SAICM Strategic Approach to International Chemical Management SAICM OECD SIDS Initial Assessment Report 2006 NEDO
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2 SAICM Strategic Approach to International Chemical Management SAICM OECD SIDS Initial Assessment Report 2006 NEDO
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4 CAS
5 PNEC AIST-SHANEL
6 N,N- =N- AO, 2001, 2004 OECD NOAEL EHE MOE AIST-SHANEL AIST-Standardized Hydrology-based Assessment tool for chemical Exposure Load PEC PNEC 1
7 1. (AO) R 3 N + -O R 3 N=O R 3 N O AO AO 1.1 CAS AO CAS R N + (CH 3 ) 2 O R C 12 N,N =N C 12 AO C 10 C 16 AO 1. CAS CAS C 10 AO N,N =N C 12 AO N,N =N C 14 AO N,N =N C 16 AO N,N =N C AO N,N C =N AO N,N =N 1.2 CH 3 C n H 2n+1 N O (n=10 16) CH C AO 2 2. C AO C 10 AO C 12 H 27 NO C 12 AO C 14 H 31 NO C 14 AO C 16 H 35 NO C 16 AO C 18 H 39 NO
8 2. C AO C 12.6 AO C 12.6 AO C 12.6 AO Devinsky et al. (1985) TSCA ITC (1983) Pa TSCA ITC (1983) 4.1 The Procter&Gamble Co. (2002A) (g/l) The Procter&Gamble Co. (2002B) n log <2.7 The Procter&Gamble Co. (2002C) 3-2. EPIWIN (ver 3.0) AO C 10 AO C 12 AO C 14 AO C 16 AO Pa C 12 AO AO t t t t * 3.2 AO 5 AO 3
9 5. AO (%) AO AO 1 AO AO AO AO PRTR 1 4
10 5. NEDO C 12 AO SIDS Initial Assessment Report For SIAM 22 DRAFT C 12 AO AO AO EHE NOAEL AO C 12 AO LD mg/kg 1267 mg/kg LD mg/kg 271 mg/kg LD mg/kg The Procter & Gamble Co., 1976B, 1978I; U.S. NIOSH, 2002;, 1990 C 12 C AO 3 2 ml/kg 520mg AO/kg LD mg/kg (C AO) The Procter & Gamble Co., 1978A, 1978B, 1978C, 1978D; Hoechst AG, 1978, 1983A, 1987; Onyx Chemical, 1985A, 1985B C 12 AO 2 mg 24 1% ( ) U.S. NIOSH, 2002 C 12 AO 1 % 5 ~30 % Onyx Chemical Co., 1973A, 1973B, 1986; Hoechst AG, 1978B, 1983B, 1983C, 1983D; The Procter & Gamble Co., 1978E, 1978F, 1978G C 12 AO 0.2 % 0.1 ml % 0.3 5
11 ml % 0.5 % Maximization, 1990 C AO as is % (v/v) Buehler The Procter & Gamble Co., 1978H AO NOAEL mg/kg/day 80 mg/kg/day mg/kg/day 52.6 mg /kg/day 6. AO NOAEL (mg/kg/day) LOAEL (mg/kg/day) (mg/kg/day) C AO C AO C AO LOAEL 112 0, 63, 112, , 80, 150, / 0, 40, 196, 390 0, 39, 195, , 4.24, 42.3, , 5.23, 52.6, 107 The Procter & Gamble Co. (1980) The Procter & Gamble Co. (1977A) Cardin et al. (1985) C 12 AO 0, 50, 100, 200 mg /kg/day 20 2/3 C 12 AO 200 mg/kg/day 6-18 C 12 AO 0, 40, 80, 160 mg/kg/day 29 6
12 6-19 AO 7. AO NOAEL (mg/kg/day) NOAEL (mg/kg/day) (mg/kg/day) 6.5 C 12 AO ,750,1500, 3000ppm, Lion Corp. 0,188,375,750ppm (750 ppm 40 mg/kg (1979) /day ) F0; 7-17 (F0; 20 2/3 100 C 12 AO 100 (200; (200; F1 10 ) 20 ) ) 0, 50, 100, 200 Lion Corp. (1980) C 12 AO F0; , 40, 80, Lion Corp. (1981) C AO F0; (100; (100; 0, 25, 100, 200 ) 25 ) The Procter & Gamble Co. (1999) C 12 AO S9 250 g/plate DNA Inoue et al., 1980 C 12 AO mg/kg AO 7
