CosmoBioNews No.70
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1 September No.70
2 CONTENTS SeptemberNo
3 CosmoBioNews No.70 1
4 m Chemotaxis CytoSelectCell Migration Assay kit Haptotaxis CytoSelectCell Migration Assay kit 24well 24well 24well 24well 96well 96well 96well 24well 24well 24well 24well 8m 8m 3m 3m 3m 5m 8m 8m 8m 8m 8m CBA-100 CBA-101 CBA-102 CBA-103 CBA-104 CBA-105 CBA-106 CBA-100-COL CBA-101-COL CBA-100-FN CBA-101-FN 80,000 83,000 81,000 84,000 82,000 85,000 85,000 72,000 98,000 89,000 98,000 Memo 2 CosmoBioNews No.70
5 In vitro m CytoSelectCell Invasion Assay kit 24well 24well 24well 24well 24well 24well 96well 96well 96well 8m 8m 8m 8m 8m 8m 8m 8m 8m ECM ECM ECM CBA-110 CBA-110-COL CBA-110-LN CBA-111 CBA-111-COL CBA-111-LN CBA-112 CBA-112-COL CBA-112-LN 78, ,000 94,000 77,000 90,000 94,000 97,000 98, ,000 CytoSelect CytoSelectMigration and Invasion Assay Kit 24well 24well 96well 8m 8m 8m ECM ECM ECM CBA-100-C CBA-101-C CBA-106-C 156, , ,000 CosmoBioNews No.70 3
6 CytoSelect48-well Cell Adhesion Assay Kit 48well 48well 48well 48well 48well 48well 48well 48well 48well 48well 48well 48well CBA-050 CBA-051 CBA-052 CBA-053 CBA-056 CBA-057 CBA-058 CBA-059 CBA-060 CBA-061 CBA-070 CBA ,000 70,000 61,000 70,000 61,000 70,000 61,000 70,000 64,000 73,000 90,000 97,000 Memo 4 CosmoBioNews No.70
7 In vivo DIVAA Angiogenesis Assay Kit DIVAA Starter Kit (FGF/VEGF & AngioRack included) K SK 48 test 94, ,000 Directed In Vivo Angiogenesis Assay Inhibition Kit IK 48 test 102,000 TIMP-2MMP2 In vitro R Endothelial Tube Formation Assay (In vitro Angiogenesis) CBA ,000 CosmoBioNews No.70 5
8 CosmoBioNews No.70 6 Cignal
9 Cignal C/EBP Reporter Assay Kit Cignal CRE Reporter Assay Kit Cignal E2F Reporter Assay Kit Cignal p53 Pathway Reporter Assay Kit Cignal ERE Reporter Assay Kit Cignal GRE Reporter Assay Kit Cignal HIF Pathway Reporter Assay Kit Cignal ISRE Reporter Assay Kit Cignal GAS Reporter Assay Kit Cignal SRE Reporter Assay Kit Cignal AP1 Reporter Assay Kit Cignal Myc Reporter Assay Kit Cignal NFkB Pathway Reporter Assay Kit Cignal RBP-Jk Reporter Assay Kit Cignal NFAT Reporter Assay Kit Cignal RARE Reporter Assay Kit Cignal SMAD Reporter Assay Kit Cignal TCF/LEF Reporter Assay Kit C/EBP camp/pka Cell Cycle p53/dna Damage Estrogen Receptor Glucocorticoid Receptor Hypoxia Type I Interferon Interferon Gamma MAPK/ERK MAPK/JNK c-myc NFB Notch PKC/Ca++ Retinoic Acid Receptor TGF Wnt C/EBP CREB E2F/DP1 p53 Estrogen Receptor(ER) Glucocorticoid Receptor(GR) Hypoxia-inducible factor-1(hif-1) STAT1/STAT2 STAT1/STAT1 Elk-1/SRF AP-1 Myc/Max NFB RBP-Jk NFAT Retinoic Acid Receptor(RAR) SMAD2/SMAD3/SMAD4 TCF/LEF 80,000/1kit CCS-001L CCS-002L CCS-003L CCS-004L CCS-005L CCS-006L CCS-007L CCS-008L CCS-009L CCS-010L CCS-011L CCS-012L CCS-013L CCS-014L CCS-015L CCS-016L CCS-017L CCS-018L GFP 80,000/1kit CCS-002G CCS-010G CCS-011G CCS-013G CCS-017G CCS-018G Cignal Finder10 Cignal Finder Cancer 10-Pathway Reporter Array Wnt, Notch, p53/dna