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- へいぞう こやぎ
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1 [2,4-Dichlorophenol, CAS No ] 2,4-2,4-DCP 4- -1,3-2,4-DCP C 6 H 4 Cl 2 O OH Cl 45 1) ) d 25 = Cl 60 1) 16 Pa (25) 1) Log Pow = ) BOD0 4 2) 4.5 g/l (20) 1) 1) 13 1) 3) 1) HSDB, 2001; 2) 3), 1982;,
2 1) 2,4-2,4-DCP( ) (EPA, 2000) 100 2,4-DCP (10) mg/l 1.2 mg/l 2,4-DCP Kintz et al., ,4-DCP( ) 20 (EPA, 2000) 2,4-DCP( ) mg/l 2,4-DCP (EPA, 2000) 2,4-DCP 1 EPA OSHA 2,4-DCP CANPR(Chemical Advisory and Notice of Potential Risk) EPA, ,4-DCP 2,4,5-29 ( ) 11 Bleiberg et al, 1964 ( German Chemical Society, 1988) 2) (1) in vitro -1 2,4-DCP (ER) M Kramer et al., 1999; CERI, ,4-DCP (ERE) (E2 1/130,000)Nishihara et al., 2000MCF-7 Jones et al., ,4-DCP Tran et al., ,4-DCP M ERE CERI, 2001a 2,4-DCP (CERI, 2003) (CERI, 2003) 2
3 (2) -2, 3 OECD 8 Wistar Hannover 2,4-DCP mg/kg/day 3 2,4-DCP mg/kg/day µg/kg/day CERI2001b OECD 8 Wistar Hannover 2,4-DCP mg/kg/day 10 2,4-DCP mg/kg/day 0.4 mg/kg/day CERI, 2001b C57BL/6 AKR (6 //)2,4-DCP 74 mg/kgdmso C57BL/6 18 AKR 19 C57BL/6 AKR 40 4 (6/251 DMSO 1/229 )(1 )(2 )(1 ) NTIS, 1968a F344 (34 /) ,4-DCP( 99.2%) mg/kg/day( ) mg/kg/day 375 mg/kg/day 750 mg/kg/day (4/34 ) 750 mg/kg/day 2,4-DCP 750 mg/kg/day Rodwell et al., SD 2,4-DCP( 99) ppm ( mg/kg/day ) ppm 300 ppm 6 Exon et al.,1984; Exon & Koller, 1985 Wistar Hannover 2,4-DCP 05002,0008,000 ppm (: mg/kg/day : mg/kg/day ) 2 2,000 ppm F 0 3
4 F 0 F 1 8,000 ppm F 0 F 1 F 0 F 1 F 0 F 0 8,000 ppm F 1 F 1 F 1 F 2 F 1 2,000 ppm 8,000 ppm F 1 F 1 F 1 NOAEL 500 ppm (: 33.4 mg/kg/day : 49.1 mg/kg/day) NOAEL 2,000 ppm (: 134 mg/kg/day : 194 mg/kg/day) (, 2003) in vitro CB 6 F 1 CD-1 DCP mm 2,5-3,4-3,5-DCP 2,4-DCP 2,4-DCP mg/kg/day 90 CD-1 2,4-DCP 2,5-3,4-3,5-DCP Seyler et al., ) (1) -1(German Chemical Society, 1988; EHC, 1989; NTIS, 1968b) LD 50 LC 50-1 German Chemical Society, * LD 50 1, mg/kg 1) 580-4,000 mg/kg* 2 47 mg/kg 3 LC 50 LD 50 > 2,000 mg/kg 3 4
5 LD mg/kg mg/kg 2 LD 50 1,730 mg/kg 2 LDLo LDLo * 1) German Chemical Society, ) EHC, ) NTIS, 1968b ( 2,4-DCP ) (2) -4 B6C3F 1 (10 //) 2,4-DCP 9902,5005,00010,000 20,00040,000 ppm 13 10,000 ppm 20,000 ppm 40,000 ppm 3 US.NTP, 1989 ddn 7 // 2,4-DCP ( mg/kg/day )6 230 mg/kg/day NOEL 100 mg/kg/day, 1972 B6C3F 1 (50 //)2,4-DCP 05,00010,000 ppm (:08001,300 mg/kg/day : mg/kg/day)2 10,000 ppm ( 11/50, 5,000 ppm 33/49, 10,000 ppm 42/48) (US.NTP, 1989) F344 (5 //)2,4-DCP 02001,0005,00020,000 ppm ( ,782 mg/kg/day )4 OECD TG40720,000 ppm -GTP German Chemical Society, 1996 F344 (10 //) 2,4-DCP 99 02,5005,000 10,00020,00040,000 ppm 13 10,000 ppm 20,000 ppm 20,000 ppm 40,000 ppm US.NTP, 1989 NOEL 10,000 ppm (1,000 mg/kg/day ) 5,000 ppm (500 mg/kg/day ) ( German Chemical Society, 1996) F344 2,4-DCP 99 05,00010,000 ppm ( mg/kg/day )02,5005,000ppm ( mg/kg/day )2 ( 25/45 5,000ppm 38/48 10,000 ppm 42/46) (US.NTP, 1989) 5