13 The Procter & Gamble Co., ( C AO) AO % (w/v) 104 AO % (w/v) 0.1 ml 1 / 3 / 104 Cardin et al, AO AO AO AO 7 % 3 % AO AO cm 2 Human & Environmental Risk Assessment on Ingredients of Household Cleaning Products cm 2 1/2 THE SCCP'S NOTES OF GUIDANCE cm 2 AO C 12 AO g/ /cm 2 Rice, kg 1) 1980 (cm 2 ) ( g/ / cm 2 ) 45/60( ) 3 / /50 (kg) 4.10 ( g/kg/ ) 2) 1440 (cm 2 ) ( g/ / cm 2 ) 10/60 ( ) 1 / /50 (kg) 0.22 ( g/kg/ ) 8
14 3) (cm 2 ) ( g/ / cm 2 ) 10/60 ( ) 1 / /50 (kg) 2.32 ( g/kg/ ) ) AO C 12 AO g/ cm cm 2 / / 120 cm cm 2 50 AO 4.81 g/ / (, 1990) 50kg AO ( g/cm 2 ) 3700(cm 2 / / ) /50(kg) 0.10 ( g/kg/ ) 2) AO AO 0.78 g/g 1.4 g/g 0.17 g/g 0.24 g/g (, 1990) 1.4 g/g 0.24 g/g g/ g/ 15 AO 1.4 ( g/g) 283.9(g/ / ) 0.24 ( g/g) 116.4(g/ / ) /50 (kg) 8.51( g/kg/ ) 3) 2L/ AO g/l 0.08 g/l 0.08 g/l, ( g/l) 2(L/ / ) 0.16 ( g/ / ) 9
15 5.2.3 EHE 8 AO EHE 15( g/kg/ ) 8. ( g/kg/ ) EHE NOAEL EHE (MOE) NOAEL NEDO 104 NOAEL MOE NOAEL 42.3 mg/kg/day MOE AO MOE NEDO NOAEL / EHE 42.3 (mg/kg/ )/0.015(mg/kg/ ) 2820 NEDO 100 SIDS Initial Assessment Report For SIAM 22 DRAFT NOAEL overall NOAEL weight of evidence approach 80 mg/kg/day 91 10
16 NOAEL LOAEL NOAEL MOE MOE SIDS NOAEL / EHE 80(mg/kg/ )/0.015(mg/kg/ ) 5333 SIDS 100 MOE NEDO 2820 SIDS Initial Assessment Report For SIAM 22 DRAFT AO 11
17 6. AO OECD Belanger et al, 1996; NEDO, 2007; OECD, 2006; Sanderson et al., 2009 AO C 12 AO 100 mg/l 30 mg/l 28 (BOD) GC 63 % 100 %, 1995 C 12 AO AO OECD 9 AO The Procter&Gamble, 1996B; The Procter&Gamble, 1996F; Vandepitte and Debaere, 2007 AO 9. AO (%) C 10 OECD 301E 97 Th. Goldschmidt AG (1997) C 12.9 OECD 301B 63 The Procter&Gamble (1977B) C 13 OECD 301D 93 Akzo Chemie (1987) C 13.5 OECD 301D 82 Akzo Nobel Chemicals (1990I) C 17.2 OECD 301D 79 Akzo Nobel Chemicals (1990G) C 18 OECD 301D 60 Akzo Chemical International B.V. (1990G) AO 10 AO OECD 303A 99 % % AO 12
18 AO 10. AO C 12 C C 12 C OECD 303A >99.8% The Procter&Gamble Co.(1996E) >99.8% The Procter&Gamble Co.(1996D) >99% 2003B >96% The Procter&Gamble Co.(2001), >94.9% >99.5% The Procter&Gamble Co.(1996A) AO 11 AO Pseudokirchneriella subcapitata 72hr 50% EC 72hr 20% ErC, 10% ErC mg/l mg/l Desmodesmus subspicatus 72hr EC 50 72hr ErC 20, ErC mg/l mg/l 72hr EC mg/l 11. AO mg/l <C 13 72hr EC * Pseudokirchneriella OECD (2006) C hr ErC 20, ErC ** subcapitata C 12 C 18 72hr ErC 20, ErC Sanderson et al. (2009) <C 13 72hr EC * Desmodesmus OECD (2006) C hr ErC 20, ErC ** subspicatus C 12 C 18 72hr ErC 20, ErC Sanderson et al. (2009) <C 13 Chlorella 1.7 Diatoma 72hr EC Anabaena 5.3 OECD (2006) *Bruce and Versteeg (1992) **Fendinger et al. (1994) C
19 6.2.2 AO 12 C 12 AO 48hr EC mg/l 21 NOEC 0.36 mg/l AO mg/l 12. AO mg/l C 12 Daphnia magna 48hr EC day NOEC 1996B Kao (2001B) B 21day NOEC 0.7 Maki (1979) C 13 C hr EC 50 >C C day NOEC0.28 OECD (2006) AO 13 C 12 AO 96hr 50% LC 29.9 mg/l mg/l 302 NOEC 0.42 mg/l AO 14
