proc. Natl. Acad. Sci. USA,, Giraldez, A.J., Copley, R.R., & Cohen, S.M.Dev. Cell,, Kreuger, J., Perez, L., Giraldez, A.J., & Cohen, S.M. Dev. Cell,, Traister, A., Shi, W., & Filmus, J.Biochem. J.,, Yanaka, N.Biosci. Biotechnol. Biochem.,, Sabharwal, P., Lee, C., Park, S., Rao, M., & Sockanathan, S. Neuron,, Park, S., Lee, C., Sabharwal, P., Zhang, M., Meyers, C.L., & Sockanathan, S.Science,, Roth, A. & Duhrsen, U.Eur. J. Haematol.,, Kawagoe, K., Kitamura, D., Okabe, M., Taniuchi, I., Ikawa, M., Watanabe, T., Kinoshita, T., & Takeda, J.Blood,, Almeida, A.M., Murakami, Y., Layton, D.M., Hillmen, P., Sellick, G.S., Maeda, Y., Richards, S., Patterson, S., Kotsianidis, I., Mollica, L., Crawford, D.H., Baker, A., Ferguson, M., Roberts, I., Houlston, R., Kinoshita, T., & Karadimitris, A. Nat. Med.,, Johnston, J.J., Gropman, A.L., Sapp, J.C., Teer, J.K., Martin,
11 J.M., Liu, C.F., Yuan, X., Ye, Z., Cheng, L., Brodsky, R.A., & Biesecker, L.G.Am.J.Hum.Genet.,, Krawitz, P.M., Murakami, Y., Hecht, J., Kruger, U., Holder, S.E., Mortier, G.R., Delle Chiaie, B., De Baere, E., Thompson, M.D., Roscioli, T., Kielbasa, S., Kinoshita, T., Mundlos, S., Robinson, P.N., & Horn, D.Am. J. Hum. Genet.,, Krawitz, P.M., Schweiger, M.R., Rodelsperger, C., Marcelis, C., Kolsch, U., Meisel, C., Stephani, F., Kinoshita, T., Murakami, Y., Bauer, S., Isau, M., Fischer, A., Dahl, A., Kerick, M., Hecht, J., Kohler, S., Jager, M., Grunhagen, J., de Condor, B.J., Doelken, S., Brunner, H.G., Meinecke, P., Passarge, E., Thompson, M.D., Cole, D.E., Horn, D., Roscioli, T., Mundlos, S., & Robinson, P.N.Nat. Genet.,, Maydan, G., Noyman, I., Har-Zahav, A., Neriah, Z.B., Pasmanik-Chor, M., Yeheskel, A., Albin-Kaplanski, A., Maya, I., Magal, N., Birk, E., Simon, A.J., Halevy, A., Rechavi, G., Shohat, M., Straussberg, R., & Basel-Vanagaite, L.J. Med. Genet.,, Ng, B.G., Hackmann, K., Jones, M.A., Eroshkin, A.M., He, P., Wiliams, R., Bhide, S., Cantagrel, V., Gleeson, J.G., Paller, A.S., Schnur, R.E., Tinschert, S., Zunich, J., Hegde, M.R., & Freeze, H.H.Am.J.Hum.Genet.,, Kvarnung, M., Nilsson, D., Lindstrand, A., Korenke, G.C., Chiang, S.C., Blennow, E., Bergmann, M., Stodberg, T., Makitie, O., Anderlid, B.M., Bryceson, Y.T., Nordenskjold, M.,&Nordgren,A.J. Med. Genet.,, Hansen, L., Tawamie, H., Murakami, Y., Mang, Y., ur Rehman, S., Buchert, R., Schaffer, S., Muhammad, S., Bak, M., Nothen, M.M., Bennett, E.P., Maeda, Y., Aigner, M., Reis, A., Kinoshita, T., Tommerup, N., Baig, S.M., & Abou Jamra, R.Am.J.Hum.Genet.,, Krawitz, P.M., Murakami, Y., Riess, A., Hietala, M., Kruger, U., Zhu, N., Kinoshita, T., Mundlos, S., Hecht, J., Robinson, P.N., & Horn, D.Am.J.Hum.Genet.,, Kuki, I., Takahashi, Y., Okazaki, S., Kawaki, H., Ehara, E., Inoue, N., Kinoshita, T., & Murakami, Y.Neurology,, Murakami, Y., Kanzawa, N., Saito, K., Krawitz, P.M., Mundlos, S., Robinson, P.N., Karadimitris, A., Maeda, Y., & Kinoshita, T.J. Biol. Chem.,,