Damage, TGF, Cell cycle, NFB, Myc/Max, Hypoxia, MAPK/ERK, MAPK/JNK Cignal Finder Immune Response 10-Pathway Reporter Array NFB, PKC/Ca ++, IFN Type 1, IFN, MAPK/ERK, MAPK/JNK, TGF, camp/pka, C/EBP, Glucocorticoid Receptor Cignal Finder Development 10-Pathway Reporter Array Notch, Wnt, Myc/Max, NFB, TGF, Cell Cycle/pRb-E2F, C/EBP, camp/pka, MAPK/ERK, MAPK/JNK Cignal Finder Toxicity 10-Pathway Reporter Array p53 DNA Damage, Hypoxia, NFB, Glucocorticoid Receptor, Cell Cycle/pRB-E2F, MAPK/ERK, MAPK/JNK, PKC/Ca ++, TGF, Myc/Max 212tube strips 210,000 CCA-001L CCA-002L CCA-003L CCA-004L 3 95,000 CCA-101L-3 CCA-102L-3 CCA-103L-3 CCA-104L-3 R ,000 CCA-101L-12 CCA-102L-12 CCA-103L-12 CCA-104L-12 CosmoBioNews No.70 7
10 PVDF PVDF ELISpotPRO ELISpotPLUS precoated ELISpotPLUS ELISpotkit gmr Akt, phospho Ser473 EGF Receptor, phospho Tyr1068 ERK1/ERK2, phospho Thr202/Tyr204 HGF R/c-MET, phospho Tyr1234/Tyr1235 MEK1, phospho Ser218/Ser222 p38 MAP Kinase, phospho Thr180/Tyr182 p70, phospho S6 Kinase, Thr389 PDGF Receptor, phospho Tyr751 PDGF Receptor, phospho Tyr1021 STAT6, phospho Tyr641 Total HIF-1 alpha Total HSP70 Total Akt Total EGF Receptor Total ERK1/ERK2 Total HGF R/c-MET MEK2, phospho Ser222/Ser226 Total p38 MAP Kinase Total p70 Total PDGF Receptor Total PDGF Receptor Total STAT6 Total Cytochrom c Total Cytochrom c Human/Mouse/Rat Human Human/Mouse/Rat Human Human/Mouse Human/Mouse Human/Mouse Human Human Human/Mouse Human/Mouse Human/Mouse KCB887 KCB1095 KCB1018 KCB2480 KCB2506 KCB869 KCB8963 KCB1767 KCB2316 KCB3717 KCB1935 KCB ,000 94,000 83,000 94,000 94,000 94,000 94,000 94,000 94,000 94,000 94,000 75,000 8 CosmoBioNews No.70
11
12 R Airway Inflammation Panel Atopic Dermatitis Panel Extended Cardiovascular Panel Diabetes Panel Growth and Differentiation Panel Immune Regulation Panel Inflammation Panel Multiple Sclerosis Panel Extended Obesity Panel Pain Panel Preeclampsia Panel Rheumatoid Arthritis Panel Sepsis/Septic shock Panel Systemic Lupus Erythematosus Panel TNF/TNF-R Panel Transplantation Panel Tumor Biology Panel BMS899-3FF BMS899-4FF BMS899-5FF BMS899-6FF BMS899-7FF BMS899-8FF BMS899-9FF BMS899-10FF BMS899-11FF 136, , , , , , , , ,000 3% 4% 5% 6% 7% 8% 9% 10% 11% IL-6, slcam-1, IL-8, se-selectin, IL-10(iNGF), MCP-1, IL-17A, IFN-, IL-12p70, TNF-, IL-5, IL-4, svcam-1, IL-13, scd30 slcam-1, TNF-, IL-5, IL-4, IL-13, scd30 IL-6, slcam-1, IL-8, CRP(sE-selectin, MPO), MCP-1, t-pa, scd40l, TNF-, IL-1(PAI-1), Adiponectin, svcam-1, sp-selectin IL-6, slcam-1, IL-8, CRP(MIP-1), IL-10(NGF), MCP-1, MIP-1(tPA), IFN-, Leptin(TNF-), TNF-, IL-1(PAI-1), Adiponectin, Iso-Insulin, Resistin, IFN- IL-6, G-CSF, IL-8, IL-10(NGF), MCP-1, IL-2, IFN-, IL-12p70(IL-23), TNF-, IL-1, IL-5, IL-4, IL-13, IFN- IL-6, IL-10, IFN-, scd40l, IL-12p70(IL-23), TNF-, IL-4, IL-13, scd30(ifn-) IL-6, G-CSF(slCAM-1), IL-8, CRP(sE-selectin, MIP-1), IL-10, MCP-1, IL-17A(MIP-1, specam-1, specam-1, stnf-r1), IFN-, scd40l, IL-12p70(IL-23), TNF-, IL-1, IL-4, svcam-1, IL-13(MIG, sp-selectin), scd30(ifn-) slcam-1, IL-8, IL-10, MCP-1, IL-17A(MIP-1), IFN-, IL-12p70, TNF-, TNF-, IL-4, svcam-1, scd30 