20 13. AO mg/l C 12 C 13 C 14 Oryzias latipes 96hr LC B Pimephales promelas 96hr LC day NOEC day NOEC> day NOEC day NOEC > day NOEC day NOEC>0.88 Danio hr LC 50 Oncorhynchus 13 >C 16 Danio 96hr LC Procter&Gamble (1976A) OECD (2006) 6.3 PNEC PNEC SSD: Species Sensitivity Distribution PNEC Belanger et al, 1996; HERA, 2007; OECD, 2005; OECD, 2006; Sanderson et al., 2009; Versteeg et al., 1999;, 2010 SSD PNEC 14 1 Belanger et al, 1996; Sanderson et al., 2009 SSD Versteeg et al., 1999; Sanderson et al., 2009 SSD PNEC PNEC 15
21 14. PNEC PNEC g/l Belanger et al.(1996), 50 Sanderson et al.(2009) C 12.9 SSD 23 Sanderson et al.(2009) AO 15 AO 2002 C AO Miura et al., 2008;, AA C g/l AO g/l 0.12 g/l,2003b;, AO AO 0.12 g/l 95 PEC 16
22 15. ( ) / g/l nd 1.9 nd 0.37 nd g/l g/l nd 1.AO AIST-SHANEL AIST-SHANEL Ishikawa et al., 2007 PRTR 1 km LAS Ishikawa et al., 2007 AO 16 17
23 17 AO g/l PEC g/l The Procter&Gamble Co.(1996D, 1996E) NEDO (2007) (g/l) 190 Brown et al.(1975) Koc L/kg PcKoc Win (2003) (day) 4 OECD (2006) 17. g/l g/l < < < < < < <
24 18. AIST-SHANEL AO g/l * * 6.5 PEC PNEC 19 PEC SSD PNEC 19. PEC PNEC PEC g/l PNEC g/l SSD AO 19
25 8. 1) Akzo Chemie (1987) Biodegradability of a number of nitrogen derivatives (MU-30). 2) Akzo Nobel Chemicals (1990I) Biodegradation of CAS RN ) Akzo Nobel Chemicals (1990G) Biodegradation of CAS RN ) Akzo Chemicals International B.V. (1990G) Biodegradability of CAS RN ) Belanger, S.E., Rupe, K.L., Lowe, R.L., Johnson, D. and Pan, Y. (1996) A flow-through laboratory microcosm suitable for assessing effects of surfactants on natural periphyton. Environ. Toxicol. Water. Quality. 11, ) Brown, S.L., Chan, F.Y., Jones, J.L., Liu, D.H. and Mc. Caleb., K.E. (1975) Research program on hazard priority ranking of manufactured chemicals (chemicals 61-79). NTIS PB Stanford Res. Inst., Menlo Park. CA. 7) Cardin, C.W., Domeyer, B.E. and Bjorkquist, L. (1985) Toxicological evaluation of commercial alkyldimethylamine oxides: Two-year chronic feeding and dermal studies. Fundam. Appl. Toxicol., 5, ) Devinsky, F, Leitmanova, A, Lacko, I and Krasnec, L. (1985) Amine Oxides-XIII: Iodine complex with non-aromatic amine oxides. Tetrahedron., 41, ) European Union (EU) (2003) Technical Guidance Document on Risk Assessment in support of Commission Directive 93/67/EEC on Risk Assessment for new notified substance, 337 pp. 10) HERA (2007) Linear Alkylbenzene sulphonate. Version 3.0, October ) Hoechst AG(1978B) Orientierende Prüfung auf Haut- und Schleimhautverträglichkeit von CAS RN (dimethylcocosfettaminoxid 30%ig) an Kaninchen. 12) Human & Environmental Risk Assessment on Ingredients of Household Cleaning Products, Guidance Document Methodology(2005) 13) Hoechst AG(1978) Akute orientierende orale Toxizität von CAS RN (dimethylcocosfettaminoxid 30%ig in Wasser), an weiblichen SPF-Wistar-Ratten. 