6 3 SD (10 /)2,4-DCP ppm ( mg/kg/day ) ppm (Exon et al., 1985) EPA NOEL 3 ppm0.5 mg/kg/day NOAEL 30 ppm5 mg/kg/day IRIS, 1988 WHO 6 NOEL 100 mg/kg/day, µg/kg/day TDI EHC, (1) -2 L5178 CHO CHO (Hilliard et al., 1998; US.NTP, 1981, 1989) V79 2,4-DCP V79 6- Jansson & Jansson, 1986 SD DNA (Elia et al., 1994) in vivo -2 in vitro * TA98TA1535TA100 TA1537 S9(-) 5001,000µg/plate German Chemical Society, 1988 TA98TA100TA1535 TA1537 S9(+/-) µg/plate US.NTP, 1989 TA98TA 100TA1537 S9(+/-) µg/plate US.NTP, 1989 TA98TA100TA1537 TA1535 S9(-) µg/plate US.NTP, 1989 TA98TA100YG1021 Tanaka, et al. YG1024YG1026YG1029 S9(+) µg/plate V79 (6-TG Jansson et al., ) S9(-) mg/l 1986 L5178YS9(-) mg/l US.NTP, 1989 CHO S9(+/-) S9(-): mg/l S9(+): mg/l US.NTP,
7 * CHO S9(+/-) S9-: 75 mg/l S9+: 150 mg/l CHO S9(+/-) S9-: mm S9+: mm TK6 S9(-) mm CHO S9(-) 1.2 mm1.4 mm Anderson et al., 1990 Hilliard et al., 1998 Galloway et al., 1998 CHO S9(+/-) S9-: mg/l US.NTP, 1989 S9+: mg/l V79 Onfelt, µmol/L Probst, et al., DNA 50-1,000 mmol/ml 1981 DNA SD mm Elia et al., 1994 * (2) -3-5,-6 8 B6C3F 1 (50 //)2,4-DCP ,000 10,000 ppm (:08001,300 mg/kg/day : mg/g/day )2 10,000 ppm 11/505,000 ppm 33/4910,000 ppm 42/48 ( 12/50 5,000 ppm 6/5010,000 ppm 4/50) 10,000 ppm 1 (1/50) ( 8) 2,4-DCP US.NTP, 1989 F344/N 2,4-DCP 9905,00010,000 ppm ( mg/kg/day )F344/N 02,5005,000 ppm ( mg/kg/day )2 ( 62%5,000ppm 34%10,000ppm 34%) (36.3%) 2,4-DCP US.NTP, ,4-DCP 2,4,6- US.EPAUS.NTPEU B2R 3 2,4-DCP 2,4-D (2,4- ) (EHC, 1989) ( ) 1977 IARC 2B Sutter (8-12 ) 0.3 DMBA ( ) 25µL (DMBA; 75µg)1 20 2,4-DCP 25µL ( 5 mg/ ) 7
8 /27 (48%) 24 12/16 (75%) 24 :3/27 (11%) Boutwell & Bosch, SD 2,4-DCP ppm ENU() EU() ppm 2,4-DCP ppm 2,4-DCP 2,4-DCP ENU 2,4-DCP Exon & Koller, US.EPA IRIS, 2002 EU ECB, 2000 US.NTP US.NTP, 2000 IARC IARC, 2001 ACGIH ACGIH, 2001, SD (10 /)2,4-DCP ppm ( mg/kg/day ) ppm 30 ppm DTH ) 300 ppm KLH Exon et al., 1984 F344 5 // 2,4-DCP 02001,0005,00020,000 ppm ,782 mg/kg/day 4 OECD TG ,000 ppm IgG IgM German Chemical Society, ,4-DCP (IARC, 1986) 8
9 SD (: g)10 mg/kg ( ) 2,4-DCP ( ) ,4-DCP ( ) 2,4-DCP mg/kg( ) Somani & Khalique, ,4-DCP 1(Somani & Khalique, 1982) P450 3A4 2,4-DCP in vitro 2- -1,4-2- 1,2,4-1Mehmood et al., ,4-DCP (16) (HSDB) 24 2,4-DCP(20 g/) (HSDB,2001) OH Cl O Cl OH (2) O (3) OH Cl OH OH (6) (7) Cl (1) OH (4) (5) (1) 2,4-2,4-DCP (2) 2- -1,4- (3) 2- -1,4- (4) 1,2,4-1 2,4-9
10 E2 1/130,000 in vivo 2 8,000 ppm (: 543 mg/kg/day : 768 mg/kg/day) 2,4-DCP (: 543 mg/kg/day : 768 mg/kg/day) (in vitro) (400 mg/kg/day) ( ) 10