IL-6, slcam-1, CRP(MPO), NGF, MCP-1, OPG, stnf-r1, scd40l, Leptin, TNF-, PAI-1, Adiponectin, Resistin IL-6, slcam-1, IL-8, MIP-1, IL-10(NGF), MCP-1, MIP-1, IFN-, IL-12p70, TNF-, IL-1, svcam-1 L-6, IL-8, IL-10, IFN-, IL-12p70, TNF-, Adiponectin, IL-4 IL-6, slcam-1, IL-8, se-selectin(mip-1), IL-10, slcam-3(mcp-1), IL-2, IL-17A, IL-12p70(IL-23), TNF-, IL-1, IL-4, svcam-1, IL-13(sP-selectin), scd30(ifn-) IL-6, G-CSF, IL-8, CRP(sE-selectin, MIP-1), IL-10, MCP-1, MIP-1, IFN-, IL-12p70, TNF-vIL-1(PAI-1), IL-4, svcam-1, IL-13 IL-6, IL-10(NGF), scd40l, IL-12p70, TNF-, svcam-1, IL-13, scd30(ifn-) NGF, OPG, stnf-r1, scd40l, TNF-, TNF-, scd30 IL-6, slcam-1, CRP(MIP-1), IL-10, MCP-1, IL-2, IFN-, TNF-, IL-1, IL-4, svcam-1, MIG, scd30(ifn-) IL-6, slcam-1, IL-8, se-selectin(mip-1), IL-10(NGF), slcam-3(mcp-1), IL-2, MIP-1, IFN-, scd40l, IL-23, TNF-, TNF-, IL-1, IL-4, svcam-1, sp-selectin, scd30 BMS899-12FF BMS899-13FF BMS899-14FF BMS899-15FF BMS899-16FF BMS899-17FF BMS899-18FF BMS899-19FF BMS899-20FF 400, , , , , , , , ,000 12% 13% 14% 15% 16% 17% 18% 19% 20% 10 CosmoBioNews No.70
13 10mM DMSO 96 BTK CaM Kinase II CDK CKI & II EGFR GSK IKK Insulin receptor JAK JNK MAPK MEK MLCK PI 3-Kinase PDGFR PKA PKC RAF SAPK Src-family VEGFR Screen-Well Kinase Inhibitor Library 100R/well 500R/well 2832 A plate 1 plate Screen-Well Kinase Inhibitor Library 100R/well 500R/well Calcineurin (PP2B) CD45 CDC A 2834 JSP-1 PP1 PP2A 1 plate 1 plate PRL-1 PRL-3 PTEN ACE Aminopeptidase B Calpains Caspases Cathepsins DPPIV Furin Granzyme B Kallikrein MMPs Neutrophil elastase Proteasome -Secretase Thrombin TPPII Screen-Well Protease Inhibitor Library 100R/well 500R/well 2833 A plate 1 plate CosmoBioNews No.70 11
14 Akt (S473) Chk-2 (T68) Fyn (Y420) c-jun (S63) enos (S1177) p53 (S46) Paxillin (Y118) Src (Y419) STAT5a (Y699) Yes (Y426) Akt (T308) CREB (S133) GSK-3-Catenin (S21/S9) Lck (Y394) p27 (T157) p53 (S392) PLC-1 (Y783) STAT1 (Y701) STAT5a/b (Y699) AMPK1 (T174) ERK1/2 (T202/Y204)/(T185/Y187) Hck (Y411) Lyn (Y397) p27 (T198) p70 S6 Kinase (T229) Pyk2 (Y402) STAT2 (Y689) STAT5b (Y699) AMPK2 (T172) FAK (Y397) HSP27 (S78/S82) MEK1/2 (S218/S222)/(S222/S226) p38 (T180/Y182) p70 S6 Kinase (T389) RSK1/2 (S221) STAT3 (Y705) STAT6 (Y641) -Catenin (-) Fgr (Y412) JNK pan (T183/Y185)/(T221/Y223) MSK1/2 (S376/S360) p53 (S15) p70 S6 Kinase (T421/S424) RSK1/2/3 (S380) STAT4 (Y693) TOR (S2448) Proteome Profiler Phospho-Kinase Array Kit Human ARY ,000 R InhibitorSelect 96-well Protein Kinase Library InhibitorSelect 96-well Protein Kinase Library Akt DAG FLT3 IRAK c-met PDK1 PKR Syk Aurora DNA-PK cfms JAK p70 S6 PI 3-K Rho TGF-R ATM CaMK CK 1, 2 IKK MAPK ATR Cdk ERK JNK MNK1 1 plate 1 plate Bcr-Abl EGFR IGFR Lck PDGFR PKC Src VEGFR Aurora Chk 1, 2 GSK-3 MEK SK Kinome TK AGC Atypical TKL Other Kinome CMGC CAMK AGC CK TK STE Other number of Inhibitors TK : Tyrosine Kinase Group AGC : PKA, PKG, and PKC Containing Group TKL : Tyrosine Kinase-Like Group number of Inhibitors CMGC : Cdk, MAP, GSK3, and CLK Containing Group CAMK : Ca2+/Calmodulin Dependent Protein Kinases AGC : PKA, PKG, and PKC Containing Group CK : Casein Protein Kinases TK : Tyrosine Kinase Group STE : Yeast Sterile 12 CosmoBioNews No.70