14) Hoechst AG(1978B) Orientierende Prüfung auf Haut- und Schleimhautverträglichkeit von CAS RN (dimethylcocosfettaminoxid 30%ig) an Kaninchen. 15) Hoechst AG 1983 CAS RN ; Prüfung der akuten oralen Toxizität an der männlichen und weiblichen Wistar-Ratte. 16) Hoechst AG(1983B) CAS RN ; Prüfung auf Acute dermale Reizwirkung / Ätzwirkung am Kaninchen. 17) Hoechst AG(1983C) CAS RN ; Prüfung auf Acute dermale Reizwirkung / Ätzwirkung am Kaninchen. 18) Hoechst AG(1983D) Hoe S 3406; Prüfung auf akute dermale Reizwirkung/Âtzwirkung am Kaninchen. 19) Hoechst AG(1987) CAS RN Testing for Acute Oral Toxicity in the Male and 20
26 Female Wistar Rat. 20) Inoue, K., Sunakawa, T. and Takayama, S. (1980) Studies of in vitro cell transformation and mutagenicity by surfactants and other compounds. Food Cosmet. Toxicol., 18, ) Kao (2001A) Amphitol 20N: Algal inhibition test. Safepharm Lab. Ltd., SPL project No. 140/ ) Kao (2001B) Amphitol 20N: Acute toxicity to Daphnia magna. Safepharm Lab. Ltd., SPL project No. 140/ ) Lion Corporation (1979B) Surfactant A: Effects upon the reproduction of rats treated continuously through two successive generations. 24) Lion Corporation (1980) Surfactant A: Effects of Oral Administration upon Pregnancy in the Rat (Segment II Study), sponsored by Lion Corporation Laboratory: Life Science Research, Essex, England. 25) Lion Corporation (1981) Surfactant A: Effects of oral administration upon pregnancy in the rabbit. 2. Main teratology study. 26) Maki, A. W. (1979) Correlation between Daphnia magna and Fathead minnow (Pimephales promelas). Chronic toxicity value for several classes of test substances. J. Fish Res. Board Can., 36, ) Miura, K., Nishiyama, N. and Yamamoto, A. (2008) Aquatic Environmental Monitoring of Detergent Surfactants. J. Oleo Sci., 57, ) OECD (2005) Linear Alkylbenzene Sulphonate (LAS), SIDS Initial Assessment Report. 29) OECD (2006) Amine Oxides: SIDS Initial assessment report for SIAM 22 and SIDS Dossiers (Draft). 30) Onyx Chemical Corporation(1973) Skin irritation test with rabbits. Leberco Laboratories, report # ) Onyx Chemical Corporation(1973B) Skin irritation test with rabbits. Leberco Laboratories, report # ) Onyx Chemical Co.(1985) Acute oral toxicity study with rats. Leberco Testing Inc., report # ) Onyx Chemical Co.(1985B).Acute rat oral study. Leberco Testing Inc. Assay # ) Onyx Chemical Company (1986).Report on primary skin irritation. 35) Rice, D.P. (1977) The absorption, tissue distribution, and excretion of dodesyldimethylamine oxide (DDAO) in selected animal spesies and the absorption and excretion of DDAO in man. Toxicol. Appl. Pharmacol., 39, ) SRC, Syracuse Research Corporation (2003) PcKocWin Estimation Software, ver North Syracuse, NY. 37) Sanderson, H., Tibazarwa, C., Greggs, W., Versteeg, D.J., Kasai, Y., Stanton, K. and Sedlak, R.I. 21
