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5 1 CAS CH 2 O ) 40% 50% 2) 2) -92 1) ) (-20 ) 3) 2 Pa (20 ) 4) 1ppm=1.23 mg/m 3 at 25, n- / 0.35 ( ) 5) 55 % 7) 6) 6) 3 8) 6) (OH ) 19 9) 9) ( ) 6 BOD 91 %( mg/l 30 mg/l) 8) BCF
6 9) ,263,881 t t 1, t ( ) 2) OECD 10,000 t 10) 2)
7 95 (1) EUSES 2.1 2,400km ),2) ( ) (2) µg/m / µg/m / ,5 µg/l < 1 < / µg/l < 1 < / µg/g 0.24 < / µg/l < 1 < 1 < 1 * / µg/l < 1 < 1 < / ) 490 µg/m 3 (1984) 40,000 µg/m 3 (1980) 9) 2) 3) 140 µg/l(1989) 10) 4) * 5%
8 (3) m 3 2L 2,000g 50kg µg/m 3 (1999) 62 µg/ 3 (1999) 0.78 µg/kg/day 19 µg/kg/day 1 µg/l (1997) 1 µg/l (1999) 1 µg/l (1999) 0.04 µg/kg/day 0.04 µg/kg/day 0.04 µg/kg/day 0.24 µg/g ( µg/kg/day 8.7 µg/m 3 (1999) 230 µg/ 3 (1999) 5 µg/l (1999) 5.5 µg/m 3 44 µg/l (1997) 8 µg/l (1999) 3 µg/l 1.5 µg/g ( µg/kg/day 1.7 µg/kg/day 69 µg/kg/day 1.8 µg/kg/day 0.32 µg/kg/day 0.2 µg/kg/day 0.12 µg/kg/day 60 µg/kg/day µg/kg/day 230 µg/m µg/kg/day µg/m 3 62 µg/kg/day 60 µg/kg/day 130 µg/kg/day
9 64 µg/kg/day 2.4 (µg/kg/day) (µg/kg/day) (0.04) (0.32) (0.04) ([0.12]) ) 95 2) 3) 4) (4) PEC 2.5 PEC 3 µg/l 95 2 µg/l µg/l (1999) 1 µg/l (1999) 5 µg/l (1999) 3 µg/l 2 µg/l (1999) 1) 2 95
10 1 3.1 LD mg/kg LDLo 16 mg/kg LD mg/kg LDLo 240 mg/kg LD mg/kg Wistar mg/kg/day mg/kg/day 2 82 mg/kg/day 109 mg/kg/day 15 mg/kg/day 21 mg/kg/day NOAEL GDWQ 1996 NOAEL mg/m / 7 / 3.6 mg/m mg/m 3 NOEL 1.1 mg/m 3 CD mg/kg/day mg/kg/day mg/m mg/m 3 EHC, 1989
11 0.05 ppm ppm ppm ppm ppm ppm ppm 100 ACGIH, 1992 WHO mg/m mg/m 3 NOAEL 30 2 B6C3F1 F mg/m ppm 24 6 / 5 / 17.6 mg/m mg/m mg/m WHO GDWQ 1996 IARC 2A 3 NOAEL NOAEL 15 mg/kg/day WHO 0.1mg/m 3 30
12 4 3.2 MOE 9.6 µg/kg/day 62 µg/kg/day 15 mg/kg/day µg/m µg/m µg/m µg/m mg/m µg/kg/day mg/kg/day MOE Margin of Exposure µg/m µg/m mg/m 3 MOE µg/m µg/m mg/m 3 MOE 18
13 (1) / Ref. [ µg/l] [ ] No. Phyllospora comosa NOEC MOR Phyllospora comosa LOEC MOR Scenedesmus quadricauda NR PGR ,000 Phyllospora comosa NOEC MOR ,000 Phyllospora comosa LOEC MOR ,170 µl/l Artemia sp. LC 50 MOR Daphnia pulex EC 50 IMM µl/l 62.1 µl/l 129 µl/l Ictalurus punctatus LC 50 MOR Ameiurus melas LC 50 MOR Oncorhynchus mykiss LC 50 MOR Morone saxatilis LC 50 MOR ,100 Pimephales promelas LC 50 MOR ,000 Corbicula manilensis LC 50 MOR PNEC PNEC PNEC EC 50 Median Effective Concentration): LC 50 Median Lethal Concentration): LOEC Lowest Observed Effect Concentration): NOEC No Observed Effect Concentration): NR Not Reported): IMM Immobilization): MOR Mortality): PGR Population Growth): (2) PNEC Daphnia pulex 48
14 EC 50 5,800 µg/l Morone saxatilis 96 LC 50 4,960 µg/l 1,000 4,960 µg/l PNEC 5.0 µg/l Phyllospora comosa 96 NOEC 100 µg/l 100 PNEC 1.0 µg/l PNEC PNEC µg/l (3) 4.2 PNEC PEC 1 µg/l (1999) 5 µg/l (1999) 3 µg/l PEC/ PNEC 1 µg/l (1999) 2 µg/l (1999) >2.0 1) 1) 1) 140 µg/l(1989) 1.0 µg/l >3.0 1 µg/l PEC 3 µg/l 2 µg/l PEC PNEC 3 2