15 mr mr mr mr mr mr mr LL test 60,000 mr mr mr mr mr mr LL test 60,000 CosmoBioNews No.70 13
16 Glucocorticoid Receptor (GR) (CHO-K1) Androgen Receptor (AR) (MDA-MB453) Liver X receptor (LXR ) (CHO-K1) Vitamin D Receptor (VDR) (CHO-K1) Estrogen Related Receptor (ERR) (CHO) Estrogen Receptor (ER) (U2OS) Thyroid Hormone Receptor (TR) (CHO) Thyroid Hormone Receptor (TR) (CHO) Peroxisome Proliferator Activated Receptor (PPAR ) (CHO) Retinoic Acid Receptor (RAR) (CHO) Retinoic Acid Receptor (RAR) (CHO) Retinoid X receptor (RXR) (U2OS) Liver X receptor (LXR) (CHO) Liver X receptor (LXR) (CHO) Farnesoid X Receptor (FXR) (CHO) Mineralocorticoid Receptor (MR) (CHO and U2OS) Glucocorticoid Receptor (GR) (CHO) 14 CosmoBioNews No.70
17 LavaCell Live Cell Imaging Stain LP LP R 1 mr 48, ,000 CosmoBioNews No.70 15
18 PNI03 PNIDM 22 mr 157,000 28,000 CF-1 CF6 Neomycin DR4 Neomycin, Hygromycin, Puromycin, 6-Thioguanine C57BL/ cells/vial 16,000 GSC-6101M GSC-6105M Mitomycin-C cells/vial cells/vial 11,000 11,000 GSC-6001M GSC-6005M GSC-6002M GSC-6001G GSC-6005G GSC-6004G GSC-6002G cells/vial 11,000 GSC-6001 GSC-6005 GSC-6002 Newborn Human Foreskin Fibroblasts Mitomycin-C cells/vial 33,000 GSC-3002M cells/vial 33,000 GSC-3002G cells/vial 27,000 GSC CosmoBioNews No.70
19 mr Astrocytes Endothelial Cells Fibroblasts Keratocytes Mesangial Cells Microglia Oligodendrocytes Pericytes Schwann Cells Smooth Muscle Cells Synoviocytes Urothelial Cells Cardiac Myocytes Epithelial Cells Keratinocytes Melanocytes Mesenchymal Stem Cells Neurons Osteoblasts Preadipocytes Skeletal Muscle Cells Stellate Cells Trophoblasts Human Astrocytes Astrocyte Medium vial 500 mr 156,000 26,000 Basophils Bone Marrow Cells CD4+ T Cells CD8+ T Cells CD14+ Monocytes CD19+ B Lymphocytes CD34+ Stem Cells CD133+ Stem Cells Endothelial Progenitor Cells Eosinophils Mesenchymal Stem Cells Monocyte-derived Dendritic Cells Monocyte-derived Macrophages Mononuclear Cells Myeloid Dendritic Cells Natural Killer (NK) Cells Neutrophils Pan-T Cells PBMCs Plasmacytoid Dendritic Cells Platelets Splenocytes Trophoblasts Peripheral Blood Mononuclear Cells Single donor Single donor Single donor Multi donors Nickel allergy donor IHC IF in situ hybridizationish 3H H H H H HS HS HS Cells Cells Cells Cells Cells ,000 99, ,000 51,000 71,000 37,000 37,000 37,000 CosmoBioNews No.70 17
20 m m CELLYARD beads200 CELLYARD beads g/cm g/cm 3 200m50m 500m75m g/cm g/cm bar EDTA CELLYARDbeads200 CELLYARDbeads g 100 g 500 g 50 g 100 g 500 g 18,000 28, ,000 18,000 28, ,000 OptiPrep mr 22, CosmoBioNews No.70
