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1 ² ß å ( 565 å ã { cžsžr c u 1-3) [Institute for Molecular and Cellular Biology, Osaka University, Yamada oka,suita, Osaka 565, Japan] Molecular Biology of Hepatitis B Virus
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9 6) Pasek, M., Goto, T., Gilbert, W., Zink, B., 1) Choo, Q.-L., Kuo, G., Weiner, A. J., Overby, L. R., Bradley, D. W., Houghton, M.: Science, 244, (1989) 2) Kuo, G., Choo, Q. L., Alter, H. J., Gitnick, G. L., Redeker, A. G., Purcell, R. H., Miyamura, T., Dienstag, J. L., Alter, M. J., Stevens, C. E., Tegtmeier, G. E., Bonino, F., Colombo, M., Lee, W. S., Kuo, C., Berger, K., Shuster, J. R., Overby, L. R., Bradley, D. W., Houghton, M.: Science, 244, (1989) 3 zganem, D., Varmus, H. E.: Annu. Rev. Bio chem.,56, (1987) 4) Gerlich, W. H., Robinson, W. S.: Cell, 21, (1980) 5) Charnay, P., Pourcel, C., Louise, A., Fritsch, A., Tiollais, P.: Proc. Natl. Acad. Sci. USA, 76, (1979)
10 Schaller, H., MacKay, P., Leadbetter, G., Mur ray,k.: Nature, 282, (1979) 7) Fujiyama, A., Miyanohara, A., Nozaki, C., Yo neyama,t., Ohtomo, N., Matsubara, K.: Nucleic Acids Res., 11, (1983) 8 zwill, H., Reiser, W., Weimer, T., Pfaff, E., Bus cher,m., Sprengel, R., Cattaneo, R., Schaller, H.: J. Virol., 61, (1987) 9) Su, T.-S., Lai, C.-J., Huang, J.-L., Lin, L. -H., Yauk, Y.-K., Chang, C., Lo, S. J., Han, S.-H.: J. Virol., 63, (1989) 10) Sprengel, R., Kaleta, E. F., Will, H.: J. Virol., 62, (1988) 11 ztiollais, P., Pourcel, C., Dejean, A.: Nature, 317, (1985) 12) Cattaneo, R., Will, H., Hernandez, N., Schal ler,h.: Nature, 305, (1983) 13) Tur-Kaspa, R., Burk, R. D., Shaul, Y., Shafr itz,d. A.: Proc. Natl. Acad. Sci. USA, 83, (1986) 14) Bulla, G. A., Siddiqui, A.: Virology, 170, (1989) 15) Heermann, K. H., Goldmann, U., Schwartz, W., Seyffarth, T., Baumgarten, H., Gerlich, W. H.: J. Virol., 52, (1984) 16) Neurath, A. R., Kent, S. B. H., Strick, N., Par ker,k.: Cell, 46, (1986) 17) Chisari, F. V., Filippi, P., McLachlan, A., Mi lich,d. R., Riggs, M., Lee, S., Palmiter, R., Pinkert, C. A., Brinster, R. L.: J. Virol., 60, (1986) 18) Imai, M., Yanase, Y., Nojiri, T.: Gasteroente rology,76, (1979) 19) Shlicht, H. J., Salfeld, J., Schaller, H.: J. Vi rol.,61, (1987) 20) Shlicht, H. J., Schaller, H.: J. Virol., 63, (1989) 21) Gallina, A., Bonelli, F., Zentilin, L., Rindi, G., Muttini, M., Milanesi, G.: J. Virol., 63, (1989) 22) Shlicht, H. J., Bartenschlager, R., Schaller, H.: J. Virol., 63, (1989) 23) Yaginuma, K., Shirakata, Y., Kobayashi, M., Koike, K.: Proc. Natl. Acad. Sci. USA, 84, (1987) 24 zsummers, J., Mason, W. S.: Cell, 29, (1982) 25) Toh, H., Hayashida, H., Miyata, T.: Nature, 305, (1983) 26) Bartenschlager, R., Schaller, H.: EMBO J., 7, (1988) 27) Bartenschlager, R., Radziwill, G., Schaller, H.: The 1989 meeting on hepatitis B viruses (Cold Spring Harbor, 1989) 28) Chang, I.-J., Hirsch, R., Colgrove, R., Ganem, D., Varmus, H. E.: The 1989 meeting on hepa titisb viruses (Cold Spring Harbor, 1989) 29) Bavand, M., Feitelson, M., Laub, O.: J. Virol., 63, (1989) 30) Bavand, M. R., Laub, O.: J. Virol., 62, (1988) 31) Varmus, H.: Science, 240, (1988) 32) Chang, I.