15 1 1),, (1991), (1991) 2) (2001) ) Handbook of Environmental Data on Organic Chemicals, 2nd Ed. (1983) Van Nostrand Reinhold Co. 4) IPCS (2000) International Chemical Safety Cards 5) Richardson, M. L. et al. (1993) The Dictionary of Substances and their Effects, Royal Society of Chemistry 6) ( ) (1997) 7) The Merck Index, 11th Ed. (1989) Merck & Co. Inc. 8) ( ) (1996) 9) Hazardous Substances Data Bank (HSDB) (1998) U.S.National Library Medicine 10) (1997;1998;1999;2000;2001) 13197, 13398, 13599, 13700, (2) 1 ) 11 2 ) , p54-58, , p10-14, ) 11 9 WHO:Environmental Health Criteria,Formaldehyde 10 Agency for Toxic Substances and Disease Registry:Health Assessment for Louisiana-Pacific National Priorities List(NPL) Site,Oroville,ButteCountry California,Region 9.CERCLIS No.CAD (1989) , 2 Til, H. P. et al Food Chem. Toxicol., 27: Rusch, G. M. et al Toxicol. Appl. Pharmacol Marks, T. A. et al Teratology, Air Quality Guidelines for Europe, WHO Regional Publications, European Series No.23,
16 WHO Regional Office for Europe Kerns, W. D. et al Cancer Res., 43: Environmental Health Criteria 89, IPCS IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume , supplement , Volume IRIS Integrated Risk Information System, No.0419, U.S. EPA Documentation of the Threshold Limit Values and Biological Exposure Indices, Sixth Edition, Formaldehyde, ACGIH Guidelines for Drinking-Water Quality, WHO (4) U.S.EPA AQUIRE Ref. No. 418:Chandler,J.H.Jr. and L.L.Marking (1979): Toxicity of Fishery Chemicals to the Asiatic Clam, Corbicula manilensis. Prog. Fish-Cult. 41(3): :Bringmann,G. and R.Kuhn (1959): The Toxic Effects of Waste Water on Aquatic Bacteria, Algae, and Small Crustaceans.,TR-TS-0002, (ENG TRANSL); Gesund. Ing. 80: (GER); Chem. Abstr. 53:17390G. 3217:Geiger,D.L., L.T.Brooke, and D.J.Call (1990): Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Vol. 5 Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI:332 p. 3515:Reardon,I.S. and R.M.Harrell (1990): Acute Toxicity of Formalin and Copper Sulfate to Striped Bass Fingerlings Held in Varying Salinities. Aquaculture 87(3/4): :Bills,T.D., L.L.Marking, and J.H.Chandler,Jr. (1977): Formalin: Its Toxicity to Nontarget Aquatic Organisms, Persistence, and Counteraction. Invest. Fish Control No. 73, Fish Wildl. Serv., Bur. Sport Reference 2652) :Burridge,T.R., T.Lavery, and P.K.S.Lam (1995): Acute Toxicity Tests Using Phyllospora comosa (Labillardiere), C. Agardh (Phaeophyta: Fucales) and Allorchestes compressa Dana (Crustacea: Amphipoda). Bull. Environ. Contam. Toxicol. 55(4): :Howe,G.E., L.L.Marking, T.D.Bills, and T.M.Schreier (1995): Efficacy and Toxicity of Formalin Solutions Containing Paraformaldehyde for Fish and Egg Treatments. Prog. Fish- Cult. 57(2): :Espiritu,E.Q., C.R.Janssen, and G.Persoone (1995): Cyst-Based Toxicity Tests. VII. Evaluation of the 1-h Enzymatic Inhibition Test (Fluotox) with Artemia nauplii. Environ. Toxicol. Water Qual. 10: :Van Heerden,E., J.H.J.Van Vuren, and G.J.Steyn (1995): LC50 Determination for Malachite Green and Formalin on Rainbow Trout (Oncorhynchus mykiss) Juveniles. Water S.A. 21(1): :Tisler,T. and J.Zagorc-Koncan (1997): Comparative Assessment of Toxicity of Phenol, Formaldehyde, and Industrial Wastewater to Aquatic Organisms. Water Air Soil Pollut. 97(3/4):
