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1 FUCOXANTHIN HO OCOCH 3 HO O O
2 ver.3.1 SJ FUCOXANTHIN
3 ver.3.1 SJ A HO OCOCH 3 HO O O ) Maeda H, Tsukui T, Sashima T, Hosokawa M, Miyashita K. Seaweed carotenoid, fucoxanthin, as a multi-functional nutrient. Asia Pac J Clin Nutr. 17 (Suppl 1): (2008). 2) Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Effect of medium-chain triacylglycerols on anti-obesity effect of fucoxanthin. J Oleo Sci. 56(12): (2007). 3) Maeda H, Hosokawa M, Sashima T, Miyashita K. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J Agric Food Chem. 55(19): (2007). 4) Tsukui T, Konno K, Hosokawa M, Maeda H, Sashima T, Miyashita K. Fucoxanthin and fucoxanthinol enhance the amount of docosahexaenoic acid in the liver of KKAy obese/diabetic mice. J Agric Food Chem. 55(13): (2007). 2
4 ver.3.1 SJ 5) Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med. 18(1): (2006). 6) Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun. 332(2): (2005). 7) Das SK, Hashimoto T, Kanazawa K. Growth inhibition of human hepatic carcinoma HepG2 cells by fucoxanthin is associated with down-regulation of cyclin D. Biochim Biophys Acta. 1780(4): (2008). 8) Yoshiko S, Hoyoku N. Fucoxanthin, a natural carotenoid, induces G1 arrest and GADD45 gene expression in human cancer cells. In Vivo. 21(2): (2007). 9) Kotake-Nara E, Asai A, Nagao A. Neoxanthin and fucoxanthin induce apoptosis in PC-3 human prostate cancer cells. Cancer Lett. 220(1): (2005). 10) Kotake-Nara E, Terasaki M, Nagao A. Characterization of apoptosis induced by fucoxanthin in human promyelocytic leukemia cells. Biosci Biotechnol Biochem. 69(1): (2005). 11) Hosokawa M, Kudo M, Maeda H, Kohno H, Tanaka T, Miyashita K. Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells. Biochim Biophys Acta. 1675(1-3): (2004). 12) Kotake-Nara E, Kushiro M, Zhang H, Sugawara T, Miyashita K, Nagao A. Carotenoids affect proliferation of human prostate cancer cells. J Nutr. 131(12): (2001). 13) Nishino H. Cancer chemoprevention by natural carotenoids and their related compounds. J Cell Biochem Suppl. 22:231-5 (1995). 14) Okuzumi J, Takahashi T, Yamane T, Kitao Y, Inagake M, Ohya K, Nishino H, Tanaka Y. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-ethyl-N'-nitro-N- nitrosoguanidine-induced mouse duodenal carcinogenesis. Cancer Lett. 68(2-3): (1993). 15) Okuzumi J, Nishino H, Murakoshi M, Iwashima A, Tanaka Y, Yamane T, Fujita Y, Takahashi T. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells. Cancer Lett. 55(1): (1990). 16) Sachindra NM, Sato E, Maeda H, Hosokawa M, Niwano Y, Kohno M, Miyashita K. Radical scavenging and singlet oxygen quenching activity of marine carotenoid fucoxanthin and its metabolites. J Agric Food Chem Oct 17;55(21): ) Nomura T, Kikuchi M, Kubodera A, Kawakami Y. Proton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH). Biochem Mol Biol Int. 42(2): (1997). 18) Sugawara T, Matsubara K, Akagi R, Mori M, Hirata T. Antiangiogenic activity of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. J Agric Food Chem. 54(26): (2006). 19) Shiratori K, Ohgami K, Ilieva I, Jin XH, Koyama Y, Miyashita K, Yoshida K, Kase S, Ohno S. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Exp Eye Res. 81(4): (2005). 3
5 ver.3.1 SJ 6 8, , UCP1UCP1 EPA DHA PPAR UCP1 UCP1 3T3-L M 3 3T3-L1 P<0.01 Maeda H, Hosokawa M, Sashima T, Takahashi N, Kawada T, Miyashita K. Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells. Int J Mol Med. 18(1): (2006). 4
