（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果

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1 1 CAS C 2 H 3 Cl ) 2) 1) ) ) 1- / (logp ow ) ) 4) 2980 mmhg25 1 ppm = 2.56 mg/m 3 at 25, 5) ph 7, 25 6) 5) 8.8 g/ml25 7) 3 OH OH /cm 3 10) ( ) 220nm 300nm 11) BOD 12) 16% 28 2 mg/l 44

2 13) 14) BCF 10 > 6) 40 15) ,031,692t 11,028t 547,595t 45

3 1 EUSES 2.1 2,400 km

4 µg/m / / / µg/m / µg/g / µg/l / µg/l / µg/l / µg/kg / µg/kg / µg/m µg/m µg/l

5 m 3 2 L 2,000 g 50 kg µg/m µg/kg/day 0.04 µg/m µg/kg/day µg/l µg/kg/day 0.01 µg/l µg/kg/day µg/g µg/kg/day 1.1 µg/m µg/kg/day 0.23 µg/m g/kg/day µg/m µg/kg/day 1998) µg/m µg/kg/day 0.5 µg/l µg/kg/day 0.19 µg/l µg/kg/day 0.03 µg/l µg/kg/day µg/g µg/kg/day 95 48

6 µg/kg/day 1.1 µg/m µg/kg/day µg/m µg/kg/day 0.04 µg/kg/day 0.35 µg/kg/day 0.37 µg/kg/day 2.4 µg/kg/day µg/kg/day PEC 2.5 PEC 0.19 µg/l 0.21 µg/l µg/l µg/l µg/l 0.03 µg/l µg/l

7 1 1) 3.1 LD mg/kg LC g/m 3 (15 ) LCLo g/m 3 (30 ) LCLo g/m 3 (30 ) 2) Wistar mg/kg/day / 5.0 mg/kg/day 14.1 mg/kg/day 5.0 mg/kg/day 3) NOAEL 1.7 mg/kg/day Wistar mg/kg/day / 1.3 mg/day NOAEL ) mg/kg/day Wistar ,800 mg/m / 6 / 260 mg/m mg/m 3 LOAEL 26 mg/m mg/m 3 6) Wistar ,30052,000 mg/m / 5 / 52,000 mg/m 3 1,300 mg/m 3 1,300 mg/m 3 7) Wistar ,30052,000 mg/m / 5 / 1,300 mg/m mg/m 3 8) LOAEL 130 mg/m 3 19 mg/m 3 CF ,280 mg/m

8 1,280 mg/m 3 Sprague-Dawley ,280 6,400 mg/m / 6,400 mg/m 3 1,300 mg/m 3 6,400 mg/m ,2806,400 mg/m / 9 10) NOAEL 128 mg/m 3 6,400 mg/m 3 Charles River CD ,860 mg/m / 5 / 260 mg/m 3 NOAEL 2,860 mg/m 3 LOAEL 26 mg/m mg/m ) ) 30 10,173 17) 1819) 2 Wistar mg/kg/day mg/kg/day 5.0 mg/kg/day 1 3) Sprague-Dawley Wistar 076,800 mg/m / 5I/ Swiss Syrian golden 076,800 mg/m / 5I/ 51

9 202122) 23) IARC 23) 1 3 NOAEL NOAEL 0.13 mg/kg/day LOAEL 26 mg/m mg/m 3 LOAEL 26 mg/m mg/m 3 LOAEL mg/m MOE 0.02 µg/kg/day 0.13 mg/kg/day µg/kg/day 0.04 µg/kg/day µg/m µg/m µg/m µg/m mg/m µg/kg/day 0.02 µg/kg/day 0.04 µg/kg/day 0.13 mg/kg/day MOEMargin of Exposure

10 0.042 µg/m µg/m mg/m 3 MOE µg/m µg/m mg/m 3 MOE

11 1 4.1 [µg/l] 4.1 [] a b c No ,000 Esox Iucius NR-LETH MOR ,000 Tetrahymena pyriformis IC 50 POP PNEC PNEC IC 50 Median Inhibition Concentration NR-LETH MORMortality: POPPopulation 2 PNEC PNEC Tetrahymena pyriformis 9 IC ,000 µg/l PNEC PNEC [95 ] PNEC PEC/ PEC PNEC 0.01µg/L µg/L 0.03µg/L 1999 µg/l 0.01µg/L µg/L