11 ( ) ) ACGIH (2001) American Conference of Governmental Industrial Hygienists. Documentation of the threshold limit values and biological exposure indices. Seventh Edition, Cincinnati, Ohio, 200. Anderson, B.E., Zeiger, E., Shelby, M.D., Resnick, M.A., Gulati, D.K., Ivett, J.L., and Loveday, K.S. (1990) Chromosome aberration and sister chromatid exchange test results with 42 chemicals. Environ. Mol. Mutagen., 16 (Suppl. 18), Bleiberg, J., Wallen, M., Brodkin, R., and Applebaum, I.L. (1964) Industrially acquired porphyria. Arch. Dermatol., 89, Boutwell, R.K., and Bosch, D.K. (1959) The tumor-promoting action of phenol and related compounds for mouse skin. Cancer Res., 19, ECB (2000) Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substancesannex I ( EHC (1989) Chlorophenols Other Than Pentachlorophenol. Environmental Health Criteria (EHC) 93, IPCS. Elia, M.C., Storer, R.D., McKelvey, T.W., Kraynak, A.R., Barnum, J.E., Harmon, L.S., Deluca, J.G., and Nichols, W.W. (1994) Rapid DNA degradation in primary rat hepatocyte treated with diverse cytotoxic chemicals: analysis by pulsed field gel electrophoresis and implications for alkaline elution assays. Environ. Mol. Mutagen., 24, Exon, J.H., Henningsen, G.M., Osborne, C.C., and Koller, L.D. (1984) Toxicologic, pathologic, and immunotoxic effects of 2,4-dichlorophenol in rats. J. Toxicol. Environ. Health, 14, Exon, J.H., and Koller, L.D. (1985) Toxicity of 2-chlorophenol, 2,4-dichlorophenol and 2,4,6-trichlorophenol. pp in Water Chlorineation: Chemistry, Environmental Impact and Health Effect, Jolly et al., Ed., 5. Galloway, S.M., Miller, J.E., Armstrong, M.J., Bean, C.L., Skopek, T.R., and Nichols, W.W. (1998) DNA synthesis inhibition as an indirect mechanism of chromosome aberrations: comparison of DNA-reactive and non-dna-reactive clastogens. Mutat. Res., 400, German Chemical Society(1988) 2,4-Dichlorophenol. BUA Report 31. German Chemical Society(1998) BUA Report 193 Supplementary Reports. Hazardous Substances Data Bank (HSDB), U.S. National Library of Medicine (2001). Hilliard, C.A., Armstrong, M.J., Bradt, C.I., Hill, R.B., Greenwood, S., and Galloway, S.M. (1998) Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons. Environ. Mol. Mutagen., 31, IARC (2001) IARC Monograph on the Evaluation of Carcinogenic Risks to Humans. IRIS (2002) Integrated Risk Information System, National Library of Medicine, 1)
12 ( Jansson, K., and Jansson, V. (1986) Inability of chlorophenols to induce 6-thioguanine-resistant mutants in V79 Chinese hamster cells. Mutat. Res., 171, Jones, P.A., Baker, V.A., Irwin, A.J.E., and Earl, L.K. (1998) Interpretation of the in vitro proliferation response of MCF-7 cells to potential oestrogens and non-oestrogenic substances. Toxicol. in Vitro, 12, Kintz, P., Tracqui, A., and Mangin, P. (1992) Accidental death caused by the absorption of 2,4-dichlorophenol through the skin. Arch. Toxicol., 66, Kramer, V.J., and Giesy, J.P. (1999) Specific binding of hydroxylated polychlorinated biphenyl metabolites and