02スチレンダイマー、トリマー.PDF
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1 [Styrene dimer, CAS No ; Styrene trimer, ] -1,2 C 16 H 16 C 24 H ,2 CH 2 CH 2 2, ,4, ,2-1,3, ,430 g/g 9,590 g/g 2 3 HSDB, 2001 ; 2, 1998; 3 Mayo, 1968; Kurze et al.,
2 1. 1) 2) (1) in vitro -3-1 (ER) (AR) TR, 1999;, 2000; Hirano et al., 2001; Ohno et al., 2001; Date et al., 2002 (MCF-7) (, 1999; Ohno et al., 2001) MCF-7 / Fail et al., MCF (E2) EC M E M EC M ( E2 1/68,000 ) E2 1/43,000 (Ohyama et al., 2001) (2) -4 SD % 3.17 % 4.52% 1.65% 6 ) ,000 mg/kg 1,000 mg/kg 1 mg/kg Rao et al., 1978 Wistar % 15.2% 54.3% ppm mg/kg/day 4 in vitro 2
3 160 ppm (DES) 1/20,000 Prinsen, 1996 SD mg/kg/day Fail et al., 1998) Wistar (22 1 ) GPPS8 HIPS6 EPS ) 0.33 mg/l 0.75 mg/l 3 GPPS HIPS EPS 10: mg/kg/day Bachmann et al., 1998 SD mg/kg/day 3, 1999; Date et al., 2002 (OECD ) SD mg/kg/day 7 50 µg/head/day, 2000; Date et al., 2002 SD ( ppm 8.73 ppm) 0.2 ( 2.64 ppm 32.8 ppm) 1.0 mg/kg/day ( 16.9 ppm 166 ppm)
4 mg/kg T3 T4 Nagao et al., 2000 in vitro SD (hcg) M hcg, ) (1) (2) 4) (1) -1 S9 TA98 Grifoll et al., 1990 in vitro -1 * TA98 S9(+) mg/plate * Grifoll et al.,
5 (2) -2-2 EPA IRIS, 2002 EU ECB, 2000 NTP NTP, 2000 IARC IARC, 2001 ACGIH ACGIH, 2001, ) 6) in vitro MCF µm MCF /68,000 5
6 . in vitro in vivo 6
7 ACGIH (2001) American Conference of Governmental Industrial Hygienists. Documentation of the threshold limit values and biological exposure indices. Seventh Edition, Cincinnati, Ohio, 200. Bachmann, S., Hellwig, J., Jackh, R., and Christian, M.S. (1998) Uterotrophic assay of two concentration of migrates from each of 23 polystyrenes administered orally (by gavage) to immature female rats. Drug Chem. Toxicol., 21, Date, K., Ohno, K., Azuma, Y., Hirano, S., Kobayashi, K., Sakurai, T., Nobuhara, Y. and Yamada, T. (2002) Endocrine-disrupting effects of styrene oligomers that migrated from polystyrene containers into food. Food Chem. Toxicol., 40, ECB (2000) Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances ANNEX I ( Fail, P.A., Hines, J.W., Zacharewski, T., Wu, Z.F., and Borodinsky, L. (1998) Assessment of polystyrene extract for estrogenic activity in the rat uterotrophic model and in vitro recombinant receptor reporter gene assay. Drug Chem. Toxicol., 21, Grifoll, M., Solanas, A.M., and Bayona, J. M. (1990) Characterization of genotoxic components in sediments by mass spectrometric techniques combined with Salmonella/microsome test. Arch. Environ. Contam. Toxicol., 19, Hirano, S., Tanaka, M., Date, K., Ohno, K., Kobayashi, K., Sakurai, T., Nagao, Y., Nobuhara, Y. and Yamada, T. (2001) Identification, determination, and biological evaluation of a novel styrene trimer contained in polystyrene food containers.2. J. Agric. Food Chem., 49, HSDB (2001) Hazardous Substances Data Bank, National Library of Medicine, ( IARC (2001) IARC Monograph on the Evaluation of Carcinogenic Risks to Humans. IRIS (2002) Integrated Risk Information System, National Library of Medicine ( Kurze, V.J., Stein, D.J., Simak, P., and Kaiser, R. (1970) Über die Konstitution der styrololigomeren aus der thermischen Polymerisation. Angew. Makromol. Chem., 12, Mayo, F.R. (1968) The dimerization of styrene. J. Amer. Chem. Soc., 90, Nagao, T., Wada, K., Kuwagata, M., and Ono, H. (2000) Effects of prenatal exposure to styrene dimers and trimers on reproductive function in rats. Reprod. Toxicol., 14, NTP (2000) U.S. Department of Health and Human Services, Public Health Service, National 7