12 0.01 µg/l PEC 0.19 µg/l 0.21 µg/l PNEC 30%

13 1 1) NIOSH (1997): NIOSH Pocket Guide to Chemical Hazards. 2) Hawleys Condensed Chemical Dictionary. 13th Ed. (1997): New York, NY. John Wiley & Sons, Inc. 3) CRC Handbook of Chemistry and Physics. 79th Ed. ( ) 4) Daubert, T. E. and R. P. Danner (1989): Physical and Thermodynamic Properties of Pure Chemicals Data Compilation. Washington, D.C. Taylor & Francis, Inc. 5) (2002): 6) Rathbun, R. E. (1998): US. Geol. Surv. Prof. Paper ) Delassus, P. C. and D.D. Schmidt (1981): J Chem. Eng. Data 26: ) Capel, D. E. and S. J. Larson (1995): A chemodynamic approach for estimating losses of target organic chemicals from water during sample holding time. Chemosphere 30: ) Hunkeler, D. (1999): Environ. Sci. Technol. 33: ) Atkinson, R. (1989): J. Phys. Chem., Ref. Data Monograph, 1. 11) U.S. EPA-440/ b. (1979): Water-Related Environmental Fate of 129 Priority Pollutants. 12) (2002): DATA 13) Franke, C., G. Studinger, G. Berger, S. Behliing, U. Bruckmann, D. Chors-Fresenborg and U. Joehncke (1994): The assessment of bioaccumulation: Chemosphere 29: ) Freitag, D., I. Scheunert, W. Klein and F. korte (1985): Environmental hazard profile of organic chemicals an experimental method for the assessment of the behavior of organic chemicals in the ecosphere by simple laboratory tests with carbon14-labeled chemicals. Chemosphere, 14: ) , , , , ) (2002): 13 2) (2001): 12 3) (2000): 11 4) (1999): 10 5) (1999):,Vol.28, ) (2000): 11 7) (2000): 11 8) (1998): 10 9) (1996):, Vol.3, ) (1999):, 25,

14 3 1) US National Institute for Occupational Safety and Health (NIOSH) RTECS Database. 2) IPCS (1999): Environmental Health Criteria ) Feron, V., C. F. M. Hendrikson, A. J. Speek, H. P. Til, B. J. Spit (1981): Lifespan oral toxicity study of vinyl chloride in rats. Food Cosmet. Toxicol. 19: ) Til, H.P., V.J. Feron, and H.R. Immel (1991): Lifetime (149-week) oral carcinogenicity study of vinyl chloride in rats. Food Chem. Toxicol. 29: ) Til, H.P., H.R. Immel, and V.J. Feron (1983): Lifespan oral carcinogenicity study of vinyl chloride in rats. Final report. CIVO Institutes. TNO Report No. V /291099, TSCATS Document FYI-AX , Fiche No ) Bi, W., Y. Wang, M. Huang, and D. Meng (1985): Effect of vinyl chloride on testis in rats. Ecotoxicol. Environ. Saf.10: ) Sokal, J.A., B. Baranski, J. Majka, R. Rolecki, J. Stetkiewicz, L. Ivanova-Chemishanska, T. Vergieva, G. Antonov, E. Mirkova, A. Kolakowski, S. Szendzikowski, and K. Wróblewska (1980): Experimental studies on the chronic toxic effects of vinyl chloride in rats. J. Hyg. Epidemiol. Microbiol. Immunol. 24: ) Wisniewska-Knypl, J.M.; J. Klimczak, and J. Kolakowski (1980): Monooxygenase activity and ultrastructural changes of liver in the course of chronic exposure of rats to vinyl chloride. Int. Arch. Occup. Environ. Health 46(3): ) John, J.A., F.A. Smith, B.K.J. Leong, and B.A. Schwetz (1977): The effects of maternally inhaled vinyl chloride on embryonal and fetal development in mice, rats and rabbits. Toxicol. Appl. Pharmacol. 39: ) John, A.J., F.A. Smith, and B.A. Schwetz (1981): Vinyl chloride: Inhalation teratology study in mice, rats and rabbits. Environ. Health. Perspect. 41: ) Shah, H.C. (1998): Vinyl chloride combined inhalation two-generation reproduction and developmental toxicity study in CD rats: Reproduction study -- Final report (Study No ). East Millstone, Huntingdon Life Sciences Inc., vol I, pp (Unpublished report). 12) Chemical Manufacturers Association (CMA) (1998): Vinyl chloride combined inhalation two-generation reproduction and developmental toxicity study in CD rats. Submitted by CMA to ATSDR pursuant to Memorandum of Understanding, June 26, Final Report. CMA, Arlington VA. 13) Thiess, A.M. and P. Versen (1974): [Occupational medical thoughts on the so-called 'vinyl chloride disease'.] Arbeitsmed Sozialmed Präventivmed 7: ) Lange, C. E., S. Jühe, G. Stein, and G. Veltman (1974): [The so-called vinyl chloride disease: An occupationally caused systemic sclerosis.] Int Arch Arbeitsmed 32: ) Berk, P.D., J.F. Martin, R.S. Young, J. Creech, I. J. Selikoff, H. Falk, P. Watanabe, H. Popper, L. Thomas (1976): Vinyl chloride-associated liver disease. Ann. Intern. Med. 84: ) Doss, M., C.E. Lange; and G. Veltman (1984): Vinyl chloride-induced hepatic coproporphyrinuria with transition to chronic hepatic porphyria. Klin Wochenschr 62: ) Dow Chemical Company (1986): Co-initial submission: an update of an epidemiologic study with vinyl chloride workers, (final report with cover letter dated 07/24/92 and attachments). U.S. Environmental Protection Agency/OTS public files. Document no Fiche no (1). 18) Hatch, M., J. Kline, and Z. Stein (1981): Power considerations in studies of reproductive effects of vinyl chloride and some structural analogs. Environ. Health Perspect. 41: ) Theriault, G., H. Iturra, and S. Gingras (1983): Evaluation of the association between birth-defects and exposure to ambient vinyl-chloride. Teratology 27:

15 20) Maltoni, C., G. Lefemine, A. Ciliberti, G. Cotti, D. Carretti (1980): Vinyl chloride carcinogenicity bioassays (BT project) as an experimental model for risk identification and assessment in environmental and occupational carcinogenesis. Epidemiol. Anim. Epidemiol. Hum: Cas Chlorure Vinyle Monomer (Reun. Club Carcerog. Chim.) 20th meeting date 1979, Publ. Essent, Paris, France, pp ) Maltoni, C., G. Lefemine, A. Ciliberti, G. Cotti, D. Carretti (1981): Carcinogenicity bioassay of vinyl chloride monomer: a model of risk assessment on an experimental basis. Environ. Health Perspect. 41: ) Maltoni, C., Lefemine, G., A. Ciliberti, G. Cotti, D. Carretti (1984): Experimental research on vinyl chloride carcinogenesis. In: Archives of research on industrial carcinogenesis. Vol. 2. Maltoni, C; Mehlman, MA, eds. Princeton, NJ: Princeton Scientific Publishers, Inc. 23) IARC (1987): IARC Monograph on the Evaluation of Carcinogenic Risk to Humans, Supplement ) U.S. EPAAQUIRE 2) Ref. No : Brown, E.R., T. Sinclair, L. Keith, P. Beamer, J.J. Hazdra, V. Nair, and O. Callaghan (1977) : Chemical Pollutants in Relation to Diseases in Fish. Ann.N.Y.Acad.Sci. 298: : Sauvant, M.P., D. Pepin, C.A. Groliere, and J. Bohatier (1995) : Effects of Organic and Inorganic Substances on the Cell Proliferation of L-929 Fibroblasts and Tetrahymena pyriformis GL Protozoa Used for Toxicological Bioassays. Bull.Environ.Contam.Toxicol. 55(2):

（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果

（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果 1 ( ) DBDPO CAS 1163-19-5 C 12 Br 10 O 959.2 2 1) 305 2) 3.0 1) 1- / (logp ow ) 1) 5.03 mmhg306 1) 1) 3) 4) 5) 1.010-4 6) mg/l25 3 7) OH 8) 4 9) 6 BOD 0% 14 100 mg/l 30 7) 10) BCF 5 < 42 60 mg/l 7) 50