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22 EUSES 2.1 2,400 km ,
23 2.2 µg/m / / / µg/m / µg/l / µg/l / µg/g / µg/l *5 1 63/ µg/l / µg/m ,000 µg/m µg/l * 1% 12 µg/l m 3 2 L 2,000 g 50 kg 51
24 µg/m µg/kg/day 79 µg/ µg/kg/day 1 µg/l µg/l µg/l µg/kg/day 0.04 µg/kg/day 0.04 µg/kg/day 0.24 µg/g µg/kg/day 14 µg/m µg/kg/day 6.1 µg/m µg/kg/day µg/m 3 6.9µg/kg/day µg/ µg/kg/day 160 µg/ 3 48 µg/kg/day 44 µg/l µg/l µg/kg/day 0.32 µg/kg/day 5 µg/l µg/kg/day 3 µg/l 0.12 µg/kg/day 1.5 µg/g 1999) 60 µg/kg/day µg/kg/day 14 µg/m µg/kg/day 430 µg/m µg/kg/day 60 µg/kg/day 52
25 66 µg/kg/day 2.4 µg/kg/day µg/kg/day )
26 1 1,2,3) ) 70 22% NAD NADH 6, DNA 7 DNA DNA 9,10) 2 in vitro DNA 11, DNA DNA 12) DNA DNA 11, DNA 12) in vivo 54
27 13, 14) 11, 12) DNA 1 10) ) Wistar mg/kg/day mg/kg/day 2 18) Wistar mg/kg/day 2 19) Splague-Dawley ,000 1,500 2,500 mg/l 2 1,500 mg/l (5 mg/kg/day) 15 mg/l 20) Wistar 2 N- -N - -N- (MNNG) 100 mg/l % ) Fischer mg/m / 5 / 6.7 mg/m mg/m mg/m 3 22) Fischer mg/m
28 6 / 5 / 7.2 mg/m ) Sprague-Dawley mg/m / 5 / 17.8 mg/m mg/m 3 24) Fischer mg/m / 5 / 17 mg/m mg/m 3 25) Fischer mg/m / 5 / 17.8 mg/m 3 26) ) ,561 SMR % SMR 30) SMR RR SMR RR ) 124 SMR % SMR 31) 31) WHO 32) 56
29 mg/m 3 1 WHO/GDWQ 33) IARC 2A EU 3 EPA B1 ACGIH A2 NTP R 2 A DFG *1 4 MAK *2 1) *1 Neumann 34) 2) *2 DFG Maximale Arbeitsplatzkonzentrationen 4 WHO/GDWQ 33) WHO 32) 57
30 EPA 35 Fischer ) (µg/m 3 ) -1 mg/m 3 0 0/ / / /140 Kerns 22) µg/kg/day 62 µg/kg/day 9.6 µg/kg/day 60 µg/kg/day 3.1 µg/m 3 14 µg/m (µg/m 3 ) µg/m µg/m ) 3.1 µg/m 3 14 µg/m µg/m µg/m
31 7) Exposure/Potency Index EPI Fischer ) 5% TC mg/m 3 95% 7.9 mg/m 3 mg/m 3 0 0/ / / / / /147 Monticello 23) TD 0.05 TC µg/kg/day 62 µg/kg/day 9.6 µg/kg/day 60 µg/kg/day 3.1 µg/m 3 14 µg/m mg/m 3 79 µg/m µg/m ) EPI TD 0.05 TC 0.05 EPI TC 0.05 EPI
32 TC mg/ m 3 1 1) (2000): 11. 2) (2001): 12. 3) (2001) 12. 4) (2000) 11. 5) (1999) 10. 6) (2001): 12. 7). 8) (2000): 11. 9) (2000): ) IPCS (1989): Formaldehyde : Environmental Health Criteria 89. WHO. Geneva. 11) ATSDR (1989) : Health Assessment for Louisiana - Pacific National Priorities List(NPL) Site,Oroville,ButteCountry California,Region 9. CERCLIS No.CAD ) Heck, H.d A., T.Y. Chin and M.C. Schmitz. (1983): Distribution of [ 14 C ] formaldehyde in rats after inhalation exposure. In: J.E. Gibson (ed.), Formaldehyde toxicity. Hemisphere Publishing, Washington, D.C ) Swenberg, J.A., E.A. Gross, J. Martin and J.A. Popp. (1983): Mechanisms of formaldehyde toxicity. In: J.E. Gibson (ed.), Formaldehyde toxicity. Hemisphere Publishing, Washington, D.C. 60