other substances to bovine calf uterine estrogen receptor: structure-binding relationships. Sci. Total Environ., 233, Mehmood, Z., Kelly, D.E., and Kelly, S.L. (1997) Cytochrome P450 3A4 mediated metabolism of 2,4-dichlorophenol. Chemosphere, 34, Nishihara, T., Nishikawa, J., Kanayama, T., Dakeyama, F., Saito, K., Imagawa, M., Takatori, S., Kitagawa, Y., Hori, S., and Utsumi, H. (2000) Estrogenic activities of 517 chemicals by yeast two-hybrid assay. J. Health Sci., 46, Revised edition: NTIS National Technical Information Service (1968a) Evaluation of carcinogenic, teratogenic and mutagenic activities of selected pesticides and industrial chemicals., PB NTIS National Technical Information Service (1968b) OTS Onfelt, A. (1987) Spindle disturbances in mammalian cells:. Toxicity, c-mitosis and aneuploidy with 22 different compounds. Specific and unspecific mechanisms. Mutat. Res., 182, Rodwell, E.D., Wilson, R.D., Nemec, M.D., and Mercieca, M.D. (1984) A teratology study in Fisher 344 rats with 2,4-dichlorophenol. Toxicologist, 4, 167. Rodwell, D.E., Wilson, R.D., Nemec, M.D., and Mercieca, M.D. (1989) Teratogenic assessment of 2,4-dichlorophenol in Fisher 344 rats. Fund. Appl. Toxicol., 13, Seyler, D.E., East, J.M., Condie, L.W., and Borzelleca, J.F. (1984) The use of in vitro methods for assessing reproductive toxicity. Dichlorophenols. Toxicol. Lett., 20, Somani, S.M., and Khalique, A. (1982) Distribution and metabolism of 2,4-dichlorophenol in rats. J. Toxicol.Environ. Health, 9, Somani, S.M., Smart, T., and Khalique, A. (1984) Metabolism of 2,4-dichlorophenol by isolated perfused rat liver. J. Toxicol. Environ. Health, 13, Tanaka, Y., Iwasaki, H., and Kitamori, S. (1996) Biodegradation of herbicide chlornitrofen (CNP) and mutagenicity of its degradation products. Water Sci. Technol., 34, Tran, D.Q., Klotz, D.M., Ladlie, B.L., Ide, C.F., McLachlan, J.A., and Arnold, S.F. (1996) Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem. Biophys. Res. Commun., 229, US.EPA (2000) Chemical Advisory and Notice of Potential Risk: Skin exposure to molten 12
13 2,4-dichlorophenol can cause rapid death. February 15. US.NTP (1989) Toxicology and carcinogenesis studies of 2,4-dichlorophenol in F344/N rats and BC3F1 mice. (Feed Studies).Technical Report Series 353. US.NTP (2000) U.S. Department of Health and Human Services, Public Health Service, National Toxicology Program, 9th Report on Carcinogens. CERI 2001a12 CERI 2001b11 CERI (2003). (1972) 2, 4-Dichlorophenol., 19, (1982). (2003) 13. (2001),, 43,