6 ver.3.1 SJ 67.4KKAy UCP1 5A UCP1 UCP1 -Actin UCP1 -Actin KKAy P<0.01 KKAy UCP1 P<0.05 UCP1 Maeda H, Hosokawa M, Sashima T, Funayama K, Miyashita K. Fucoxanthin from edible seaweed, Undaria pinnatifida, shows antiobesity effect through UCP1 expression in white adipose tissues. Biochem Biophys Res Commun. 332(2): (2005). KKAy 97%KKAy % 6 5
7 ver.3.1 SJ KKAy FC Fish oil P<0.01 Maeda H, Hosokawa M, Sashima T, Miyashita K. Dietary combination of fucoxanthin and fish oil attenuates the weight gain of white adipose tissue and decreases blood glucose in obese/diabetic KK-Ay mice. J Agric Food Chem. 55(19): (2007) g/ L
8 ver.3.1 SJ 10%DMSO 0.05 ml 0.05 ml PZ ml mm 1 ml 5 ml PZ (facial dermis) 510 /L 0.1L 48Well Plate 0.2mL 1 Ultra DOMA-PF Liquid () 0.38L 20L 3 Procollagen typec-peptide (PIP) EIA Kit g/L 9 7
9 ver.3.1 SJ 10%DMSO P g/L %DMSO Enz Chek Elastase Assay Kit (Molecular Probes) 8
10 ver.3.1 SJ g/L 130g/L Lwell0.3% L-DOPA70Lwell37 5 mushroom 1.6 unitsml70lwell nm B B16 9
11 ver.3.1 SJ g/L g/L B16 2mM MEM 10%FCS cells/ml24 500L 55 L 3 PBS300L nm700nm 100 -P11% -P1 L 12 control 15 L 13-P1 **: p <
12 ver.3.1 SJ % P1 Weiser-Maples 4 UV-B2000 mj/cm P L RT-PCR endothelin 1ET-1 neurotrophin-3nt-3endotherin A receptor EDNRAneurotrophin-3 receptornt3rp 75 neurotrophin receptorp 75 NTRprostaglandin E receptor 1EP1melanocortin receptor 1MC1RtyrosinaseTyr tyrosinase related protein 1Tyrp1 cyclooxygenase (COX)-2 mrna melanocortin receptor 1 COX-2 15 Control mg/kg Cont. 0.1 mg/kg 1 mg/kg 10 mg/kg 11
13 ver.3.1 SJ mrna Control 10 mg/kg COX-2p 75 NTR EP1 MC1R mrna 1 1 mrna Fucoxanthin (mg/kg) Ct of control Control Released cytokine from epidermal cell ET ± ±0.10* 1.40±0.13** 1.27±0.16* NT ± ± ± ±0.01 COX ± ± ± ±0.09* Receptor in melanocyte EDNRA ± ± ± ±0.06 NT3R ± ± ±0.11* 0.96±0.10 p75ntr ± ± ± ±0.07** EP ± ± ± ±0.09* MC1R ± ± ± ±0.06* Melanogenesis in melanocyte Tyr ± ± ± ±0.09 Tyrp ± ± ± ±0.16 Hos; HRM mg/kg 2 UVB160 mj/cm UVB 320 mj/cm 2 16 RNeasy TM Protect Mini Kit RNA RT-PCR endothelin 1ET-1neurotrophin-3NT-3endotherin A receptor EDNRAneurotrophin-3 receptor NT3Rp 75 neurotrophin receptorp 75 NTRprostaglandin E receptor 1EP1melanocortin receptor 1MC1R tyrosinasetyrtyrosinase related protein 1Tyrp1 COX-2 mrna 12
14 ver.3.1 SJ g/L 16 P. acnesgam3000 rpm10 min PBSPBS34 P. acnes S 390L25L P. acnes50 L2L10L305 50L L415 nm P1 12P1 50mg0.5 mg14 6 ph CORNEOMETER SM825(CK electronic GmbH) PH SKIN-pH-METERPH900(CK electronic GmbH)SEBUMETER SM810(CK electronic GmbH)
15 ver.3.1 SJ P< HDL kg % BMIkg/m Ω kg (%) cm cm / mm P<
16 ver.3.1 SJ HDL TG H (receptor activator of nuclear factor B ligand RANKL) 15
17 ver.3.1 SJ RAW246.7 RANKL 2.5M 5 M RAW ARAW B caspase-3 Das S.K., Ren R., Hashimoto T. and Kanazawa K. Fucoxanthin induces apoptosis in osteoclast-like cells differentiated from RAW264.7 cells. J Agric Food Chem. 58(10): (2010) ,1-2- (DPPH) 21 DPPH DPPH 16
18 ver.3.1 SJ Nomura T, Kikuchi M, Kubodera A, Kawakami Y. Proton-donative antioxidant activity of fucoxanthin with 1,1-diphenyl-2-picrylhydrazyl (DPPH). Biochem Mol Biol Int. 42(2): (1997). Glycation Advanced Glycation End ProductsAGEs AGEs AGE 30 µg/ml AGE 100 µg/ml 22 AGE ph: 7.4D- 10% 1%900 µl 100 µl nm 440 nm AGE DMSO DMSO 10% Dyer D.G. et al. Accumulation of maillard reaction products in skin collagen in diabetes and aging. J. Clin. Invest., 91, (1993). 17
19 ver.3.1 SJ 7 15 Caco-2 3 Sugawara 1) Caco-2 Caco-2 23 HO OH HO O O OH OH OH O O A A 2) 40 nmol A A 18
20 ver.3.1 SJ 19
