ARE : AU-rich element eef1a : eukaryotic elongation factor 1A eif : eukaryotic initiation factor erf : eukaryotic releasing factor NMD : nonsense-medi

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1 Regulation of mrna decay in eukaryote

2 ARE : AU-rich element eef1a : eukaryotic elongation factor 1A eif : eukaryotic initiation factor erf : eukaryotic releasing factor NMD : nonsense-mediated mrna decay Nudix : nucleoside dephosphate linked to some PABP other moiety, X : poly (A) -binding protein PRE : polypyrimidine-rich element TTP : tristetraprolin

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7 GAPDH (glyceraldehydes 3-phosphate dehydrogenase), AUH (enoyl CoA hydratase), 3-oxoacyl-CoA thiolase - Hsp (heat shock protein) 70, Hsc70, CUGBP2, KSRP,

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11 1) Carneiro, M., Schibler, U. : J. Mol. Biol., 178, (1984) 2) Yoshida, T., Wakiyama, M., Yazaki, K., Miura, K.: J. Electron Microsc.. 46, (1997) 3) Yazaki, M., Yoshida, T., Wakiyama, M., Miura, K.: J. Electron Microsc., 49, (2000) 5) Wells, S. E., Hillner, P., Vale, R., Sachs, A. B.: Mol. Cell, 2, (1998) 6) Caponigro, G., Parker, R. : Microbiol. Rev., 60, (1996) 7) Cao, D., Parker, R. : RNA, 7, (2001) 9) Freischmeyer, P. A., van Hoof, A., O'Donnell, K., Guerrerio, A. L., Parker, R., Dietz, H. C. : Science, (2002)

12 10) Van Hoof, A., Freshmeyer, P. A., Dietz, H. C., Parker, R. Science, 295, (2002) 11) Tucker, M., Valencia-Sanchez, M. A., Staples, R. R., Chen, J., Denis, C. L., Parker, R. : Cell, 104, (2001) 12) Tucker, M., Staples, R. R., Valencia-Sanchez, M. A., Muhl rad, D., Parker, R. : EMBO J., 21, (2002) 13) Chen, J., Chiang, Y.-C., Denis, C. L. : EMBO J., 21, (2002) 14) Gao, M., Fritz, D. T., Ford, L. P., Wilusz, J.: Mol. Cell, 5, (2000) 15) Baggs, J. E., Green, C. B. : Curr. Biol., 13, (2003) 16) Steiger, M., Curr-Schmid, A., Schwartz, D. C., Kiledjian, M., Parker, R.: RNA, 9, (2003) 17) Van Dijk, E., Cougot, N., Meyer, S., Babajko, S., Wahle, E., Seraphin, B.: EMBO J., 21, (2002) 18) Wang, Z., Jiao, X., Carr-Schmid, A., Kiledjian, M. : Proc. Natl. Acad. Sci. USA, 99, (2002) 19) Lykke-Anderson, J.: Mot. Cell. Biol., 22, (2002) 20) He, W., Parker, R.: Curr. Opin. Cell Biol., 12, (2000) 21) Zhang, S., Williams, C. J., Hagan, K., Peltz, S. W.: Mot. Cell. Biol., 19, (1999) 22) Coller, J. M., Tuker, M., Sheth, U., Valencia-Sanchez, M. A., Parker, R. : RNA, 7, (2001) 23) Schwartz, D., Decker, C. J., Parker, R.: RNA, 9, (2003) 24) Tharum, S., Parker, R. : Mot. Cell, 8, (2001) 25) Bashkirov, V. I., Scherthan, H., Solinger, J. A., Buerstedde, J.-M., Heyer, W.-D.: J. Cell Biol., 136, (1997) 26) Ingelfinger, D., Arndt-Jovin, D. J., Luhrmann, R., Achsel, T. : RNA, 8, (2002) 27) Van Hoof, A., Parker, R.: Cell, 99, (1999) 28) Brewer, G. : J. Biol. Chem., 273, (1998) 29) Ford, L. P., Watson, J., Keene, J. D., Wilusz, J.: Genes Dev., 13, (1999) 30) Wang, Z., Kiledjian, M. : Cell, 107, (2001) 31) Chen, C.-Y., Gherzi, R., Ong, S.-E., Chan, E. L., Raijmakers, R., Pruijn, G. J. M., Stoecklin, G., Moroni, C., Mann, M., Karin, M. : Cell, 107, (2001) 32) Mukherjee, D., GAO, M., O'Connor, J. P., Raijmakers, R., Pruijn, G., Lutz, C. S., Wilusz, J.: EMBO J., 21, (2002) 33) Liu, H., Rodgers, N. D., Jiao, X., Kiledjian, M. : EMBO J., 21, (2002) 34) Rodgers, N. D., Wang, Z., Kiledjian, M.: RNA, 8, (2002) 35) Rodgers, N. D., Wang, Z., Kiledjian, M. : J. Biol. Chem., 277, (2002) 36) Wang, Y., Liu, C. L., Storey, J. D., Tibshirani, R. J., Herschlag, D., Brown, P. 0. : Proc. Natl. Acad. Sci. USA, 99, (2002) 37) Chen, C.-Y. A., Shyu, A.-B.: Trends Biochem. Sci., 20, ) 38) Laroia, G., Cuesta, R., Brewer, G., Schneider, R. : Science, 284, (1999) 39) Mukhopadhyay, D., Houchen, C. W.. Kennedy, S., Dieck graefe, B. K., Anant, S.: Mot. Cell, 11, (2003) 40) Russell, J. E., Morales, J., Liebhaber, S. A.: Prog. Nucl. Acid. Res., 57, (1997) 41) Tillmar, L., Carlsson, C., Welsh, N. : J. Biol. Chem., 277, (2002) 42) Winzen, R., Kracht, M., Ritter, B., Wilhelm, A., Chen, C.-Y. A., Shyu, A. B., Muller, M., Gaestel, M., Resch, K., Holt mann, H. : EMBO J., 18, (1999) 43) Stoecklin, G., Ming, X.-F., Looser, R., Moroni, C. : Mot. Cell. Biol., 20, (2000) 44) Carballo, E., Lai, W. S., Blackshear, P. J.: Science, 281, (1998) 45) Vasudevan, S., Peltz, S.: Mot. Cell, 7, (2001) 46) Chen, C.-Y., Gherzi, R., Andersen, J. S., Gaietta, G., Jurchott, K., Royer, H.-D., Mann, M., Karinm M.: Gene. Dev., 14, (2000) 47) Nakamura, Y., Ito, K.: Trends Biochem. Sci., 28, (2003) 48) Hoshino, S., Imai, M., Kobayashi, T., Uchida, N., Katada, T.: J. Biol. Chem., 274, (1999) 49) Czaplinski, K., Ruiz-Echevarria, M. J., Paushkin, S. V., Han, X., Weng, Y., Perlick, H. A., Dietz, H. C., Ter-Avanesyan, M. D., Peltz, S.: Gene. Dev., 12, (1998) 50) Jacobson, A., Peltz, S. W. : in Translation control of gene expression (ed. Sonenberg, Harbor Laboratory Press, New York (2000) N.), pp , Cold Spring 51) Uchida, N., Hoshino, S., Imataka, H., Sonenberg, N., Katada, T. : J. Biol. Chem., 277, (2002)

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