33 ) Patterson, D.L., E.A. Gross, M.S. Bogdanffy and K.T. Morgan. (1986): Retention of formaldehyde gas by the nasal passages of F-344 rats. Toxicologist 6: 55. 4) Gailli, C.L., C.Ragusa, P.Resmini, and M.Marinovich (1983): Toxicological evaluation in rats and mice of the ingestion of a cheese made from milk with added formaldehyde. Food Chem. Toxicol. 21: ) Katakura,Y., R.Kishi, T.Okui, T.Ikeda and H.Miyake, (1993): Distribution of radioactivity from 14 C-formaldehyde in pregnant mice and their fetuses. Br. J. Ind. Med. 50: ) Heck H d A, M.Casanova-Schmitz, P.B.Dodd, E.N. Schachter EN, T.J.Witek, T.Tosun (1985) : Formaldehyde (CH 2 O) concentrations in the blood of humans and Fischer-344 rats exposed to CH 2 O under controlled conditions. American Industrial Hygiene Association journal, 46:1-3. 7) (2001): Canadian Environ-mental Protection Act. Priority Substances List assessment report. Formaldehyde. Ottawa, Ontario, Minister of Public Works and Government Services. 8) Casanova, M. and H.d A. Heck. (1987): Further studies of the metabolic incorporation and covalent binding of inhaled [ 3 H] and [ 14 C ] formaldehyde in Fischer-344 rats: effects of glutathione depletion. Toxicol. Appl.Pharmacol. 89: ) Monticello, T.M., K.T. Morgan, J.I. Everitt and J.A. Popp.(1989): Effects of formaldehyde gas on the respiratory tract of rhesus monkeys. Pathology and cell proliferation. Am. J.Pathol. 134: ) Casanova, M., K.T. Morgan, W.H. Steinhagen, J.I. Everitt, J.A. Popp and H.d A. Heck. (1991): Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fundam. Appl. Toxicol. 17: ) Grafström,R.C (1990)In vitro studies of aldehyde effects related to human respiratory carcinogenesis. Mutat.Res. 238: ) Grafstrom,R.C., I.C.Hsu and C.C.Harris (1993): Mutagenicity of formaldehyde in Chinese hamster lung fibroblasts: synergy with ionizing radiation and N-nitroso-N-methylurea. Chem. Biol. Interact. 86: ) Migliore, L., L. Ventura, R. Barale, N. Loprieno, S. Castellino and R. Pulci. (1989): Micronuclei and nuclear anomalies induced in the gastro-intestinal epithelium of rats treated with formaldehyde. Mutagenesis 4: ) Dallas, C.E., M.J. Scott, J.B. Ward, Jr. and J.C. Theiss.(1992): Cytogenetic analysis of pulmonary lavage and bone marrow cells of rats after repeated formaldehyde inhalation. J.Appl. Toxicol. 12: ) IARC (1987): IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Suppl.7.: ) Ward,J.B., J.A.Jr,Hokanson, E.R.Smith, L.W.Chang,.M.A.Pereira, F.B.Jr.Whorton and M.S.Legator.(1984): Sperm count,morphology and fluorescent body frequency in autopsy service workers exposed to formaldehyde.mutat.res.,130,