27 (2009) High production volume chemical amine oxide [C 8 -C 20 ] category environmental risk assessment. Risk Analysis., 29, ) Th. Goldschmidt AG (1997) Biologische Abbaubarkeit im modifizierten OECD Screening Test. Report#970303GS. 39) The Procter & Gamble Company (1976) Acute, subchronic and chronic effects of NPS on the fathead minnow (Pimephales promelas). 40) The Procter & Gamble Company(1977A) 32-Week feeding study of UDL-1000 in rabbits. 41) The Procter & Gamble (1976B) Initial submission: Acute intraperitoneal lethal dose toxicity study with UDL-1403 in rats. with cover letter dated and attachment., Scientific Assossiates Inc., S.A. No EPA Doc. No , NTIS OTS ) The Procter & Gamble Company (1977B) A biodegradability study of dodecyl-dimethylamineoxide (DDAO). 43) The Procter & Gamble Company(1978) Acute oral LD50 toxicity study of dodecyldimethylamine oxide in rats. 44) The Procter & Gamble Company (1978B) Acute Percutaneous Toxicity Study in Rabbits. 45) The Procter & Gamble Company (1978C) Acute Percutaneous Toxicity Study in the Albino Rabbit. 46) The Procter & Gamble Company (1978D) Acute percutaneous toxicity study of P0434 in rabbits. 47) The Procter & Gamble Company(1978E) Primary Eye Irritation Study in the Albino Rabbit. 48) The Procter & Gamble Company(1978F) Primary Eye Irritation Study in the Albino Rabbit. 49) The Procter & Gamble Company(1978G) Rabbit Eye Irritation Study of P ) The Procter & Gamble Company(1978H) Delayed Contact Hypersensitivity Study in Guinea Pigs of P0434. Report # ) The Procter & Gamble Company(1978I) Initial submission: K : Acute dermal toxicity (LD50) study in albino rabbits. with cover sheet and letter dated , Scientific Assossiates Inc., S.A. No , EPA Doc. No , NTIS OTS ) The Procter & Gamble Company (1980) Thirteen week subchronic dietary administration to male and female rats - P ) The Procter & Gamble Company (1983) The evaluation of dimethyl dodecylamine (DDAO) in the dominant lethal assay. Conducted: October 1(1975) R&D Report. Notebook V8192 pp ) The Procter & Gamble Company (1996A) C12/14 Amine oxide (AO) Dutch monitoring results ) The Procter & Gamble Company (1996B) Die-away of radiolabeled substrates in anaerobic sludge. 22
28 56) The Procter & Gamble Company (1996D) Effluent in river die away test with 14 C- Dimethyldodecylamine Oxide (DDAO) and intermediates. 57) The Procter & Gamble Company (1996E) Fate of 14 C-Dimethyldodecylamine Oxide (DDAO) during activated sludge treatment (CAS Test). 58) The Procter & Gamble Company (1996F) Mineralization of radiolabeled test substance in anaerobic sludge. 59) The Procter & Gamble Company(1999A) Data summary for two amine oxides, including test summaries. 60) The Procter & Gamble Company (2001) North American monitoring study for alcohol ethoxylates, amine oxide, perfume raw materials and linear alkylbenzene sulfonate. Study #E ) The Procter & Gamble Company (2002A) Determination of the adsorption of TSIN GTS02902 onto Three Soils. 