-J., Pryciak, P., Ganem, D., Varmus, H. E.: Nature, 337, (1989) 33) Schlicht, H.-J., Radziwill, G., Schaller, H.: Cell, 56, (1989) 34) Kozak, M.: Cell, 47, (1986) 35) Treinin, M., Laub, O.: Mol. Cell. Biol., 7, (1987) 36) Siddiqui, A., Jameel, S., Mapoles, J.: Proc. Natl. Acad. Sci. USA, 84, (1987) 37) Kaneko, S., Miller, R. H.: J. Virol., 62, (1988) 38) Þ { qž : ŠÌ _äx, 13, (1988) 39) Chisaka, O., Araki, K., Ochiya, T., Tsurimoto, T., Hiranyawasitte-Attatippaholkun, W., Ya naihara,n., Matsubara, K.: Gene, 60, (1987) 40) Kay, A., Mandart, E., Trepo, C., Galibert, F.:EMBO J., 4, (19 41) Pfaff, E., Salfeld, J., Gmelin, K., Schaller, H., Theilmann, L.: Virology, 158, (1987) 42) Spandau, D. F., Lee, C.-H.: J. Virol., 62, (1988) 43) Seto, E., Yen, T. S. B., Peterlin, B. M., Ou, J. -H.: Proc. Natl. Acad. Sci. USA, 85, (1988) 44) Twu, J.-S., Rosen, C. A., Haseltine, W. A., Ro binson,w. S.: J. Virol., 63, (1989) 45) Twu, J.-S., Chu, K., Robinson, W. S.: Proc. Natl. Acad. Sci. USA, 86, (1989) 46 zmatsubara, K.: J. Mol. Med., ˆó ü (1990) 47) Twu, J. -S., Schloemer, R. H.: J. Virol., 61, (1987) 48) Twu, J.-S., Robinson, W. S.: Proc. Natl. Acad. Sci. USA, 86, (1989) 49) Seto, E., Zhou, D.-X., Peterlin, B. M., Yen, T. S. B.: Virology, 173, (1989) 50) c Žq EŒã _ E Ñ ÎŽ E r Ž Y : æ48 ñ ú {ŠàŠw ï ï ( ¼ŒÃ 1989) 51 zseeger, C., Ganem, D., Varmus, H. E.: Sci ence,232, (1987) 52) Chang, C., Jeng, K., Hu, C., Lo, S. J., Su, T., Ting, L.-P., Chou, C.-K., Han, S., Pfaff, E., Salfeld, J., Schaller, H.: EMBO J., 6, (1987) 53 ztsurimoto, T., Fujiyama, A., Matsubara, K.: Proc. Natl. Acad. Sci. USA, 84, (1987) 54) Sureau, C., Romet-Lemonne, J.-L., Mullins, J. I., Essex, M.: Cell, 47, (1986) 55) Sells, M. A., Chen, M.-L., Acs, G.: Proc. Natl. Acad. Sci. USA, 84, (1987) 56) Zelent, A. Z., Sells, M. A., Shvartsman,.M., Price, P. M., Acs, G.: J. Virol., 61,
11 (1987) 57) Shih, C., Li, L.-S., Roychoudhury, S., Ho, M. -H.: Proc. Natl. Acad. Sci. USA, 86, (1989) 58) Ochiya, T., Tsurimoto, T., Ueda, K., Okubo, K., Shiozawa, M., Matsubara, K.: Proc. Natl. Acad. Sci. USA, 86, (1989) 59) Acs, G., Sells, M. A., Purcell, R. H., Price, P., Engle, R., Shapiro, M., Popper, H.: Proc. Natl. Acad. Sci. USA, 84, (1987) 60) Sureau, C., Eichberg, J. W., Hubbard, G. B., Romet-Lemonne, J. L., Essex, M.: J. Virol., 62, (1988) 61) Galle, P. R., Schicht, H. J., Fischer, M., Schal ler,h.: J. Virol., 62, (1988) 62) Hirsch, R., Colgrove, R., Ganem, D.: Virolo gy,167, (1988) 63) Farza, H., Hadchouel, M., Scotto, J., Tiollais, P., Babinet, C., Pourcel, C.: J. Virol., 62, (1988) 64 zaraki, K., Miyazaki, J., Hino, O., Tomita, N., Chisaka, O., Matsubara, K., Yamamura, K.: Proc. Natl. Acad. Sci. USA, 86, (1989) 65) Ueda, K., Tsurimoto, T., Nagahata, T., Chisa ka,o., Matsubara, K.: Virology, 169, (1989) 66) Nagahata, T., Ueda, K., Tsurimoto, T., Chisa ka,o., Matsubara, K.: J. Antibiot., 42, (1989) 67) Price, P. M., Banerjee, R., Acs, G.: Proc. Natl. Acad. Sci. USA, 86, (1989) 2088