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GPI GPI GPI-AP GPI GPI GPI GPI GPI-AP GPI GPI-AP GPI-AP GPI GPI-AP GPI GPI GPI GPI GPI A GPI-AP GPI GPI-AP B GPI GPI GPI-AP GPI-AP GPI GPI-AP GPI-AP GPI GPI UniProt GPI-AP Biochemistry of glycosylphosphatidylinositol
先天性GPI欠損症の診療ガイドライン2018改訂版
1 2 PGAP6! GPIPLD 細胞膜 ラフト ゴルジ体 PGAP4! PGAP2! PGAP3 ラフト GDP DPM1! DPM2! DPM3 MPDU1! N C PGAP 遺伝子群 N 小胞体 PIGT PIGA PIGL PIGW PIGX! PIGM PIGO PIGV PIGN PIGG! PIGB PIGF PIGF! GPAA1! PIGS! PIGU! PIGK! PGAP1
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pp. E- -SH X in vitro in vivo -SH Structure-based drug development and medical biological application of cathepsin specific inhibitors Nobuhiko Katunuma Institute for Health Sciences, Tokushima Bunri University,Nishihamabouji,
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1) Epps, H. M., Gale, E. F.: Biochem. J., 36, 619-623 (1942) 2) Monod, J.: Recherches sur la croissance des cultures bacteriennes, Ph. D. thesis. Her mann,paris (1942) 3) Magasanik, B.: Cold Spring Harbor
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64) M.L. Gefter, R.L. Russell: J. Mol. Biol., 39, 145 (1969) 65) F. Harada, F. Kimura and S. Nishimura: Biochim. Biophys. Acta., 182, 590 (1969) 65a) F.H.C. Crick: J. Mol, Biol., 19, 548 (1966); M. Nirenberg
1) Y. Hatefi: Annu. Rev. Biochem., 54, 1015 (1985). 2) H. Weiss, T. Friedrich, G. Hofhaus & D. Preis: Eur. 4) M. Yamaguchi & Y. Hatefi: Biochemistry, 32, 1935 (1993). 5) K. Leonard, H. Haiker & H. Weiss:
本文／ＡＹ３８０Ｐ
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1/68 A. 電気所 ( 発電所, 変電所, 配電塔 ) における変圧器の空き容量一覧 平成 31 年 3 月 6 日現在 < 留意事項 > (1) 空容量は目安であり 系統接続の前には 接続検討のお申込みによる詳細検討が必要となります その結果 空容量が変更となる場合があります (2) 特に記載
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The hair growth effect of minoxidil Susumu OTOMO, Ph. D. Key words : minoxidil, minoxidil sulfate, hair growth, K+-channel opener, male pattern baldness Dept. of Pharmacology, Research Center Taisho Pharmaceutical
4) H. Takayama et al.: J. Med. Chem., 45, 1949 (2002). 5) H. Takayama et al.: J. Am. Chem. Soc., 112, 8635 (2000). 6) H. Takayama et al.: Tetrahedron Lett., 42, 2995 (2001). 9) M. Kitajima et al: Chem.
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Short Review E-mail : kuwata@cc.gifu-u.ac.jp Structural medicine and structure-based drug design for prion diseases 2) Anfinsen, C. B.: Harvey Lect., 61, 95-116 (1967) 3) Carrel, R. W., Lomas, D. A.
Spatio-temporal regulation of ERK1/2 MAP kinase 20) Murphy, L. 0., MacKeigan, J. P., Blenis, J.: Mol. Cell. Biol., 24, 144-153 (2004) 21) Harada, T., Morooka, T., Ogawa, S., Nishida, E.: Nature Cell
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D., Nicola, N. A., Hilton, D. J.: Nature, 387, 917-921 (1997) 12) Alexander, W. S. : Nat. Rev. Immunol., 2,410-416 (2002) 13) Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., Shuai, K. : Science,
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1 Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan; 2 Department of Thoracic Surgery, Aichi Cancer Center, Japan;
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