62) The Procter & Gamble Company (2002B) Determination of the Dissociation Constant in Water of TSIN GTS02902 (Titration method). 63) The Procter & Gamble Company(2002C) Determination of the n-octanol/water partition coefficient (HPLC method). Test substance ID TSIN GTS ) The SCCP'S notes of guidance for the testing of cosmetic ingredients and their safety evaluation 6th revision 65) TSCA ITC (1983) Interagency Testing Committee. Information Review Dimethyl (C10-C16 Alkyl) Amine N-oxides. EPA Contract No CRCS Inc., Reston, Virginia, USA and Dynamac Corporation, Rockville, Maryland, USA. 66) U.S. NIOSH, National Institute for Occupational Safety and Health (2002) Registry of Toxic Effects of Chemical Substances, STN online. 67) Versteeg, D.J., Belanger, S.E and Carr, G.J. (1999) Understanding single species and model ecosystem sensitivity: A data based comparison. Environ. Toxicol. Chem., 18, ) 69) ) 2003b ) 1999A 10, N,N- -N- Selenastrum capricornutum. NMMP/E98/1100, ) 1999B 10, N,N- -N- Daphnia magna. 23
29 NMMP/E98/2100, ) 1999B 10, N,N- -N- Oryzias latipes. NMMP/E98/4100, ) ) ) NEDO 2007 Ver. 1.0 No. 21 N,N-Dimethyldodecylamine N-oxide. 77) (1990) - -( ),. 40, ) )
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CAS NC(CH 2 ) 4 CN 1,4- C 6 H 8 N c.c d = Pa
1 200117 21512 CAS 111693 110 NC(CH 2 ) 4 CN 1,4- C 6 H 8 N 2 108.14 1 99 2-1. 2 1 295 159 c.c. 550 3 1.7-4.9 20 d 0.965 4 3.73 = 1 0.3 Pa 0.002 mmhg20 2 log Pow-0.32 m/z 41, 1.0 68 0.54 54 0.43 4 Koc9-16
CAS H 3 C C CH 2 C 9 H tert d = hpa
1 200140 35 CAS 98839 1335-2- H 3 C C CH 2 C 9 H 10 118.18 1 99 4-tert- 1. 2-23.2 2 163164 2 54 574 3 0.96.6 20 d 4 0.9082 2 4.07 = 1 2.5 hpa 1.9 mmhg20 2 4 log Pow3.48 3.44 m/z 118, 1.0 103 0.58 91 0.21
橡アジポニトリル.PDF
1 200117 21512( ) CAS 111693 110( ) 1,4- NC(CH 2 ) 4 CN C 6 H 8 N 2 108.14 1) 99 2-1. 2) 1 2) 295 2) 159(c.c.) 3) 550 3) 1.7-4.9 vol % ( ) 3) d 20 0.965 2) 3.73 ( = 1) 4 0.3 Pa (0.002 mmhg) (20) 2) log
,161 t 9,753 t 2,408 t LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum 6 3 Selenastrum h, Sb
1 20017 1543 CAS 1309644 125 Sb 2 O 3 291.52 1 99 1. 2 655 1,425 2 2 2 3 5.2 5.67 2 2 2. 10 12,161 t 9,753 t 2,408 t 4 3. 1 2 3 4. LC 50 mg/ L EC 50 mg/l * 5 : Selenastrum 6772-h, Sb 2 O 3, : capricornutum
3, ,104 t mg/l 30 mg/l BOD mg 14 C 8, /kg 11 8, 1 11 OH = cm 3 / sec 11 OH /cm ppm
3, 3-1 200019 4800 CAS 91941 1138 3, 3-4, 4 - -3, 3 - H 2 N Cl Cl NH 2 C 12 H 10 C l2 N 2 253.13 1 95 1. 2 3, 4 132-133 402 5 >200 5 700kg/m 3 5 8.73 = 1 5.610-8 kpa 4.210-7 mmhg20 4 6 log Pow3.51 3.57
橡99-24_00 アリルアルコール.PDF
1 9924 2260 CAS 107186 H 2 C CH CH 2 OH 2- -1- C 3 H 6 O 58.08 1 99 1. 2, 3 3, 4, 5-129 96-97 2 21c.c. 24o.c. 2 6, 7 378 6, 7 2.5-18 d 20 4 0.8540 2, 5 2.00 = 1 2.7 kpa 20 mmhg204.3 kpa 32 mmhg30 4 log