34 17) Connor,T.H., J.C.Theiss, H.A.Hanna, D.K.Monteith and T.S.Matney.(1985): Genotoxicity of organic chemicals frequently found in the air of mobile homes.toxicol.lett. 25: ) Til,H.P., R.A.Woutersen, V.J.Feron, V.H.M.Hollanders and H.E. Falke (1989): Two-year drinking-water study of formaldehyde in rats. Food. chem. Toxicol. 27: ) Tobe M, K.Naito, Y.Kurokawa (1989) : Chronic toxicity study on formaldehyde administered orally to rats. Toxicology, 56: ) Soffritti,M., C.Maltoni, F.Maffei and R.Biagi, (1989): Formaldehyde:an experimental multipotential carcinogen. Toxicol. ind. Health 5: ) Takahashi,M., R.Hasegawa, F.Furukawa, K.Toyoda, H.Sato and Y.Hayashi (1986): Effects of ethanol,potassium metabisulfite,formaldehyde and hydrogen peroxide on gastric carcinogenesis in rats after initiation with N -methyl-n -nitro-n -nitrosoguanidine. Jpn. J. Cancer Res. 77: ) Kerns,W.D., K.L.Pavkov, D.J.Donofrio, E.J.Gralla, and J.A.Swenberg. (1983): Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. Cancer Res. 43: ) Monticello,T.M., J.A.Swenberg, E.A.Gross, J.R.Leininger, J.S.Kimbell, S.Seilkop, T.B.Starr, J.E.Gibson and K.T.Morgan (1996): Correlation of regional and nonlinear formaldehyde - incuced nasal cancer with proliferating populations of cells, Cancer Res. 56: ) Sellakumar,A.R., C.A. Snyder, J.J.Solomon, and R.E.Albert (1985): Carcinogenicity of formaldehyde and hydrogen chloride in rats. Toxicol. Appl. Pharmacol. 81: ) Tobe,M., T. Kaneko, Y. Uchida (1985): Studies of the inhalation toxicity of formaldehyde. National Sanitary and Medical Laboratory Service (Japan) : ) Kamata,E., M.Nakadate, O.Uchida, Y.Ogawa, S.Suzuki, T.Kaneko, M.Saito and Y.Kurokawa (1997): Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats, J. Toxicol. Sci. 22: ) IARC(1995): IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 62: Wood Dust and Formaldehyde. : ) Linos,A., A.Blair, K.P.Cantor, L. Burmeister, S.V nlier, R.W.Gibson, L.Schuman and G.Everett (1990): Leukemia and non-hodgkin s lymphoma among embalmers and funeral directors (Letter to the Editor).J.natl Cancer Inst. 82:66. 29) Blair,A., P.Stewart, M.O'Berg, W.Gaffey, J.Walrath, J.Ward, R.Bales, S.Kaplan, and D.Cubit. (1986): Mortality among industrial workers exposed to formaldehyde. JNCI 76: ) Blair, A., P.A. Stewart, R.N. Hoover, J.F. Fraumeni, J. Walrath, M. O Berg and W. Gaffey.(1987): Cancers of the nasopharynx and oropharynx and formaldehyde exposure.j. Natl. Cancer Inst. 78: ) Blair,A., P.A.Stewart, and R.N.Hoover (1990): Mortality from lung cancer among workers employed in formaldehyde industries. Am. J. Indust. Med. 17: ) WHO (2000): Air quality guidelines for Europe, 2nd ed. Copenhagen, (WHO Regional Publications, European Series, No. 91). 33) WHO/Guidelines for Drinking Water Quality. Second Edition. Vol.2.(1996): 16.8 Formaldehyde :
35 34) H.-G. Neumann, H.W.Thielmann,J.G.Filser,H.-P.Gelbke, H.Greim,H.Kappus, K.H.Norpoth, U.Reuter, S.Vamvakas, P.Wardenbach and H.-E.Wichmann(1977): Regulatory Toxicology and Pharmacology. 26: ) EPA (1991): IRIS(Integrated Risk Information System). No.419, Formaldehyde. 63
