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p,p -DDT 1 p,p -DDT 1,1,1- -2,2- (4- ) CAS 50-29-3 C 14 H 9 Cl 5 354.5 2 109 1) 260 2) 1.5 1) 1.6010-7 mmhg (20 ) 3) 1ppm=14.50 mg/m 3 at 25, n- / 6.366.38 1) 1) 3 4) BOD 0 % ( 2 100 mg/l 30 mg/l) 4) BCF5,10024,400 ( 10 1 µg/l), 6,08025,900 ( 10 0.1 µg/l) 4) 4 1948 9 27 1971 5 1 5) 1981 5) 5)

95 (1) EUSES 2.1 2,400km 2 800 1),2) 2.1 0.002 0.26 89.8 9.9 () (2) 2.2 2.2 g/m 3 µg/l µg/l µg/g µg/g µg/l µg/l ( ) µg/g ( ) µg/g <0.0001 < 0.05 < 0.05 0.00037 < 0.01 < 0.0002 < 0.002 < 0.005 < 0.005 < 0.05 < 0.05 0.00056 < 0.01 < 0.002 < 0.005 < 0.005 0.00015 < 0.01 0.0039 *0.15 0.0001 0.05 0.05 0.00005 0.01 0.0002 0.002 0.005 0.005 0/10 0/42 0/4 57/57 4/94 0/20 0/76 0/90 0/4 2001 1999 1998 1998 1998 2001 1995 1998 1998 1) 0.0001 µg/m 3 7) 2) 0.05 µg/l(1994) 5 1.36 (1984) 8) 3) 0.2 µg/g (1998) 9) 4)* 5% 2 3 4 5 4 2 6 4 4

(3) 2.3 15m 3 2L2,000g 0.15g 50kg 2.3 0.0001 µg/m 3 (2001) 0.05 µg/l (1999) 0.05 µg/l (1998) 0.0002 µg/l (2001) 0.00003 µg/kg/day 0.002 µg/kg/day 0.002 µg/kg/day 0.000008 µg/kg/day 0.00037 µg/g (1998) 0.015 µg/kg/day 0.01 µg/g (1998) 0.0001 µg/m 3 (2001) 0.00003 µg/kg/day 0.0002 µg/l (2001) 0.05 µg/l (1999) 0.05 µg/l (1998) 0.0039 µg/g (1998) 0.00003 µg/kg/day 0.002 µg/kg/day 0.002 µg/kg/day 0.000008 µg/kg/day 0.16 µg/kg/day 0.017 µg/g (1998) 0.00005 µg/kg/day 2.4 0.00003 µg/kg/day 0.0001 µg/m 3 0.16 µg/kg/day 0.16 µg/kg/day 0.16 µg/kg/day

2.4 (µg/kg/day) 0.00003 0.00003 0.002 0.002 (0.002) (0.002) (µg/kg/day) (0.000008) (0.000008) 0.015 0.16 0.00003 0.00005 0.01703 0.16205 0.01706 0.16208 1) 2) (4) PEC 2.5 PEC 0.0002 µg/l 0.002 µg/l 2.5 0.0002 µg/l (2001) 0.002 µg/l (1995) 0.0002 µg/l (2001) 0.002 µg/l (1995)

1 3.1 TDLo16 mg/kg 2.5 mg/kg/day LD 50 113 mg/kg LD 50 2,500 mg/kg LD 50 280 mg/kg 25 0 1 5 10 50 ppm 0 0.05 0.25 0.5 2.5 mg/kg/day 27 5 ppm 1 ppm 1 ppm 0.05 mg/kg/day NOEL JMPR1984 NOAEL 6.25 mg/kg/day 10 mg/kg/day 0.25 mg/kg/day ADI GDWQ1996 NOAEL ADI Sprague-Dawley 12 6 1 020200 mg/kg 01 10 mg/kg/day 3 52 49 2 1 16 24 1624 52 21 200 mg/kg 10 mg/kg/day NOEL p,p'- DDT 80 %o,p-ddt 17 %p,p'-dde 2 % JMPR1984 25 0.25 mg/kg/day NOAEL 0.06 mg/kg/day

2 2 mg/kg/day IARC 2B 3 NOAEL NOAEL 0.05 mg/kg/day NOEL NOAEL 0.25 mg/kg/day 0.06 mg/kg/day 4 3.2 MOE 0.017 µg/kg/day 0.16 µg/kg/day 0.06 mg/kg/day 380 0.017 µg/kg/day 0.16 0.06 mg/kg/day MOE Margin of Exposure 380

(1) 4.1 4.1 Ref. No. [ µg/l] / [] Cyclotella nana 14 C uptake 1 2680 900,000 Spirulina platensis LC 50 MOR 14 17259 *0.36 Daphnia pulex EC 50 IMM 2 888 *0.070.4 Corophium insidiosum LC 50 MOR 4 9755 Daphnia magna EC 50 IMM 2 10871 0.50 Daphnia magna EC 50 REP 14 5525 0.61 Daphnia magna EC 50 REP 14 5525 0.63 Bosmina longirostris EC 50 IMM 2 10658 0.67 Daphnia magna EC 50 REP 14 5525 0.68 Daphnia magna EC 50 IMM 2 10871 0.75 Daphnia magna EC 50 REP 14 5525 0.99 Daphnia magna EC 50 IMM 1 10871 1.0 Gammarus lacustris LC 50 MOR 4 885 1.1 Daphnia magna EC 50 IMM 2 10871 1.1 Cancer magister EC 50 IMM 4 2264 1.3 Daphnia magna EC 50 IMM 2 10871 1.4 Gammarus lacustris LC 50 MOR 1 885 1.72 Bosmina longirostris EC 50 IMM 2 10658 2.1 Gammarus lacustris LC 50 MOR 2 885 2.67 Daphnia pulex EC 50 IMM 2 10658 4.7 Gammarus lacustris LC 50 MOR 1 885 5.6 Gammarus lacustris LC 50 MOR 1 885 7.6 Gammarus lacustris LC 50 MOR 1 885 8.0 Gammarus lacustris LC 50 MOR 1 885 12 Gammarus lacustris LC 50 MOR 4 885 42 Daphnia magna EC 50 IMM 1 10871 71 Daphnia magna EC 50 IMM 1 10871 98 Daphnia magna EC 50 IMM 1 10871 510 Daphnia magna EC 50 IMM 1 10871

