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1 pp. Why are thermophilic proteins thermally stable Satoshi Akanuma, Akihiko Yamagishi Department of Molecular Biology, Tokyo University of Pharmacy and Life Sciences, Horinouchi, Hachioji, Tokyo, Japan N U GNU GNU
2 N U K GNU GNU HNU T SNU GNU GNU GNU Tm Tm Tm Tm GNU Tm Thermus thermophilus - IPMDH IPMDH Tm Tm GNU Tm Tm M Tm T Tm Tm Tm Tm N U X ki U X N X kobs t kobs ku kikf ki t ln kobs
3 kobs t kobs M kobs T t M t T kobs t kobs t kobs t Sulfolobus islandicus DNA ORF Thermotoga maritima LDH LDH Haney Methanococcus jannaschii Methanocaldococcus jannaschii Methanococcus Methanococcus GC Gln Asn Thr SerGln Asn Ser Thr Glu Arg Lys α α α α α α α Glu Met Ala Leu α Petukhov Facchiano α α α α GNU Thermococcus ko-
4 α α NH CO α α dakaraensis HII Dong Ile Leu Ala Cp Cp GNU β Pyrococcus horikoshii CutA CutA T. maritima DNA HU Tm Arg LysGluLys Bacillus stearothermophilus HU Tm GluLys Pyrococcus furiosus P. furiosus Lys Glu Greaves Warwicker Kumer Nussinov IPMDH
5 - IPMDH Tm T. thermophilus IPMDH A IPMDH Tm S. tokodaii IPMDH B IPMDH Sulfolobus tokodaii IPMDH S. tokodaii IPMDH T. thermophilus IPMDH α IPMDH Leu Val Glu Met IPMDH IPMDH Leu Val IPMDH P. horikoshii PhAcP PhAcP IPMDH Bacillus amyloliquefaciens α-tm B. licheniformis α-tm T. thermophilus IPMDH Cp
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