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橡96-07.PDF
1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
![化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]](/thumbs/104/163316306.jpg "化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]")
(1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16
CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4
2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7
橡フタル酸ブチルベンジル.PDF
1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow
橡99-24_00 アリルアルコール.PDF
1 9924 2260 CAS 107186 H 2 C CH CH 2 OH 2- -1- C 3 H 6 O 58.08 1 99 1. 2, 3 3, 4, 5-129 96-97 2 21c.c. 24o.c. 2 6, 7 378 6, 7 2.5-18 d 20 4 0.8540 2, 5 2.00 = 1 2.7 kpa 20 mmhg204.3 kpa 32 mmhg30 4 log
CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa
1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16
3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
98-02.PDF
1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
,161 t 9,753 t 2,408 t LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum 6 3 Selenastrum h, Sb
1 20017 1543 CAS 1309644 125 Sb 2 O 3 291.52 1 99 1. 2 655 1,425 2 2 2 3 5.2 5.67 2 2 2. 10 12,161 t 9,753 t 2,408 t 4 3. 1 2 3 4. LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum
橡96-01.PDF
1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20
,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
![化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]](/thumbs/39/20157433.jpg "化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]")
1,3-1,3- (1) 1,3-1,3- - CAS 542-75-6 C 3 H 4 Cl 2 110.97 2 1) -84 2) 108 2,3) 112 (trans-) 4) 104 (cis-) 4) 1.225 (20 ) 2) 5.2 kpa (39 mmhg) (25 ) 2) 4.5 kpa (34 mmhg) (25 ) 4) 5.7 kpa (43 mmhg) (25 )
橡三酸化二アンチモン.PDF
1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
CAS H 3 C C CH 2 C 9 H tert d = hpa
1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21
,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
橡アジポニトリル.PDF
1 200117 21512( ) CAS 111693 110( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N 2 108.14 1) 99 2-1. 2) 1 2) 295 2) 159(c.c.) 3) 550 3) 1.7-4.9 vol % ( ) 3) d 20 0.965 2) 3.73 ( = 1) 4 0.3 Pa (0.002 mmhg) (20) 2) log
t 492 t mg/l 30 mg/l BOD 95 OH = cm 3 / sec 25 8 OH /cm 3 12 = ph ph
2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
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(1) 1,2- DMP CAS 131-11-3 C 10 H 10 O 4 194.2 2 1) 5.5 2,3) 283.7 2,3) 1.192 (20 ) 4) 133 Pa (1 mmhg) (20 ) 5) 1ppm=7.94 mg/m 3 at 25, n- / 1.56 ( ) 6) 4) ( )3.2 (30 ph 7)11.6 (30 ph 9)25 (18 ph 9) 5)
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BCF: Bioconcentration Factor EC 50 : Median Effect Concentration 1 50 EEC: Estimated Environmental Concentration EHI: Estimated Human Intake EUSES: Europian Union System for the Evaluation of Substances