21 e-myco Mycoplasma PCR Detection Kit tube 54,000 M-Solution1&2 M-Solution 1&2 Antibiotics(100x) ,000 Phosphatase Substrate NEGATIVE MicroCystest kit POSITIVE Toxin ZE/MC48 ZE/MC96 (48Well) (96Well) 90, ,000 CosmoBioNews No.70 19
22 DetectX Urinary Creatinin Detection kit DetectX Serum Creatinin Detection kit K002-H1 KB02-H1 1kit 1kit 44,000 44,000 i-lenti sirna Lentifectin G074 1 mr 26, CosmoBioNews No.70
23 shrna shrna CosmoBioNews No.70 21
24 mr mr R R R R R R R R mr R SERVA ICPL Triprex Kit ,000 MSOMX-S OMX-S Device pc 65, CosmoBioNews No.70
25 1) Guiotto, A. et al.(2004) Bioorg. Med. Chem. 12, ) Wong, S. S.(1991) p. 13, CRC Press 3) Caliceti, P. et al.(1993) J. Bioact. Comp. Polym. 8, ) Frank Leenders, celares GmbH, Berlin, Germany.(2006) 6,39-40 Anti PEG Human WB/ELISA Biotin WB/ELISA/IHC gmr gmr gmrgmr g g 100g 100g 60,000 70,000 2D 2D 144(W)145(L)0.9(t) 144(W)145(L)0.9(t) 144(W)145(L)0.9(t) 184(W)185(L)0.9(t) 184(W)185(L)0.9(t) 184(W)185(L)0.9(t) 160(W)160(L)5.1(t) 160(W)160(L)5.1(t) 160(W)160(L)5.1(t) 200(W)200(L)5.1(t) 200(W)200(L)5.1(t) 200(W)200(L)5.1(t) % 1020% 1020% 420% 1020% 1020% ,000 22,000 22,000 33,000 33,000 33,000 DPE DPE set 96,000 1 set 120,000 CosmoBioNews No.70 23
26 Phire Hot Start DNA Polymerase F-120S F-120L 200 rxn 1000 rxn 18,000 68,000 DNARelease DNARelease F set 17,000 Dot storager A B DNA Dot storager 1 well type Dot storager 24 well type Dot storager 96 well type CB-001 CB-002 CB sheet 5 sheet 5 sheet 8,000 15,000 15, CosmoBioNews No.70
27 25 CosmoBioNews No.70 ER PPAR PPAR VDR FXR MR TRTR L Lindeleyin Ginseniside-Rg1 Resveratrol Genistein Resveratrol Isoprenols Phytol Isohumurone Resveratrol Isoprenols Abietic acid Curcuminoids Glycyrin Capsaicin Isohumurone Guggul TreeGuggulsterone RCAS ,000 98,000 ERERPPARPPAR PPAR VDRMRTRTR RXRRXRRXR 100, ,000 60,000 75,000
28 550R DNADNARNA RNA dsdnarna AC100V 50/60Hz 341W)315(D)349(H) mm 15 kg DNA RNA Genomic DNA Plant Genomic DNA Plasmid DNA Total RNA Viral RNA Mag Genex PNE ,300,000 Genomic DNA kit Plant Genomic DNA kit Plasmid DNA kit Total RNA kit Viral RNA kit test 96 test 96 test 96 test 96 test 33,600 33,600 38,400 33,600 33, CosmoBioNews No.70
29 27 CosmoBioNews No.70 VoL. 28
30 20S Proteasome A-Subunit 26S Proteasome Subunit 10 A Disintegrin And Metalloproteinase Domain 17 A27L ABC2 ACTIVATING NK RECEPTOR PRECURSOR ACVRL1 Adhesion Molecule DNAm-1 ADAM 3A AGE 4 AGTR 2 AKAP 7 AKAP 8L AKAP 9 AKAP-associated Sperm Protein Alcohol Dehydrogenase Alkylation Repair Homolog 8 ALOX12 Aminopeptidase LRAP/ERAP2 Aminopeptidase O/ONPEP Amyloid A4 Variant 40 Anaphase Promoting Complex 10 Anaphase Promoting Complex Subunit 7 Anaphylatoxin C3a Receptor Anterior Pharynx Defective 1 Homolog A Anthrax Ames Sterne & Vollum Strains Anthrax Ames Strain Antigen Ki-67 APEX Nuclease Apg 1B Apoptosis Inducing Factor Apoptosis Related Protein Apr-1 Apoptotic Protease Activating Factor 1 ASB1 ASC1 Transporter Asialoglycoprotein Receptor H1 Aspartyl hydroxylase ASPL Protein ATG9A ATP1A1 Aurora A kinase B5R Bcl 2 Binding Athanogene 1 Bcl 2 Interacting Killer Bcl 2 L13 BNP