14 -1 in vitro ER [ 3 H]-E2 IC50 >510-5 M Kramer et al., (E M) 1999 ER ER IC50 >10-4 M CERI, 2001a ( ER ) (E M) Gal4 DNA REC M ER Nishihara et ER (E M) al., 2000 Gal4 TIF2 - (E21/130,000) 10-6 M 2,4-DCP Tran et al., M M (2,4-DCP) 10-6 M 2,4-DCP M( ) M (2,4-DCP) M( ) 12 ER ER M ER CERI, 2001a HeLa M (E2PC50: <10 11 M) MCF M Jones et al., M (2,4-DCP) M (E2) 6 (10-14 M M E2 ) AR AR RBA AR CERI, 2003 ( AR ) M AR CERI, 2003 ( ) AR AR CV M AR CERI, 2003 ( M ) AR AR CHO-K M M (2,4-DCP) M DHT M (DHT) ER: ; E2: 17- ; REC10: 10-7 E2 10 ; PC50: E2 50 ; IC50: E2 50 ; AR: ; DHT: 14
15 CERI, Wistar ( mg/kg/day 2001b Hannover ) / 6 8 mg/kg µg/kg/day CERI, (Wistar ( mg/kg/day 2001b Hannover ) ) mg/kg/day (TP) 0.4 mg/kg/day mg/kg/day NTIS, (C57BL/6) (DMSO) ( a 6 ) / 6-15 (AKR) ( 19 6 ) / (4/40 ) (1/40 ) (2/40 ) (1/40 ) :200 mg/kg/day Rodwell et (F344) ( ( 20 mg/kg/day al., ) 34 / ) 375 mg/kg/day 750 mg/kg/day (4/34 ) :750 mg/kg/day ppm 300 ppm Exon, et al., SD , mg/kg/day Exon & (6 )30 ppm Koller, 10 / ( ) 300ppm 15
16 ,000 (Wistar 8,000 ppm (: 0F 0, 2003 Hannover ,000 ppm ) (F0 5 F 0 mg/kg/day 10 : ( 768 mg/kg/day F 0 F1 3 ) 24// 2 )) F 0 F 1 F 0 F 1 2,000 ppm 8,000 ppm F 1 8,000 ppm F 1 F 0 F 1 2,000 ppm ( ) 2,000 ppm 8,000 ppm F 1 8,000 ppm F 1 2,000 ppm 8,000 ppm F 2 8,000 ppm F 2 8,000 ppm NOAEL 500 ppm (: 33.4 mg/kg/day : 49.1 mg/kg/day) NOAEL 2,000 ppm (: 134 mg/kg/day : 194 mg/kg/day) NOAEL 2,000 ppm (: 134 mg/kg/day : 194 mg/kg/day) 16
17 -3 in vitro Seyler et al., ( CD-1 CB 6 F 1 ) 500 mg/kg/day mm 1984 (0.4 ml, ) 17
18 ,500 5,000 10,000 20,0002,500 ppm US.NTP, 1989 (B6C3F 1 ) 10 / 40,000 ppm 10,000 ppm 20,000 ppm 20,000 ppm 40,000 ppm ( 8/9 3/10 ) NOEL 10,000 ppm(1,500 mg/kg/day ) % 3 0.2, 1972 (ddn ) 7 / mg/kg/day (2 ) (1 ) (2 ) NOEL=100 mg/kg/day 205,00010,000 ppm 10,000 ppm US.NTP, 1989 (B6C3F 1 ) 50 / mg/kg/day mg/kg/day ( 11/50 33/4942/48) ,000 5,000 20,000 ppm 20,000 ppm German (F344 ( ,782 mg/kg/day -GTP Chemical ) ) Society, / ,500 5,000 10,000 20,00010,000 ppm US.NTP, 1989 (F344 ) 10 / 40, 000 ppm 20,000 ppm 40,000 ppm NOEL 10,000 ppm 5,000 ppm 2 05,00010,000 ppm 5,000 ppm (F344 ( mg/kg/day ) ) 02, ppm ( 25/45 38/48 50 / ( mg/kg/day ) 42/46) 10,000 ppm ppm 300 ppm Exon & Koller, SD 3 ( mg/kg/day ) (13 ) 10 / NOEL=3 ppm (0.5 mg/kg/day 3 -(15-18 ) ) NOAEL=30 ppm (5mg/kg/day ) 18
19 ,00010,000 ppm 5,000 ppm US.NTP, 1989 B6C3F1 50 / mg/kg/day mg/kg/day 11/505,000 ppm 33/49 10,000 ppm42/48 10,000 ppm F / 2 05,00010,000 ppm US.NTP, mg/kg 02, ppm mg/kg ( 62% 34% 36.3%) -6 DMBA/Vehicle : 1/14 (7%) DMBA* DMBA/2,4-DCP Sutter, µL : 13/27 (48%) 8-12 (75µg)1 ( ) 24 (25µL5 mg/animal ) DMBA/Vehicle : 3/27 (11%) DMBA/2,4-DCP : 12/16 (75%) Boutwell Bosch, SD EU ppm (13 Exon & Koller, NO / ppm ) / *DMBA9,10-Dimethyl-1,2-benzanthracence 19
20 ppm Exon et al., SD mg/kg/day 300 ppm 1984, Exon & Koller, 10 / ppm DTH 3 -(15 13 ) 300 ppm KLH 4 (F344 ) 5 / ,000 5,000 20,000 ppm ( ,782 mg/kg/day ) 20,000 ppm IgG IgM German Chemical Society,
0724ジクロロフェノール.PDF