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（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果
1,4-1 1,4- p- 1, 4-1, 4- CAS 123-91-1 C 4 H 8 O 2 88.11 2 1) 2) 11.80 3) 1- / (logp ow ) 101.1 760 mmhg 3) 1.033720 4) 37 mmhg25 5) 1 ppm = 3.60 mg/m 3 at 25, 6) -0.27 7) 8) 9) 3 7) 7) 10) 11) OH NO NO
0774 CAS No. 111-15-9 2014 3 25 0774 1 3 1 3 11 3 12 3 13 3 2 3 3 4 31 4 32 4 4 4 5 1 5 11 5 12 5 13 5 14 5 15 5 16 6 17 6 2 7 21 7 22 7 23 7 1 7 2 8 3 8 3 8 31 8 32 9 33 9 34 9 35 9 36 9 37 10 1 10
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
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p,p -DDT 1 p,p -DDT 1,1,1- -2,2- (4- ) CAS 50-29-3 C 14 H 9 Cl 5 354.5 2 109 1) 260 2) 1.5 1) 1.6010-7 mmhg (20 ) 3) 1ppm=14.50 mg/m 3 at 25, n- / 6.366.38 1) 1) 3 4) BOD 0 % ( 2 100 mg/l 30 mg/l) 4) BCF5,10024,400
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化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
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(1) CAS 108-88-3 C 7 H 8 92.13 2 3.14 1) -95 2) 110.6 2) 0.866 (20 ) 2) 2.93 kpa (22 mmhg) (20 ) 3) 5.33 kpa (40 mmhg) (31.8 ) 3) 1ppm=3.77 mg/m 3 at 25, n- / 2.69 ( ) 3) 4) 4) 0.067 % (w/w) (23.5 ) 2,5)
資料２
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平成26年度 化学物質分析法開発報告書
N,N- N,N-Dimethylacetamide Acethyldimethylamine CAS 127-19-5 C 4 H 9 NO 87.12 ~ 87.14 87.68413 163-165 C 1) - 18.59 C 2) 1 mg/l 25 C 3) 3.3 hpa 2 C 4) log P ow -.77 2).9429 2/4 C 1) 3.1 4) 1.31E - 8 atm-m
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Quantitative Risk Assessment on the Public Health Impact of Pathogenic Vibrio parahaemolyticus in Raw Oyster 1 15 5 23 48 2 21 1 16 1 16 1 11 3 1 3 4 23 1 2 16 12 16 5 6 Hazard IdentificationExposure
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[Styrene dimer, CAS No. 25247-68-1; Styrene trimer, 28213-80-1] -1,2 C 16 H 16 C 24 H 24 208.2 312.3 4 7 2-1,2 CH 2 CH 2 2,4- -1-2,4,6- -1-1,2-1,3,5-760 21,430 g/g 9,590 g/g 2 3 HSDB, 2001 ; 2, 1998; 3
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資料３ 諸外国における位置づけ
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報告書 H22-2A-09
061-0293 1757 TEL 0133-23-1211 2.0% 0.5% in vitro QOL Quality of Life 1 MCE-400 400 mpa s Duck Algin 350M M/G 0.8 70 80 C 20% 50 C 1.0% 5 C SV-10 5 C 10 ml E TV 20H model E 1 34 R24 1 ml 5 C 30 6 12 30
（Ⅱ）化学物質の環境リスク初期評価（13物質）の結果
1 CAS 75-01-4 C 2 H 3 Cl 62.50 2 1) 2) 1) -153.7 3) -13.3 3) 1- / (logp ow ) 0.910620 3) 4) 2980 mmhg25 1 ppm = 2.56 mg/m 3 at 25, 5) 1.52 9.91 ph 7, 25 6) 5) 8.8 g/ml25 7) 3 OH OH 510 5 /cm 3 10) ( )
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CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation
CHEMOTHERAPY CHEMOTHERAPY Fig. 1 Body weight changes of pregnant mice treated orally with AM- 715 Day of sestation CHEMOTHERAPY Table 1 Preliminaly test of AM- 715 1): Mean } SD *: Significant difference