Precursor Bone Morphogenetic Protein 2 Bone Morphogenetic Protein 6 Bone Morphogenetic Protein 7 Bone Morphogenetic Protein Receptor Type 1B Brain Specific Protein P25 BRCTD1 Breast Cancer estrogen Resistance 1 Bromodomain Containing 4 Bromodomain Containing 7 BSD Domain Containing 1 BSRP A Butyrophilin 2 C21 orf7 Form A-D C6.1a Calsenilin like Protein Caltractin, Isoform 1 CARTPT CASKIN 1 Caspase Recruitment Domain Family Member 8 Cbl interacting Protein Sts-1 CCL16 CCL26 CCNA2 CCND3 CD136 CD156c CD183 CD1w3 CD243 CD298 CD44H CDCA3 Cell Division Control Protein 2 Cerebellin 1 Channel Kinase 1 Chloride Channel Protein 6 ICN A BET KAL RSD RSD RSD EPT SRT SRT RKL FGI ZYM B RSD SRT RSD RSD C SPS CBX CBX SRT SRT BLD SRT SRT KAL RSD BET LS-B LS-B LS-C A A LS-C LS-C LS-C LS-C KG133 FAB3659A LS-C LS-C LS-C LS-C LS-C LS-C LS-C AF3830 AF LS-B LS-C LS-C LS-B AHP1378 AHP1377 LS-B LS-B LS-C LS-B LS-B LS-C ASC-101AP LS-C LS-C LS-C LS-B LS-C LS-C LS-B LS-B LS-B MAB36041 LS-B LS-B LS-C LS-C LS-C AHP1448 LS-B LS-B LS-B LS-C AF4916 AF4917 LS-C LS-B LS-B LS-C LS-C LS-B LS-B LS-C LS-C CBX00639 CBX00672 AHP1321 AHP MCA1647G AHP1311 KS131 FAB4948A A A LS-B LS-B LS-B LS-C R 50 g 50 g 100 g 0.1 mg 25 g 100 g 250 g 100 g 10 g 100 test 100 g 100 g 100 g 100 g 200 g 100 g 1 each 100 g 100 g 100 R 50 g 50 R 250 g 50 g 1 mg 1 mg 50 g 10 g 50 R 100 g 50 g 50 g 50 R 100 g 100 g 100 g 100 R 50 R 100 g 100 g 100 g 50 g 50 g 50 g 100 g 50 g 50 g 100 g 100 g 100 g 50 g 50 g 50 g 50 g 100 g 100 g 100 g 100 g 50 g 50 g 50 R 50 g 200 R 50 g 50 g 100 g 100 g 100 g 100 g 50 g 50 g 50 g 0.25 mg 50 g 50 g 100 test 0.1 mg 50 g 50 g 50 R 100 g 30,600 62,000 62,000 53,000 68,000 42,000 64,000 73, ,000 55,000 64,000 74,000 74,000 74,000 53,000 40,000 74,000 10, ,000 74,000 60,000 62,000 43,000 56,000 62,000 49, ,000 62,000 81,000 55,000 62,000 62,000 43,000 79,000 87,000 74,000 71,000 62,000 72,000 47,500 53,000 62,000 62,000 62,000 42,000 62,000 62,000 70,000 70,000 74,000 52,900 62,000 62,000 62,000 74,000 74,000 74,000 74,000 62,000 62,000 47, ,000 75,000 62,000 62,000 75,000 75,000 39,000 39,000 51,100 52,500 22,500 29,800 51,100 55,000 64,000 68,000 62,000 62,000 62,000 74,000 Chloride Intracellular Channel 5 Cholecystokinin c-jun N-Terminal Kinase 3 Claudin 10b CMV Coagulation Factor 9 Collagen 25 1 Collagen 1 type 18 Collagen 1 type 6 Collapsin Response Mediator Protein 1 Colony Stimulating Factor 3 Receptor CPSF 100 CPSF 160 CPSF3 Creatine Kinase MT 2 CX orf6 MAGE L2 MAP4K4 MAP7 MCEMP1 MDM 4 Melatonin 1B Metalloproteinase Inhibitor 1 METTL3 MGL 1 / 2 MGL1 MLANA MRE11A MUC 45 Muscarinic Receptor M3 Muscle Creatine Kinase Myosin 18A Myotonin Protein Kinase N - Acylneuraminate Phosphatase NCK Adaptor Protein 2 Nei Endonuclease 8 Like 3 Nel Like Protein Ng3 Protein Nitric Oxide Synthase 3 NRARP NUCKS Nudix T Cell + Neurophils T Cell Receptor -Va24-JaQ TACR2 CPL RSD SIG RSD BET BET M BET BET RSD BET RSD RSD CPL SRT BET N RSD BET T SRT RSD SRT LS-B LS-C MAB4279 SIG LS-C