Database Center for Life Science Online Service 35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Ka
35) [Laboratory of Hepatitis Viruses II, Department of Enteroviruses, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo 141, Japan] Hepatitis C Virus 1) Choo, Q.-L., Kuo, G., Weiner,
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Vol.1 C ontents 1 2 cell-free EMBO J Proc. Natl. Acad. Sci. USA NatureEMBO J 3 RNA NatureEMBO J Nature EMBO J 4 5 HCV HCV HCV HCV RNA HCV in situ 6 7 8 Nat Struct Mol Biol J Biol Chem Nat Commun J Virol
Minamiooya, Machida, Tokyo 194, Japan] RNA World, A Key Step in the Origin of Life : Inspection from the View Point of Biological Evolution 1) Crick, F. H. C.: Sym. Soc. Exp. Biol., 12, 548-555
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1) Bittner, J. J.: Science, 84, 162 (1936) 13) Michalides, R., van Ooyen, A., Nusse, R.: Curr. Top. Microbiol. Immunol., 106, 57-74 (1983) 2 z Yamamoto, K. R.: Ann. Rev. Genn., 19, 209-252 (1985) 3) Evans,
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5200) [Department of Biochemistry, Miyazaki Medical College, Kihara, Kiyotake-cho, Miyazaki 889-16, Japan] Natriuretic Peptide Family: ANP and BNP 1) de Bold, A. J.: Science, 230, 767-770 (1985)
468 羽 表1 全 症 例 の 血 中HBV関 田 元 連 マー カー と肝 組 織 中HBVDNAの 関係 * 非 癌 部 に つ い て も検 討 制限酵素未処理 右 端 の 数 字 はsize 図1 代 表 的 オ ー トラ ジオ グラ ム Hind markerを 示 す(単 位Kbp) IIIに 上 る 切 断 肝 細 胞 癌 に お け るHBVDNAの 組 込み HBV関 (症 例7)
Review Fumio Imamoto1, Takefumi Sone1, Kazuhide Yahata1, Yukari Sasaki1, Masatoshi Takagi2, Kazuhiro Maeshima2, Naoko 25) Dong, W. K. et al.: Gene, 91, 217-223 (1990) 26) Masatsugu, T. et al.:
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Establishment and progress of Sendai virus engineering 2) Schnell, M. J., Mebatsion, T., Conzelmann, K.-K.: EMBO J., 13,4195-4203(1994) 3) Kato, A. et al.: Genes Cells, 1, 569-579 (1996) 4) Nagai,
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Chiharu Ueguchi, E-mail : cueguchi@agr.nagoya-u.ac.jp Molecular mechanism and biological function of the cytokinin signal tansduction pathway 1) Miller, C. 0., Skoog, F., von Saltza, M. H., Strong,
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Database Center for Life Science Online Service Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sap
Miho Shimizu, [Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060, Japan] Molecular Basis of Triplet Repeat Diseases : Genetic Instabillity and Unusual DNA
Fig.1 Procedures of the spot tests for the detection of serum HBV-DNA
Key words: HBV DNA, HBV carrier, HBeAg Fig.1 Procedures of the spot tests for the detection of serum HBV-DNA 昭 和61年2月20日 87 Table 1 Comparison of HBeAg/anti-HBe Fig.2 Comparison of the sensitivity of the
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2) Shin, S. I., Fredman, V. H., Risser, P., Pol lack,r.: Proc. Natl. Acad. Sci. USA, 72, 4435-4439 (1975) 3) Marquardt, H., Todaro, G. J.: J. Biol. Chem., 256, 6859-6865 (1981) 4) Dicker, P., Pohjanpelto,