Mugil cephalus LC 50 MOR 5 276 0.26 Mugil cephalus LC 50 MOR 4 276 0.26 Micrometrus minimus TL 50 MOR 4 611 0.45 Gambusia affinis TL 50 MOR 4 6033 0.45 Cymatogaster aggregata LC 50 MOR 4 611 0.53 Morone saxatilis TL 50 MOR 4 602 0.8 Oncorhynchus kisutch LT 50 MOR 14 2298 0.85 Oncorhynchus clarki TLmMOR 4 964 1 Rasbora heteromorpha LC 50 MOR 2 542 1.08 Mystus gulio LC 50 MOR 5 276 1.4 Rasbora heteromorpha LC 50 MOR 1 542 2 Leiostomus xanthurus EC 50 2 646 3.0 Poecilia reticulata TL 50 MOR 4 6038 3.4 Lepomis macrochirus LC 50 MOR 4 2076 3.9 Kuhlia sandvicensis TL 50 MOR 4 6038 Pteronarcella badia LC 50 MOR 4 889 3.5 Claassenia sabulosa LC 50 MOR 4 889 4.2 Aedes cantans LC 50 MOR 2 5162 7.0 Pteronarcys california LC 50 MOR 4 889 7.2 Culex pipiens molestus LC 50 MOR 2 5162 9.28 Crassostrea madrasensis LC 50 MOR 5 276 11.05 Katelysia opima LC 50 MOR 5 276 11.28 Meretrix casta LC 50 MOR 5 276 20 Hydropsyche sp. LC 50 MOR 6 2822 30 Hydropsyche recurvata LC 50 MOR 6 2822 30 Hydropsyche morosa LC 50 MOR 6 2822 PNEC PNEC PNEC EC 50 Median Effective Concentration): LC 50 Median Lethal Concentration): TLmMedian Tolerance Limit): TL 50 Median Tolerance Limit): LT 50 Mean Survival Time): IMMImmobilization): MORMortality): REPReproduction): (2) PNEC Cyclotella nana 14 C 24 EC 50 10 µg/l Daphnia magna 48 EC 50 0.50 µg/l Mugil cephalus 5 LC 50 0.20 µg/l Pteronarcella badia 96 LC 50

1.9 µg/l 100 0.20 µg/l PNEC 0.002 µg/l PNEC 100 0.002 µg/l (3) 4.2 PEC 0.0002 µg/l (2001) 0.0002 µg/l (2001) 0.002 <0.1 0.002 µg/l (1995) 0.002 µg/l (1995) µg/l <1 1) 0.005 µg/g dry 0.005 µg/g dry (1998) 0.005 µg/g dry 0.005 µg/g dry (1998) (1998) (1998) 1) 0.05 µg/l(1994) 5 1.36 (1984) 0.0002 µg/l 0.002 µg/l PEC 0.0002 µg/l 0.002 µg/l PEC PNEC 0.1 PEC/PNEC 1

1 1IPCS (1995) International Chemical Safety Cards 2Chemfinderhttp://Chemfinder.Camsoft.com/ 3BIDLEMAN, TF & FOREMAN, WT (1987) [SRC MPBPWIN v1.40] 4() (1992) 5,,,, (1988), (2) 1 () 10 2 () 12 3 4 SPEED'98 (1999) 5 () 10 () 6 8, p435-453, 1998 7R.M.Hoff et al:atmospheric Deposition of Toxic Chemicals to the Great Lakes:A Review of data through 1994,Atmospheric Environment,30(20),3505-3527(1994) 8Yang Y.,Sheng G et al:organochlorinated Compounds in Water of the Pearl River Delta Region, Environ.Monit.Assess.,44(1),569-575 9 25 33-42 (1990) 3 1 1994, 2Laug, E. P. et al.1950j. Pharmacol. Exp. Ther., 98: 268-273. 3Joint FAO/WHO Meeting on Pesticide Residues1985FAO Plant Production and Protection Paper 67. 4Ottoboni, A.1969Toxicol. Appl. Pharmacol., 14: 74-81. 5Tomatis, L. et al.1972int. J. Cancer, 10:489-506. 6Joint FAO/WHO Meeting on Pesticide Residues2000Pesticide residues in food 2000 : DDT Environmental Health Criteria 9, DDT and its derivatives, IPCS1979. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 51974; Supplement 71987; Volume 531991. IRIS Integrated Risk Information System, No.0147, DDT, U.S. EPA1997.

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QSAR Predictions for Polycyclic Hydrocarbons Representative for Great Lakes Contaminants. Bull. Environ. Contam. Toxicol. 59(5): 834-840. 10871:Passino-Reader,D.R., J.P.Hickey, and L.M.Ogilvie (1997): Toxicity to Daphnia pulex and QSAR Predictions for Polycyclic Hydrocarbons Representative for Great Lakes Contaminants. Bull. Environ. Contam. Toxicol. 59(5): 834-840. 17259:Bednarz, T. (1981): The Effect of Pesticides on the Growth of Green and Blue Green Algae Cultures. Acta. Hydrobiol. 23(2): 155-172.