橡フタル酸ブチルベンジル.PDF
1 97 7 3 1312 CAS 85 68 7 O BBP 1, 2- C 19 H 20 O 4 312.4 C C O O O (CH 2 ) 3 1 99.9 % 1. 2-35 3 2, 3 370 3, 4 199 d 25 4 1.117 2 10.8 = 1 5 1.15 10-3 Pa 8.6 10-6 mmhg 20 5 253 Pa 1.9 mmhg 200 5 log Pow
t 492 t mg/l 30 mg/l BOD 95 OH = cm 3 / sec 25 8 OH /cm 3 12 = ph ph
2-1 200169 2740 CAS 110-49-6 1103 2- O H 3 C C O CH 2 CH 2 O CH 3 C 5 H 10 O 3 118.13 200168 2-1 99 2-1. 2 2, 3-65 2, 3 144145 45 o.c. 3 392 3 1.512.3 d19 1.009 2 4.07 = 1 30 Pa 0.23 mmhg20 2 4 log Pow0.10
98-02.PDF
1 982 2207 CAS 67630 2- H 3 C H 3 C CH OH C 3 H 8 O 60.10 1 99.9 % n- 1. 2-88.5 3 82.5 3 11.7c.c. 455 4 212 d 20 4 0.78505 3 2.1 = 1 4 4.4 kpa 33 mmhg20 4 log Pow0.05 0.07 5 m/z45, 1.0 43 0.19 27 0.17
CAS O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) % 2- A BHT , 4
2-1 9628 31307 CAS 117817 2- O C O * DOP* DEHP 2- C O O * n- C 24 H 38 O 4 390.56 CH 2 CH 2 CH 2 CH 3 CH (CH 2 ) 3 1 99 % 2- ABHT 1. 2-55 3 3, 4 386 171 350 6 0.1 % d 20 4 0.9861 4 13.48 0.30410-4 Pa 2.2810-7
,309 t 22,069 t 7,240 t µg/l µg/l < ,431-70, , , mg/l m
1 20019 1527 CAS 1317368 1230 PbO 223.20 1 99 1. 2 888 2 9.53 0.017 g/l 20 3 3 2 2. 10 29,309 t 22,069 t 7,240 t 4 1 3. 1 2 3.5 6 1 µg/l 9.1-24 2 µg/l < 43 6 27,431-70,000 4.5-1,300 13.4-17 31.7 0.48-3,459
橡96-01.PDF
1 961 31 CAS 71432 C 6 H 6 78.11 1) 99 % 1. 5.5 2) 80.1 2) -11 3) 293563 3) 1.48.0% 3) d 20 0.8786 4) 2.77 ( = 1) 4) 4 13.33 kpa (100 mmhg) (26.9) 2) log Pow2.13 ( ) 5) 2.14 ( ) 6) m/z78 ( 1.0 )77 ( 0.20
,977 t 157,977 t mg l mg l BOD 9398 % OH = cm 3 / sec 11 = cm 3 / sec OH = /
1 9625 2219 CAS 75569 1, 2-1, 2- H 2 C CH CH 3 C 3 H 6 O 58.08 1 99 % 1. 2 2, 3-112.13 2, 3 34.23-37 449 2.8-37 % 2 d 0 4 0.859 4 d 20 0.8304 2 2, 4 2.00 = 1 53.33 kpa 400 mmhg18 59.33 kpa 445 mmhg20 5
橡三酸化二アンチモン.PDF
1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2) 2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum
0 0 0 0............ PNEC.............................. PNECsed.................. 0 0 0 0 PNEC logpow. * Oncorhynchus mykisslc0. mg/l UFs0,000 0.000 mg/l0. µg/lpnec PNECwater PNECwater * Sangster, J. ()
橡96-07.PDF
1 967 2482 CAS 50000 CH 2 O 30.03 2952% 12.5 % 1. 2) -92 2) -19.5 2) 5085 3) 424 3) 7.073.0% 4) 20 d 4 0.815 5) 1.03 ( = 1) 5) 1.33 kpa (10 mmhg) (-88.0) 2) log Pow0.35 ( ) 6) 0.35 ( ) 7) 1) m/z 29 ( 1.0
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
![化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]](/thumbs/104/163316306.jpg "化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]")
(1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16
SAICM Strategic Approach to International Chemical Management SAICM alkyl ether sulphate; AES) Human & Environmental Risk
1992 21 2002 2006 SAICM Strategic Approach to International Chemical Management SAICM 2009 2011 alkyl ether sulphate; AES) Human & Environmental Risk Assessment on ingredients of household cleaning products