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Database Center for Life Science Online Service Database Center for Life Science Online Service Database Center for Life Science Online Service Database Center for Life Science Online Service SMN (Survival
Database Center for Life Science Online Service School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferati
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School of Medicine, Seiryo-machi, Sendai 980, Japan] Biological Role of NDP-kinase in Cell Proliferation and Activation Mechanism of GTP Binding Proteins by the Enzyme 3) Nishizuka, Y.: Nature,
Short Review E-mail : kuwata@cc.gifu-u.ac.jp Structural medicine and structure-based drug design for prion diseases 2) Anfinsen, C. B.: Harvey Lect., 61, 95-116 (1967) 3) Carrel, R. W., Lomas, D. A.
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Kazumitsu Ueda, [Department of Applied Life Science, Kyoto University Graduate School of Agriculture, Kitashirakawa, Sakyo-ku, Kyoto 606-01, Japan] Molecular Mechanisms for Drug Transport by MDR1/P-glycoprotein
Stress-responsive MAP kinases 15) Lu, H. T., Yang, D. D., Wysk, M., Gatti, E., Mellman, I., Davis, R. J., Flavell, R. A. : EMBO J., 18,1845-1857 (1999) 16) Lu, B., Yu, H., Chow, C., Li, B., Zheng,
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Database Center for Life Science Online Service Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara,
Masami Horikoshi, Ryosuke Himukai, Takashi Kuzuhara, E-mail : horikosh@iam.u-tokyo.ac.jp http://www.iam.u-tokyo.ac.jp/homasami/ 1) Jacob, F., Monod, J. : J. Mol. Biol., 3, 318-356 (1961) 2) Ptashne,
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drug development Toshimi Michigami, E-mail : michigami@mch.pref.osaka.jp Keiichi Ozono, E-mail : keioz@ped.med.osaka-u.ac.jp The progress in the research on vitamin D 1) McCollum, E. V. et al.:
tary adenylate cyclase activating polypeptide ; PA-
Conformation of a peptide ligand bound to its G-protein coupled receptor and its implication for ligand transportation tary adenylate cyclase activating polypeptide ; PA- molecular biology (ed. Rich,
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図8SINEの SINEと3'末 親 と な って い るLINEの 系 統 関係 端 を共 有 して い るLINEは 赤 色 で 示 す, 報 告 さ れ て い るす べ て のLINEは11の ら れ る.そ れ ぞ れ のLINEの グル ー プ に分 け あ い だ にお い て 水 平 的 な交 流 が な い と仮 定 す る と,こ の11に 分 け られ る こ のLINE え
Novel chemical mediators in the resolution of inflammation Charles N. Serhan Key words E-mail : marita@nih.go.jp Charles N. Serhan Brigham & Women's Hospital/Harvard Medical School 1) Serhan, C. N.,
Correlation between molecular evolution of P450s and evolution of plant secondary metabolism Masaharu Mizutani E-mail : mizutani@scl.kyoto-u.ac.jp URL : http://biofun.kuicr.kyoto-u.ac.jp/index-j.html 13)
Database Center for Life Science Online Service Vol.48 No.16 (2003)
Database Center for Life Science Online Service Key words Kikuya Kato, E-mail : kkato@bs.aist-nara. ac.jp http://love2.aist-nara.ac.jp Shin Ishii, E-mail : ishii@is.aist-nara.ac.jp http://hawaii.aist-nara.