AF4317 LS-B LS-B LS-B LS-C A A A A LS-C LS-C LS-C LS-B A A A A AF4994 LS-C LS-A LS-B A A AF4297 AF4938 LS-B LS-B AHP1355 LS-C A A LS-C LS-A LS-B LS-B LS-C LS-C LS-B AF4814 A A LS-B MCA805G AF4988 AHP g 50 R 100 g 100 g 1 mr 100 g 100 g 50 g 50 g 50 g 100 g 0.02 mg 0.02 mg 100 g 100 g 100 g D DDX 23 LS-C g F FAN SCB SC g J Junction Plakoglobin LS-B g L LMAN2 CBX CBX g Ls30647 LS-C g Lysosome Membrane Protein 2 LS-B R 50 g 0.1 mg 0.02 mg 100 g 100 g 50 g 50 g 0.02 mg 100 g 100 g 50 g 50 g 1 mr 50 g 500 R 0.1 mg 100 g 50 g 50 g 50 g 100 g 100 g 50 g 100 g 0.1 mg 50 g 0.25 mg 100 g 50 g 62,000 56,100 71,000 42,000 81,000 70,000 74,000 62,000 62,000 62,000 82,000 68,000 68,000 74,000 74,000 74,000 74,000 49,000 62,000 39,000 70,000 62,000 62,000 68,000 68,000 74,000 74,000 62,000 62,000 68,000 74,000 74,000 62,000 62,000 59,100 51,100 57,000 68,000 64,000 62,000 62,000 62,000 64,000 74,000 62,000 74,000 68,000 62,000 O OGR1 Opalin SRT CAC AHP1354 RIK-B-OP 50 g 100 g 51,100 50,000 P P619 LS-C R 43,000 PABP4 BET A A 0.02 mg 68,000 PIP1 BET A A 0.02 mg 68,000 PIWIL2 LFR LF-MA R 63,000 Q Quinone Oxidoreductase Homolog LS-C g 81,000 S SCN3B LS-B g 62,000 Septin 9 LS-C g 70,000 SMARCAD1 BET A A 0.1 mg 68,000 SMARCAD1 BET A A 0.02 mg 68,000 SNAPC 2 LS-C g 74,000 SnRNP Assembly Defective 1 Homolog LS-B g 62,000 Splicing Factor 3b LS-C g 74,000 Splicing Factor U2af 65 Kd Subunit LS-C g 74,000 SPRR 2A LS-B R 62,000 Src Substrate Cortactin LS-C R 96,000 Sterol O-acyltransferase 2 LS-C R 72,000 SUMO 1 Activating Enzyme Subunit 1 LS-B g 62,000 SUMO 1 Activating Enzyme Subunit 2 LS-C g 53,000 Surfeit 6 LS-C g 74,000 Synapsin 1 / 2 SPS R 75,000 Synaptonemal Complex Protein 3 LS-C g 72,000 29,800 74,000 50, CosmoBioNews No.70
31 Tale Homeobox Protein Meis22 T-box Brain 1 Protein Thioredoxin Reductase 3 THOC5 THOC5 THRA Thyroid Receptor Interacting Protein 6 Thyrotroph Embryonic Factor Titin Immunoglobulin Domain Protein TNF Ligand Superfamily Member 14 Toll Like Receptor 3 Toll-like Receptor Adaptor Molecule 1 Transcription Factor AP 2 TRIM 14 Tuberous sclerosis 2 Tumor Endothelial Marker 7 Precursor Twist Homolog Ubiquitin activating Enzyme E1 Homolog Ubiquitin Ribosomal Protein L40 UTP18/WDR50 Velis 1, 2, 3 Voltage Dependent Anion Channel 1 Voltage Dependent Anion Channel 2 Von Willebrand Factor A Domain Containing 1 CBX PTI U V SPS LS-C LS-C LS-C LS-B LS-C CBX00637 LS-C LS-C LS-B LS-C LS-B LS-C LS-B LS-B LS-C LS-C LS-B LS-C A A LS-B LS-B LS-B g 100 g 100 g 50 g 100 g 100 g 250 g 100 g 50 g 25 g 25 g 50 g 100 g 50 g 50 g 100 g 100 g 50 g 50 R 0.02 mg 200 R 50 g 50 g 50 g 74,000 64,000 56,000 62,000 64,000 39,000 68,000 74,000 62,000 45,000 39,000 62,000 74,000 62,000 62,000 59,000 74,000 62,000 72,000 68,000 75,000 62,000 62,000 62,000 VSIG2 VSIG3 WARP WC4 WDR3 WDR46 Wolfram Syndrome 1 Xanthine Dehydrogenase/oxidase Xanthine Dehydrogenase/oxidase X-Linked Helicase II X-Linked Helicase II X-linked Inhibitor Of Apotosis Protein XIAP ZC3H11A ZFP106 Zinc and