8 Toxicology Program, 9th Report on Carcinogens. Ohno, K., Azuma, Y., Nakano, S., Kobayashi, T., Hirano, S., Nobuhara, Y. and Yamada, T. (2001). Assessment of styrene oligomers eluted from polystyrene-made food containers for estrogenic effects in vitro assays. Food Chem. Toxicol., 39, Ohyama, K., Nagai, F., and Tsuchiya, Y. (2001) Certain styrene oligomers have proliferative activity on MCF-7 human breast tumor cells and binding affinity for human estrogen receptor α. Environ. Health Perspect, 109, Prinsen, M.K. (1996) Determination of oestrogenic activity of F2L5250 in the Tiecco test with rats. TNO-report, , 1-27, TNO Nutrition and Food Research Institute, Utrechtseweg, The Netherlands (USEPA TSCA 8(e) report, 8EHQ ). Rao, K.S., Murray, J.S. John, J.A., Crawford, A.A., and Jersey, G.C. (1978) Evaluation of the estrogenic potential of condensate from a polystyrene manufacturing plant. Dow Chemical U.S.A. (USEPA TSCA 8(e) report, 8EHQ , 1995). (1998)., 39, (2001)., 43, (1999)., 40, ,
9 -1 NSD-01 2,4-Diphenyl-1-butene, 1999; CH 2, 2000 Hirano et al., 2001 NSD-08 cis-1,2-diphenylcyclobutane NSD-09 trans-1,2-diphenylcyclobutane NST-01 2,4,6-Tripheyl-1-hexene CH 2 NST-02 * ) 1,3,5-Triphenylcyclohexane 1e,3e,5a-Triphenylcyclohexane, 1e,3e,5e-Triphenylcyclohexane NST-03 1e-Phenyl-4e-(1 -phenylethyl)tetralin (1S*-Phenyl-4S*-(1R*-phenylethyl)tetralin, 1S*-Phenyl-4R*-(1S*-phenylethyl)tetralin, 1S*-Phenyl-4S*-(1S*-phenylethyl)tetralin, 1S*-Phenyl-4R*-(1R*-phenylethyl)tetralin H 3 C NST-12 ** ) 1e-Phenyl-4a-(2-phenylethyl)tetralin 9
10 NST-13 (1S*,6R*,7S*,8S*,11R*)-6,11- Hirano et al., diphenyltricyclo[6,2,2,0 2,7 ]dodeca-2,9-diene 2001 * ) 1999 ** )
11 -2 Ohyama et al. *), SD-1 1,3-Diphenylpropane Ohyama et al., 2001; SD-2 2,4-Diphenyl-1-butene NSD-01, 1999; SD-3 cis-1,2-diphenylcyclobutane NSD-08, 2000 SD-4 trans-1,2-diphenylcyclobutane NSD-09 ST-1 2,4,6-Tripheyl-1-hexene NST-01 ST-2 1a-Phenyl-4a-(1 -phenylethyl)tetralin ST-3 1a-Phenyl-4e-(1 -phenylethyl)tetralin NST-03 ST-4 1e-Phenyl-4a-(1 -phenylethyl)tetralin (4 ST-5 1e-Phenyl-4e-(1 -phenylethyl)tetralin ) ST-6 1,3,5-Triphenylcyclohexane 1e,3e,5a NST-02 ST-7 1e,3e,5e *) 11
12 -3 in vitro ER 10-5 M E2 ER, 1999 ( 1 ER) (E2 IC M) 3 AR M DHT AR, ) ( AR) (DHT IC M) ER 10-5 M E2 ER, 2000 ( 1 ER) (E2 IC M) AR M DHT AR, 2000 ( 3 AR) 2) (DHT IC M) TR 10-5 M T4 TR, 2000 ( AR) (T4 IC M) ER M E2 ER Hirano et al., 2) ( ER) (E2 IC M) 2001 E2 SD-1,2,3,4 IC ER Ohyama 4 M M SD 4 ST et al.,2001 3) 7 ST-1,2,3,4,5 IC ER M M ( ST M E2 1/43,000 ) ST M (E2 IC M) 1.0 ER Fail et al., 4) (MCF-7) ER mg/ml ,1999; (MCF-7) M Hirano et al., E M FBS 3 DME 4 2) 12 well plate cells/well SD-3,4 EC M Ohyama (MCF-7) 4 ST-1,3,4,5 EC ) M SD2 ST4 et al., SD-1,2,ST-2,6, M ( cells/well ( E2 EC M) E2 1/68,000 ) 1) ER: ; AR: ; TR: ; E2: 17 - ; SD: ; ST: ; DHT: ; T4: ; IC15, IC20, IC50: E ; EC30, EC50: E
13 . 2) -1 3) -2 4) :
14 -4 (SD 22 ) (SD 21 ) ,000 mg/kg Rao et al., ,000 mg/kg 1) Fail et al., ) 3 ( ) 3 23 Bachmann et al., (Wistar22 3) ) ( ) , 1999; (SD( mg/kg/day Hirano et al., 21 ) ) ( ) 1 (3 ) (4 ) 4) , 2000 (SD 7 mg/kg/day 4 ) ( ) ( 3 ) 1 (3 ) (3 ) 4) 50 µg/animal/day mg/kg/day, 2000 (F344 7 ) 3 (6 ) 1 (3 ) (3 ) 4) (SD mg/kg/day Nagao et al., ) 1h 10 M, 1999 (SD hcg 7 1 3h (3 ) (3 ) 4) 14
15 1) % 2) : ) GPPS8 HIPS6 EPS 0.33 mg/l ) -1 5) 0.04 mg/kg/day ppm 8.73 ppm0.2 mg/kg/day 2.64 ppm 32.8 ppm1.0 mg/kg/day 16.9 ppm 166 ppm 15
,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
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