21 ver.3.1 SJ Sugawara T, Baskaran V, Tsuzuki W, Nagao A. Brown algae fucoxanthin is hydrolyzed to fucoxanthinol during absorption by Caco-2 human intestinal cells and mice. J Nutr. 132(5): (2002). Asai A, Sugawara T, Ono H, Nagao A. Biotransformation of fucoxanthinol into amarouciaxanthin A in mice and HepG2 cells: formation and cytotoxicity of fucoxanthin metabolites. Drug Metab Dispos. 32(2): (2004). 160 nmol/ 1 A (nmol/l) (nmol/g) () () Hashimoto et al., Br. J. Nutr., 102 (2), (2009) (nmol/g) 200 (nmol/l) (nmol/g) (nmol/g) () A 160 nmol// A (nmol/g) (nmol/g)
22 ver.3.1 SJ 26 A P P1 21
23 ver.3.1 SJ -WSP H 1 H 0.5~1.0 mg -5 10~20 mg/day -1 50~100 mg/day -P1 50~100 mg/day -WSP ~1000 mg/day -WSP g/100g 0.8 g/100g 0.5 g/100g 0.1 g/100g g/100g 83.6 g/100g 0.0 g/100g 0.0 g/100g 20.5g/100g 15.5 g/100g kcal/100g 815 kcal/100g 3 90 mg/100g 18 mg/100g 0.2 g/100 g 0.0 g/100 g 22
24 ver.3.1 SJ -P1 -WSP g/100g 0.2 g/100g 0.2 g/100g 0.0 g/100g g/100g 1.0 g/100g 0.2 g/100g 0.0 g/100g 87.9 g/100g 98.8g/100g kcal/100g 404 kcal/100g 3 43 mg/100g 4.3 mg/100g 0.1 g/100 g 0.0 g/100 g (++) WSP P Sprague-Dawley 154~168 g 120~138 g mg/kg LD mg/kg ICR3236 g mg/kg 1000 mg/kg 2000 mg/kg 24 23
25 ver.3.1 SJ Giemasa F344/DuCrj %2.0%4.0% ) 2) 3) 4) 5) C-1C 1kg5kg 5 24
26 ver.3.1 SJ - P1 -WSP0.1 - PC1 -WSPC0.1 1kg5kg P1-WSP0.1 -PC1 / -5C-1C / -WSPC0.1 / INCI -PC1Cyclodextrin, Caprylic/Capric Triglyceride, Tocopherol, Laminaria Japonica Extract, Fucoxanthin -5C-1CCaprylic/Capric Triglyceride, Laminaria Japonica Extract, Fucoxanthin, Tocopherol -WSPC0.1Maltosyl Cyclodextrin, Cyclodextrin, Maltose, Caprylic/Capric Triglyceride, Tocopherol, Laminaria Japonica Extract, Fucoxanthin 25
27 ver.3.1 SJ 2 26
28 ver.3.1 SJ 27
29 ver.3.1 SJ 28
30 ver.3.1 SJ 29
31 ver.3.1 SJ 30
32 ver.3.1 SJ 31
33 ver.3.1 SJ 32
34 ver.3.1 SJ 33
35 ver.3.1 SJ TEL(0586) () FAX(0586) URL/ F TEL (03) FAX (03) p
36 ver.3.1 SJ 35
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RYZA IL & FAT CHEMICAL C., LTD. SAKURA EXTRACT Ver.1.4MK Ver. 1.4MK 1) 1300 1929 1 Ver. 1.4MK Sakura 1-caffeoyl---D-glucopyranoside quercetin 3---D-glucopyranoside 1) :, 4, 11-22 (1995). 2 Ver. 1.4MK 3
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79 +.* + 1/* A + 80, E + + Bioaccessibility +, 81,. 0* nm bo, Caco-, +* - - 82 - Caco, + Pow +, b-carotene ;,, a-carotene ; -, b-cryptoxanthin ;., lutein ; /, zeaxanthin ; 0, canthaxanthin ; 1, astaxanthin
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ORYZA OIL & FAT CHEMICAL CO., LTD. フコキサンチン FUCOXANTHIN HO OCOCH 3 HO O O ver. 4.ST フコキサンチン FUCOXANTHIN 1. はじめに 昆布は, 藍藻類 珪藻類 緑藻類 褐藻類 紅藻類などの種類に分類される海藻のうち, 褐藻類に属する海藻です 昆布は全世界で生育しており, 北半球に 26 属, 南半球に 9 属が確認されています
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ORYZA POLYAMINE ORYZA POLYAMINE -P -PC -LC 1. Ver.1.0 MM ver. 1.0MM 1) Roseeuw D.I. et al., Epidermal keratinocytes actively maintain their intracellular polyamine levels. Cell Tissue Kinet. 16, 493-504
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ORYZA OIL & FAT CHEMICAL CO., LTD. ALPHA LIPOIC ACID --P () --P80 () --WSP8 () --L1 () --PC () --PC80 () --WSPC8 () --LC1 () ver. 5.1HS ver5.1 HS 1. ALPHA LIPOIC ACID 16 3 31 0331009 - () 19 5 24 0524001
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Arterioscler Thromb Vasc Biol., 27, 2400 2406 (2007) J. Agri. Food Chem., 59, 4544 4552 (2011) Bioorg. Med. Chem. Lett., 21, 1786 1791 (2011) Advanced glycation end products (AGEs) AGEs AGEs AGEs HbA1c
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