Ring Finger 2 Zinc Finger Protein 768 Zinc Finger Protein 786 Zinc Finger Protein 84 Zinc Finger Protein Hsal2 ZNF295 Zona Pellucida Sperm-binding Protein 3a RSD RSD W RSD SRT BET BET X Z BET BET BET AF4766 AF4915 AF4927 MCA1648G A A A A LS-C LS-C LS-C LS-C LS-C LS-B A A A A LS-C LS-C LS-C LS-C LS-C A A LS-C g 100 g 100 g 0.25 mg 0.02 mg 0.1 mg 100 R 1 mr 1000 g 100 g 100 g 50 g Y YY1 CBX CBX g 0.1 mg 0.02 mg 100 g 100 g 100 g 100 g 50 g 0.1 mg 25 g 74,000 74,000 74,000 29,800 68,000 68,000 72,000 66,000 60,000 73,000 73,000 62,000 39,000 68,000 68,000 64,000 74,000 74,000 74,000 79,000 68,000 45,000 Anti Opalin Rabbit Mouse/Rat WB/IHC/IP RIK-B-OP 100g 50,000 Anti Neurofilament H/M Anti Schwann Cell/peripheral myelin Mouse Mouse Human Mouse/Human/Rat IHC IHC GU01-M02AS-A GU01-M01AS-A 50R 50R 30,000 30,000 CosmoBioNews No.70 29
32 Rat HGF EIA Mouse HGF EIA Rat Mouse 1Z81C 1Z85C 96 test 95, test 95,000 IgG anti-hev EIA IgM anti-hev EIA 1Z21C 96 test 120,000 1Z22C 96 test 120,000 Memo 30 CosmoBioNews No.70
33 Canine fetoprotein EIA kit Canine 1. Madsen AC et al.: J Surg Res 28:71-76, Lowseth LA et al.: J Am Vet Med assoc 199: , PG-CAFP EIA 98,000 THBR1-AS THBR2 2ZTHBR1 2ZTHBR2 2 mr 2 mr 40,000 40,000 Memo CosmoBioNews No.70 31
34 Use of bacterial poison/antidote systems in molecular biology : selective killing and how they can make the antibiotics obsolete. Dr. Cedric Y. Szpirer Head of product development at Delphi Genetics 32 CosmoBioNews No.70
35 EPT CosmoBioNews No.70 33
36
セルシグナリング / リンタンパク質検出 印の項目が測定可能です MAPmates パネル Multi-pathway パネル Akt/PKB Akt/PKB ATF2 BAD Active Caspase 3 (Ser473) (Thr308) (Thr69/71) (Ser112) Erk/MA
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21 5 28 2007 2008 CARElk CARPXR CAR CAR EST cdna CAR CAR 10FCS 96 SW480 HepG2 anti-lamin A/C anti-phospho-histone H3 anti-cyclin D1 G1 anti-cyclin A S CAR lamin A/C CAR Fig. 1 Lamin A/C /G1 lamin A/C G1
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ELISA Novex Life Technologies ELISA Novex ELISA 3 ELISA 5 14 ready-to-use 1 * 10 pg/ml 10 pg/ml 10 pg/ml * 5 250 pg/ml 5 250 pg/ml** 5 2,000 pg/ml * 4 2.5 4 3.5 1 1 1 1 50 HRP-TMB HRP-TMB R-PE Luminex
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TNF ファミリー 腫瘍壊死因子 ( Tumor Necrosis Factor: TNF) は 固形がんに対して出血性の壊死を誘導する因子として発見されたサイトカインです TNF ファミリーには TNF-α リンフォトキシンα Fas リガンドや TRAIL などのアポトーシス誘導に関与するサイトカインのほか RANK リガンド OX40 リガンド APRIL など 20 種類近くに因子が同定されています
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21 1 26 1 US6759035University of Southern California 1. A method for decreasing graft rejection of a solid organ by a recipient comprising: a) isolating peripheral blood mononuclear cells (PBMC) from a
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インターロイキン インターロイキンは リンパ球や単球 マクロファージなどの免疫反応への寄与が知られる白血球から産生されることから 細胞間 ( inter-) 白血球 ( leukocyte -leukin) より Interleukin と名づけられました 現在までに 30 種類以上のインターロイキンが同定され 発見された順番に番号が付与されており 中にはケモカイン ( IL-8) やインターフェロン
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