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アデノウイルスベクターの改良と応用 7 ン トネ ガ テ ィ ブ を用 い てRel NF-κBの シグナル の不 活 化 を 試 み た そ の 結 果 IκBの ド ミナ ン トネ ガ テ ィ ブ を ニ ワ ト リ胚 肢 芽 に 接 種 した 群 で は 発 現 率 は低 い もの の 四 肢 の 形 成 阻 害 が 認 め られ この 結 果 は頂 堤 AER)を 除 去 した も の の表
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Database Center for Life Science Online Service archlaboratories, 4-1-1 Miyazaki, Miyamae-ku, Kawasaki-shi, Kanagawa 213, Japan] Developmental Genetics of Caenorhabditis elegans Database Center for
Database Center for Life Science Online Service Structure and function of nitric oxide synthases
Structure and function of nitric oxide synthases 3) Furchgott, R. F., Zawadzki, J. V. : Nature, 288,373-376 (1980) 4) Palmer, R. M., Ferrige, A. G., Moncada, S.: Nature, 327,524-5260987) 5) Alderton,
Database Center for Life Science Online Service Discovery, analysis and chemical mechanism of protein splicing
Discovery, analysis and chemical mechanism of protein splicing VMA1 VMA1 2) Anraku, Y.: Genes to Cells, 2, 359-367 (1997) 3) Perler, F. B.: Cell, 92,1-4 (1998) 4) Perler, F. B.: Trends Biochem.
Database Center for Life Science Online Service Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie
Matthias P. Mayer*, Toshifumi Tomoyasu* *, Bernd Bukau*, Institut fiir Biochemie and Molekularbiologie Universitat Freiburg Zentrum fur Molekulare Biologie (ZMBH) Universitat Heidelberg E-mail : bukau@zmbh.uni-heidelberg.de
E-mail : tmatsumo@house.rbc.kyoto-u.ac.jp htm Spindle checkpoint : Cell cycle regulation by a signal emitted from kinetochores http://www.rbc.kyoto-u.ac.jp/radiation_system/m-index. 19) Yao, X., Abrieu,
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1) Murphy, T.H., Miyamoto, M., Sastre, A., Schnaar, R.L., Coyle, J.T.: Neuron, 2, 1547-1558 (1989) 2) Pellegrini-Giampietro, D.E., Cherici, G., Ale siani,m., Carla, V., Moroni, F.: J. Neuro science,10,
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Short Review Hidenori Takagi, Fumio Takaiwa, E-mail : takaiwa@nias.affrc.go.jp 13) Hirahara, K. et al. : J. Allergy Clin. Immunol., 102, 961-967 (1998) 14) Takagi, H. et al.: Proc. Natl. Acad. Sci.
Review Database Center for Life Science Online Service Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
Review Masanori Mishima, p Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge E-mail : m.mishima @gurdon.cam.ac.uk http://www.gurdon.cam.ac.uk/groups/mishima.html Cytokinesis :
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10) Shinagawa, H., Kato, T., Ise, T., Makino, K., Acad. Sci. USA, 82, 4336-4340 (1985) Sci. USA, 85, 1811-1815 (1988) 19 zwoodgate, R., Rajagopalan, M., Lu, C., Echols, H.: Proc. Natl. Acad. Sci. USA,
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