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Key words: E. coli O 157: H7, fosfomycin, verotoxin, mouse infection
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平成26年度 化学物質分析法開発報告書
2,2-2,2 -Iminodiethanol Diethanol amine CAS 111-42-2 C 4 H 11 NO 2 105.1356-105.0790-28 C 1) 1.0881 g/cm 3 1)
VOL. 21 NO. 2 CHEMOTHERAPY 395
394 CHEMOTHERAPY MAR. 1973 VOL. 21 NO. 2 CHEMOTHERAPY 395 396 CHEMOTHERAPY MAR. 1973 VOL. 21 NO. 2 CHEMOTHERAPY 397 398 CHEMOTHERAPY MAR. 1973 VOL. 2 1 NO. 2 CHEMOTHERAPY 399 400 CHEMOTHERAPY MAR. 1973
CHEMOTHERAPY APR. 1984
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平成26年度 化学物質分析法開発報告書
2,2-2,2 -Iminodiethanol Diethanol amine CAS 111-42-2 C 4 H 11 NO 2 105.1356-105.0790-28 C 1) 1.0881 g/cm 3 1)
参考資料５ 農薬評価書 メタアルデヒド（食品安全委員会資料）
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Isotope News 2017年10月号 No.753
Ishioka Noriko ₁ はじめに RI RI RI RI ₂ 悪性褐色細胞腫と治療の現状 3,000 90 I meta- Iiodo-benzylguanidine I-MIBG 1 ₃ α 線の標的アイソトープ治療 2016 6 223 RaCl2 223 Ra 223 Ra 14 表 1 α 線と β 線の違い -decay (42%) Eα = 5.9 MeV At 7.2 h EC
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CHEMOTHERAPY APR Fig. 1 Chemical structure of cefotetan (CTT, YM09330)
CHEMOTHERAPY APR. 1982 Fig. 1 Chemical structure of cefotetan (CTT, YM09330) VOL.30 S-1 CHEMOTHERAPY Fig. 2 Comparison of standard curves of CTT on various test organisms by cylinder plate method Column
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137 7 33 pco 2 2005 pco 2 340ppm pco 2 http://www.data.kishou.go.jp/kaiyou/shindan/sougou/html/1.4.html GEOSECS Geochemical Ocean Sections Study Nakano et al.(2006) 1 pco 2 500m 500ppm 1,000m 1,000ppm
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1% 1 mg 1 mg 2 CTD 6 Section 2.6.1 Introduction 2.6.1 H 1 descarboethoxyloratadinesch 34117 7.9 SCH 34117 2.6.1-1 O OC 2 H 5 Cl N N JAN Loratadine (JANINN) ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]
CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection
20mg CTD 2.4 2.4 2.4... 5 2.4.1... 5 2.4.2... 7 2.4.3... 10 2.4.4... 13 2.4.5... 18 2.4.6... 20 3 2.4 2.4 2.4.1 JNS002 ( HSPC) N-(Carbonyl-methoxypolyethylene glycol 2000)-1,2- distearoyl-sn-glycero-3-phosphoethanolamine
Fig. 1. Structures of NM394, NAD-358 and NAD-245 Fig. 2. Typical HPLC chromatograms of NM394 in human plasma by organic solvent extraction method (a): Blank plasma (b): Plasma spiked with NM394 and internal
PowerPoint プレゼンテーション
ICH 日本シンポジウム 2015 平成 27 年 7 月 23 日 M7 Addendum: DNA 反応性 ( 変異原性 ) 不純物の評価及び管理 国立医薬品食品研究所 変異遺伝部 本間正充 これまでの経緯と進捗状況 2010 年 6 月タリン会議 SC でトピック化決定 2010 年 11 月福岡対面会議 (1) ガイドラインタイトルの変更, 適用範囲, 一般原則 2012 年 11 月サンディエゴ対面会議
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OECD OECD NOEC 14 7296 LC 50 EC 50 7296 4896 OECD TG210Fish, Early-life Stage toxicity Test ISO 12890Water quality - Determination of toxicity to embryos and larvae of freshwater fish Semi-static method
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