http://www.who.int/ipcs/publications/ehc/en/index.html EHC 1 2 3 4 / EHC http://www.nihs.go.jp/dcbi/publist/ehchsg/ 1-8) WHO/IPCS CICAD (Concise Inter
3 [ ] Priority IARC JMPR 2004 10 Priority 1 Priority 1 Priority 2 Priority 3 Priority 1 1-1) CERI) http://www.cerij.or.jp/ceri_jp/koukai/sheet/sheet_indx4.htm http://www.safe.nite.go.jp/data/sougou/pk_list.html?table_name=hyoka&rank=sh
化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
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1,3-1,3- (1) 1,3-1,3- - CAS 542-75-6 C 3 H 4 Cl 2 110.97 2 1) -84 2) 108 2,3) 112 (trans-) 4) 104 (cis-) 4) 1.225 (20 ) 2) 5.2 kpa (39 mmhg) (25 ) 2) 4.5 kpa (34 mmhg) (25 ) 4) 5.7 kpa (43 mmhg) (25 )
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化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]
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(1) 1,2- DMP CAS 131-11-3 C 10 H 10 O 4 194.2 2 1) 5.5 2,3) 283.7 2,3) 1.192 (20 ) 4) 133 Pa (1 mmhg) (20 ) 5) 1ppm=7.94 mg/m 3 at 25, n- / 1.56 ( ) 6) 4) ( )3.2 (30 ph 7)11.6 (30 ph 9)25 (18 ph 9) 5)
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BCF: Bioconcentration Factor EC 50 : Median Effect Concentration 1 50 EEC: Estimated Environmental Concentration EHI: Estimated Human Intake EUSES: Europian Union System for the Evaluation of Substances
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2,2-2,2 -Iminodiethanol Diethanol amine CAS 111-42-2 C 4 H 11 NO 2 105.1356-105.0790-28 C 1) 1.0881 g/cm 3 1)
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2,2-2,2 -Iminodiethanol Diethanol amine CAS 111-42-2 C 4 H 11 NO 2 105.1356-105.0790-28 C 1) 1.0881 g/cm 3 1)
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資料 4 厚生労働省発薬生 0907 第 69 号平成 3 0 年 9 月 7 日 薬事 食品衛生審議会会長橋田充殿 厚生労働大臣加藤勝信 諮問書 下記の事項について 毒物及び劇物取締法 ( 昭和 25 年法律第 303 号 ) 第 23 条の 2 の規定に基づき 貴会の意見を求めます 記 メルカプト酢酸及びこれを含有する製剤 ( ただし メルカプト酢酸 1% 以下を含有するものを除く ) の毒物及び劇物取締法に基づく劇物の指定について
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32 2008 pp. 93 106 1 Received October 30, 2008 The purpose of this study is to examine the effects of aerobics training class on weight loss for female students in HOKURIKU UNIVERSITY. Seventy four female
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Annual 2002 Report Financial Highlights 2002 2001 2000 2002 2,581,399 2,750,418 2,680,611 19,372 28,402 26,494 11,173 213 4.17 3.89 1.64 $ 0.031 907,150 979,695 889,220 6,807 4,030,596 4,232,011 4,172,459
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1,a) 2 4 WC C WC C Grading Student programs for visualizing progress in classroom Naito Hiroshi 1,a) Saito Takashi 2 Abstract: To grade student programs in Computer-Aided Assessment system, we propose
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