[2,4-Dichlorophenol, CAS No. 120-83-2] 2,4-2,4-DCP 4- -1,3-2,4-DCP C 6 H 4 2 O 163.0 45 1) 210.0 1) 1. 383 d 60 25 = 1) 1) 16 Pa(25) 1) Log Pow = 3.06 2) BOD0 4 4.5 g/l(20) 1) 1) 3) 1) 1) HSDB, 2001; 2),
橡96-07.PDF
1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0
3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
CAS H 3 C C CH 2 C 9 H tert d = hpa
1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21
,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
t 492 t mg/l 30 mg/l BOD 95 OH = cm 3 / sec 25 8 OH /cm 3 12 = ph ph
2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
橡フタル酸ブチルベンジル.PDF
1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow
,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa
1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16
CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4
2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7
98-02.PDF
1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
,161 t 9,753 t 2,408 t LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum 6 3 Selenastrum h, Sb
1 20017 1543 CAS 1309644 125 Sb 2 O 3 291.52 1 99 1. 2 655 1,425 2 2 2 3 5.2 5.67 2 2 2. 10 12,161 t 9,753 t 2,408 t 4 3. 1 2 3 4. LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum
橡99-24_00 アリルアルコール.PDF
1 9924 2260 CAS 107186 H 2 C CH CH 2 OH 2- -1- C 3 H 6 O 58.08 1 99 1. 2, 3 3, 4, 5-129 96-97 2 21c.c. 24o.c. 2 6, 7 378 6, 7 2.5-18 d 20 4 0.8540 2, 5 2.00 = 1 2.7 kpa 20 mmhg204.3 kpa 32 mmhg30 4 log
橡96-01.PDF
1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20
橡アジポニトリル.PDF
1 200117 21512( ) CAS 111693 110( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N 2 108.14 1) 99 2-1. 2) 1 2) 295 2) 159(c.c.) 3) 550 3) 1.7-4.9 vol % ( ) 3) d 20 0.965 2) 3.73 ( = 1) 4 0.3 Pa (0.002 mmhg) (20) 2) log
http://www.who.int/ipcs/publications/ehc/en/index.html EHC 1 2 3 4 / EHC http://www.nihs.go.jp/dcbi/publist/ehchsg/ 1-8) WHO/IPCS CICAD (Concise Inter
3 [ ] Priority IARC JMPR 2004 10 Priority 1 Priority 1 Priority 2 Priority 3 Priority 1 1-1) CERI) http://www.cerij.or.jp/ceri_jp/koukai/sheet/sheet_indx4.htm http://www.safe.nite.go.jp/data/sougou/pk_list.html?table_name=hyoka&rank=sh
橡三酸化二アンチモン.PDF
1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
01オクタクロロスチレン.PDF
[Octachlorostyrene, CAS No. 29082-74-4] ( ) OCS C 8 C l8 379.71 0.0018 Pa (25 ) Log Pow = 6.29 ( ) 2) 0.00174 mg/l (25 ) HSDB, 2001; 2 PHYSPROP, 2000. 1 1. 1) (OCS) 9 OCS OCS 75 4 Selden et al., 1997 2
02スチレンダイマー、トリマー.PDF
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1,3-1,3- (1) 1,3-1,3- - CAS 542-75-6 C 3 H 4 Cl 2 110.97 2 1) -84 2) 108 2,3) 112 (trans-) 4) 104 (cis-) 4) 1.225 (20 ) 2) 5.2 kpa (39 mmhg) (25 ) 2) 4.5 kpa (34 mmhg) (25 ) 4) 5.7 kpa (43 mmhg) (25 )
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(1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16
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